Futibatinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Futibatinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Futibatinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS8 ribosomal protein S8 0.072835
RPL37A ribosomal protein L37a 0.0617313
RPL23 ribosomal protein L23 0.0581381
RPS3 ribosomal protein S3 0.0568386
RPL9 ribosomal protein L9 0.049454
RPS12 ribosomal protein S12 0.0477242
ENO2 enolase 2 (gamma, neuronal) 0.0459521
RPL26 ribosomal protein L26 0.0413713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0408202
FTH1 ferritin, heavy polypeptide 1 0.0380436
RPLP1 ribosomal protein, large, P1 0.0376294
GSE1 Gse1 coiled-coil protein 0.033914
VIM vimentin 0.0336777
RPL31 ribosomal protein L31 0.0315127
HLA-A major histocompatibility complex, class I, A 0.031221
RPL36 ribosomal protein L36 0.030776
LOC102724023 ES1 protein homolog, mitochondrial 0.0304698
INTS6 integrator complex subunit 6 0.0298105
RPL13A ribosomal protein L13a 0.0292968
HSPB1 heat shock 27kDa protein 1 0.0287449
TMSB10 thymosin beta 10 0.0285846
RPL37 ribosomal protein L37 0.0282346
RPS17 ribosomal protein S17 0.0263644
FER1L6 fer-1-like family member 6 0.0257039
RPS6 ribosomal protein S6 0.0254922
MT2A metallothionein 2A 0.024644
S100A11 S100 calcium binding protein A11 0.0239837
SMAD3 SMAD family member 3 0.0234804
BRD4 bromodomain containing 4 0.0228036
RPL27 ribosomal protein L27 0.0227628
EEF1G eukaryotic translation elongation factor 1 gamma 0.0227522
RPL30 ribosomal protein L30 0.022628
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0218372
NDRG1 N-myc downstream regulated 1 0.0213642
FTL ferritin, light polypeptide 0.0209841
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.020245
HMGA1 high mobility group AT-hook 1 0.019922
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0198442
PSD3 pleckstrin and Sec7 domain containing 3 0.0198268
BCOR BCL6 corepressor 0.0196415
MMP24OS MMP24 opposite strand 0.0194292
SEPTIN9 septin 9 0.0194127
IGF2 insulin-like growth factor 2 0.0193367
ZBTB7A zinc finger and BTB domain containing 7A 0.0188751
FGFR2 fibroblast growth factor receptor 2 0.0186717
UBAP2 ubiquitin associated protein 2 0.018372
AKAP12 A kinase (PRKA) anchor protein 12 0.0182345
FMNL2 formin-like 2 0.0181909
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.018104
SPRY4 sprouty homolog 4 (Drosophila) 0.017905
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0177003
RPL34 ribosomal protein L34 0.0172545
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0171639
TIMP1 TIMP metallopeptidase inhibitor 1 0.0170745
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0170101
PACS1 phosphofurin acidic cluster sorting protein 1 0.0168867
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0167862
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0166831
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0166343
UNC13A unc-13 homolog A (C. elegans) 0.0165811
RPL35 ribosomal protein L35 0.0163977
ATN1 atrophin 1 0.0163783
RPS27 ribosomal protein S27 0.0161399
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0160792
HMGA2 high mobility group AT-hook 2 0.0160373
PABPN1 poly(A) binding protein, nuclear 1 0.0159286
RPL18 ribosomal protein L18 0.015888
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0158353
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0156221
GLIS3 GLIS family zinc finger 3 0.0156214
ITGA10 integrin, alpha 10 0.0155183
GLI3 GLI family zinc finger 3 0.0154046
FOXA2 forkhead box A2 0.0152448
MNT MAX network transcriptional repressor 0.0151258
INF2 inverted formin, FH2 and WH2 domain containing 0.014916
RPS14 ribosomal protein S14 0.0146425
CDH13 cadherin 13 0.0146421
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0145599
STC1 stanniocalcin 1 0.0143364
ELL2 elongation factor, RNA polymerase II, 2 0.0143297
HLA-B major histocompatibility complex, class I, B 0.0142201
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.014171
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0141041
RPL11 ribosomal protein L11 0.014066
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0139345
CD44 CD44 molecule (Indian blood group) 0.0138883
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0138776
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0138092
IRS1 insulin receptor substrate 1 0.0138084
NALF1 NALCN channel auxiliary factor 1 0.013754
ANKRD12 ankyrin repeat domain 12 0.0136931
PRMT2 protein arginine methyltransferase 2 0.013411
HDAC4 histone deacetylase 4 0.013398
LMO7 LIM domain 7 0.0133567
PDE10A phosphodiesterase 10A 0.0132016
GLI2 GLI family zinc finger 2 0.0131562
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0130534
MYO10 myosin X 0.0130255
CAPN2 calpain 2, (m/II) large subunit 0.0129647
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0129308

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.145222
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.13623
