Futibatinib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Futibatinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.126632
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0982862
VIM vimentin 0.092047
FTH1 ferritin, heavy polypeptide 1 0.0903176
NAMPT nicotinamide phosphoribosyltransferase 0.0828332
TMSB10 thymosin beta 10 0.0729555
MT2A metallothionein 2A 0.0672593
RPLP1 ribosomal protein, large, P1 0.0651202
FTL ferritin, light polypeptide 0.0606126
CD44 CD44 molecule (Indian blood group) 0.0568582
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0516378
EIF1 eukaryotic translation initiation factor 1 0.0428238
OSMR oncostatin M receptor 0.0418718
RPS8 ribosomal protein S8 0.0385342
B2M beta-2-microglobulin 0.0381227
BASP1 brain abundant, membrane attached signal protein 1 0.0381092
RPS19 ribosomal protein S19 0.0376571
STC1 stanniocalcin 1 0.0372277
AKAP12 A kinase (PRKA) anchor protein 12 0.035672
RPS6 ribosomal protein S6 0.0340685
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0335558
GOLGA4 golgin A4 0.0333803
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0329791
RPL23 ribosomal protein L23 0.0320825
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0305296
EEF2 eukaryotic translation elongation factor 2 0.0301538
YBX3 Y box binding protein 3 0.0299292
LOC112694756 uncharaterized LOC112694756 0.0298849
PTMA prothymosin, alpha 0.0288905
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0288703
LMAN1 lectin, mannose-binding, 1 0.028839
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0286617
RPL36 ribosomal protein L36 0.0285938
RPL37 ribosomal protein L37 0.0281374
ANGPTL4 angiopoietin-like 4 0.0276706
RPL37A ribosomal protein L37a 0.0273777
RPL34 ribosomal protein L34 0.0273607
AKAP9 A kinase (PRKA) anchor protein 9 0.0271574
RPS12 ribosomal protein S12 0.0271274
RNF24 ring finger protein 24 0.0271207
RPS3 ribosomal protein S3 0.0256404
RPL31 ribosomal protein L31 0.0253781
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0248241
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0240715
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0233885
RPL9 ribosomal protein L9 0.0228015
RPL12 ribosomal protein L12 0.0227148
C15ORF48 chromosome 15 open reading frame 48 0.022474
RPL19 ribosomal protein L19 0.0222038
NDRG1 N-myc downstream regulated 1 0.0221144
RPL18 ribosomal protein L18 0.0220056
RPL32 ribosomal protein L32 0.0219765
RPL5 ribosomal protein L5 0.021602
RPLP0 ribosomal protein, large, P0 0.021589
LOC102724023 ES1 protein homolog, mitochondrial 0.0214717
CTNND1 catenin (cadherin-associated protein), delta 1 0.0212252
H1-0 H1.0 linker histone 0.0211653
KLF6 Kruppel-like factor 6 0.0211292
KPNB1 karyopherin (importin) beta 1 0.0205849
RPL30 ribosomal protein L30 0.0205497
RACK1 receptor for activated C kinase 1 0.0204496
RPS21 ribosomal protein S21 0.0203307
TPT1 tumor protein, translationally-controlled 1 0.0202196
RPS17 ribosomal protein S17 0.0202192
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0201799
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.020094
RPS27 ribosomal protein S27 0.019758
RPL13A ribosomal protein L13a 0.0196401
EREG epiregulin 0.0195317
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0193759
ZEB2 zinc finger E-box binding homeobox 2 0.0186136
OGA O-GlcNAcase 0.018525
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0185018
HMGA1 high mobility group AT-hook 1 0.0184937
IL1R1 interleukin 1 receptor, type I 0.0184795
PNRC1 proline-rich nuclear receptor coactivator 1 0.0181047
RPS29 ribosomal protein S29 0.017901
CANX calnexin 0.0178363
RPS13 ribosomal protein S13 0.017726
UGP2 UDP-glucose pyrophosphorylase 2 0.0172698
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0172438
S100A6 S100 calcium binding protein A6 0.0171154
RPS16 ribosomal protein S16 0.0170882
HAS2 hyaluronan synthase 2 0.0169662
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0168291
PRRC2C proline-rich coiled-coil 2C 0.0168223
RPL11 ribosomal protein L11 0.0167976
SYAP1 synapse associated protein 1 0.0167825
ATP5MC2 ATP synthase membrane subunit c locus 2 0.0166733
NPC1 Niemann-Pick disease, type C1 0.0164963
ECE1 endothelin converting enzyme 1 0.0163109
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0162312
RPL35A ribosomal protein L35a 0.0161967
WDR45B WD repeat domain 45B 0.0159109
SEC61G Sec61 gamma subunit 0.0159108
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0157417
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0155867
HLA-B major histocompatibility complex, class I, B 0.0155386
UGCG UDP-glucose ceramide glucosyltransferase 0.0152453
CAB39 calcium binding protein 39 0.015212

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.215008
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.184379
FN1 fibronectin 1 -0.165311
SDK1 sidekick cell adhesion molecule 1 -0.162947
CDH13 cadherin 13 -0.143276
