G2/M Checkpoints Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-69481
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Genes

137 proteins participating in the G2/M Checkpoints pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABRAXAS1 abraxas 1, BRCA1 A complex subunit
ADRM1 adhesion regulating molecule 1
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BABAM1 BRISC and BRCA1 A complex member 1
BABAM2 BRISC and BRCA1 A complex member 2
BARD1 BRCA1 associated RING domain 1
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLSPN claspin
DBF4 DBF4 zinc finger
DNA2 DNA replication helicase/nuclease 2
EXO1 exonuclease 1
GTSE1 G-2 and S-phase expressed 1
H2AX H2A.X variant histone
H2BC1 H2B clustered histone 1
H2BC11 H2B clustered histone 11
H2BC12 H2B clustered histone 12
H2BC12L H2B clustered histone 12 like
H2BC13 H2B clustered histone 13
H2BC14 H2B clustered histone 14
H2BC15 H2B clustered histone 15
H2BC17 H2B clustered histone 17
H2BC21 H2B clustered histone 21
H2BC26 H2B clustered histone 26
H2BC3 H2B clustered histone 3
H2BC4 H2B clustered histone 4
H2BC5 H2B clustered histone 5
H2BC9 H2B clustered histone 9
H3-4 H3.4 histone, cluster member
H4C1 H4 clustered histone 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HUS1 HUS1 checkpoint homolog (S. pombe)
KAT5 K(lysine) acetyltransferase 5
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCM8 minichromosome maintenance complex component 8
MDC1 mediator of DNA-damage checkpoint 1
MRE11 MRE11 homolog, double strand break repair nuclease
NBN nibrin
NSD2 nuclear receptor binding SET domain protein 2
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
ORC3 origin recognition complex, subunit 3
ORC4 origin recognition complex, subunit 4
ORC5 origin recognition complex, subunit 5
ORC6 origin recognition complex, subunit 6
PIAS4 protein inhibitor of activated STAT, 4
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RMI1 RecQ mediated genome instability 1
RMI2 RecQ mediated genome instability 2
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPS27A ribosomal protein S27a
SEM1 SEM1 26S proteasome subunit
SFN stratifin
TOP3A topoisomerase (DNA) III alpha
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UIMC1 ubiquitin interaction motif containing 1
WEE1 WEE1 G2 checkpoint kinase
WRN Werner syndrome, RecQ helicase-like
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta