GATA2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description GATA binding protein 2|This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 2624)
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Genes

328 genes differentially expressed following the GATA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM3D family with sequence similarity 3, member D 3.08335
SLC46A3 solute carrier family 46, member 3 3.08335
SPINK6 serine peptidase inhibitor, Kazal type 6 3.08335
NANOS3 nanos homolog 3 (Drosophila) 3.08335
DNASE1L2 deoxyribonuclease I-like 2 3.08335
GFRA3 GDNF family receptor alpha 3 3.08335
SSTR1 somatostatin receptor 1 3.08335
OSGIN1 oxidative stress induced growth inhibitor 1 3.08335
TM4SF20 transmembrane 4 L six family member 20 3.08335
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 3.08335
SLC25A45 solute carrier family 25, member 45 3.08335
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.08335
SCG2 secretogranin II 3.08335
SLC22A14 solute carrier family 22, member 14 3.08335
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.08335
TSSK6 testis-specific serine kinase 6 3.08335
SBK3 SH3 domain binding kinase family, member 3 3.08335
FAM187B family with sequence similarity 187, member B 3.08335
LAPTM5 lysosomal protein transmembrane 5 3.08335
CD274 CD274 molecule 3.08335
SELPLG selectin P ligand 3.08335
ASB15 ankyrin repeat and SOCS box containing 15 3.08335
WDR87 WD repeat domain 87 3.08335
AADACL2 arylacetamide deacetylase-like 2 3.08335
AADACL4 arylacetamide deacetylase-like 4 3.08335
OR7A17 olfactory receptor, family 7, subfamily A, member 17 3.08335
CRH corticotropin releasing hormone 3.08335
DIO3 deiodinase, iodothyronine, type III 3.08335
CAPS calcyphosine 3.08335
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.08335
RNF133 ring finger protein 133 3.08335
TMC8 transmembrane channel-like 8 3.08335
OVCH1 ovochymase 1 3.08335
HMX1 H6 family homeobox 1 3.08335
ETV7 ets variant 7 3.08335
RAB20 RAB20, member RAS oncogene family 3.08335
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.08335
CCDC146 coiled-coil domain containing 146 3.08335
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.08335
ARHGAP36 Rho GTPase activating protein 36 3.08335
GFAP glial fibrillary acidic protein 3.08335
ASB10 ankyrin repeat and SOCS box containing 10 3.08335
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 3.08335
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.08335
GPR21 G protein-coupled receptor 21 3.08335
HCRTR2 hypocretin (orexin) receptor 2 3.08335
NRROS negative regulator of reactive oxygen species 3.08335
KDM5A lysine (K)-specific demethylase 5A 3.08335
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.08335
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.08335
PNMA8B PNMA family member 8B 3.08335
SQOR sulfide quinone oxidoreductase 3.08335
H2BC1 H2B clustered histone 1 3.08335
ERVW-1 endogenous retrovirus group W, member 1 3.08335
HAO2 hydroxyacid oxidase 2 (long chain) 3.08335
GBP3 guanylate binding protein 3 3.08335
UNC93A unc-93 homolog A (C. elegans) 3.08335
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.08335
PROP1 PROP paired-like homeobox 1 3.08335
VGLL2 vestigial-like family member 2 3.08335
DERPC DERPC proline and glycine rich nuclear protein 3.08335
LORICRIN loricrin cornified envelope precursor protein 3.08335
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.08335
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.08335
FAM240C family with sequence similarity 240 member C 3.08335
LINC02268 long intergenic non-protein coding RNA 2268 3.08335
NOTCH2NLB notch 2 N-terminal like B 3.08335
LOC124902436 talanin 3.08335
H4C12 H4 clustered histone 12 3.08335
TUBB8B tubulin beta 8B 3.08335
GARIN6 golgi associated RAB2 interactor family member 6 3.08335
CLXN calaxin 3.08335
STMN4 stathmin-like 4 3.08335
SRGN serglycin 3.08335
CCR4 chemokine (C-C motif) receptor 4 3.08335
TCF23 transcription factor 23 3.08335
INSRR insulin receptor-related receptor 3.08335
