Futibatinib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Futibatinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.102256
TPT1 tumor protein, translationally-controlled 1 0.0786842
MT2A metallothionein 2A 0.0778009
H1-0 H1.0 linker histone 0.07536
B2M beta-2-microglobulin 0.0646135
PTMA prothymosin, alpha 0.0643476
RPS6 ribosomal protein S6 0.0609951
RPS21 ribosomal protein S21 0.0583207
TMSB4X thymosin beta 4, X-linked 0.0563813
LMNA lamin A/C 0.0549916
RPS8 ribosomal protein S8 0.0528606
ENO1 enolase 1, (alpha) 0.0491274
RPLP1 ribosomal protein, large, P1 0.04856
RPS19 ribosomal protein S19 0.0474375
LOC112694756 uncharaterized LOC112694756 0.0467643
RPL8 ribosomal protein L8 0.0465046
RPL37 ribosomal protein L37 0.0457825
STC1 stanniocalcin 1 0.0455188
GNAS GNAS complex locus 0.0447932
TMSB10 thymosin beta 10 0.042906
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0426521
CLU clusterin 0.041624
KRT17 keratin 17, type I 0.0411915
RPL23 ribosomal protein L23 0.0405674
RPL12 ribosomal protein L12 0.0398235
MT1X metallothionein 1X 0.0397186
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0394885
IFITM1 interferon induced transmembrane protein 1 0.0393754
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0388445
EFHD2 EF-hand domain family, member D2 0.0371972
RPS24 ribosomal protein S24 0.0354641
KLF5 Kruppel-like factor 5 (intestinal) 0.0344686
RPL30 ribosomal protein L30 0.0341901
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0341129
FOXP1 forkhead box P1 0.0325986
RPS3 ribosomal protein S3 0.0324188
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0323915
S100A9 S100 calcium binding protein A9 0.0321365
RPL34 ribosomal protein L34 0.0318433
RPL26 ribosomal protein L26 0.0317817
MT1E metallothionein 1E 0.0317639
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0312915
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0308965
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0308438
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0307128
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0294907
S100A6 S100 calcium binding protein A6 0.029011
AOPEP aminopeptidase O (putative) 0.0289907
RPLP2 ribosomal protein, large, P2 0.0289275
RPS4X ribosomal protein S4, X-linked 0.0287116
PKM pyruvate kinase, muscle 0.0283203
RPL32 ribosomal protein L32 0.028089
RPL35 ribosomal protein L35 0.0280397
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0275309
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0273748
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0273638
ZFP36L1 ZFP36 ring finger protein-like 1 0.0272691
CELF1 CUGBP, Elav-like family member 1 0.0272666
RPL5 ribosomal protein L5 0.0272465
TRIM56 tripartite motif containing 56 0.027206
PLAT plasminogen activator, tissue 0.0270618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0267027
CSNK1E casein kinase 1, epsilon 0.026661
RPS16 ribosomal protein S16 0.0263033
RPS27 ribosomal protein S27 0.0260339
KTN1 kinectin 1 (kinesin receptor) 0.0260282
RPL7A ribosomal protein L7a 0.0258998
RPL27A ribosomal protein L27a 0.0258606
CD99 CD99 molecule 0.0257821
HLA-B major histocompatibility complex, class I, B 0.0254672
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0254077
RPLP0 ribosomal protein, large, P0 0.0250769
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0249558
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0248122
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0245383
RPL36A ribosomal protein L36a 0.0245292
ZMYND8 zinc finger, MYND-type containing 8 0.0244353
PNRC1 proline-rich nuclear receptor coactivator 1 0.0243391
GUK1 guanylate kinase 1 0.0242393
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0241277
RPS27A ribosomal protein S27a 0.0239643
MYOF myoferlin 0.0234274
BHLHE40 basic helix-loop-helix family, member e40 0.0232358
YBX3 Y box binding protein 3 0.0232119
IFITM3 interferon induced transmembrane protein 3 0.0231568
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0228134
NAMPT nicotinamide phosphoribosyltransferase 0.0225827
ATF4 activating transcription factor 4 0.0225279
RPL11 ribosomal protein L11 0.02219
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0221343
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0220581
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0220382
AKAP9 A kinase (PRKA) anchor protein 9 0.0215572
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0214819
FSCN1 fascin actin-bundling protein 1 0.0211641
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0210661
SMIM44 small integral membrane protein 44 0.0209814
RPL37A ribosomal protein L37a 0.020979
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0209649
S100A2 S100 calcium binding protein A2 0.0206833

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.107834
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0776619
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0691309
