GATA4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description GATA binding protein 4|This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] (NCBI Entrez Gene Database, 2626)
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Genes

341 genes differentially expressed following the GATA4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.18698
IGFL3 IGF-like family member 3 3.18698
GNLY granulysin 3.18698
OR4F17 olfactory receptor, family 4, subfamily F, member 17 3.18698
TRIM15 tripartite motif containing 15 3.18698
PCDHB8 protocadherin beta 8 3.18698
FOXA1 forkhead box A1 3.18698
TCHH trichohyalin 3.18698
TBX15 T-box 15 3.18698
RRAD Ras-related associated with diabetes 3.18698
NRAP nebulin-related anchoring protein 3.18698
PI16 peptidase inhibitor 16 3.18698
GPR55 G protein-coupled receptor 55 3.18698
CFHR4 complement factor H-related 4 3.18698
LAPTM5 lysosomal protein transmembrane 5 3.18698
FOLR1 folate receptor 1 (adult) 3.18698
CD6 CD6 molecule 3.18698
ZACN zinc activated ligand-gated ion channel 3.18698
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.18698
RASL10A RAS-like, family 10, member A 3.18698
MYO7B myosin VIIB 3.18698
MAP3K7CL MAP3K7 C-terminal like 3.18698
IYD iodotyrosine deiodinase 3.18698
CCL5 chemokine (C-C motif) ligand 5 3.18698
OLIG1 oligodendrocyte transcription factor 1 3.18698
BATF basic leucine zipper transcription factor, ATF-like 3.18698
LCN12 lipocalin 12 3.18698
UBA7 ubiquitin-like modifier activating enzyme 7 3.18698
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 3.18698
SOWAHB sosondowah ankyrin repeat domain family member B 3.18698
NPIPA7 nuclear pore complex interacting protein family, member A7 3.18698
NPIPA8 nuclear pore complex interacting protein family, member A8 3.18698
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 3.18698
RNF133 ring finger protein 133 3.18698
ASGR2 asialoglycoprotein receptor 2 3.18698
PRR29 proline rich 29 3.18698
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.18698
GMFB glia maturation factor, beta 3.18698
ASB12 ankyrin repeat and SOCS box containing 12 3.18698
RSPO3 R-spondin 3 3.18698
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.18698
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.18698
GYPB glycophorin B (MNS blood group) 3.18698
GPR21 G protein-coupled receptor 21 3.18698
UNC45B unc-45 homolog B (C. elegans) 3.18698
SFTPB surfactant protein B 3.18698
PCDH8 protocadherin 8 3.18698
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.18698
KCNU1 potassium channel, subfamily U, member 1 3.18698
LOC124906892 uncharacterized LOC124906892 3.18698
FAM237B family with sequence similarity 237 member B 3.18698
NECTIN4 nectin cell adhesion molecule 4 3.18698
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.18698
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.18698
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.18698
HTRA4 HtrA serine peptidase 4 3.18698
STMN4 stathmin-like 4 3.18698
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.18698
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.18698
TMEM40 transmembrane protein 40 3.18698
H2BC3 H2B clustered histone 3 3.18698
TMEM270 transmembrane protein 270 3.18698
OR1R1 olfactory receptor family 1 subfamily R member 1 3.18698
ACKR5 atypical chemokine receptor 5 3.18698
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.18698
TEKTL1 tektin like 1 3.18698
WASL-DT WASL divergent transcript 3.18698
REELD1 reeler domain containing 1 3.18698
CIMAP1C ciliary microtubule associated protein 1C 3.18698
CIMAP1B ciliary microtubule associated protein 1B 3.18698
ARMH2 armadillo like helical domain containing 2 3.18698
STPG3 sperm-tail PG-rich repeat containing 3 3.18698
RDH8 retinol dehydrogenase 8 (all-trans) 3.18698
OR52E4 olfactory receptor, family 52, subfamily E, member 4 3.18698
SYT15 synaptotagmin XV 3.18698
TFEC transcription factor EC 3.18698
IL5 interleukin 5 3.18698
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.18698
GOLGA7B golgin A7 family, member B 3.18698
GOLGA6L2 golgin A6 family-like 2 3.18698
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.18698
DAO D-amino-acid oxidase 3.18698
TRIM60 tripartite motif containing 60 3.18698