GDF10 growth differentiation factor 10 3.08335
TFEC transcription factor EC 3.08335
TMCO2 transmembrane and coiled-coil domains 2 3.08335
C10ORF67 chromosome 10 open reading frame 67 3.08335
CATSPER3 cation channel, sperm associated 3 3.08335
RHOXF2 Rhox homeobox family, member 2 3.08335
DTHD1 death domain containing 1 3.08335
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.08335
LRRC3C leucine rich repeat containing 3C 3.08335
GC group-specific component (vitamin D binding protein) 3.08335
SPATA22 spermatogenesis associated 22 3.08335
FAM228B family with sequence similarity 228, member B 3.08335
DYNLRB2 dynein, light chain, roadblock-type 2 3.08335
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.08335
CNTN6 contactin 6 3.08335
ASIC3 acid sensing (proton gated) ion channel 3 3.08335
PLEK2 pleckstrin 2 3.08335
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 3.08335
IL1R2 interleukin 1 receptor, type II 3.08335
SLFN14 schlafen family member 14 3.08335
KLF2 Kruppel-like factor 2 3.08335
KLK11 kallikrein-related peptidase 11 3.08335
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 3.08335
CALML6 calmodulin-like 6 3.08335
AGR3 anterior gradient 3 3.08335
PLCD4 phospholipase C, delta 4 3.08335
DBX2 developing brain homeobox 2 3.08335
POU3F3 POU class 3 homeobox 3 3.08335
ADGRF1 adhesion G protein-coupled receptor F1 3.08335
C20ORF144 chromosome 20 open reading frame 144 3.08335
CHRM1 cholinergic receptor, muscarinic 1 3.08335
HHIPL2 HHIP-like 2 3.08335
SIRPG signal-regulatory protein gamma 3.08335
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.08335
ITGB7 integrin, beta 7 3.08335
TPPP3 tubulin polymerization-promoting protein family member 3 3.08335
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.08335
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.08335
SCML4 sex comb on midleg-like 4 (Drosophila) 3.08335
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 3.08335
MAB21L1 mab-21-like 1 (C. elegans) 3.08335
POU2AF1 POU class 2 associating factor 1 3.08335
BTNL3 butyrophilin-like 3 3.08335
GOLGA6C golgin A6 family, member C 3.08335
FOXE1 forkhead box E1 3.08335
ADGRA1 adhesion G protein-coupled receptor A1 3.08335
RGS11 regulator of G-protein signaling 11 3.08335
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.08335
EVPLL envoplakin-like 3.08335
TMEM132D transmembrane protein 132D 3.08335
TAT tyrosine aminotransferase 3.08335
PYHIN1 pyrin and HIN domain family, member 1 3.08335
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.08335
PRTN3 proteinase 3 3.08335
ZBED6 zinc finger, BED-type containing 6 3.08335
SOSTDC1 sclerostin domain containing 1 3.08335
TPRX1 tetra-peptide repeat homeobox 1 3.08335
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 3.08335
GOLGA8K golgin A8 family, member K 3.08335
GOLGA8N golgin A8 family, member N 3.08335
GOLGA8O golgin A8 family, member O 3.08335
CLCF1 cardiotrophin-like cytokine factor 1 3.08335
GOLGA8T golgin A8 family, member T 3.08335
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 3.08335
GSDMC gasdermin C 3.08335
STAP1 signal transducing adaptor family member 1 3.08335
SPAG6 sperm associated antigen 6 3.08335
TMEM132C transmembrane protein 132C 3.08335
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.08335
HP haptoglobin 3.08335
PRR29 proline rich 29 3.08335
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.08335
MB myoglobin 3.08335
SNX15 sorting nexin 15 3.08335
FBXO47 F-box protein 47 3.08335
PASD1 PAS domain containing 1 3.08335
POU4F1 POU class 4 homeobox 1 3.08335
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.08335
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.08335
AMDHD1 amidohydrolase domain containing 1 3.08335
CXORF58 chromosome X open reading frame 58 3.08335
ZPBP zona pellucida binding protein 3.08335
RGS8 regulator of G-protein signaling 8 3.08335
ZC2HC1B zinc finger, C2HC-type containing 1B 3.08335
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.08335
TMEM176A transmembrane protein 176A 3.05557
