| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Futibatinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Futibatinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.119845 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0856145 |
| EXT1 | exostosin glycosyltransferase 1 | 0.081056 |
| LAMB3 | laminin, beta 3 | 0.0770986 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0655843 |
| RBM25 | RNA binding motif protein 25 | 0.0654765 |
| SDC4 | syndecan 4 | 0.0565907 |
| PTMA | prothymosin, alpha | 0.0504146 |
| RPL9 | ribosomal protein L9 | 0.045883 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0456761 |
| HLA-A | major histocompatibility complex, class I, A | 0.0455731 |
| RPS3 | ribosomal protein S3 | 0.0428991 |
| FTL | ferritin, light polypeptide | 0.0387251 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0378525 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0377481 |
| AREG | amphiregulin | 0.0372748 |
| RPL37A | ribosomal protein L37a | 0.0360424 |
| YBX3 | Y box binding protein 3 | 0.0351219 |
| G0S2 | G0/G1 switch 2 | 0.0339506 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0337011 |
| MT2A | metallothionein 2A | 0.0324053 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0320046 |
| HLA-B | major histocompatibility complex, class I, B | 0.0313896 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.031327 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0311544 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0299231 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0298611 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0297994 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0279672 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0263564 |
| LMNA | lamin A/C | 0.0262909 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0260844 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0255805 |
| RPS8 | ribosomal protein S8 | 0.0250566 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0247953 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0243948 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0243529 |
| RPLP1 | ribosomal protein, large, P1 | 0.0240869 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0238182 |
| VEGFA | vascular endothelial growth factor A | 0.0236185 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0230954 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0225125 |
| MKI67 | marker of proliferation Ki-67 | 0.022101 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 0.0216979 |
| RUNX1 | runt-related transcription factor 1 | 0.0215757 |
| RPS19 | ribosomal protein S19 | 0.0213751 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0213556 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0210607 |
| RPL36AL | ribosomal protein L36a-like | 0.0202976 |
| B2M | beta-2-microglobulin | 0.0202459 |
| H1-0 | H1.0 linker histone | 0.0197949 |
| IER5 | immediate early response 5 | 0.0195842 |
| TBCA | tubulin folding cofactor A | 0.019071 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0189496 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0187844 |
| RPS29 | ribosomal protein S29 | 0.018761 |
| RPL36 | ribosomal protein L36 | 0.0184367 |
| RPL23 | ribosomal protein L23 | 0.0182395 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0178834 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.0177798 |
| TMSB10 | thymosin beta 10 | 0.0175958 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0175564 |
| AGRN | agrin | 0.0173619 |
| FAM193A | family with sequence similarity 193, member A | 0.0173024 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.017166 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.0171037 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0170597 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0167588 |
| S100A11 | S100 calcium binding protein A11 | 0.0167332 |
| HDGF | hepatoma-derived growth factor | 0.0166509 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0166392 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0166379 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0165037 |
| MTDH | metadherin | 0.0164515 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0164282 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0162917 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0160925 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.0160674 |
| PKM | pyruvate kinase, muscle | 0.0160544 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0155616 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0153387 |
| PLEC | plectin | 0.0151723 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0150506 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0149502 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0145597 |
| SMAD3 | SMAD family member 3 | 0.0142992 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0142484 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0141597 |
| CDK13 | cyclin-dependent kinase 13 | 0.0141516 |
| RPL18 | ribosomal protein L18 | 0.0139421 |
| UPP1 | uridine phosphorylase 1 | 0.0138998 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.0138823 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0138618 |
| FHIT | fragile histidine triad | 0.0138444 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0137895 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0137492 |
| RNF213 | ring finger protein 213 | 0.0134791 |
| GPX4 | glutathione peroxidase 4 | 0.0133908 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0132312 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0132086 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.266881 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.265027 |
| POTEF | POTE ankyrin domain family, member F | -0.201427 |
| ACTG1 | actin gamma 1 | -0.163704 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.116931 |
| TSC22D2 | TSC22 domain family, member 2 | -0.087775 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0832082 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.080628 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.073141 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0682667 |
| KRT7 | keratin 7, type II | -0.0680887 |
| ANXA2 | annexin A2 | -0.0678068 |
| LMO7 | LIM domain 7 | -0.0654185 |
| ASPH | aspartate beta-hydroxylase | -0.0614841 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0590627 |
| LDHA | lactate dehydrogenase A | -0.0571311 |
| UBC | ubiquitin C | -0.0555575 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0546323 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0534629 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0514672 |
| PTK2 | protein tyrosine kinase 2 | -0.0504968 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0461329 |
| SQSTM1 | sequestosome 1 | -0.0443896 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0435241 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0433767 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0430562 |
| RACK1 | receptor for activated C kinase 1 | -0.0424844 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0413021 |
| ENO1 | enolase 1, (alpha) | -0.0404926 |
| RPLP0 | ribosomal protein, large, P0 | -0.0396527 |
| TMSB4X | thymosin beta 4, X-linked | -0.0393368 |
| S100A6 | S100 calcium binding protein A6 | -0.0392184 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0385925 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0384522 |
| CTSB | cathepsin B | -0.0381113 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0378951 |
| CD2AP | CD2-associated protein | -0.0378823 |
| RPL35A | ribosomal protein L35a | -0.0378183 |
| TMEM123 | transmembrane protein 123 | -0.0376989 |
| LAMC2 | laminin, gamma 2 | -0.0375346 |
| RPS23 | ribosomal protein S23 | -0.0372837 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.037044 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0361387 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0361304 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0360497 |
| KRT18 | keratin 18, type I | -0.0347641 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0347318 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0347184 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0345509 |
| DSG2 | desmoglein 2 | -0.0341771 |
| ZNF292 | zinc finger protein 292 | -0.0341726 |
| COPA | coatomer protein complex, subunit alpha | -0.0340602 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0340506 |
| YBX1 | Y box binding protein 1 | -0.0335341 |
| EZR | ezrin | -0.0333276 |
| RPL8 | ribosomal protein L8 | -0.0332284 |
| HMGA1 | high mobility group AT-hook 1 | -0.0329518 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0327201 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0320458 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0320391 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0313657 |
| PGK1 | phosphoglycerate kinase 1 | -0.0312088 |
| TFG | TRK-fused gene | -0.0307413 |
| ARF1 | ADP-ribosylation factor 1 | -0.0307087 |
| RPL27A | ribosomal protein L27a | -0.0305795 |
| RPL4 | ribosomal protein L4 | -0.0304005 |
| KRT8 | keratin 8, type II | -0.029833 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0298292 |
| IRF6 | interferon regulatory factor 6 | -0.0296494 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0295693 |
| ARRDC3 | arrestin domain containing 3 | -0.0294275 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0293156 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0291304 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0285899 |
| RHOA | ras homolog family member A | -0.028464 |
| AHNAK | AHNAK nucleoprotein | -0.0283249 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0282771 |
| RPS24 | ribosomal protein S24 | -0.0281987 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0280966 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0280232 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0279741 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.027784 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0277409 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0276339 |
| DTNA | dystrobrevin, alpha | -0.027612 |
| VIM | vimentin | -0.0271674 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0271326 |
| FAM13A | family with sequence similarity 13, member A | -0.0270708 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.02702 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0269284 |
| MCL1 | myeloid cell leukemia 1 | -0.0266624 |
| RPS25 | ribosomal protein S25 | -0.0264748 |
| USP3 | ubiquitin specific peptidase 3 | -0.0264526 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0259003 |
| CD109 | CD109 molecule | -0.0257678 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.025268 |
| TPM3 | tropomyosin 3 | -0.0247983 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0246745 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0246389 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0245381 |