NKX2-6 NK2 homeobox 6 3.18698
OR5H2 olfactory receptor, family 5, subfamily H, member 2 3.18698
RNF113B ring finger protein 113B 3.18698
RUNX3 runt-related transcription factor 3 3.18698
WNT9B wingless-type MMTV integration site family, member 9B 3.18698
PNPLA1 patatin-like phospholipase domain containing 1 3.18698
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.18698
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.18698
CSN2 casein beta 3.18698
S100B S100 calcium binding protein B 3.18698
PRR4 proline rich 4 (lacrimal) 3.18698
INSRR insulin receptor-related receptor 3.18698
MYOG myogenin (myogenic factor 4) 3.18698
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.18698
HHEX hematopoietically expressed homeobox 3.18698
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.18698
AQP9 aquaporin 9 3.18698
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.18698
CLEC7A C-type lectin domain family 7, member A 3.18698
DEK DEK proto-oncogene 3.18698
COMP cartilage oligomeric matrix protein 3.18698
SLC22A24 solute carrier family 22, member 24 3.18698
AZIN2 antizyme inhibitor 2 3.18698
CARD6 caspase recruitment domain family, member 6 3.18698
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.18698
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.18698
CATIP ciliogenesis associated TTC17 interacting protein 3.18698
PAGE2B P antigen family, member 2B 3.18698
POTEF POTE ankyrin domain family, member F 3.18698
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.18698
PTCRA pre T-cell antigen receptor alpha 3.18698
IGF2 insulin-like growth factor 2 3.18698
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.18698
ZNF365 zinc finger protein 365 3.18698
FOXE3 forkhead box E3 3.18698
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.18698
FATE1 fetal and adult testis expressed 1 3.18698
IGFALS insulin-like growth factor binding protein, acid labile subunit 3.18698
ADAM2 ADAM metallopeptidase domain 2 3.18698
FAM177B family with sequence similarity 177, member B 3.18698
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 3.18698
RGS13 regulator of G-protein signaling 13 3.18698
HKDC1 hexokinase domain containing 1 3.18698
AKR1B15 aldo-keto reductase family 1, member B15 3.18698
CCL25 chemokine (C-C motif) ligand 25 3.18698
OR52L1 olfactory receptor, family 52, subfamily L, member 1 3.18698
CPA3 carboxypeptidase A3 (mast cell) 3.18698
C2CD4B C2 calcium-dependent domain containing 4B 3.18698
PCDHGA3 protocadherin gamma subfamily A, 3 3.18698
PCDHGB5 protocadherin gamma subfamily B, 5 3.18698
IL9R interleukin 9 receptor 3.18698
VAV1 vav 1 guanine nucleotide exchange factor 3.18698
DLX1 distal-less homeobox 1 3.18698
MC4R melanocortin 4 receptor 3.18698
MEIS1 Meis homeobox 1 3.18698
IL27 interleukin 27 3.18698
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.18698
GBX2 gastrulation brain homeobox 2 3.18698
SFTA2 surfactant associated 2 3.18698
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.18698
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.18698
DRC7 dynein regulatory complex subunit 7 3.18698
PODN podocan 3.18698
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 3.18698
CCDC87 coiled-coil domain containing 87 3.18698
FGF5 fibroblast growth factor 5 3.18698
GOLGA8N golgin A8 family, member N 3.18698
ERAP2 endoplasmic reticulum aminopeptidase 2 3.18698
PCDHGB2 protocadherin gamma subfamily B, 2 3.18698
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.18698
QRFP pyroglutamylated RFamide peptide 3.18698
IP6K3 inositol hexakisphosphate kinase 3 3.18698
INSM1 insulinoma-associated 1 3.18698
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.18698
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.18698
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.18698
IFNK interferon, kappa 3.18698
IFNE interferon, epsilon 3.18698
PENK proenkephalin 3.18698
CTSS cathepsin S 3.18698
CA5A carbonic anhydrase VA, mitochondrial 3.18698
IBSP integrin-binding sialoprotein 3.18698
MMP12 matrix metallopeptidase 12 3.18698
BCL2L15 BCL2-like 15 3.18698
ZNF644 zinc finger protein 644 3.18698
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.18698
WFDC13 WAP four-disulfide core domain 13 3.18698
