Futibatinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Futibatinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.145668
TPT1 tumor protein, translationally-controlled 1 0.105765
TMSB10 thymosin beta 10 0.0901033
RPLP1 ribosomal protein, large, P1 0.0840802
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0825878
VIM vimentin 0.074184
RPS6 ribosomal protein S6 0.071307
PTMA prothymosin, alpha 0.0635355
RPS24 ribosomal protein S24 0.0608158
RPS12 ribosomal protein S12 0.0545679
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0533643
RPS8 ribosomal protein S8 0.0509471
RPL36A ribosomal protein L36a 0.0495467
RPLP2 ribosomal protein, large, P2 0.0494482
LMNA lamin A/C 0.0462957
RPL12 ribosomal protein L12 0.0456049
RPS21 ribosomal protein S21 0.0454087
SOX4 SRY (sex determining region Y)-box 4 0.0451898
RPL7A ribosomal protein L7a 0.0450632
RPS19 ribosomal protein S19 0.0448556
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0426161
RPL26 ribosomal protein L26 0.0422717
RPL23 ribosomal protein L23 0.0416095
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0408801
RPL9 ribosomal protein L9 0.0393945
RPL35A ribosomal protein L35a 0.0378123
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0370859
RPL34 ribosomal protein L34 0.0370221
EXT1 exostosin glycosyltransferase 1 0.0365994
RPS23 ribosomal protein S23 0.0362605
PDLIM5 PDZ and LIM domain 5 0.0346656
RPS14 ribosomal protein S14 0.0341691
AKAP13 A kinase (PRKA) anchor protein 13 0.0334053
BASP1 brain abundant, membrane attached signal protein 1 0.0333204
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0310073
RPL18 ribosomal protein L18 0.0309413
PABPN1 poly(A) binding protein, nuclear 1 0.0298272
SH3KBP1 SH3-domain kinase binding protein 1 0.0294382
NFE2L2 nuclear factor, erythroid 2-like 2 0.0291107
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.02821
RPS13 ribosomal protein S13 0.0280434
RPL31 ribosomal protein L31 0.0278974
RPS25 ribosomal protein S25 0.0274576
RPLP0 ribosomal protein, large, P0 0.0271669
MT2A metallothionein 2A 0.0270513
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0257586
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0253709
CD109 CD109 molecule 0.0253297
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0252934
RPS28 ribosomal protein S28 0.0250242
CBX3 chromobox homolog 3 0.024633
EIF1 eukaryotic translation initiation factor 1 0.0245265
RPL37 ribosomal protein L37 0.0238002
RPS17 ribosomal protein S17 0.0237452
S100A6 S100 calcium binding protein A6 0.0236693
RPS27 ribosomal protein S27 0.0232532
TUBA1B tubulin, alpha 1b 0.0232333
ASTN2 astrotactin 2 0.023172
FTH1 ferritin, heavy polypeptide 1 0.0225828
RPL11 ribosomal protein L11 0.0224434
MGST1 microsomal glutathione S-transferase 1 0.0217401
MFSD12 major facilitator superfamily domain containing 12 0.0211505
PFN1 profilin 1 0.020885
RPL5 ribosomal protein L5 0.020723
MIDN midnolin 0.0206773
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0205373
RPL36 ribosomal protein L36 0.0201521
KPNB1 karyopherin (importin) beta 1 0.0200835
RPL32 ribosomal protein L32 0.0195894
RPS4X ribosomal protein S4, X-linked 0.0195592
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0192871
NACA nascent polypeptide-associated complex alpha subunit 0.01918
POTEF POTE ankyrin domain family, member F 0.0190828
PA2G4 proliferation-associated 2G4, 38kDa 0.018909
RACK1 receptor for activated C kinase 1 0.0189011
NT5C2 5'-nucleotidase, cytosolic II 0.0188928
WWOX WW domain containing oxidoreductase 0.0187126
RASAL2 RAS protein activator like 2 0.018654
IRS2 insulin receptor substrate 2 0.0183875
RPS3 ribosomal protein S3 0.0181718
NAP1L1 nucleosome assembly protein 1-like 1 0.0180721
EIF4A1 eukaryotic translation initiation factor 4A1 0.0180175
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0179924
RPL37A ribosomal protein L37a 0.0176757
FMNL2 formin-like 2 0.017612
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0175131
ACTN4 actinin, alpha 4 0.0174795
RUNX1 runt-related transcription factor 1 0.0172175
CUX1 cut-like homeobox 1 0.0169824
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0168754
VCL vinculin 0.0168618
NCOR2 nuclear receptor corepressor 2 0.016793
PRKN parkin RBR E3 ubiquitin protein ligase 0.0165247
RPL8 ribosomal protein L8 0.0165047
RPS16 ribosomal protein S16 0.016415
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0162938
TNRC18 trinucleotide repeat containing 18 0.0161212
CREB5 cAMP responsive element binding protein 5 0.0161147
PCBP2 poly(rC) binding protein 2 0.0160412
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0159417

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.42998
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.142148
NAMPT nicotinamide phosphoribosyltransferase -0.131035
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.126248
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126162
