GAMG Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from Glioblastoma Tumour (Cell Model Passports, SIDM01055)
External Link https://depmap.org/portal/cell_line/ACH-000098
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Genes

263 gene knockdowns changing fitness of GAMG relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
DOCK10 dedicator of cytokinesis 10 13.0764
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 8.97938
GPC1 glypican 1 7.0368
KIAA0232 KIAA0232 6.48655
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 6.44712
RNF111 ring finger protein 111 6.43724
GZF1 GDNF-inducible zinc finger protein 1 5.92699
TRIP10 thyroid hormone receptor interactor 10 5.87267
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 5.77568
OSTM1 osteopetrosis associated transmembrane protein 1 5.75051
FOXC2 forkhead box C2 5.69925
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 5.65703
EVA1A eva-1 homolog A (C. elegans) 5.61566
OR5H14 olfactory receptor, family 5, subfamily H, member 14 5.47075
DIPK2A divergent protein kinase domain 2A 5.37552
TAS2R31 taste receptor, type 2, member 31 5.0503
MORC4 MORC family CW-type zinc finger 4 5.00658
GLCE glucuronic acid epimerase 4.9012
SREBF2 sterol regulatory element binding transcription factor 2 4.79856
SQSTM1 sequestosome 1 4.41274
ISL2 ISL LIM homeobox 2 4.36915
MMUT methylmalonyl-CoA mutase 4.35819
SEPTIN9 septin 9 4.27992
CDC20B cell division cycle 20B 4.279
IL1R1 interleukin 1 receptor, type I 4.27404
FAM20B family with sequence similarity 20, member B 4.23745
ATG10 autophagy related 10 4.16264
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 4.1015
NAIF1 nuclear apoptosis inducing factor 1 4.04456
LBX1 ladybird homeobox 1 3.99072
PGAP2 post-GPI attachment to proteins 2 3.9255
GMEB1 glucocorticoid modulatory element binding protein 1 3.84349
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.82309
ZBTB41 zinc finger and BTB domain containing 41 3.76756
BTBD2 BTB (POZ) domain containing 2 3.72148
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 3.68859
ATRN attractin 3.66848
GATA5 GATA binding protein 5 3.66494
MET MET proto-oncogene, receptor tyrosine kinase 3.62467
TSPAN4 tetraspanin 4 3.62242
CSNK2A1 casein kinase 2, alpha 1 polypeptide 3.58719
CXXC5 CXXC finger protein 5 3.57457
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 3.57275
PPP1R15A protein phosphatase 1, regulatory subunit 15A 3.55465
ARL1 ADP-ribosylation factor-like 1 3.54971
JAG1 jagged 1 3.5291
SACS sacsin molecular chaperone 3.51297
CCL2 chemokine (C-C motif) ligand 2 3.49336
BTBD1 BTB (POZ) domain containing 1 3.48161
RABL3 RAB, member of RAS oncogene family-like 3 3.48089
LCE3E late cornified envelope 3E 3.4251
F2R coagulation factor II (thrombin) receptor 3.42393
ZIC3 Zic family member 3 3.40207
TMEM165 transmembrane protein 165 3.33078
EXT2 exostosin glycosyltransferase 2 3.32409
TSPAN3 tetraspanin 3 3.30037
OR51T1 olfactory receptor, family 51, subfamily T, member 1 3.28791
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 3.27559
PRR23B proline rich 23B 3.26827
LIPE lipase, hormone-sensitive 3.25121
C12ORF49 chromosome 12 open reading frame 49 3.2415
EXTL3 exostosin-like glycosyltransferase 3 3.23968
FGFR1 fibroblast growth factor receptor 1 3.23753
TRIM67 tripartite motif containing 67 3.21647
CMYA5 cardiomyopathy associated 5 3.21013
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.20241
TNS3 tensin 3 3.20192
LPAR1 lysophosphatidic acid receptor 1 3.19553
MBNL2 muscleblind-like splicing regulator 2 3.19483
SP3 Sp3 transcription factor 3.18623
PKD2 polycystic kidney disease 2 (autosomal dominant) 3.14716
KRT40 keratin 40, type I 3.14602
IFNAR1 interferon (alpha, beta and omega) receptor 1 3.14305
MPST mercaptopyruvate sulfurtransferase 3.12995
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.11221
FBXO42 F-box protein 42 3.09973
SRRM4 serine/arginine repetitive matrix 4 3.09272
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 3.07393
AKAP13 A kinase (PRKA) anchor protein 13 3.07268
ZBTB10 zinc finger and BTB domain containing 10 3.03413
HOXB1 homeobox B1 3.02306
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 3.0171
RSU1 Ras suppressor protein 1 3.0155
BRPF3 bromodomain and PHD finger containing, 3 3.01302
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.0115
GAB1 GRB2-associated binding protein 1 3.00845
