GB1 Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description cell line derived from central nervous system (Cancer Cell Line Encyclopedia)
External Link https://depmap.org/portal/cell_line/ACH-000738
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Genes

186 gene knockdowns changing fitness of GB1 relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 8.16596
SETD6 SET domain containing 6 5.99539
SOX3 SRY (sex determining region Y)-box 3 5.88959
DDIT3 DNA-damage-inducible transcript 3 5.82717
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 5.05711
PDE1B phosphodiesterase 1B, calmodulin-dependent 4.96933
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 4.82812
APOF apolipoprotein F 4.60731
VSTM4 V-set and transmembrane domain containing 4 4.54438
PRSS54 protease, serine, 54 4.27578
GLI1 GLI family zinc finger 1 4.26554
ARHGAP9 Rho GTPase activating protein 9 4.03576
MAP2K7 mitogen-activated protein kinase kinase 7 3.91445
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 3.86249
AAAS achalasia, adrenocortical insufficiency, alacrimia 3.86058
SALL2 spalt-like transcription factor 2 3.85101
NMS neuromedin S 3.84489
MYLK3 myosin light chain kinase 3 3.76231
HBS1L HBS1-like translational GTPase 3.75918
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 3.75116
SH3PXD2A SH3 and PX domains 2A 3.74742
KRT72 keratin 72, type II 3.74116
AIP aryl hydrocarbon receptor interacting protein 3.68712
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 3.64139
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 3.60357
MTO1 mitochondrial tRNA translation optimization 1 3.51643
SCAF4 SR-related CTD-associated factor 4 3.50023
PCDHA9 protocadherin alpha 9 3.48535
CEP68 centrosomal protein 68kDa 3.38058
TP53TG5 TP53 target 5 3.35456
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 3.34891
CEP44 centrosomal protein 44kDa 3.30915
CEP120 centrosomal protein 120kDa 3.25541
CAPNS2 calpain, small subunit 2 3.24227
GTPBP8 GTP-binding protein 8 (putative) 3.23715
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 3.2244
SACS sacsin molecular chaperone 3.19882
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 3.17294
MTIF3 mitochondrial translational initiation factor 3 3.10619
XKR8 XK, Kell blood group complex subunit-related family, member 8 3.06826
CREBZF CREB/ATF bZIP transcription factor 3.02569
COL13A1 collagen, type XIII, alpha 1 3.01689
PET100 PET100 homolog (S. cerevisiae) 3.00544
CSK c-src tyrosine kinase 2.97643
EXT2 exostosin glycosyltransferase 2 2.96276
CD44 CD44 molecule (Indian blood group) 2.93398
COQ3 coenzyme Q3 methyltransferase 2.93115
JTB jumping translocation breakpoint 2.9263
CA14 carbonic anhydrase XIV 2.90165
TBCCD1 TBCC domain containing 1 2.88761
MBD6 methyl-CpG binding domain protein 6 2.86727
UBXN11 UBX domain protein 11 2.86368
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa 2.86186
WNT10B wingless-type MMTV integration site family, member 10B 2.85172
GIMAP6 GTPase, IMAP family member 6 2.85134
PHOSPHO1 phosphatase, orphan 1 2.84879
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 2.83564
NUBPL nucleotide binding protein-like 2.82062
GLIS3 GLIS family zinc finger 3 2.81716
PRCD progressive rod-cone degeneration 2.81557
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 2.81417
GTPBP10 GTP-binding protein 10 (putative) 2.80626
TRIR telomerase RNA component interacting RNase 2.80095
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 2.77406
PDGFB platelet-derived growth factor beta polypeptide 2.77205
MTERF3 mitochondrial transcription termination factor 3 2.75916
ATP5L2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2 2.75053
GFM2 G elongation factor, mitochondrial 2 2.73859
MRM3 mitochondrial rRNA methyltransferase 3 2.73834
BOLA3 bolA family member 3 2.72131
KIAA1671 KIAA1671 2.7195
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 2.71697
RTN4IP1 reticulon 4 interacting protein 1 2.71633
GPR45 G protein-coupled receptor 45 2.7155
RILPL1 Rab interacting lysosomal protein-like 1 2.7134
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.70033
CYTH3 cytohesin 3 2.67457
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.67151
MRPL13 mitochondrial ribosomal protein L13 2.6536
CREB5 cAMP responsive element binding protein 5 2.64463
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.61367
IPCEF1 interaction protein for cytohesin exchange factors 1 2.60907
CISH cytokine inducible SH2-containing protein 2.59325
MTERF4 mitochondrial transcription termination factor 4 2.58196
SOCS5 suppressor of cytokine signaling 5 2.57709
CENPU centromere protein U 2.57239
TFB1M transcription factor B1, mitochondrial 2.57062
SLC46A2 solute carrier family 46, member 2 2.56171
TREM1 triggering receptor expressed on myeloid cells 1 2.553
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.54881
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.54312
KRT14 keratin 14, type I 2.53084
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.52322
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.51046
MDC1 mediator of DNA-damage checkpoint 1 2.50052
IQCF1 IQ motif containing F1 2.49785
TRH thyrotropin-releasing hormone 2.47958
CTXN3 cortexin 3 2.4657
CEP295 centrosomal protein 295kDa 2.4517
ACAD9 acyl-CoA dehydrogenase family, member 9 2.44931
POC1A POC1 centriolar protein A 2.44738
TMEM242 transmembrane protein 242 2.425
CENPJ centromere protein J 2.42119
ARID1A AT rich interactive domain 1A (SWI-like) 2.41516
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 2.40998
KIFC3 kinesin family member C3 2.40579
FOXM1 forkhead box M1 2.40469
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 2.3998
LEMD2 LEM domain containing 2 2.39582
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 2.39134
NUP188 nucleoporin 188kDa 2.38799
MRPL52 mitochondrial ribosomal protein L52 2.3813
COA6 cytochrome c oxidase assembly factor 6 2.37687
ZSCAN20 zinc finger and SCAN domain containing 20 2.36727
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 2.33854
TRUB2 TruB pseudouridine (psi) synthase family member 2 2.3294
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.3154
IER3 immediate early response 3 2.31406
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 2.31309
RNF10 ring finger protein 10 2.31094
KDSR 3-ketodihydrosphingosine reductase 2.30646
SOWAHA sosondowah ankyrin repeat domain family member A 2.30177
RCAN3 RCAN family member 3 2.30172
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 2.29879
GRSF1 G-rich RNA sequence binding factor 1 2.29594
CENPO centromere protein O 2.2944
FKBP15 FK506 binding protein 15, 133kDa 2.28838
POU2F1 POU class 2 homeobox 1 2.28421
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.28372
SYCN syncollin 2.26328
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.26121
USB1 U6 snRNA biogenesis 1 2.25872
RTL8A retrotransposon Gag like 8A 2.25856
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.25317
MIPEP mitochondrial intermediate peptidase 2.2393
SNX15 sorting nexin 15 2.2325
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 2.23013
GSC2 goosecoid homeobox 2 2.22119
SMYD5 SMYD family member 5 2.21352
PDX1 pancreatic and duodenal homeobox 1 2.21282
PTF1A pancreas specific transcription factor, 1a 2.21203
C3ORF38 chromosome 3 open reading frame 38 2.20971
RGCC regulator of cell cycle 2.20574
CAB39 calcium binding protein 39 2.18873
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 2.18662
PYURF PIGY upstream reading frame 2.17542
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.16188
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.16152
USP35 ubiquitin specific peptidase 35 2.15674
CD52 CD52 molecule 2.15545
ZBTB39 zinc finger and BTB domain containing 39 2.15278
MT1G metallothionein 1G 2.14568
TUT4 terminal uridylyl transferase 4 2.14517
NUP35 nucleoporin 35kDa 2.14105
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.14064
GJA1 gap junction protein, alpha 1, 43kDa 2.12332
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.12008
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.1159
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.11381
PALB2 partner and localizer of BRCA2 2.09691
TEDC1 tubulin epsilon and delta complex 1 2.0942
MRPS17 mitochondrial ribosomal protein S17 2.07373
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 2.07284
CBLN4 cerebellin 4 precursor 2.07231
PRDM15 PR domain containing 15 2.06329
RBM34 RNA binding motif protein 34 2.0621
NRTN neurturin 2.0567
ANKRD23 ankyrin repeat domain 23 2.04425
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.04257
PRADC1 protease-associated domain containing 1 2.04008
MRM2 mitochondrial rRNA methyltransferase 2 2.03803
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 2.03457
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.03265
PLA2G12B phospholipase A2, group XIIB 2.02982
ZBTB46 zinc finger and BTB domain containing 46 2.02427
DIDO1 death inducer-obliterator 1 2.02061
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 2.02003
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.01888
MT1A metallothionein 1A 2.01858
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.0155
MTRF1L mitochondrial translational release factor 1-like 2.01332
GPSM2 G-protein signaling modulator 2 2.00826
ODR4 odr-4 GPCR localization factor homolog 2.00733
RPUSD3 RNA pseudouridylate synthase domain containing 3 2.00517
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.00503
NFU1 NFU1 iron-sulfur cluster scaffold 2.00298