EYA4 EYA transcriptional coactivator and phosphatase 4 3.05557
RPLP1 ribosomal protein, large, P1 3.03043
VIT vitrin 3.02485
ZNF99 zinc finger protein 99 3.02485
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 2.98089
KCTD6 potassium channel tetramerization domain containing 6 2.96479
MORN3 MORN repeat containing 3 2.90153
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.8998
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.85856
SLC9D1 solute carrier family 9 member D1 2.85517
OR3A2 olfactory receptor, family 3, subfamily A, member 2 2.83734
RNF144A ring finger protein 144A 2.76259
COPS5 COP9 signalosome subunit 5 2.63306
RPL8 ribosomal protein L8 2.59898
SFRP5 secreted frizzled-related protein 5 2.58476
SYNPO2L synaptopodin 2-like 2.58476
ASIC2 acid sensing (proton gated) ion channel 2 2.49253
CCDC138 coiled-coil domain containing 138 2.44866
SH3PXD2A SH3 and PX domains 2A 2.42294
DZIP1 DAZ interacting zinc finger protein 1 2.41745
ZBTB10 zinc finger and BTB domain containing 10 2.40837
DCDC2B doublecortin domain containing 2B 2.39653
PRSS50 protease, serine, 50 2.39653
GATA4 GATA binding protein 4 2.39653
C6ORF58 chromosome 6 open reading frame 58 2.39174
ACOT8 acyl-CoA thioesterase 8 2.37547
SSBP1 single-stranded DNA binding protein 1, mitochondrial 2.34876
FABP12 fatty acid binding protein 12 2.34508
MUC16 mucin 16, cell surface associated 2.34508
GFRAL GDNF family receptor alpha like 2.34508
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 2.31641
ZNF253 zinc finger protein 253 2.29749
ARMC3 armadillo repeat containing 3 2.28916
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 2.28658
CCDC66 coiled-coil domain containing 66 2.28335
NSL1 NSL1, MIS12 kinetochore complex component 2.27147
ZNF496 zinc finger protein 496 2.24775
H2BC21 H2B clustered histone 21 2.23095
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.23095
SC5D sterol-C5-desaturase 2.22914
UGT8 UDP glycosyltransferase 8 2.19468
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2.18556
FSTL5 follistatin-like 5 2.18303
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.149
SLC51A solute carrier family 51, alpha subunit 2.149
INHA inhibin, alpha 2.11579
ATAD3C ATPase family, AAA domain containing 3C 2.11579
C16ORF54 chromosome 16 open reading frame 54 2.11579
SERF1B small EDRK-rich factor 1B (centromeric) 2.11579
CFAP141 cilia and flagella associated protein 141 2.11579
ASMT acetylserotonin O-methyltransferase 2.11579
USP35 ubiquitin specific peptidase 35 2.11579
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.11126
NCK1 NCK adaptor protein 1 2.10915
TMEM175 transmembrane protein 175 2.08488
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.06588
GLUD1 glutamate dehydrogenase 1 2.06227
CCNE1 cyclin E1 2.05268
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.04736
TTI1 TELO2 interacting protein 1 2.04736
ARTN artemin 2.03641
FZD2 frizzled class receptor 2 2.02926
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.02926
DRG1 developmentally regulated GTP binding protein 1 2.02612
SLIT1 slit homolog 1 (Drosophila) 2.01377
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.00617
PDCD7 programmed cell death 7 2.00605
ARL16 ADP-ribosylation factor-like 16 2.00605

decreased expression

Symbol Name Standardized Value
OCM oncomodulin -3.08335
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) -3.08335
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -3.08335
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.08335
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -3.08335
TUBA8 tubulin, alpha 8 -3.08335
KCNIP3 Kv channel interacting protein 3, calsenilin -3.08335
ZMYND15 zinc finger, MYND-type containing 15 -3.08335
NRXN1 neurexin 1 -3.08335
TMIGD2 transmembrane and immunoglobulin domain containing 2 -3.08335
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -3.08335
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -3.08335
ANXA1 annexin A1 -3.08335
TMEM86A transmembrane protein 86A -3.08335
