| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Futibatinib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Futibatinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.125141 |
| FTL | ferritin, light polypeptide | 0.0794776 |
| NDRG1 | N-myc downstream regulated 1 | 0.0660553 |
| AREG | amphiregulin | 0.0559226 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0524676 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.052467 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0491788 |
| RPS3 | ribosomal protein S3 | 0.0421228 |
| KLHL29 | kelch-like family member 29 | 0.0414116 |
| ATF5 | activating transcription factor 5 | 0.0400582 |
| RPL9 | ribosomal protein L9 | 0.0374133 |
| RPS6 | ribosomal protein S6 | 0.037369 |
| RPL23 | ribosomal protein L23 | 0.0346387 |
| RPLP1 | ribosomal protein, large, P1 | 0.0342093 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.033665 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.031926 |
| LCN2 | lipocalin 2 | 0.0314557 |
| ANKRD11 | ankyrin repeat domain 11 | 0.030408 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0282109 |
| RPS8 | ribosomal protein S8 | 0.0278891 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0271042 |
| CMIP | c-Maf inducing protein | 0.0260742 |
| TMSB10 | thymosin beta 10 | 0.0257335 |
| RPL13A | ribosomal protein L13a | 0.0256099 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0255803 |
| S100P | S100 calcium binding protein P | 0.0251767 |
| HLA-A | major histocompatibility complex, class I, A | 0.0247858 |
| INTS6 | integrator complex subunit 6 | 0.0244477 |
| RPS12 | ribosomal protein S12 | 0.0243103 |
| RPL26 | ribosomal protein L26 | 0.0238675 |
| RPL37A | ribosomal protein L37a | 0.0238131 |
| MORF4L2 | mortality factor 4 like 2 | 0.0236572 |
| BRD4 | bromodomain containing 4 | 0.0221323 |
| CBX4 | chromobox homolog 4 | 0.0219382 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0219222 |
| HKDC1 | hexokinase domain containing 1 | 0.0211172 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0210562 |
| HM13 | histocompatibility (minor) 13 | 0.0207258 |
| LMNA | lamin A/C | 0.0201401 |
| RPS17 | ribosomal protein S17 | 0.0200031 |
| RBM39 | RNA binding motif protein 39 | 0.0195313 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0194192 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0191071 |
| MMP24OS | MMP24 opposite strand | 0.0185093 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0184826 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0183855 |
| RUNX1 | runt-related transcription factor 1 | 0.0181719 |
| SEC61G | Sec61 gamma subunit | 0.0181346 |
| USP36 | ubiquitin specific peptidase 36 | 0.0180802 |
| ATXN1 | ataxin 1 | 0.0178609 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0177673 |
| PMM2 | phosphomannomutase 2 | 0.0176891 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0176609 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0175849 |
| PTMA | prothymosin, alpha | 0.0174624 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0170852 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0166853 |
| CUX1 | cut-like homeobox 1 | 0.0166821 |
| ATF4 | activating transcription factor 4 | 0.016257 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0157033 |
| RPS19 | ribosomal protein S19 | 0.0156505 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.015511 |
| LAMB3 | laminin, beta 3 | 0.015501 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0154748 |
| RPL34 | ribosomal protein L34 | 0.0154176 |
| RPL18 | ribosomal protein L18 | 0.0153056 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0151353 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0150693 |
| RPL30 | ribosomal protein L30 | 0.0147898 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0147777 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0146425 |
| HLA-B | major histocompatibility complex, class I, B | 0.0145772 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0143909 |
| IGF2 | insulin-like growth factor 2 | 0.0141175 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0138691 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.013783 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0137664 |
| IER3 | immediate early response 3 | 0.0137522 |
| JUP | junction plakoglobin | 0.0137351 |
| TMEM258 | transmembrane protein 258 | 0.0136634 |
| AUTS2 | autism susceptibility candidate 2 | 0.0135659 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0135398 |
| BSDC1 | BSD domain containing 1 | 0.0134938 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0134313 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0133665 |
| RPL36 | ribosomal protein L36 | 0.0133143 |
| TOP1 | topoisomerase (DNA) I | 0.0132324 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.013175 |
| RBM25 | RNA binding motif protein 25 | 0.013162 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0130959 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0130718 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0130475 |
| UNC5B | unc-5 homolog B (C. elegans) | 0.0130314 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.012981 |
| CTBP2 | C-terminal binding protein 2 | 0.0129488 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0129427 |
| RPL27 | ribosomal protein L27 | 0.0129353 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.0128404 |