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 3.00776
TRIO trio Rho guanine nucleotide exchange factor 3.00569
CHD1 chromodomain helicase DNA binding protein 1 3.00197
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.9778
PEAK1 pseudopodium-enriched atypical kinase 1 2.95761
HPDL 4-hydroxyphenylpyruvate dioxygenase-like 2.95615
CADM3 cell adhesion molecule 3 2.95491
KIAA0355 KIAA0355 2.9368
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.92848
TMEM63B transmembrane protein 63B 2.92049
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2.91603
B3GAT3 beta-1,3-glucuronyltransferase 3 2.91332
STK11 serine/threonine kinase 11 2.90134
OSR2 odd-skipped related transciption factor 2 2.89967
CNGB1 cyclic nucleotide gated channel beta 1 2.8946
LRRC39 leucine rich repeat containing 39 2.89357
GAL3ST1 galactose-3-O-sulfotransferase 1 2.88226
PPP1R21 protein phosphatase 1, regulatory subunit 21 2.87924
ZBTB46 zinc finger and BTB domain containing 46 2.87825
TRIM43 tripartite motif containing 43 2.86618
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.85924
AHDC1 AT hook, DNA binding motif, containing 1 2.84668
MMD monocyte to macrophage differentiation-associated 2.84459
OR52J3 olfactory receptor, family 52, subfamily J, member 3 2.79298
DNALI1 dynein, axonemal, light intermediate chain 1 2.78415
EXT1 exostosin glycosyltransferase 1 2.7564
HCRTR2 hypocretin (orexin) receptor 2 2.73286
AGTR2 angiotensin II receptor, type 2 2.72481
ZNF219 zinc finger protein 219 2.71023
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.69373
HSPB1 heat shock 27kDa protein 1 2.69311
MCOLN1 mucolipin 1 2.69239
CPD carboxypeptidase D 2.68697
ZAR1L zygote arrest 1-like 2.68224
ATG3 autophagy related 3 2.67912
FYCO1 FYVE and coiled-coil domain containing 1 2.65284
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.63762
DOT1L DOT1-like histone H3K79 methyltransferase 2.61752
SCN9A sodium channel, voltage gated, type IX alpha subunit 2.61697
POC1B POC1 centriolar protein B 2.61561
SLA Src-like-adaptor 2.61003
ZSWIM3 zinc finger, SWIM-type containing 3 2.60709
OR13J1 olfactory receptor, family 13, subfamily J, member 1 2.60458
EEF2K eukaryotic elongation factor 2 kinase 2.58861
ZNF555 zinc finger protein 555 2.57877
CCHCR1 coiled-coil alpha-helical rod protein 1 2.56673
SCYL2 SCY1-like 2 (S. cerevisiae) 2.55687
FRS2 fibroblast growth factor receptor substrate 2 2.55236
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 2.54532
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 2.53899
TUBB4A tubulin, beta 4A class IVa 2.53414
NRTN neurturin 2.53109
CHRM2 cholinergic receptor, muscarinic 2 2.52629
GOLM1 golgi membrane protein 1 2.51924
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.51151
ZXDA zinc finger, X-linked, duplicated A 2.49546
FNDC3B fibronectin type III domain containing 3B 2.49125
BDKRB2 bradykinin receptor B2 2.47216
TIMP2 TIMP metallopeptidase inhibitor 2 2.46875
CLCN7 chloride channel, voltage-sensitive 7 2.46823
FOXG1 forkhead box G1 2.46192
SOX15 SRY (sex determining region Y)-box 15 2.45834
HIST1H3J histone cluster 1, H3j 2.43935
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.43916
MTAP methylthioadenosine phosphorylase 2.43363
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.42817
ANGPTL8 angiopoietin like 8 2.42639
USF2 upstream transcription factor 2, c-fos interacting 2.4228
GABARAP GABA(A) receptor-associated protein 2.42219
THBS4 thrombospondin 4 2.41866
VAT1L vesicle amine transport 1-like 2.4014
FGR FGR proto-oncogene, Src family tyrosine kinase 2.39447
PTCHD4 patched domain containing 4 2.38771
COP1 COP1 E3 ubiquitin ligase 2.36726
WNT8B wingless-type MMTV integration site family, member 8B 2.36612
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.3486
YPEL3 yippee-like 3 (Drosophila) 2.34501
NFE2L2 nuclear factor, erythroid 2-like 2 2.34316
SETD6 SET domain containing 6 2.34286
CREBZF CREB/ATF bZIP transcription factor 2.3232
CSMD1 CUB and Sushi multiple domains 1 2.32155
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.31631
PTPRF protein tyrosine phosphatase, receptor type, F 2.30695
CLEC18B C-type lectin domain family 18, member B 2.30236
C15ORF61 chromosome 15 open reading frame 61 2.29862
SPAG17 sperm associated antigen 17 2.294
TRIM3 tripartite motif containing 3 2.27263
IL1RAP interleukin 1 receptor accessory protein 2.26934
RHOG ras homolog family member G 2.26831