LMOD2 leiomodin 2 (cardiac) -3.08335
ACOT1 acyl-CoA thioesterase 1 -3.08335
POLR1H RNA polymerase I subunit H -3.08335
SAPCD1 suppressor APC domain containing 1 -3.08335
FMO1 flavin containing monooxygenase 1 -3.08335
XKRX XK, Kell blood group complex subunit-related, X-linked -3.08335
TCAP titin-cap -3.08335
CD27 CD27 molecule -3.08335
MAGIX MAGI family member, X-linked -3.08335
GPR83 G protein-coupled receptor 83 -3.08335
SAMD15 sterile alpha motif domain containing 15 -3.08335
CSP2 CS pseudogene 2 -3.08335
RAB11FIP1 RAB11 family interacting protein 1 (class I) -3.08335
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -3.08335
TUBA3D tubulin, alpha 3d -3.08335
FOXP3 forkhead box P3 -3.08335
CALM2 calmodulin 2 (phosphorylase kinase, delta) -3.05529
CYTIP cytohesin 1 interacting protein -2.98721
SETDB2 SET domain, bifurcated 2 -2.98166
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -2.93489
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.90153
EFHB EF-hand domain family, member B -2.88969
ARID1B AT rich interactive domain 1B (SWI1-like) -2.85856
TRAM2 translocation associated membrane protein 2 -2.77606
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.77169
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.75051
SAFB scaffold attachment factor B -2.70332
TCTA T-cell leukemia translocation altered -2.63306
TULP1 tubby like protein 1 -2.58476
DYNLT5 dynein light chain Tctex-type family member 5 -2.541
LENG9 leukocyte receptor cluster (LRC) member 9 -2.49495
STAP2 signal transducing adaptor family member 2 -2.49189
LNPK lunapark, ER junction formation factor -2.48193
C1R complement component 1, r subcomponent -2.46634
IDO1 indoleamine 2,3-dioxygenase 1 -2.46634
CD248 CD248 molecule, endosialin -2.46634
BTF3L4 basic transcription factor 3-like 4 -2.39653
TMEM256 transmembrane protein 256 -2.32159
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.31641
MRM3 mitochondrial rRNA methyltransferase 3 -2.31281
ZZZ3 zinc finger, ZZ-type containing 3 -2.30192
JTB jumping translocation breakpoint -2.2979
KIAA1549 KIAA1549 -2.29749
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 -2.2974
CDC42SE2 CDC42 small effector 2 -2.27099
PRDM6 PR domain containing 6 -2.26052
ALX3 ALX homeobox 3 -2.26052
SHBG sex hormone-binding globulin -2.26052
PLA2G10 phospholipase A2, group X -2.26052
NCAN neurocan -2.25028
ANAPC10 anaphase promoting complex subunit 10 -2.23394
SALL4 spalt-like transcription factor 4 -2.22107
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.22107
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -2.21116
KANSL1L KAT8 regulatory NSL complex subunit 1-like -2.19848
RAB9B RAB9B, member RAS oncogene family -2.19266
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 -2.18628
GJD3 gap junction protein, delta 3, 31.9kDa -2.18556
UPK1A uroplakin 1A -2.18556
ACOT13 acyl-CoA thioesterase 13 -2.18153
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.17331
BCL2L12 BCL2-like 12 (proline rich) -2.16411
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -2.14808
KIAA2012 KIAA2012 -2.13274
C1ORF53 chromosome 1 open reading frame 53 -2.13274
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.13204
ACOX3 acyl-CoA oxidase 3, pristanoyl -2.1291
SRR serine racemase -2.11579
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 -2.10472
SIRPA signal-regulatory protein alpha -2.06227
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.05497
TCP11L2 t-complex 11, testis-specific-like 2 -2.05497
PCDHB10 protocadherin beta 10 -2.05497
GPR34 G protein-coupled receptor 34 -2.05497
DUSP18 dual specificity phosphatase 18 -2.05497
LHFPL3 lipoma HMGIC fusion partner-like 3 -2.04736
SCN4B sodium channel, voltage gated, type IV beta subunit -2.04257
DCLRE1A DNA cross-link repair 1A -2.04257
IMP3 IMP3, U3 small nucleolar ribonucleoprotein -2.0178
IL6ST interleukin 6 signal transducer -2.01402
SPIN2B spindlin family, member 2B -2.01402
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.01227
RBM12B RNA binding motif protein 12B -2.00617