G-361 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Homo sapiens (human); skin; malignant melanoma cell line; established from a 31 year old caucasian male. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001584)
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Genes

347 genes with high or low expression in G-361 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.59125
SFT2D2 SFT2 domain containing 2 3.18765
GRSF1 G-rich RNA sequence binding factor 1 3.13689
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.06648
CHMP1B charged multivesicular body protein 1B 2.98956
RFPL2 ret finger protein-like 2 2.7361
EN2 engrailed homeobox 2 2.71415
MERTK MER proto-oncogene, tyrosine kinase 2.69998
RFPL3 ret finger protein-like 3 2.59793
SLC39A6 solute carrier family 39 (zinc transporter), member 6 2.59502
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.58646
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.56315
APOLD1 apolipoprotein L domain containing 1 2.53915
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.52773
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.51238
APOD apolipoprotein D 2.47868
VGF VGF nerve growth factor inducible 2.45633
CYTH3 cytohesin 3 2.44502
CREM cAMP responsive element modulator 2.41085
PPARA peroxisome proliferator-activated receptor alpha 2.34079
ITGA9 integrin, alpha 9 2.33804
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.33492
COPA coatomer protein complex, subunit alpha 2.27133
PRKD3 protein kinase D3 2.26635
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 2.25977
CEMIP cell migration inducing protein, hyaluronan binding 2.25728
FNDC3A fibronectin type III domain containing 3A 2.25217
SLC16A6 solute carrier family 16, member 6 2.18139
MCTP2 multiple C2 domains, transmembrane 2 2.17661
MOCOS molybdenum cofactor sulfurase 2.17643
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.17
PLD1 phospholipase D1, phosphatidylcholine-specific 2.16481
MCF2 MCF.2 cell line derived transforming sequence 2.16128
TRIM62 tripartite motif containing 62 2.15691
NAV2 neuron navigator 2 2.15453
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.14188
ATP10A ATPase, class V, type 10A 2.14072
DYNLT3 dynein, light chain, Tctex-type 3 2.06894
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.05112
CREB5 cAMP responsive element binding protein 5 2.048
ADCY1 adenylate cyclase 1 (brain) 2.03766
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.03607
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.0296
FBLN5 fibulin 5 2.02955
ANKRD53 ankyrin repeat domain 53 2.02256
CALU calumenin 2.00237
CDX4 caudal type homeobox 4 1.99723
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 1.99161
ASB4 ankyrin repeat and SOCS box containing 4 1.97618
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 1.97105
CRYGA crystallin, gamma A 1.9626
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 1.95774
PAEP progestagen-associated endometrial protein 1.93237
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 1.9103
XYLB xylulokinase homolog (H. influenzae) 1.90777
CCL1 chemokine (C-C motif) ligand 1 1.90568
LMAN1 lectin, mannose-binding, 1 1.89967
GPR161 G protein-coupled receptor 161 1.8939
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 1.89348
TNP1 transition protein 1 (during histone to protamine replacement) 1.8906
DCAKD dephospho-CoA kinase domain containing 1.89013
ANGPTL3 angiopoietin-like 3 1.88687
NR4A3 nuclear receptor subfamily 4, group A, member 3 1.88555
ATF7 activating transcription factor 7 1.88072
SOCS3 suppressor of cytokine signaling 3 1.87889
PDE4B phosphodiesterase 4B, cAMP-specific 1.87226
OXNAD1 oxidoreductase NAD-binding domain containing 1 1.86347
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.85335
TPMT thiopurine S-methyltransferase 1.85142
OR3A2 olfactory receptor, family 3, subfamily A, member 2 1.84609
STAB1 stabilin 1 1.83786
EMC1 ER membrane protein complex subunit 1 1.82521
BTD biotinidase 1.81846
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.81625
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.81588
CSPG4 chondroitin sulfate proteoglycan 4 1.80654
PITX3 paired-like homeodomain 3 1.8052
OLFM1 olfactomedin 1 1.79933
COG5 component of oligomeric golgi complex 5 1.79903
GIPR gastric inhibitory polypeptide receptor 1.79548
BIN3 bridging integrator 3 1.79174