ADAM10 ADAM metallopeptidase domain 10 -0.131534
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.11569
TMSB4X thymosin beta 4, X-linked -0.11454
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.110327
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0973418
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0971596
VCL vinculin -0.0957612
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0891619
SSBP2 single-stranded DNA binding protein 2 -0.0844515
FLNB filamin B, beta -0.0794007
NBEA neurobeachin -0.0784115
GOLGA4 golgin A4 -0.0756083
PTMA prothymosin, alpha -0.0754917
ECT2 epithelial cell transforming 2 -0.0717795
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0716802
ZNF292 zinc finger protein 292 -0.0712512
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0700501
DLG1 discs, large homolog 1 (Drosophila) -0.0691625
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0641172
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0629907
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0619998
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0613219
CAMKMT calmodulin-lysine N-methyltransferase -0.0591853
ZEB1 zinc finger E-box binding homeobox 1 -0.0546202
QKI QKI, KH domain containing, RNA binding -0.0543982
GARS1 glycyl-tRNA synthetase 1 -0.0537025
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0534389
JMJD1C jumonji domain containing 1C -0.0527528
RTN4 reticulon 4 -0.0522595
TJP1 tight junction protein 1 -0.0522015
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0520289
EGFR epidermal growth factor receptor -0.0514777
EML4 echinoderm microtubule associated protein like 4 -0.0512479
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0511207
CDC73 cell division cycle 73 -0.0509742
DSCAM Down syndrome cell adhesion molecule -0.0507162
PDE4D phosphodiesterase 4D, cAMP-specific -0.0499272
TFG TRK-fused gene -0.0493663
PDE4B phosphodiesterase 4B, cAMP-specific -0.0487925
DPYD dihydropyrimidine dehydrogenase -0.0486156
NF1 neurofibromin 1 -0.0484976
RBM39 RNA binding motif protein 39 -0.0479305
KDM3A lysine (K)-specific demethylase 3A -0.0474734
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0472359
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0472081
PDIA3 protein disulfide isomerase family A, member 3 -0.0472071
NUP58 nucleoporin 58 -0.0471578
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0467166
PARD3 par-3 family cell polarity regulator -0.0465074
TXNRD1 thioredoxin reductase 1 -0.0458988
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.045759
SMNDC1 survival motor neuron domain containing 1 -0.0457168
SLC38A2 solute carrier family 38, member 2 -0.0455672
NFIA nuclear factor I/A -0.0455378
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.045308
EZR ezrin -0.044831
POTEF POTE ankyrin domain family, member F -0.0446829
RNF145 ring finger protein 145 -0.0439082
BIRC6 baculoviral IAP repeat containing 6 -0.0431708
HDLBP high density lipoprotein binding protein -0.0430514
FBXO11 F-box protein 11 -0.0424516
SOX6 SRY (sex determining region Y)-box 6 -0.0414817
NBAS neuroblastoma amplified sequence -0.04113
SBF2 SET binding factor 2 -0.0409988
TXNIP thioredoxin interacting protein -0.0406859
EVI5 ecotropic viral integration site 5 -0.0405713
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0403121
ANK2 ankyrin 2, neuronal -0.0402121
WAC WW domain containing adaptor with coiled-coil -0.0401087
RHOA ras homolog family member A -0.0397478
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0396577
EXOC6B exocyst complex component 6B -0.0395047
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0390242
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0388089
USP3 ubiquitin specific peptidase 3 -0.0387958
HDAC9 histone deacetylase 9 -0.0387911
NCKAP1 NCK-associated protein 1 -0.0386073
S100A6 S100 calcium binding protein A6 -0.0382757
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.038061
SEC31A SEC31 homolog A (S. cerevisiae) -0.0377791
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.037389
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0373404
PTBP2 polypyrimidine tract binding protein 2 -0.037277
ELOVL5 ELOVL fatty acid elongase 5 -0.0371642
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0370766
MATR3 matrin 3 -0.0368551
LDHA lactate dehydrogenase A -0.0359598
CENPF centromere protein F, 350/400kDa -0.0353551
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0350408
PDGFC platelet derived growth factor C -0.0350316
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0349197
EEF2 eukaryotic translation elongation factor 2 -0.0348365
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0346105
CALR calreticulin -0.0338652
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.033636
ANXA1 annexin A1 -0.033447
WDR43 WD repeat domain 43 -0.0333934
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0332373