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11073
PDE4D phosphodiesterase 4D, cAMP-specific -0.108993
EFNA5 ephrin-A5 -0.0965908
PDE10A phosphodiesterase 10A -0.0925973
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0891669
IGFBP3 insulin-like growth factor binding protein 3 -0.0825812
LIMCH1 LIM and calponin homology domains 1 -0.0764088
ASPH aspartate beta-hydroxylase -0.0729736
DST dystonin -0.069852
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0698482
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0664092
PGK1 phosphoglycerate kinase 1 -0.0660493
CANX calnexin -0.0642066
ELL2 elongation factor, RNA polymerase II, 2 -0.059437
FNDC3B fibronectin type III domain containing 3B -0.0586531
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0543875
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0542782
SOD2 superoxide dismutase 2, mitochondrial -0.0522756
PSD3 pleckstrin and Sec7 domain containing 3 -0.0519085
MYOF myoferlin -0.0506933
NCOA7 nuclear receptor coactivator 7 -0.0504117
TBXT T-box transcription factor T -0.0473082
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0455743
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0421066
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0419593
COL8A1 collagen, type VIII, alpha 1 -0.0419567
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0414734
PDIA3 protein disulfide isomerase family A, member 3 -0.0413509
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0383082
BZW1 basic leucine zipper and W2 domains 1 -0.0377169
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0373749
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0372243
IL6 interleukin 6 -0.0367012
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0365827
TGFBI transforming growth factor, beta-induced, 68kDa -0.0365125
FAM13A family with sequence similarity 13, member A -0.0363935
RGS2 regulator of G-protein signaling 2 -0.0347263
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0333495
ANTXR1 anthrax toxin receptor 1 -0.0333147
PCBP3 poly(rC) binding protein 3 -0.0331818
OASL 2'-5'-oligoadenylate synthetase-like -0.0330912
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.032893
TMX4 thioredoxin-related transmembrane protein 4 -0.0328598
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0314611
LDHA lactate dehydrogenase A -0.0304102
KDM3A lysine (K)-specific demethylase 3A -0.0304005
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0302066
GLIS3 GLIS family zinc finger 3 -0.0301293
ESYT2 extended synaptotagmin-like protein 2 -0.0300285
RIGI RNA sensor RIG-I -0.0294914
DNER delta/notch-like EGF repeat containing -0.0293404
TRIO trio Rho guanine nucleotide exchange factor -0.0291923
PBX1 pre-B-cell leukemia homeobox 1 -0.0279355
SPAG9 sperm associated antigen 9 -0.0279237
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0279144
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0276241
ESM1 endothelial cell-specific molecule 1 -0.0272261
KMT2E lysine (K)-specific methyltransferase 2E -0.0269941
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0269842
RAB3B RAB3B, member RAS oncogene family -0.0265766
EPHA4 EPH receptor A4 -0.0264734
EXOC4 exocyst complex component 4 -0.0264183
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0263164
NEK7 NIMA-related kinase 7 -0.0262895
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.026279
LMAN1 lectin, mannose-binding, 1 -0.0260875
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0260087
FTL ferritin, light polypeptide -0.0259122
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0258619
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0255393
LAMB1 laminin, beta 1 -0.0252976
GIGYF2 GRB10 interacting GYF protein 2 -0.0252047
COL5A2 collagen, type V, alpha 2 -0.0250863
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0248842
WARS1 tryptophanyl-tRNA synthetase 1 -0.0245993
PDE7B phosphodiesterase 7B -0.0245743
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0244087
DOCK4 dedicator of cytokinesis 4 -0.0243432
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.024342
AHR aryl hydrocarbon receptor -0.0241935
PDIA6 protein disulfide isomerase family A, member 6 -0.0237152
GOLGA4 golgin A4 -0.0232069
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0231265
NGLY1 N-glycanase 1 -0.0229599
TPR translocated promoter region, nuclear basket protein -0.0228075
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0225598
CTNND2 catenin (cadherin-associated protein), delta 2 -0.022534
AFF4 AF4/FMR2 family, member 4 -0.0224026
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.0222608
MXI1 MAX interactor 1, dimerization protein -0.0221234
SETX senataxin -0.021742
ZBTB38 zinc finger and BTB domain containing 38 -0.0216918
ADGRB3 adhesion G protein-coupled receptor B3 -0.0213763
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0213709
ZNF292 zinc finger protein 292 -0.0213112