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1.78656
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 1.7801
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.77768
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 1.77209
CRYBA4 crystallin, beta A4 1.76781
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 1.76535
POM121 POM121 transmembrane nucleoporin 1.76357
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 1.76028
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 1.75942
PRKCD protein kinase C, delta 1.75789
EDN3 endothelin 3 1.75764
MYEF2 myelin expression factor 2 1.75503
ZFYVE16 zinc finger, FYVE domain containing 16 1.75067
OCA2 oculocutaneous albinism II 1.74566
SRY sex determining region Y 1.74062
CSNK1G1 casein kinase 1, gamma 1 1.73507
PRUNE2 prune homolog 2 (Drosophila) 1.72059
FEZF2 FEZ family zinc finger 2 1.71987
PMEL premelanosome protein 1.71837
LPAR6 lysophosphatidic acid receptor 6 1.71638
FAHD2A fumarylacetoacetate hydrolase domain containing 2A 1.70476
ZNF471 zinc finger protein 471 1.70318
CYSLTR2 cysteinyl leukotriene receptor 2 1.70316
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 1.70109
B3GAT1 beta-1,3-glucuronyltransferase 1 1.69586
PLEKHA5 pleckstrin homology domain containing, family A member 5 1.69179
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 1.69089
MMP8 matrix metallopeptidase 8 1.68862
TBX19 T-box 19 1.68741
BSG basigin (Ok blood group) 1.68317
FRMD4A FERM domain containing 4A 1.67728
LAMA1 laminin, alpha 1 1.67419
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.67107
MRPL35 mitochondrial ribosomal protein L35 1.66953
XPO4 exportin 4 1.66927
TAS2R13 taste receptor, type 2, member 13 1.66761
ANKRD28 ankyrin repeat domain 28 1.66465
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 1.66206
FKBP14 FK506 binding protein 14, 22 kDa 1.66155
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 1.66071
MDH1 malate dehydrogenase 1, NAD (soluble) 1.65805
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 1.64917
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 1.64793
CTSL cathepsin L 1.64487
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 1.64229
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.6419
IL3 interleukin 3 1.64065
ACTL7A actin-like 7A 1.63523
IL5 interleukin 5 1.63404
NUP93 nucleoporin 93kDa 1.63331
HCRT hypocretin (orexin) neuropeptide precursor 1.6268
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 1.62259
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 1.61143
SCARB2 scavenger receptor class B, member 2 1.61055
ITGB8 integrin, beta 8 1.60771
ITGA7 integrin, alpha 7 1.60699
MRPL44 mitochondrial ribosomal protein L44 1.60668
SSH1 slingshot protein phosphatase 1 1.60591
ZNF343 zinc finger protein 343 1.60574
TYR tyrosinase 1.60476
HBP1 HMG-box transcription factor 1 1.604
IL1RAP interleukin 1 receptor accessory protein 1.59836
HSPE1 heat shock 10kDa protein 1 1.59209
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 1.58929
NPHP1 nephronophthisis 1 (juvenile) 1.58135
CDH19 cadherin 19, type 2 1.57402
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 1.56803
NXT2 nuclear transport factor 2-like export factor 2 1.56705
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 1.56444
QPCT glutaminyl-peptide cyclotransferase 1.55865
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 1.55495
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 1.55309
CDK2 cyclin-dependent kinase 2 1.55238
MITF microphthalmia-associated transcription factor 1.54752
USP36 ubiquitin specific peptidase 36 1.5472
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.546
MAGEB2 melanoma antigen family B2 1.54487
GIMAP4 GTPase, IMAP family member 4 1.54068
MREG melanoregulin 1.53669
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 1.53277
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 1.53228
TYRP1 tyrosinase-related protein 1 1.53216
SLC45A2 solute carrier family 45, member 2 1.53043
IQCE IQ motif containing E 1.53026
CRTAC1 cartilage acidic protein 1 1.52493
SORBS1 sorbin and SH3 domain containing 1 1.52172
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.52104
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1.52004
ATOX1 antioxidant 1 copper chaperone 1.51601
IGSF3 immunoglobulin superfamily, member 3 1.51021
DRD4 dopamine receptor D4 1.50919
RNF144A ring finger protein 144A 1.50323
