GADD45A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description growth arrest and DNA-damage-inducible, alpha|This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 1647)
External Link http://www.ncbi.nlm.nih.gov/gene/1647
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85 interacting proteins for GADD45A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADAP1 ArfGAP with dual PH domains 1
AICDA activation-induced cytidine deaminase
ASCC2 activating signal cointegrator 1 complex subunit 2
BAG6 BCL2-associated athanogene 6
C14ORF1 chromosome 14 open reading frame 1
CCNB1 cyclin B1
CDAN1 codanin 1
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK11A cyclin-dependent kinase 11A
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPB centromere protein B, 80kDa
CHD3 chromodomain helicase DNA binding protein 3
CLEC3B C-type lectin domain family 3, member B
CRELD2 cysteine-rich with EGF-like domains 2
DCTN2 dynactin 2 (p50)
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1G eukaryotic translation elongation factor 1 gamma
EGR1 early growth response 1
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FBN3 fibrillin 3
FTL ferritin, light polypeptide
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBP2 guanylate binding protein 2, interferon-inducible
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
HIST1H1A histone cluster 1, H1a
HIST1H2AI histone cluster 1, H2ai
HIST1H4F histone cluster 1, H4f
HIST2H2BE histone cluster 2, H2be
HIST3H3 histone cluster 3, H3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
IGHM immunoglobulin heavy constant mu
IGSF21 immunoglobin superfamily, member 21
JMJD1C jumonji domain containing 1C
KHSRP KH-type splicing regulatory protein
LMO4 LIM domain only 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MIDN midnolin
MPP1 membrane protein, palmitoylated 1, 55kDa
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRBP1 nuclear receptor binding protein 1
NUCB2 nucleobindin 2
PCNA proliferating cell nuclear antigen
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PPARA peroxisome proliferator-activated receptor alpha
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
QARS glutaminyl-tRNA synthetase
RAI1 retinoic acid induced 1
RARA retinoic acid receptor, alpha
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RPS2 ribosomal protein S2
RPS7 ribosomal protein S7
RXRA retinoid X receptor, alpha
SACK1D scaffolding CK1 anchoring protein D
SH3GLB1 SH3-domain GRB2-like endophilin B1
SPTBN4 spectrin, beta, non-erythrocytic 4
SYNE4 spectrin repeat containing, nuclear envelope family member 4
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TDG thymine-DNA glycosylase
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TP53 tumor protein p53
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBR1 ubiquitin protein ligase E3 component n-recognin 1
VIM vimentin
ZHX1 zinc fingers and homeoboxes 1
ZNF135 zinc finger protein 135