G6PD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description glucose-6-phosphate dehydrogenase|This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2539)
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Genes

353 genes differentially expressed following the G6PD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.87404
PDIA2 protein disulfide isomerase family A, member 2 2.87404
ZNF662 zinc finger protein 662 2.87404
TM4SF5 transmembrane 4 L six family member 5 2.87404
HES3 hes family bHLH transcription factor 3 2.87404
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.87404
RIMBP2 RIMS binding protein 2 2.87404
NOD2 nucleotide-binding oligomerization domain containing 2 2.87404
MYBPC1 myosin binding protein C, slow type 2.87404
DUSP10 dual specificity phosphatase 10 2.87404
SKOR2 SKI family transcriptional corepressor 2 2.87404
AKR1C4 aldo-keto reductase family 1, member C4 2.87404
IL22RA1 interleukin 22 receptor, alpha 1 2.87404
CELF3 CUGBP, Elav-like family member 3 2.87404
HHEX hematopoietically expressed homeobox 2.87404
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.87404
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.87404
CFAP74 cilia and flagella associated protein 74 2.87404
LURAP1L leucine rich adaptor protein 1-like 2.87404
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.87404
ZCCHC4 zinc finger, CCHC domain containing 4 2.87404
RXFP3 relaxin/insulin-like family peptide receptor 3 2.87404
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.87404
ENTHD1 ENTH domain containing 1 2.87404
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.87404
CCL5 chemokine (C-C motif) ligand 5 2.87404
LRRC55 leucine rich repeat containing 55 2.87404
BHLHE40 basic helix-loop-helix family, member e40 2.87404
GMFG glia maturation factor, gamma 2.87404
KCNIP3 Kv channel interacting protein 3, calsenilin 2.87404
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.87404
CHL1 cell adhesion molecule L1-like 2.87404
ZNF341 zinc finger protein 341 2.87404
NPIPA8 nuclear pore complex interacting protein family, member A8 2.87404
GPR101 G protein-coupled receptor 101 2.87404
CRYGA crystallin, gamma A 2.87404
ATG4A autophagy related 4A, cysteine peptidase 2.87404
NRROS negative regulator of reactive oxygen species 2.87404
FAM221B family with sequence similarity 221, member B 2.87404
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.87404
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.87404
LRG1 leucine-rich alpha-2-glycoprotein 1 2.87404
TUBB1 tubulin, beta 1 class VI 2.87404
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.87404
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.87404
SSTR3 somatostatin receptor 3 2.87404
TAL2 T-cell acute lymphocytic leukemia 2 2.87404
MYOM2 myomesin 2 2.87404
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.87404
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 2.87404
THSD1 thrombospondin, type I, domain containing 1 2.87404
LOC124900192 uncharacterized LOC124900192 2.87404
VSIR V-set immunoregulatory receptor 2.87404
SPATS1 spermatogenesis associated, serine-rich 1 2.87404
C3AR1 complement component 3a receptor 1 2.87404
UNC93A unc-93 homolog A (C. elegans) 2.87404
CLDN16 claudin 16 2.87404
HTRA4 HtrA serine peptidase 4 2.87404
SPEM1 spermatid maturation 1 2.87404
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 2.87404
FMOD fibromodulin 2.87404
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.87404
ODAD1 outer dynein arm docking complex subunit 1 2.87404
LOC112694756 uncharaterized LOC112694756 2.87404
PLAAT4 phospholipase A and acyltransferase 4 2.87404
FAM90A24 family with sequence similarity 90 member A24 2.87404
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.87404
LIPT2-AS1 LIPT2 antisense RNA 1 2.87404
CIMAP1B ciliary microtubule associated protein 1B 2.87404
MDFIC2 MyoD family inhibitor domain containing 2 2.87404
CBY2 chibby family member 2 2.87404
ATP5MGL ATP synthase membrane subunit g like 2.87404
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.87404
TBXT T-box transcription factor T 2.87404
LORICRIN loricrin cornified envelope precursor protein 2.87404
PDF peptide deformylase (mitochondrial) 2.87404
PROX2 prospero homeobox 2 2.87404
PAPOLB poly(A) polymerase beta (testis specific) 2.87404
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.87404
DMBX1 diencephalon/mesencephalon homeobox 1 2.87404
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.87404
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.87404
MSX1 msh homeobox 1 2.87404
C10ORF67 chromosome 10 open reading frame 67 2.87404
ANXA13 annexin A13 2.87404
PTGDR2 prostaglandin D2 receptor 2 2.87404
C1ORF87 chromosome 1 open reading frame 87 2.87404
PRB4 proline-rich protein BstNI subfamily 4 2.87404
SPDYC speedy/RINGO cell cycle regulator family member C 2.87404
PRR4 proline rich 4 (lacrimal) 2.87404
CCR3 chemokine (C-C motif) receptor 3 2.87404
ASB4 ankyrin repeat and SOCS box containing 4 2.87404
FCMR Fc fragment of IgM receptor 2.87404
VSIG8 V-set and immunoglobulin domain containing 8 2.87404
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.87404
OSTN osteocrin 2.87404
TUBA4B tubulin, alpha 4b 2.87404
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.87404
GPR83 G protein-coupled receptor 83 2.87404
SAMD15 sterile alpha motif domain containing 15 2.87404
ABHD15 abhydrolase domain containing 15 2.87404
EFHB EF-hand domain family, member B 2.87404
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.87404
SERINC4 serine incorporator 4 2.87404
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.87404
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.87404
CGB2 chorionic gonadotropin, beta polypeptide 2 2.87404
CAGE1 cancer antigen 1 2.87404
CCDC179 coiled-coil domain containing 179 2.87404
TEX19 testis expressed 19 2.87404
ZCCHC18 zinc finger, CCHC domain containing 18 2.87404
PDZRN4 PDZ domain containing ring finger 4 2.87404
TDRD15 tudor domain containing 15 2.87404
CALHM1 calcium homeostasis modulator 1 2.87404
PLA2G2C phospholipase A2, group IIC 2.87404
PCDHGB5 protocadherin gamma subfamily B, 5 2.87404
A3GALT2 alpha 1,3-galactosyltransferase 2 2.87404
RSAD2 radical S-adenosyl methionine domain containing 2 2.87404
MR1 major histocompatibility complex, class I-related 2.87404
CDC20B cell division cycle 20B 2.87404
FATE1 fetal and adult testis expressed 1 2.87404
RESP18 regulated endocrine-specific protein 18 2.87404
TIGD3 tigger transposable element derived 3 2.87404
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.87404
ASTL astacin-like metallo-endopeptidase (M12 family) 2.87404
IL9R interleukin 9 receptor 2.87404
ARL13A ADP-ribosylation factor-like 13A 2.87404
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.87404
HLA-DMB major histocompatibility complex, class II, DM beta 2.87404
CPN2 carboxypeptidase N, polypeptide 2 2.87404
LIF leukemia inhibitory factor 2.87404
STRC stereocilin 2.87404
MB myoglobin 2.87404
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.87404
BCL2A1 BCL2-related protein A1 2.87404
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.87404
OPTC opticin 2.87404
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.87404
GPR150 G protein-coupled receptor 150 2.87404
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 2.87404
MORN5 MORN repeat containing 5 2.87404
PRSS38 protease, serine, 38 2.87404
GPR62 G protein-coupled receptor 62 2.87404
TMEM247 transmembrane protein 247 2.87404
CSF1R colony stimulating factor 1 receptor 2.87404
C1ORF105 chromosome 1 open reading frame 105 2.87404
EFCAB12 EF-hand calcium binding domain 12 2.87404
MSMP microseminoprotein, prostate associated 2.87404
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.87404
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.87404
LRRC74A leucine rich repeat containing 74A 2.87404
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.87404
OR11G2 olfactory receptor, family 11, subfamily G, member 2 2.87404
SLITRK1 SLIT and NTRK-like family, member 1 2.87404
ANXA9 annexin A9 2.87404
ASCL5 achaete-scute family bHLH transcription factor 5 2.87404
ASCL2 achaete-scute family bHLH transcription factor 2 2.87404
GPR179 G protein-coupled receptor 179 2.87404
LRRC38 leucine rich repeat containing 38 2.87404
GCSAML germinal center-associated, signaling and motility-like 2.87404
CALD1 caldesmon 1 2.87404
ADRA1B adrenoceptor alpha 1B 2.87404
FRMPD1 FERM and PDZ domain containing 1 2.87404
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.87404
EPX eosinophil peroxidase 2.87404
PITX3 paired-like homeodomain 3 2.87404
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.87404
ITLN2 intelectin 2 2.87404
STAP1 signal transducing adaptor family member 1 2.87404
ANKRD13C ankyrin repeat domain 13C 2.87404
CARD9 caspase recruitment domain family, member 9 2.87404
PLGLB2 plasminogen-like B2 2.87404