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 3.10187
PCP4L1 Purkinje cell protein 4 like 1 3.09621
RNF227 ring finger protein 227 3.03275
TMED9 transmembrane emp24 protein transport domain containing 9 2.98288
H4C9 H4 clustered histone 9 2.93552
FER1L6 fer-1-like family member 6 2.89617
PAXBP1 PAX3 and PAX7 binding protein 1 2.85585
IFITM1 interferon induced transmembrane protein 1 2.75825
BCL2L1 BCL2-like 1 2.74815
NME5 NME/NM23 family member 5 2.71381
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.71381
SH3BP1 SH3-domain binding protein 1 2.70096
SEC63 SEC63 homolog (S. cerevisiae) 2.69085
NTNG1 netrin G1 2.68431
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase 2.64024
MTX1 metaxin 1 2.60515
RANBP2 RAN binding protein 2 2.4959
TTC38 tetratricopeptide repeat domain 38 2.47126
OGA O-GlcNAcase 2.4337
LRRD1 leucine-rich repeats and death domain containing 1 2.42753
CCDC69 coiled-coil domain containing 69 2.38881
CSTA cystatin A (stefin A) 2.38881
LRRC43 leucine rich repeat containing 43 2.38881
FBXL19 F-box and leucine-rich repeat protein 19 2.38802
HIPK4 homeodomain interacting protein kinase 4 2.38773
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 2.38175
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 2.34521
ATP5F1A ATP synthase F1 subunit alpha 2.33563
REEP5 receptor accessory protein 5 2.33348
PDLIM5 PDZ and LIM domain 5 2.33072
OPCML opioid binding protein/cell adhesion molecule-like 2.33003
PLPP2 phospholipid phosphatase 2 2.30276
MEGF10-DT MEGF10 divergent transcript 2.30231
USHBP1 Usher syndrome 1C binding protein 1 2.26781
LCNL1 lipocalin-like 1 2.26456
FIMP1 fertilization-influencing membrane protein 1 2.26456
CA10 carbonic anhydrase X 2.26456
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2.234
RPL6 ribosomal protein L6 2.22865
CDC6 cell division cycle 6 2.22526
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 2.20738
PLSCR3 phospholipid scramblase 3 2.18421
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 2.17898
GMPR guanosine monophosphate reductase 2.16659
RHOC ras homolog family member C 2.16007
CCDC32 coiled-coil domain containing 32 2.16007
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 2.16007
TSACC TSSK6 activating co-chaperone 2.15551
SCG3 secretogranin III 2.15369
HEG1 heart development protein with EGF-like domains 1 2.14896
TOPBP1 topoisomerase (DNA) II binding protein 1 2.14482
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.14371
ZNF37A zinc finger protein 37A 2.13875
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.12128
MAMDC4 MAM domain containing 4 2.12128
KISS1R KISS1 receptor 2.12128
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 2.12128
ZNF425 zinc finger protein 425 2.08675
FBXO33 F-box protein 33 2.0783
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.04305
CTTN cortactin 2.04305
SLIT2 slit homolog 2 (Drosophila) 2.0084
CNTNAP5 contactin associated protein-like 5 2.00263
GRIP1 glutamate receptor interacting protein 1 2.0019

decreased expression

Symbol Name Standardized Value
ATG4B autophagy related 4B, cysteine peptidase -3.18698
CD177 CD177 molecule -3.18698
ZMYND15 zinc finger, MYND-type containing 15 -3.18698
PRELP proline/arginine-rich end leucine-rich repeat protein -3.18698
INHBA inhibin, beta A -3.18698
CCDC110 coiled-coil domain containing 110 -3.18698
UNC80 unc-80 homolog (C. elegans) -3.18698
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -3.18698
TIGD3 tigger transposable element derived 3 -3.18698
ERAS ES cell expressed Ras -3.18698
UNC13C unc-13 homolog C (C. elegans) -3.18698
JUP junction plakoglobin -3.18698
C2ORF78 chromosome 2 open reading frame 78 -3.18698
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -3.18698
ARRDC4 arrestin domain containing 4 -3.18698
FBLN7 fibulin 7 -3.18698
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -3.18698
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -3.18698
NINJ2 ninjurin 2 -3.18698
CAPS calcyphosine -3.18698
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -3.18698
TLR2 toll-like receptor 2 -3.18698
SLC45A2 solute carrier family 45, member 2 -3.18698
TBX10 T-box 10 -3.18698
NHLH1 nescient helix loop helix 1 -3.18698
SMIM31 small integral membrane protein 31 -3.18698
