Futibatinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Futibatinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.0632053
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0594731
RPLP1 ribosomal protein, large, P1 0.0511256
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0460397
KTN1 kinectin 1 (kinesin receptor) 0.0452127
EEF2 eukaryotic translation elongation factor 2 0.0444788
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0441354
RPS19 ribosomal protein S19 0.0425604
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0408403
RPS8 ribosomal protein S8 0.0374288
RPL23 ribosomal protein L23 0.0364594
YBX3 Y box binding protein 3 0.0347019
RPL34 ribosomal protein L34 0.0339371
PCBP2 poly(rC) binding protein 2 0.0335904
RPL35A ribosomal protein L35a 0.0327653
RPS4X ribosomal protein S4, X-linked 0.0326683
TFPI2 tissue factor pathway inhibitor 2 0.0317622
RPS27 ribosomal protein S27 0.0313666
RAB7A RAB7A, member RAS oncogene family 0.0295265
RPL5 ribosomal protein L5 0.0290426
PER1 period circadian clock 1 0.0286356
KDM6B lysine (K)-specific demethylase 6B 0.0284432
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0281676
RPS6 ribosomal protein S6 0.0276081
EGR1 early growth response 1 0.0274867
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0274846
RTN4 reticulon 4 0.0273525
BRD2 bromodomain containing 2 0.0269783
RPL12 ribosomal protein L12 0.0267684
RBM25 RNA binding motif protein 25 0.0262455
BRD4 bromodomain containing 4 0.0258072
RPL9 ribosomal protein L9 0.0257572
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0255091
RPS17 ribosomal protein S17 0.0246052
RPL37A ribosomal protein L37a 0.024598
TPI1 triosephosphate isomerase 1 0.0243447
PFN1 profilin 1 0.0236114
PFDN2 prefoldin subunit 2 0.0233513
RPL8 ribosomal protein L8 0.0229233
EEF1G eukaryotic translation elongation factor 1 gamma 0.0224885
NACA nascent polypeptide-associated complex alpha subunit 0.0222567
MEF2D myocyte enhancer factor 2D 0.0216329
RPL37 ribosomal protein L37 0.0215157
ATP5F1E ATP synthase F1 subunit epsilon 0.0206646
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0205963
RPL36 ribosomal protein L36 0.0205569
RPL28 ribosomal protein L28 0.0205141
FTH1 ferritin, heavy polypeptide 1 0.0201786
LOC102724023 ES1 protein homolog, mitochondrial 0.0199427
RPL26 ribosomal protein L26 0.0199302
MT2A metallothionein 2A 0.019881
GARS1 glycyl-tRNA synthetase 1 0.0196816
RPLP2 ribosomal protein, large, P2 0.0195867
EIF1 eukaryotic translation initiation factor 1 0.0194488
RPL31 ribosomal protein L31 0.0193253
RPS12 ribosomal protein S12 0.0193171
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0192573
YBX1 Y box binding protein 1 0.0192106
FTL ferritin, light polypeptide 0.0190513
AKAP9 A kinase (PRKA) anchor protein 9 0.018828
SEPTIN7 septin 7 0.0187106
RPL35 ribosomal protein L35 0.0185115
RPS15 ribosomal protein S15 0.0184674
TUBA1B tubulin, alpha 1b 0.0184462
EIF5B eukaryotic translation initiation factor 5B 0.0182457
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0181255
PABPN1 poly(A) binding protein, nuclear 1 0.018028
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0179901
RPS21 ribosomal protein S21 0.0179734
AXL AXL receptor tyrosine kinase 0.0175144
RPLP0 ribosomal protein, large, P0 0.0170699
KMT2D lysine (K)-specific methyltransferase 2D 0.0168117
SESN2 sestrin 2 0.0166485
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0165947
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0165729
RPS23 ribosomal protein S23 0.0164538
RPS20 ribosomal protein S20 0.0163525
HLA-A major histocompatibility complex, class I, A 0.0163117
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0162796
RPS10 ribosomal protein S10 0.0160819
LRRC23 leucine rich repeat containing 23 0.0160716
HMGA1 high mobility group AT-hook 1 0.0158702
RPL18 ribosomal protein L18 0.0156766
RPL21 ribosomal protein L21 0.0156449
PNN pinin, desmosome associated protein 0.015587
RPL7A ribosomal protein L7a 0.0155077
EIF4A1 eukaryotic translation initiation factor 4A1 0.0155022
SMC4 structural maintenance of chromosomes 4 0.0155012
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0154904
SFPQ splicing factor proline/glutamine-rich 0.0154551
PTMS parathymosin 0.0154251
RPL27 ribosomal protein L27 0.0153112
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0153061
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0152583
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0152108
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0151912
CSNK1E casein kinase 1, epsilon 0.0151279
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0147291
RPS16 ribosomal protein S16 0.0147166
RPL30 ribosomal protein L30 0.0146559

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.200383
THSD4 thrombospondin, type I, domain containing 4 -0.14231
RAD51B RAD51 paralog B -0.125567
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.121652
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.110487
GRAMD1B GRAM domain containing 1B -0.109555
EXOC4 exocyst complex component 4 -0.0941051
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0854509
TAS2R14 taste receptor, type 2, member 14 -0.0783124
PDE4D phosphodiesterase 4D, cAMP-specific -0.0782792
HMGA2 high mobility group AT-hook 2 -0.0730665
NCOA7 nuclear receptor coactivator 7 -0.0627953
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0622754
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0618277
IGF1R insulin-like growth factor 1 receptor -0.0616938
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0590665
VCL vinculin -0.0585885
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0580457
AHNAK AHNAK nucleoprotein -0.0578331
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0570816
NF1 neurofibromin 1 -0.0548652
OSMR oncostatin M receptor -0.0540408
ATXN1 ataxin 1 -0.0530731
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0528955
SMAD3 SMAD family member 3 -0.0512477
TRIO trio Rho guanine nucleotide exchange factor -0.0504671
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0497058
ZBTB20 zinc finger and BTB domain containing 20 -0.0492728
ADAR adenosine deaminase, RNA-specific -0.0491392
FNDC3B fibronectin type III domain containing 3B -0.0484047
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0482465
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0482437
RIMS2 regulating synaptic membrane exocytosis 2 -0.0481483
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0470155
EML4 echinoderm microtubule associated protein like 4 -0.0462908
RNF213 ring finger protein 213 -0.0448387
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0437103
DENND5B DENN/MADD domain containing 5B -0.0436655
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0431335
RERE arginine-glutamic acid dipeptide (RE) repeats -0.042965
BBX bobby sox homolog (Drosophila) -0.0421973
EGFR epidermal growth factor receptor -0.0410755
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0409297
FMNL2 formin-like 2 -0.0405289
RYR3 ryanodine receptor 3 -0.0397359
ZFAND3 zinc finger, AN1-type domain 3 -0.0396068
EHBP1 EH domain binding protein 1 -0.039537
USP34 ubiquitin specific peptidase 34 -0.0394313
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.038713
PTK2 protein tyrosine kinase 2 -0.037975
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0374616
MACF1 microtubule-actin crosslinking factor 1 -0.0363551
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0363522
TPM4 tropomyosin 4 -0.0362761
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.035374
PDE10A phosphodiesterase 10A -0.0347735
BABAM2 BRISC and BRCA1 A complex member 2 -0.0346883
CUX1 cut-like homeobox 1 -0.0346255
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0343299
SENP6 SUMO1/sentrin specific peptidase 6 -0.0340744
CDK17 cyclin-dependent kinase 17 -0.0337049
THADA thyroid adenoma associated -0.0336801
STC1 stanniocalcin 1 -0.0336716
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0336633
CCDC91 coiled-coil domain containing 91 -0.0332729
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0330901
CSDE1 cold shock domain containing E1, RNA-binding -0.0328973
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0325165
AFF3 AF4/FMR2 family, member 3 -0.0324699
ARB2A ARB2 cotranscriptional regulator A -0.0324228
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0324149
NABP1 nucleic acid binding protein 1 -0.0319298
SMYD3 SET and MYND domain containing 3 -0.031773
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0317643
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0315299
WDR70 WD repeat domain 70 -0.0315036
MMP12 matrix metallopeptidase 12 -0.0314213
BMP5 bone morphogenetic protein 5 -0.0313499
SBF2 SET binding factor 2 -0.0309804
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0308969
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0304938
CD2AP CD2-associated protein -0.0304477
PYGL phosphorylase, glycogen, liver -0.0302753
BICD1 bicaudal D homolog 1 (Drosophila) -0.0300898
ATG7 autophagy related 7 -0.0299889
DENND1A DENN/MADD domain containing 1A -0.0298501
BASP1 brain abundant, membrane attached signal protein 1 -0.0294586
TLK1 tousled-like kinase 1 -0.0294341
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0293917
LDHA lactate dehydrogenase A -0.0293609
TBC1D5 TBC1 domain family, member 5 -0.0292741
BCAS3 breast carcinoma amplified sequence 3 -0.0292728
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0292483
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0290534
ETV6 ets variant 6 -0.0286669
WWTR1 WW domain containing transcription regulator 1 -0.0286456
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0284056
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0281132
CCND1 cyclin D1 -0.0281051
PGK1 phosphoglycerate kinase 1 -0.0280145