SPDEF SAM pointed domain containing ETS transcription factor 2.87404
CLDN9 claudin 9 2.84124
PRDM11 PR domain containing 11 2.79554
WWP2 WW domain containing E3 ubiquitin protein ligase 2 2.79275
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 2.74734
TRHR thyrotropin-releasing hormone receptor 2.74734
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.67549
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 2.64578
MRPL14 mitochondrial ribosomal protein L14 2.62253
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.6047
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 2.57285
RGS2 regulator of G-protein signaling 2 2.57285
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.55142
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.53843
NOTCH2 notch 2 2.49601
PAIP2 poly(A) binding protein interacting protein 2 2.46114
STON1 stonin 1 2.46008
FRMD6 FERM domain containing 6 2.43052
TMEM161B transmembrane protein 161B 2.42616
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.41924
TCP11 t-complex 11, testis-specific 2.41924
MYNN myoneurin 2.41206
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.40878
CXCR5 chemokine (C-X-C motif) receptor 5 2.40581
FER1L6 fer-1-like family member 6 2.40581
ANXA2 annexin A2 2.40452
AMZ2 archaelysin family metallopeptidase 2 2.38902
LYPLA2 lysophospholipase II 2.3864
PEX10 peroxisomal biogenesis factor 10 2.38123
SVOPL SVOP-like 2.38123
LRMDA leucine rich melanocyte differentiation associated 2.3696
CKM creatine kinase, muscle 2.36715
GPATCH2 G patch domain containing 2 2.36676
FSTL4 follistatin-like 4 2.35863
PLD6 phospholipase D family, member 6 2.34493
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 2.31299
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 2.31299
GOLGA8A golgin A8 family, member A 2.31061
FPGS folylpolyglutamate synthase 2.29778
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 2.27232
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 2.2689
MAD2L1BP MAD2L1 binding protein 2.26649
SNX18 sorting nexin 18 2.18178
EML4 echinoderm microtubule associated protein like 4 2.18178
DMXL2 Dmx-like 2 2.17105
MTERF2 mitochondrial transcription termination factor 2 2.16879
ECPAS Ecm29 proteasome adaptor and scaffold 2.16164
PDE4A phosphodiesterase 4A, cAMP-specific 2.15751
ZNF30 zinc finger protein 30 2.15346
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 2.13433
MAP3K21 mitogen-activated protein kinase kinase kinase 21 2.13217
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.12745
MAP1S microtubule-associated protein 1S 2.12202
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.11744
HDAC7 histone deacetylase 7 2.11722
TJAP1 tight junction associated protein 1 (peripheral) 2.10476
UBE2C ubiquitin-conjugating enzyme E2C 2.10476
MTBP MDM2 binding protein 2.10476
RBBP9 retinoblastoma binding protein 9 2.0966
OSMR oncostatin M receptor 2.08721
MOGAT1 monoacylglycerol O-acyltransferase 1 2.08721
ZNF574 zinc finger protein 574 2.06858
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.06858
C22ORF23 chromosome 22 open reading frame 23 2.05976
COPB1 coatomer protein complex, subunit beta 1 2.03995
HACL2 2-hydroxyacyl-CoA lyase 2 2.0078

decreased expression

Symbol Name Standardized Value
DUSP9 dual specificity phosphatase 9 -2.87404
SLC9C2 solute carrier family 9, member C2 (putative) -2.87404
SH3RF3 SH3 domain containing ring finger 3 -2.87404
IL2RB interleukin 2 receptor, beta -2.87404
IL18R1 interleukin 18 receptor 1 -2.87404
IRX3 iroquois homeobox 3 -2.87404
NLRP2 NLR family, pyrin domain containing 2 -2.87404
VWC2L von Willebrand factor C domain containing protein 2-like -2.87404
ANGPTL4 angiopoietin-like 4 -2.87404
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.87404
CD300A CD300a molecule -2.87404
BOLL boule-like RNA-binding protein -2.87404
CNBD1 cyclic nucleotide binding domain containing 1 -2.87404
STAB1 stabilin 1 -2.87404
RCSD1 RCSD domain containing 1 -2.87404
CORT cortistatin -2.87404
STX19 syntaxin 19 -2.87404
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.87404
ACTL6B actin-like 6B -2.87404
ZFP3 ZFP3 zinc finger protein -2.87404
CCDC127 coiled-coil domain containing 127 -2.87404
NXPE1 neurexophilin and PC-esterase domain family, member 1 -2.87404
ATP13A4 ATPase type 13A4 -2.87404
LOC124904542 uncharacterized LOC124904542 -2.87404
GJA5 gap junction protein, alpha 5, 40kDa -2.87404
COLEC10 collectin sub-family member 10 (C-type lectin) -2.87404