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.50209
TWISTNB TWIST neighbor 1.50169
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 1.48319
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 1.48105
ZKSCAN5 zinc finger with KRAB and SCAN domains 5 1.47826
CAPN7 calpain 7 1.47135
CHL1 cell adhesion molecule L1-like 1.46967
CES1P1 carboxylesterase 1 pseudogene 1 1.46372
SLCO5A1 solute carrier organic anion transporter family, member 5A1 1.46101
ECE2 endothelin converting enzyme 2 1.46096
LIM2 lens intrinsic membrane protein 2, 19kDa 1.45647
LRRC59 leucine rich repeat containing 59 1.45554
HMBOX1 homeobox containing 1 1.45414
MYBPC3 myosin binding protein C, cardiac 1.45308
KRT36 keratin 36, type I 1.45101
STYXL1 serine/threonine/tyrosine interacting-like 1 1.44951
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 1.44946
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 1.44469
SLC41A3 solute carrier family 41, member 3 1.44155
SDC3 syndecan 3 1.44117
CD5L CD5 molecule-like 1.43868
NCK2 NCK adaptor protein 2 1.43822
MATN1 matrilin 1, cartilage matrix protein 1.43735
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.43731
TBL2 transducin (beta)-like 2 1.43712
RETN resistin 1.43368
GPR143 G protein-coupled receptor 143 1.43018
AQP8 aquaporin 8 1.42899
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 1.42639
PDIA3 protein disulfide isomerase family A, member 3 1.42225
ARNT aryl hydrocarbon receptor nuclear translocator 1.42153
NPAS2 neuronal PAS domain protein 2 1.42039
CLDN17 claudin 17 1.41984
NOL8 nucleolar protein 8 1.41879
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 1.41674

low expression

Symbol Name Standardized Value
PPP6R1 protein phosphatase 6, regulatory subunit 1 -3.53172
PSKH1 protein serine kinase H1 -3.07001
NUMB numb homolog (Drosophila) -2.98871
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.91277
TXNRD2 thioredoxin reductase 2 -2.80908
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.76533
HIRIP3 HIRA interacting protein 3 -2.66503
JRK Jrk homolog (mouse) -2.63417
RGS12 regulator of G-protein signaling 12 -2.60157
TAGLN transgelin -2.46426
BTBD7 BTB (POZ) domain containing 7 -2.45591
GNL1 guanine nucleotide binding protein-like 1 -2.39335
COL1A2 collagen, type I, alpha 2 -2.36242
TRPV1 transient receptor potential cation channel, subfamily V, member 1 -2.35654
SIRT6 sirtuin 6 -2.34543
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.33171
TMEM160 transmembrane protein 160 -2.32368
PIAS4 protein inhibitor of activated STAT, 4 -2.30402
SH2B1 SH2B adaptor protein 1 -2.22776
SCAND1 SCAN domain containing 1 -2.17977
HLA-DOA major histocompatibility complex, class II, DO alpha -2.17936
PLXNA3 plexin A3 -2.1785
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.17166
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.15224
GLTSCR1 glioma tumor suppressor candidate region gene 1 -2.12826
RBM22 RNA binding motif protein 22 -2.12252
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.12185
STRN4 striatin, calmodulin binding protein 4 -2.11017
SRA1 steroid receptor RNA activator 1 -2.08462
RCE1 Ras converting CAAX endopeptidase 1 -2.06395
RBPJ recombination signal binding protein for immunoglobulin kappa J region -2.05793
FBXW4 F-box and WD repeat domain containing 4 -2.03356
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.02188
RPL36AL ribosomal protein L36a-like -2.01857
PKNOX1 PBX/knotted 1 homeobox 1 -1.9917
CBX5 chromobox homolog 5 -1.98398
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 -1.98233
GPSM3 G-protein signaling modulator 3 -1.97111
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -1.96757
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -1.96728
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -1.96244
TBC1D17 TBC1 domain family, member 17 -1.96107
RNF167 ring finger protein 167 -1.95432
PHC3 polyhomeotic homolog 3 (Drosophila) -1.94843
GRM7 glutamate receptor, metabotropic 7 -1.93613
MAPK8 mitogen-activated protein kinase 8 -1.93329
ZNF410 zinc finger protein 410 -1.92543
FGFR1OP FGFR1 oncogene partner -1.91944
SNW1 SNW domain containing 1 -1.89606
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -1.89299
ERH enhancer of rudimentary homolog (Drosophila) -1.88326
CACNB1 calcium channel, voltage-dependent, beta 1 subunit -1.87997
NPR2 natriuretic peptide receptor 2 -1.87239