| GNAS | GNAS complex locus | 0.0127519 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | 0.0127308 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.133896 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.124501 |
| NPSR1 | neuropeptide S receptor 1 | -0.0991698 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0942724 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0880895 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0823303 |
| KRT18 | keratin 18, type I | -0.0752932 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0656754 |
| FAT1 | FAT atypical cadherin 1 | -0.0651335 |
| ANXA2 | annexin A2 | -0.0626029 |
| EZR | ezrin | -0.0579774 |
| POTEF | POTE ankyrin domain family, member F | -0.056821 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0566187 |
| TMEM123 | transmembrane protein 123 | -0.0544313 |
| ITGA6 | integrin, alpha 6 | -0.0542664 |
| EMP1 | epithelial membrane protein 1 | -0.0501335 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0499183 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0477568 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0470767 |
| S100A6 | S100 calcium binding protein A6 | -0.0454954 |
| AHR | aryl hydrocarbon receptor | -0.0430235 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0418059 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0414195 |
| KRT8 | keratin 8, type II | -0.0411109 |
| S100A10 | S100 calcium binding protein A10 | -0.0404631 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0390896 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0376167 |
| EHBP1 | EH domain binding protein 1 | -0.0374857 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0372742 |
| INSIG1 | insulin induced gene 1 | -0.0347086 |
| LYZ | lysozyme | -0.0343662 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0333248 |
| ANLN | anillin, actin binding protein | -0.0331977 |
| DSG2 | desmoglein 2 | -0.032384 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0314342 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0310385 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0305477 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.030524 |
| CALR | calreticulin | -0.0304322 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0303461 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0297142 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0287779 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0287021 |
| B2M | beta-2-microglobulin | -0.0285779 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0284342 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0281697 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0280827 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.027766 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0274759 |
| PLS1 | plastin 1 | -0.0274678 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0271182 |
| CLTC | clathrin, heavy chain (Hc) | -0.0270423 |
| ABHD2 | abhydrolase domain containing 2 | -0.026895 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0265374 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0264954 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0262578 |
| TMC5 | transmembrane channel-like 5 | -0.0261519 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0261208 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0259725 |
| ASPH | aspartate beta-hydroxylase | -0.0255698 |
| GPX2 | glutathione peroxidase 2 | -0.0251482 |
| CD2AP | CD2-associated protein | -0.0247433 |
| KRT19 | keratin 19, type I | -0.0243755 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0243727 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0242477 |
| ECT2 | epithelial cell transforming 2 | -0.0242075 |
| TRAK1 | trafficking protein, kinesin binding 1 | -0.0238336 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0235592 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0234781 |
| XPO1 | exportin 1 | -0.0234314 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0234249 |
| EPCAM | epithelial cell adhesion molecule | -0.0234068 |
| SIK3 | SIK family kinase 3 | -0.0232056 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0230898 |
| PLSCR1 | phospholipid scramblase 1 | -0.0228454 |
| CDK6 | cyclin-dependent kinase 6 | -0.0225303 |
| PRSS3 | protease, serine, 3 | -0.0224502 |
| LMO7 | LIM domain 7 | -0.0222471 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0221887 |
| GDA | guanine deaminase | -0.0221387 |
| MUC17 | mucin 17, cell surface associated | -0.0220382 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.021974 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0219099 |
| AGR2 | anterior gradient 2 | -0.0217892 |
| MYADM | myeloid-associated differentiation marker | -0.0214037 |
| TUBA1B | tubulin, alpha 1b | -0.0210644 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0210481 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0203716 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0201968 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0200235 |
| GOLGA4 | golgin A4 | -0.0195715 |
| TPM4 | tropomyosin 4 | -0.0193759 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0193169 |
| TRAM1 | translocation associated membrane protein 1 | -0.0193155 |
| ETNK1 | ethanolamine kinase 1 | -0.0192056 |
| ACTG1 | actin gamma 1 | -0.0191435 |
| COBL | cordon-bleu WH2 repeat protein | -0.0191389 |
| YAP1 | Yes-associated protein 1 | -0.0191047 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0188498 |
| MKI67 | marker of proliferation Ki-67 | -0.0187037 |
