Futibatinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

144 genes differentially expressed following the Futibatinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.140909
VIM vimentin 0.124042
NDRG1 N-myc downstream regulated 1 0.119947
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.10716
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.102403
SYT1 synaptotagmin I 0.0987505
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0937824
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0884363
NAV1 neuron navigator 1 0.0880289
TPT1 tumor protein, translationally-controlled 1 0.0830062
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0800275
AKAP12 A kinase (PRKA) anchor protein 12 0.0728538
EFNA5 ephrin-A5 0.0699075
JMJD1C jumonji domain containing 1C 0.069118
ZSWIM6 zinc finger, SWIM-type containing 6 0.0682644
FNDC3B fibronectin type III domain containing 3B 0.0669221
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0655047
GOLGA4 golgin A4 0.0601551
PRKCA protein kinase C, alpha 0.0593979
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0579655
FLNB filamin B, beta 0.055243
IGF2 insulin-like growth factor 2 0.0538069
EPS8 epidermal growth factor receptor pathway substrate 8 0.0533083
GMDS GDP-mannose 4,6-dehydratase 0.0522956
EEF2 eukaryotic translation elongation factor 2 0.0501857
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0484855
BPTF bromodomain PHD finger transcription factor 0.0471051
DSCAM Down syndrome cell adhesion molecule 0.0463561
ERRFI1 ERBB receptor feedback inhibitor 1 0.0462748
RAD51B RAD51 paralog B 0.0448619
CANX calnexin 0.043689
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0417303
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0416684
CSNK1A1 casein kinase 1, alpha 1 0.0401319
RPL37A ribosomal protein L37a 0.0393643
PARD3 par-3 family cell polarity regulator 0.0387425
RPL15 ribosomal protein L15 0.0374089
ANXA2 annexin A2 0.0366213
GRB10 growth factor receptor-bound protein 10 0.0347668
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0325463
HMGA1 high mobility group AT-hook 1 0.0324379
FHIT fragile histidine triad 0.0295799
RPL11 ribosomal protein L11 0.0289126
ESYT2 extended synaptotagmin-like protein 2 0.0268856
EGR1 early growth response 1 0.0267612
BACE2 beta-site APP-cleaving enzyme 2 0.022823
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0224704
ZBTB20 zinc finger and BTB domain containing 20 0.0224473
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0217572
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0216049
EIF1 eukaryotic translation initiation factor 1 0.0185276
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0169857
RPS19 ribosomal protein S19 0.0164794
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0157266
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0152026
ASPH aspartate beta-hydroxylase 0.0147678
LIMCH1 LIM and calponin homology domains 1 0.0140086
NF1 neurofibromin 1 0.0137377
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0130286
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0130061
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0125823
EXT1 exostosin glycosyltransferase 1 0.0109079
LOC112694756 uncharaterized LOC112694756 0.0104374
RPS6 ribosomal protein S6 0.0102701
ANKRD12 ankyrin repeat domain 12 0.00753315
LAMA4 laminin, alpha 4 0.00672553
TTC3 tetratricopeptide repeat domain 3 0.00648994
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.00571123
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0048472
PCBP3 poly(rC) binding protein 3 0.00473805
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00415043
ALCAM activated leukocyte cell adhesion molecule 0.00262334
FN1 fibronectin 1 0.002041
GAPDH glyceraldehyde-3-phosphate dehydrogenase 5.92214E-4
AREG amphiregulin 4.47081E-4
LPP LIM domain containing preferred translocation partner in lipoma 1.8446E-4

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.288218
MT2A metallothionein 2A -0.129699
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.119533
LDHA lactate dehydrogenase A -0.105694
FTL ferritin, light polypeptide -0.094474
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0873621
MYO6 myosin VI -0.0846395
USP34 ubiquitin specific peptidase 34 -0.0813163
SBF2 SET binding factor 2 -0.0729996
SLTM SAFB-like, transcription modulator -0.0686992
YBX3 Y box binding protein 3 -0.0671042
CCNI cyclin I -0.0601232
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0586111
RPL8 ribosomal protein L8 -0.0574332
RPLP1 ribosomal protein, large, P1 -0.0527426
TRIO trio Rho guanine nucleotide exchange factor -0.0527195
TMSB10 thymosin beta 10 -0.0507037
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0504636
RPL19 ribosomal protein L19 -0.047914
MYO1E myosin IE -0.0470176
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0467926
RUNX1 runt-related transcription factor 1 -0.045908
POTEF POTE ankyrin domain family, member F -0.045427
RPS3 ribosomal protein S3 -0.0437677
TPM4 tropomyosin 4 -0.0424976
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0424781
SMYD3 SET and MYND domain containing 3 -0.0395737
PRRC2C proline-rich coiled-coil 2C -0.0371982
PTK2 protein tyrosine kinase 2 -0.0352014
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0350334
RPS12 ribosomal protein S12 -0.0340857
KMT2E lysine (K)-specific methyltransferase 2E -0.0329482
PKM pyruvate kinase, muscle -0.0313236
RPS8 ribosomal protein S8 -0.0306064
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0293182
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.027072
FAM13A family with sequence similarity 13, member A -0.0261887
HMGA2 high mobility group AT-hook 2 -0.0257691
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0256865
KTN1 kinectin 1 (kinesin receptor) -0.0251011
ENO1 enolase 1, (alpha) -0.0249193
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0248254
FMNL2 formin-like 2 -0.0229637
ELL2 elongation factor, RNA polymerase II, 2 -0.022551
KMT2C lysine (K)-specific methyltransferase 2C -0.0224524
MYOF myoferlin -0.0220841
PTMA prothymosin, alpha -0.0220359
PGK1 phosphoglycerate kinase 1 -0.0219877
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0208166
STC1 stanniocalcin 1 -0.0205236
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0201039
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0192449
MACF1 microtubule-actin crosslinking factor 1 -0.0190755
B2M beta-2-microglobulin -0.0170701
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0166495
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0161743
CD44 CD44 molecule (Indian blood group) -0.0154868
TM4SF1 transmembrane 4 L six family member 1 -0.0131092
WNK1 WNK lysine deficient protein kinase 1 -0.00898222
SEPTIN9 septin 9 -0.00838185
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.00712096
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00668886
RPL23 ribosomal protein L23 -0.00659243
RPS13 ribosomal protein S13 -0.00433082
AKAP9 A kinase (PRKA) anchor protein 9 -0.00353932
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00325041
HSPD1 heat shock 60kDa protein 1 (chaperonin) -5.48907E-4
FTH1 ferritin, heavy polypeptide 1 -6.55985E-5