PI15 peptidase inhibitor 15 -2.87404
NOXO1 NADPH oxidase organizer 1 -2.87404
HES4 hes family bHLH transcription factor 4 -2.87404
GP1BA glycoprotein Ib (platelet), alpha polypeptide -2.87404
TIGD2 tigger transposable element derived 2 -2.87404
IL11 interleukin 11 -2.87404
DDTL D-dopachrome tautomerase-like -2.87404
LRRC19 leucine rich repeat containing 19 -2.87404
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.87404
AVIL advillin -2.87404
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.87404
MSR1 macrophage scavenger receptor 1 -2.87404
C8G complement component 8, gamma polypeptide -2.87404
NT5DC4 5'-nucleotidase domain containing 4 -2.87404
BHLHA15 basic helix-loop-helix family, member a15 -2.87404
CNRIP1 cannabinoid receptor interacting protein 1 -2.87404
TEX14 testis expressed 14 -2.82369
KCTD11 potassium channel tetramerization domain containing 11 -2.82369
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.82369
ACBD4 acyl-CoA binding domain containing 4 -2.74492
C7ORF25 chromosome 7 open reading frame 25 -2.74492
P3H3 prolyl 3-hydroxylase 3 -2.6652
AKAP11 A kinase (PRKA) anchor protein 11 -2.6652
SCML1 sex comb on midleg-like 1 (Drosophila) -2.62253
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -2.60684
RAP1A RAP1A, member of RAS oncogene family -2.5937
TNIK TRAF2 and NCK interacting kinase -2.58139
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 -2.53608
MTNR1A melatonin receptor 1A -2.53608
SPATC1 spermatogenesis and centriole associated 1 -2.53608
PHAX phosphorylated adaptor for RNA export -2.53015
CHD3 chromodomain helicase DNA binding protein 3 -2.52784
SMO smoothened, frizzled class receptor -2.4871
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 -2.48613
NUP42 nucleoporin 42 -2.48613
CERS5 ceramide synthase 5 -2.46008
SUCLG1 succinate-CoA ligase, alpha subunit -2.40584
F2R coagulation factor II (thrombin) receptor -2.3864
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.38123
MIS18BP1 MIS18 binding protein 1 -2.3696
ZNF202 zinc finger protein 202 -2.33882
OCA2 oculocutaneous albinism II -2.32657
RFX8 RFX family member 8, lacking RFX DNA binding domain -2.32121
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.31299
ZNF418 zinc finger protein 418 -2.30952
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.29131
EML1 echinoderm microtubule associated protein like 1 -2.28387
HBS1L HBS1-like translational GTPase -2.26484
ARMCX4 armadillo repeat containing, X-linked 4 -2.22264
LIN54 lin-54 DREAM MuvB core complex component -2.21173
KIAA1671 KIAA1671 -2.21117
SRP54 signal recognition particle 54kDa -2.20862
TMEM209 transmembrane protein 209 -2.18178
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.15629
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -2.15246
FEN1 flap structure-specific endonuclease 1 -2.15246
FUT2 fucosyltransferase 2 (secretor status included) -2.13433
ATG2B autophagy related 2B -2.13433
SLC49A3 solute carrier family 49 member 3 -2.13217
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -2.13217
MEIS2 Meis homeobox 2 -2.13217
SPDYA speedy/RINGO cell cycle regulator family member A -2.13128
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 -2.12038
RBM15B RNA binding motif protein 15B -2.11145
SLTM SAFB-like, transcription modulator -2.10893
AAK1 AP2 associated kinase 1 -2.10476
RPP14 ribonuclease P/MRP 14kDa subunit -2.10476
CLSTN1 calsyntenin 1 -2.10375
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.10345
SDC2 syndecan 2 -2.10336
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -2.10128
PANK2 pantothenate kinase 2 -2.09571
WNT9A wingless-type MMTV integration site family, member 9A -2.09571
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.09104
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.08975
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 -2.08975
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.08975
SCRN3 secernin 3 -2.07956
IL18BP interleukin 18 binding protein -2.07899
ISYNA1 inositol-3-phosphate synthase 1 -2.07899
XPO5 exportin 5 -2.06532
CCNH cyclin H -2.06471
CDO1 cysteine dioxygenase type 1 -2.06471
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.03537
MAP2K1 mitogen-activated protein kinase kinase 1 -2.03537
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -2.03537
SPAG5 sperm associated antigen 5 -2.03537
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.01863
PROM1 prominin 1 -2.00737