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.117373
GRB10 growth factor receptor-bound protein 10 -0.108766
DPYD dihydropyrimidine dehydrogenase -0.10228
HMGA2 high mobility group AT-hook 2 -0.0970743
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0935121
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0831726
PSD3 pleckstrin and Sec7 domain containing 3 -0.0814822
NRG1 neuregulin 1 -0.0776404
EFNA5 ephrin-A5 -0.0740439
MAML3 mastermind-like 3 (Drosophila) -0.0668376
MTSS1 metastasis suppressor 1 -0.0660205
GPC6 glypican 6 -0.0626281
DST dystonin -0.0624038
USP34 ubiquitin specific peptidase 34 -0.0608189
MEF2A myocyte enhancer factor 2A -0.0567377
LRMDA leucine rich melanocyte differentiation associated -0.0526582
CDK14 cyclin-dependent kinase 14 -0.052297
MACF1 microtubule-actin crosslinking factor 1 -0.0517015
ASPH aspartate beta-hydroxylase -0.0485364
MSRB3 methionine sulfoxide reductase B3 -0.0476065
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0470999
RAD51B RAD51 paralog B -0.0462879
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.045956
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0457002
FBN1 fibrillin 1 -0.0440939
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0425929
TAS2R14 taste receptor, type 2, member 14 -0.04255
TRIO trio Rho guanine nucleotide exchange factor -0.0419576
MECOM MDS1 and EVI1 complex locus -0.0417067
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0415157
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0413137
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0402352
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0402264
OXR1 oxidation resistance 1 -0.0401142
PRKCA protein kinase C, alpha -0.040084
ATXN1 ataxin 1 -0.0398869
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0398096
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0392764
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.039189
SYT1 synaptotagmin I -0.0388906
PRELID2 PRELI domain containing 2 -0.0386167
RAI14 retinoic acid induced 14 -0.03752
SOD2 superoxide dismutase 2, mitochondrial -0.0361486
ZNF804A zinc finger protein 804A -0.036034
FNDC3B fibronectin type III domain containing 3B -0.0359211
PTK2 protein tyrosine kinase 2 -0.0357778
DIAPH2 diaphanous-related formin 2 -0.0356392
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0355791
PDLIM5 PDZ and LIM domain 5 -0.0350265
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0340634
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0335581
IGFBP3 insulin-like growth factor binding protein 3 -0.0330272
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0327507
ANTXR2 anthrax toxin receptor 2 -0.0325921
AADAC arylacetamide deacetylase -0.032578
MAML2 mastermind-like 2 (Drosophila) -0.0318215
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0318044
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0317599
DLG1 discs, large homolog 1 (Drosophila) -0.0317527
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0312391
RASAL2 RAS protein activator like 2 -0.0310899
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0309901
CUX1 cut-like homeobox 1 -0.0307986
GLIS3 GLIS family zinc finger 3 -0.0307847
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0305857
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0305203
JARID2 jumonji, AT rich interactive domain 2 -0.0303002
EGFR epidermal growth factor receptor -0.0301555
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0300158
EFCAB13 EF-hand calcium binding domain 13 -0.0299362
FAM20C family with sequence similarity 20, member C -0.0298669
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0296754
EXT1 exostosin glycosyltransferase 1 -0.0294099
KCTD16 potassium channel tetramerization domain containing 16 -0.0293078
DTNA dystrobrevin, alpha -0.0292111
PIAS2 protein inhibitor of activated STAT, 2 -0.0290833
THSD4 thrombospondin, type I, domain containing 4 -0.0289276
CLIC4 chloride intracellular channel 4 -0.0289248
GREB1L growth regulation by estrogen in breast cancer-like -0.0289095
CFAP20DC CFAP20 domain containing -0.0288876
LPP LIM domain containing preferred translocation partner in lipoma -0.0288585
HDAC4 histone deacetylase 4 -0.0286022
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0284964
TRPS1 trichorhinophalangeal syndrome I -0.0282769
COL7A1 collagen, type VII, alpha 1 -0.0280938
TBC1D22A TBC1 domain family, member 22A -0.0280489
SUMF1 sulfatase modifying factor 1 -0.028011
INTS6 integrator complex subunit 6 -0.0275477
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0274955
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0274812
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0274379
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0272186
NAV1 neuron navigator 1 -0.0271666
TMEM165 transmembrane protein 165 -0.0270902
FNIP1 folliculin interacting protein 1 -0.0268643