RABL2A RAB, member of RAS oncogene family-like 2A 2.26489
TNRC18 trinucleotide repeat containing 18 2.26329
KDM4A lysine (K)-specific demethylase 4A 2.25906
ACACA acetyl-CoA carboxylase alpha 2.25794
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.25727
RAI14 retinoic acid induced 14 2.25355
MYO1E myosin IE 2.25115
BCAR1 breast cancer anti-estrogen resistance 1 2.24815
CTSS cathepsin S 2.24191
RELN reelin 2.23735
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.23539
RAB5C RAB5C, member RAS oncogene family 2.23263
POTEF POTE ankyrin domain family, member F 2.2305
CTRL chymotrypsin-like 2.22592
TRAPPC13 trafficking protein particle complex 13 2.22239
C1QTNF7 C1q and tumor necrosis factor related protein 7 2.21455
XCL2 chemokine (C motif) ligand 2 2.21425
SLITRK5 SLIT and NTRK-like family, member 5 2.20565
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 2.20159
OR11L1 olfactory receptor, family 11, subfamily L, member 1 2.19926
PIGO phosphatidylinositol glycan anchor biosynthesis, class O 2.19184
CBX1 chromobox homolog 1 2.19124
GLB1L2 galactosidase, beta 1-like 2 2.18891
TOMM34 translocase of outer mitochondrial membrane 34 2.18357
MITD1 MIT, microtubule interacting and transport, domain containing 1 2.18019
CHD2 chromodomain helicase DNA binding protein 2 2.17922
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 2.17672
DOK5 docking protein 5 2.17245
COG2 component of oligomeric golgi complex 2 2.1714
CTSW cathepsin W 2.16894
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.16268
TENT4A terminal nucleotidyltransferase 4A 2.157
LEMD2 LEM domain containing 2 2.15508
PAQR8 progestin and adipoQ receptor family member VIII 2.15476
PDZD7 PDZ domain containing 7 2.15461
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 2.15251
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.14932
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.14744
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 2.1341
OR10T2 olfactory receptor, family 10, subfamily T, member 2 2.13302
CCDC51 coiled-coil domain containing 51 2.13268
GAPVD1 GTPase activating protein and VPS9 domains 1 2.13062
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 2.12937
TMEM220 transmembrane protein 220 2.12691
CASKIN2 CASK interacting protein 2 2.11969
CCDC6 coiled-coil domain containing 6 2.11678
FASN fatty acid synthase 2.11617
CHSY1 chondroitin sulfate synthase 1 2.11425
IFI27L2 interferon, alpha-inducible protein 27-like 2 2.11069
NDRG1 N-myc downstream regulated 1 2.10864
LAMC3 laminin, gamma 3 2.10794
LMNA lamin A/C 2.10722
RXRA retinoid X receptor, alpha 2.1018
ZNF44 zinc finger protein 44 2.10129
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.10054
TMEM132E transmembrane protein 132E 2.09629
PDS5B PDS5 cohesin associated factor B 2.09546
BBS2 Bardet-Biedl syndrome 2 2.09122
CEP162 centrosomal protein 162kDa 2.09013
PPP1R16B protein phosphatase 1, regulatory subunit 16B 2.08225
DPH2 DPH2 homolog (S. cerevisiae) 2.07776
TTBK1 tau tubulin kinase 1 2.07649
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.07009
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 2.06876
NPAS3 neuronal PAS domain protein 3 2.06229
CLSTN2 calsyntenin 2 2.06081
CLEC14A C-type lectin domain family 14, member A 2.05795
CD38 CD38 molecule 2.05765
MARK4 MAP/microtubule affinity-regulating kinase 4 2.05654
RGMB repulsive guidance molecule family member b 2.05493
COG7 component of oligomeric golgi complex 7 2.03812
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) 2.03487
PCIF1 PDX1 C-terminal inhibiting factor 1 2.03181
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.03065
PRICKLE2 prickle homolog 2 (Drosophila) 2.02979
CXCL2 chemokine (C-X-C motif) ligand 2 2.02947
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.02732
OR8B2 olfactory receptor, family 8, subfamily B, member 2 2.02731
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 2.02258
KRT81 keratin 81, type II 2.02238
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 2.02172
GOLGA7B golgin A7 family, member B 2.01773
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.01385
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 2.00795
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2.00405
CEP85L centrosomal protein 85kDa-like 2.00115
GOLT1B golgi transport 1B 2.00076
FGD1 FYVE, RhoGEF and PH domain containing 1 2.00065