PDE4D phosphodiesterase 4D, cAMP-specific -0.0603534
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0596515
PDLIM5 PDZ and LIM domain 5 -0.0569381
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0560292
SLC35F3 solute carrier family 35, member F3 -0.0555557
POTEF POTE ankyrin domain family, member F -0.0527566
RIGI RNA sensor RIG-I -0.0484676
INTS6 integrator complex subunit 6 -0.0477894
PODXL podocalyxin-like -0.0463596
PSD3 pleckstrin and Sec7 domain containing 3 -0.0451682
EGR1 early growth response 1 -0.0446503
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0438572
GRB10 growth factor receptor-bound protein 10 -0.0430187
NRIP1 nuclear receptor interacting protein 1 -0.0422912
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0406133
DPYD dihydropyrimidine dehydrogenase -0.0384928
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0381085
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0348952
LAMC2 laminin, gamma 2 -0.0343988
SOX5 SRY (sex determining region Y)-box 5 -0.0340904
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0335395
FNDC3A fibronectin type III domain containing 3A -0.0333349
MBNL1 muscleblind-like splicing regulator 1 -0.0329048
PICALM phosphatidylinositol binding clathrin assembly protein -0.0326632
ASPH aspartate beta-hydroxylase -0.0325308
NAV2 neuron navigator 2 -0.0324704
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.030939
COPA coatomer protein complex, subunit alpha -0.0301663
MECOM MDS1 and EVI1 complex locus -0.0286847
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0286323
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0282299
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0280442
IARS1 isoleucyl-tRNA synthetase 1 -0.027817
BCAR3 breast cancer anti-estrogen resistance 3 -0.0275013
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0274953
EXOC4 exocyst complex component 4 -0.0271473
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0265028
DENND1A DENN/MADD domain containing 1A -0.0264609
ATXN1 ataxin 1 -0.0263567
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0261523
PLXNA2 plexin A2 -0.0258653
TNS3 tensin 3 -0.0253824
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0253393
HDAC9 histone deacetylase 9 -0.0244518
FNDC3B fibronectin type III domain containing 3B -0.0243475
ANO1 anoctamin 1, calcium activated chloride channel -0.0241899
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0240522
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0240343
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0239017
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0236957
PLS3 plastin 3 -0.0236866
CDK6 cyclin-dependent kinase 6 -0.0235174
SETX senataxin -0.0232157
SULF1 sulfatase 1 -0.0231111
FLNB filamin B, beta -0.0230905
ISG15 ISG15 ubiquitin-like modifier -0.0230085
RCOR1 REST corepressor 1 -0.0229203
AMOTL1 angiomotin like 1 -0.0228517
SMYD3 SET and MYND domain containing 3 -0.0228113
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0227277
FRMD6 FERM domain containing 6 -0.0219453
UTRN utrophin -0.0217472
THSD4 thrombospondin, type I, domain containing 4 -0.0217053
ESYT2 extended synaptotagmin-like protein 2 -0.0216491
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0212469
SPAG9 sperm associated antigen 9 -0.0211878
ANKRD11 ankyrin repeat domain 11 -0.0211375
HMGA2 high mobility group AT-hook 2 -0.0211244
AHRR aryl-hydrocarbon receptor repressor -0.0208242
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0206051
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0203667
SBF2 SET binding factor 2 -0.0203627
ARF4 ADP-ribosylation factor 4 -0.0202876
CAPRIN2 caprin family member 2 -0.0200216
ANXA2 annexin A2 -0.0200149
TRA2A transformer 2 alpha homolog (Drosophila) -0.0197103
FLNA filamin A, alpha -0.0193403
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0192507
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.0192145
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0191955
BLTP1 bridge-like lipid transfer protein family member 1 -0.0190958
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.018728
SUCO SUN domain containing ossification factor -0.0182572
COG6 component of oligomeric golgi complex 6 -0.0182167
SEC24D SEC24 family member D -0.0181863
LMO7 LIM domain 7 -0.0181829
JMJD1C jumonji domain containing 1C -0.0181094
TRIO trio Rho guanine nucleotide exchange factor -0.0180338
NCKAP5 NCK-associated protein 5 -0.0179596
PCF11 PCF11 cleavage and polyadenylation factor subunit -0.01785
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0178021
ATF6 activating transcription factor 6 -0.0177216
TBC1D5 TBC1 domain family, member 5 -0.0176713
DMXL1 Dmx-like 1 -0.0176451
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0175822
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0175644
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0175613