| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Futibatinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Futibatinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.112448 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0652546 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0569713 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0469261 |
| RAI1 | retinoic acid induced 1 | 0.0389697 |
| EZR | ezrin | 0.0381571 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0363751 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0355367 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0344562 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.032798 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0318057 |
| TMEM41B | transmembrane protein 41B | 0.0310741 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0308778 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0306479 |
| RTN4 | reticulon 4 | 0.0274019 |
| HMGA1 | high mobility group AT-hook 1 | 0.0245944 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0223733 |
| YBX3 | Y box binding protein 3 | 0.022192 |
| BRD4 | bromodomain containing 4 | 0.0207958 |
| AREG | amphiregulin | 0.0183971 |
| TOP1 | topoisomerase (DNA) I | 0.0175919 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0164187 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0161374 |
| CENPF | centromere protein F, 350/400kDa | 0.0160386 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.016024 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0159568 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0156879 |
| FOSL1 | FOS-like antigen 1 | 0.0154698 |
| MORF4L2 | mortality factor 4 like 2 | 0.0154119 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0153701 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0151801 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.015004 |
| GOLGA4 | golgin A4 | 0.0148601 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0143364 |
| NUP58 | nucleoporin 58 | 0.0143111 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0142506 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0142435 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0140825 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0140625 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0136306 |
| RBM25 | RNA binding motif protein 25 | 0.0136284 |
| MKI67 | marker of proliferation Ki-67 | 0.0135998 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0134375 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0132673 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0132303 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0131189 |
| EMP1 | epithelial membrane protein 1 | 0.0130041 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0127333 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0126679 |
| USP36 | ubiquitin specific peptidase 36 | 0.0124771 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0123988 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0123978 |
| ATN1 | atrophin 1 | 0.0123559 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.012077 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0119563 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0119429 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0118823 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0118636 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0118368 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0117925 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0117072 |
| BRD2 | bromodomain containing 2 | 0.0114314 |
| HYOU1 | hypoxia up-regulated 1 | 0.0113986 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0113898 |
| ATXN2L | ataxin 2-like | 0.011255 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.011201 |
| CALU | calumenin | 0.0111774 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0111675 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0110867 |
| SRP54 | signal recognition particle 54kDa | 0.0109706 |
| WDR43 | WD repeat domain 43 | 0.0109613 |
| JMJD1C | jumonji domain containing 1C | 0.0109574 |
| KIF14 | kinesin family member 14 | 0.0109036 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.010857 |
| MT1E | metallothionein 1E | 0.0108516 |
| SPAG9 | sperm associated antigen 9 | 0.0108415 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0107404 |
| MSN | moesin | 0.0107241 |
| MTDH | metadherin | 0.0107004 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0106215 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0105525 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0105395 |
| COPA | coatomer protein complex, subunit alpha | 0.0105192 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0105106 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0105057 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0104134 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0103856 |
| RNF145 | ring finger protein 145 | 0.0103787 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0103361 |
| PCBP2 | poly(rC) binding protein 2 | 0.0103195 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0102981 |
| CENPE | centromere protein E, 312kDa | 0.010191 |
| EP300 | E1A binding protein p300 | 0.0101894 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0101174 |
| CDCP1 | CUB domain containing protein 1 | 0.0100961 |
| MT1X | metallothionein 1X | 0.0100939 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0100716 |
| PER1 | period circadian clock 1 | 0.0100646 |
| PCM1 | pericentriolar material 1 | 0.0100297 |
| YBX1 | Y box binding protein 1 | 0.00996694 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.206161 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.196082 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.184737 |
| DST | dystonin | -0.166579 |
| CD44 | CD44 molecule (Indian blood group) | -0.162658 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.157646 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.132492 |
| CADM2 | cell adhesion molecule 2 | -0.123287 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.110617 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0930324 |
| EHBP1 | EH domain binding protein 1 | -0.0842497 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0782979 |
| VIM | vimentin | -0.0779376 |
| HLA-B | major histocompatibility complex, class I, B | -0.0742498 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0726468 |
| TNS3 | tensin 3 | -0.0722615 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0721289 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0717454 |
| PRELID2 | PRELI domain containing 2 | -0.0661371 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.06601 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0659618 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0654323 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0647742 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0637677 |
| RIGI | RNA sensor RIG-I | -0.0623269 |
| PDE10A | phosphodiesterase 10A | -0.0592107 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.058949 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0578471 |
| RAD51B | RAD51 paralog B | -0.0573691 |
| EPHA4 | EPH receptor A4 | -0.0571678 |
| TMSB4X | thymosin beta 4, X-linked | -0.0565497 |
| RNF213 | ring finger protein 213 | -0.0563348 |
| EFNA5 | ephrin-A5 | -0.0547143 |
| DNER | delta/notch-like EGF repeat containing | -0.0532057 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0522559 |
| FMNL2 | formin-like 2 | -0.051271 |
| SP100 | SP100 nuclear antigen | -0.0512413 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0507269 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0504718 |
| HDAC9 | histone deacetylase 9 | -0.0491708 |
| MYOF | myoferlin | -0.049126 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0478515 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0471088 |
| VCL | vinculin | -0.0466107 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0452801 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0449595 |
| EXOC4 | exocyst complex component 4 | -0.0441824 |
| APP | amyloid beta (A4) precursor protein | -0.043953 |
| PLSCR1 | phospholipid scramblase 1 | -0.0414269 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0408355 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.039958 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0397732 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0394942 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0394669 |
| PTK2 | protein tyrosine kinase 2 | -0.039142 |
| DENND1A | DENN/MADD domain containing 1A | -0.0381268 |
| EGFR | epidermal growth factor receptor | -0.0381145 |
| ENO1 | enolase 1, (alpha) | -0.0379847 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0376741 |
| RPL35A | ribosomal protein L35a | -0.0368445 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0365136 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0360868 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0358005 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0354907 |
| AEBP2 | AE binding protein 2 | -0.0345943 |
| DPH6 | diphthamine biosynthesis 6 | -0.0344911 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0339786 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0337218 |
| CAPRIN2 | caprin family member 2 | -0.0318317 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0305927 |
| SMYD3 | SET and MYND domain containing 3 | -0.0302397 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.030153 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0294053 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0293262 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.028891 |
| TPRG1 | tumor protein p63 regulated 1 | -0.0288752 |
| PARD3 | par-3 family cell polarity regulator | -0.0288333 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0286482 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0282725 |
| FNIP1 | folliculin interacting protein 1 | -0.0281904 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0281548 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0279489 |
| ZNF217 | zinc finger protein 217 | -0.0275848 |
| PTMA | prothymosin, alpha | -0.0275653 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0274424 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.027297 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0272746 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0267284 |
| RPS24 | ribosomal protein S24 | -0.0262172 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0259622 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0258803 |
| LRRC49 | leucine rich repeat containing 49 | -0.0258103 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.025451 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0253706 |
| PHF3 | PHD finger protein 3 | -0.0253575 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0252362 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0250646 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0248874 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.024551 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0245141 |