PLEK pleckstrin -1.86937
SBNO2 strawberry notch homolog 2 (Drosophila) -1.8687
KPTN kaptin (actin binding protein) -1.86024
ATL2 atlastin GTPase 2 -1.85335
STK11 serine/threonine kinase 11 -1.85012
CLASRP CLK4-associating serine/arginine rich protein -1.8254
PNPLA2 patatin-like phospholipase domain containing 2 -1.80476
MCRS1 microspherule protein 1 -1.80345
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene -1.80135
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -1.80112
ALOX5 arachidonate 5-lipoxygenase -1.79842
ZBTB44 zinc finger and BTB domain containing 44 -1.7905
TRAFD1 TRAF-type zinc finger domain containing 1 -1.77996
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -1.75981
E4F1 E4F transcription factor 1 -1.74943
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -1.74687
IRF9 interferon regulatory factor 9 -1.73554
RANBP3 RAN binding protein 3 -1.73062
UBE2D1 ubiquitin-conjugating enzyme E2D 1 -1.72389
HDAC2 histone deacetylase 2 -1.71961
PEX26 peroxisomal biogenesis factor 26 -1.71399
MEST mesoderm specific transcript -1.70919
RAB1B RAB1B, member RAS oncogene family -1.70405
DGCR8 DGCR8 microprocessor complex subunit -1.70135
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -1.69476
ZNF768 zinc finger protein 768 -1.6933
RBM25 RNA binding motif protein 25 -1.66108
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -1.64602
AQP4 aquaporin 4 -1.63128
VEZT vezatin, adherens junctions transmembrane protein -1.62061
DOPEY1 dopey family member 1 -1.62055
LSR lipolysis stimulated lipoprotein receptor -1.60864
ZNF580 zinc finger protein 580 -1.60466
CLTB clathrin, light chain B -1.6038
CLK4 CDC-like kinase 4 -1.60106
LAD1 ladinin 1 -1.59792
CCDC109B coiled-coil domain containing 109B -1.59324
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -1.59004
GABARAP GABA(A) receptor-associated protein -1.58877
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -1.58655
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -1.58198
ARHGAP24 Rho GTPase activating protein 24 -1.58093
FBXL6 F-box and leucine-rich repeat protein 6 -1.57992
PIGO phosphatidylinositol glycan anchor biosynthesis, class O -1.57506
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa -1.56769
INTS7 integrator complex subunit 7 -1.56138
WHSC1 Wolf-Hirschhorn syndrome candidate 1 -1.55862
MAP2K7 mitogen-activated protein kinase kinase 7 -1.55742
DOK2 docking protein 2, 56kDa -1.54714
BMP15 bone morphogenetic protein 15 -1.54287
NEIL1 nei endonuclease VIII-like 1 (E. coli) -1.5357
PLCE1 phospholipase C, epsilon 1 -1.53147
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -1.53032
DCLRE1C DNA cross-link repair 1C -1.53029
CAPN10 calpain 10 -1.52153
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -1.51713
CAMK2G calcium/calmodulin-dependent protein kinase II gamma -1.51536
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -1.515
ZNHIT2 zinc finger, HIT-type containing 2 -1.51089
EFCAB2 EF-hand calcium binding domain 2 -1.51006
ADGRB3 adhesion G protein-coupled receptor B3 -1.50768
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -1.50727
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -1.50394
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 -1.50126
MFSD10 major facilitator superfamily domain containing 10 -1.48974
U2AF2 U2 small nuclear RNA auxiliary factor 2 -1.48963
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -1.48693
H3F3A H3 histone, family 3A -1.48483
MTRF1L mitochondrial translational release factor 1-like -1.47708
SYT1 synaptotagmin I -1.4767
UBAP1 ubiquitin associated protein 1 -1.47276
PGAP3 post-GPI attachment to proteins 3 -1.47229
NEURL1 neuralized E3 ubiquitin protein ligase 1 -1.46966
KIF1C kinesin family member 1C -1.4666
ZNF211 zinc finger protein 211 -1.46482
DICER1 dicer 1, ribonuclease type III -1.46269
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -1.45398
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -1.45331
ARID4A AT rich interactive domain 4A (RBP1-like) -1.44483
MXD3 MAX dimerization protein 3 -1.43826
CNOT2 CCR4-NOT transcription complex, subunit 2 -1.43332
CNOT6 CCR4-NOT transcription complex, subunit 6 -1.43177
MOBP myelin-associated oligodendrocyte basic protein -1.42825
TRIM8 tripartite motif containing 8 -1.42509
SF3B5 splicing factor 3b, subunit 5, 10kDa -1.41853
MAML1 mastermind-like 1 (Drosophila) -1.41622