| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Futibatinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Futibatinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.146412 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0901227 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0861894 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0830228 |
| MUC16 | mucin 16, cell surface associated | 0.0819524 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.079156 |
| INHBA | inhibin, beta A | 0.0775957 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0710279 |
| EGR1 | early growth response 1 | 0.066012 |
| EGFR | epidermal growth factor receptor | 0.0643168 |
| CNKSR3 | CNKSR family member 3 | 0.0642214 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0640036 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0634466 |
| COL1A1 | collagen, type I, alpha 1 | 0.0631106 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0612388 |
| LAMC2 | laminin, gamma 2 | 0.0611296 |
| VGF | VGF nerve growth factor inducible | 0.0598672 |
| SVIL | supervillin | 0.058759 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0578262 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0577651 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0573142 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0565875 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0557448 |
| TXNRD1 | thioredoxin reductase 1 | 0.0547196 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0541435 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0539684 |
| SBF2 | SET binding factor 2 | 0.0538895 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0538619 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0532526 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.052562 |
| RNF144A | ring finger protein 144A | 0.0525281 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0524022 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.0523747 |
| GPC6 | glypican 6 | 0.0520832 |
| SMAD3 | SMAD family member 3 | 0.0516359 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0513212 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0507283 |
| MYO1E | myosin IE | 0.0498816 |
| RPLP1 | ribosomal protein, large, P1 | 0.0476361 |
| AEBP2 | AE binding protein 2 | 0.0475003 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0473645 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0464747 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0456319 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0451587 |
| FOSL1 | FOS-like antigen 1 | 0.0449459 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0447273 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0445253 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0440977 |
| DIAPH2 | diaphanous-related formin 2 | 0.0440786 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.044028 |
| RPL30 | ribosomal protein L30 | 0.0438729 |
| SP100 | SP100 nuclear antigen | 0.043431 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0429219 |
| CD44 | CD44 molecule (Indian blood group) | 0.0427616 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0425767 |
| FAF2 | Fas associated factor family member 2 | 0.0423543 |
| SEPTIN9 | septin 9 | 0.0421066 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0418354 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0409696 |
| ZNF207 | zinc finger protein 207 | 0.0407718 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0406853 |
| LOXL2 | lysyl oxidase-like 2 | 0.0406436 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0404814 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0404765 |
| USP3 | ubiquitin specific peptidase 3 | 0.0396885 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0396835 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0396378 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.039389 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0388132 |
| RNF24 | ring finger protein 24 | 0.0387567 |
| CDK6 | cyclin-dependent kinase 6 | 0.038657 |
| MYO10 | myosin X | 0.0382882 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.038251 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0372123 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0371538 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0369323 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0366714 |
| MYO6 | myosin VI | 0.0365049 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0363612 |
| ERBIN | erbb2 interacting protein | 0.0361074 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0360052 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0358872 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0358239 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0357867 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0356897 |
| CMIP | c-Maf inducing protein | 0.0356845 |
| SON | SON DNA binding protein | 0.0356699 |
| CLIC4 | chloride intracellular channel 4 | 0.0353735 |
| HLA-A | major histocompatibility complex, class I, A | 0.035238 |
| ZNF644 | zinc finger protein 644 | 0.0351212 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0350884 |
| EMP1 | epithelial membrane protein 1 | 0.0347434 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0345806 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.034533 |
| CLSTN1 | calsyntenin 1 | 0.034394 |
| MYO1D | myosin ID | 0.0341108 |
| USP36 | ubiquitin specific peptidase 36 | 0.0340436 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0339896 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0334711 |
| FBXO11 | F-box protein 11 | 0.0334513 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.212712 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.117719 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.110775 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.101955 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0872996 |
| AHNAK | AHNAK nucleoprotein | -0.0828961 |
| KIAA1217 | KIAA1217 | -0.0812872 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0759694 |
| ANXA2 | annexin A2 | -0.0739312 |
| VIM | vimentin | -0.0731756 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0731345 |
| PHF21A | PHD finger protein 21A | -0.0706043 |
| TMSB10 | thymosin beta 10 | -0.0704918 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0670395 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0662608 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0660941 |
| PRELID2 | PRELI domain containing 2 | -0.066001 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0657043 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0638227 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0637319 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0626008 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0605703 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0593377 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0593014 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0581269 |
| CDCP1 | CUB domain containing protein 1 | -0.0576838 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0571424 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0564573 |
| ASPH | aspartate beta-hydroxylase | -0.0555364 |
| NEBL | nebulette | -0.0546688 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0526831 |
| USP53 | ubiquitin specific peptidase 53 | -0.0524698 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0518808 |
| PARD3 | par-3 family cell polarity regulator | -0.0512356 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0510396 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0495609 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0491819 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0488943 |
| S100A10 | S100 calcium binding protein A10 | -0.0487254 |
| SMYD3 | SET and MYND domain containing 3 | -0.0483587 |
| PDE10A | phosphodiesterase 10A | -0.0482161 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0479176 |
| NBEA | neurobeachin | -0.0478418 |
| PERP | PERP, TP53 apoptosis effector | -0.0476467 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0471564 |
| RBM39 | RNA binding motif protein 39 | -0.0457238 |
| WDR45B | WD repeat domain 45B | -0.0450731 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0447652 |
| DENND1A | DENN/MADD domain containing 1A | -0.0442495 |
| LAMB1 | laminin, beta 1 | -0.0440688 |
| LMAN1 | lectin, mannose-binding, 1 | -0.043717 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0427519 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0421728 |
| ENO1 | enolase 1, (alpha) | -0.0418528 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0416989 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0409987 |
| SEC24D | SEC24 family member D | -0.0408217 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0404717 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0404355 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0402056 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0401809 |
| SUCO | SUN domain containing ossification factor | -0.0401311 |
| NUMB | numb homolog (Drosophila) | -0.0400784 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0398204 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0388738 |
| WWOX | WW domain containing oxidoreductase | -0.0385892 |
| RIGI | RNA sensor RIG-I | -0.0383382 |
| RUFY1 | RUN and FYVE domain containing 1 | -0.0383358 |
| GOLGB1 | golgin B1 | -0.0370644 |
| ARF1 | ADP-ribosylation factor 1 | -0.0366622 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0363169 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0354397 |
| CANX | calnexin | -0.0351153 |
| MORF4L1 | mortality factor 4 like 1 | -0.0348866 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.03464 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0345101 |
| DSG2 | desmoglein 2 | -0.0344616 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.034367 |
| TMEM41B | transmembrane protein 41B | -0.0339391 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0336966 |
| CDK12 | cyclin-dependent kinase 12 | -0.0334722 |
| MSI2 | musashi RNA-binding protein 2 | -0.0333788 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0333753 |
| AUTS2 | autism susceptibility candidate 2 | -0.0333156 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0329932 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0329453 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0328215 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0328084 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0326516 |
| BPTF | bromodomain PHD finger transcription factor | -0.0325817 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0325373 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0321386 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.032092 |
| CEP350 | centrosomal protein 350kDa | -0.0318617 |
| B2M | beta-2-microglobulin | -0.0311092 |
| PLS3 | plastin 3 | -0.0310307 |
| PEG10 | paternally expressed 10 | -0.0309918 |
| RPS19 | ribosomal protein S19 | -0.0305599 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0304519 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0303986 |