SPATS1 spermatogenesis associated, serine-rich 1 -3.18698
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -3.18698
H4C1 H4 clustered histone 1 -3.18698
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -3.18698
RIN3 Ras and Rab interactor 3 -3.18698
RGCC regulator of cell cycle -3.18698
CDK20 cyclin-dependent kinase 20 -3.18698
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -3.18698
GLIPR1L2 GLI pathogenesis-related 1 like 2 -3.18698
KCTD21 potassium channel tetramerization domain containing 21 -3.18698
BAHCC1 BAH domain and coiled-coil containing 1 -3.18698
CRHR1 corticotropin releasing hormone receptor 1 -3.18698
ASIC4 acid sensing (proton gated) ion channel family member 4 -3.18698
TNR tenascin R -3.18698
SEC14L4 SEC14-like 4 (S. cerevisiae) -3.18698
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -3.18698
KDM1A lysine (K)-specific demethylase 1A -3.18356
RCSD1 RCSD domain containing 1 -3.18252
MAPK15 mitogen-activated protein kinase 15 -3.14443
ASNS asparagine synthetase (glutamine-hydrolyzing) -3.07864
PUM2 pumilio RNA-binding family member 2 -3.02065
C1ORF226 chromosome 1 open reading frame 226 -3.01077
HDGF hepatoma-derived growth factor -2.89617
AFAP1 actin filament associated protein 1 -2.78626
NANS N-acetylneuraminic acid synthase -2.73089
CPTP ceramide-1-phosphate transfer protein -2.70407
CREBRF CREB3 regulatory factor -2.64087
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -2.614
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.59025
FAM216A family with sequence similarity 216, member A -2.55712
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.54784
PCDH9 protocadherin 9 -2.4562
PLPP3 phospholipid phosphatase 3 -2.43686
OSTN osteocrin -2.42773
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.42773
BRICD5 BRICHOS domain containing 5 -2.42773
DGKE diacylglycerol kinase, epsilon 64kDa -2.39277
EPSTI1 epithelial stromal interaction 1 (breast) -2.39214
PRR16 proline rich 16 -2.38773
ACO2 aconitase 2, mitochondrial -2.38016
KLK10 kallikrein-related peptidase 10 -2.36134
NPIPB12 nuclear pore complex interacting protein family member B12 -2.35251
PYM1 PYM homolog 1, exon junction complex associated factor -2.34813
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 -2.33882
EFCAB5 EF-hand calcium binding domain 5 -2.33882
GALM galactose mutarotase (aldose 1-epimerase) -2.33166
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -2.33003
C16ORF86 chromosome 16 open reading frame 86 -2.33003
CXORF38 chromosome X open reading frame 38 -2.33003
HOOK1 hook microtubule-tethering protein 1 -2.30144
CD200R1 CD200 receptor 1 -2.29197
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.28037
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.28037
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -2.26456
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.23552
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.22865
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.22865
MYLK4 myosin light chain kinase family, member 4 -2.22865
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 -2.22865
HCST hematopoietic cell signal transducer -2.22865
SFXN3 sideroflexin 3 -2.22865
WNK4 WNK lysine deficient protein kinase 4 -2.22865
CRYGB crystallin, gamma B -2.22865
ERN2 endoplasmic reticulum to nucleus signaling 2 -2.22865
MT1G metallothionein 1G -2.22526
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 -2.22526
LMBR1L limb development membrane protein 1-like -2.19647
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.18296
TALDO1 transaldolase 1 -2.18296
ZNF3 zinc finger protein 3 -2.15104
IFNLR1 interferon, lambda receptor 1 -2.15104
AKR1C1 aldo-keto reductase family 1, member C1 -2.13792
SF3B3 splicing factor 3b, subunit 3, 130kDa -2.10679
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -2.10679
ANXA6 annexin A6 -2.10561
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.10544
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.06335
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -2.05222
DSE dermatan sulfate epimerase -2.03921
CGGBP1 CGG triplet repeat binding protein 1 -2.03187
CLTRN collectrin, amino acid transport regulator -2.03187