GCN2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description eukaryotic translation initiation factor 2 alpha kinase 4|This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 440275)
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100 substrates of the kinase GCN2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
TNS1 tensin 1
SART1 squamous cell carcinoma antigen recognized by T cells
LASP1 LIM and SH3 protein 1
EHBP1 EH domain binding protein 1
SON SON DNA binding protein
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
YES1 YES proto-oncogene 1, Src family tyrosine kinase
PLEC plectin
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
KLF10 Kruppel-like factor 10
TMF1 TATA element modulatory factor 1
OGG1 8-oxoguanine DNA glycosylase
TAOK3 TAO kinase 3
TJP1 tight junction protein 1
KAT7 K(lysine) acetyltransferase 7
KIF20A kinesin family member 20A
BHLHE40 basic helix-loop-helix family, member e40
PECAM1 platelet/endothelial cell adhesion molecule 1
MFAP1 microfibrillar-associated protein 1
SFXN5 sideroflexin 5
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2
ZRANB2 zinc finger, RAN-binding domain containing 2
AZI2 5-azacytidine induced 2
MYO18A myosin XVIIIA
MCM3 minichromosome maintenance complex component 3
CMKLR1 chemerin chemokine-like receptor 1
ZNF608 zinc finger protein 608
NEBL nebulette
UFL1 UFM1-specific ligase 1
ACTA2 actin, alpha 2, smooth muscle, aorta
SEC62 SEC62 homolog (S. cerevisiae)
PHF10 PHD finger protein 10
PRRC2B proline-rich coiled-coil 2B
SFPQ splicing factor proline/glutamine-rich
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
IGF1R insulin-like growth factor 1 receptor
RBBP8 retinoblastoma binding protein 8
RHOBTB3 Rho-related BTB domain containing 3
ACTA1 actin, alpha 1, skeletal muscle
GRB2 growth factor receptor-bound protein 2
MYH11 myosin, heavy chain 11, smooth muscle
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
ZNF24 zinc finger protein 24
RANBP2 RAN binding protein 2
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
CHEK2 checkpoint kinase 2
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
FKBP15 FK506 binding protein 15, 133kDa
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
DST dystonin
FAM219A family with sequence similarity 219, member A
DIAPH1 diaphanous-related formin 1
FASN fatty acid synthase
KIAA1328 KIAA1328
ACTC1 actin, alpha, cardiac muscle 1
LMNA lamin A/C
CCDC50 coiled-coil domain containing 50
WAPAL wings apart-like homolog (Drosophila)
INF2 inverted formin, FH2 and WH2 domain containing
ANTXR2 anthrax toxin receptor 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
HLA-A major histocompatibility complex, class I, A
ANAPC5 anaphase promoting complex subunit 5
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
SLC38A2 solute carrier family 38, member 2
RIF1 replication timing regulatory factor 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
INTS12 integrator complex subunit 12
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
ANTXR1 anthrax toxin receptor 1
MORC3 MORC family CW-type zinc finger 3
CLK2 CDC-like kinase 2
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
FTSJ3 FtsJ homolog 3 (E. coli)
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
SPN sialophorin
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
MCPH1 microcephalin 1
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
PTK2 protein tyrosine kinase 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
RGPD3 RANBP2-like and GRIP domain containing 3
EPHB4 EPH receptor B4
CABIN1 calcineurin binding protein 1
CTTN cortactin
PDCD6 programmed cell death 6
SP100 SP100 nuclear antigen
ACTB actin, beta
SMIM1 small integral membrane protein 1 (Vel blood group)
LAT2 linker for activation of T cells family, member 2
ZNF407 zinc finger protein 407
CLASP2 cytoplasmic linker associated protein 2
CLASP1 cytoplasmic linker associated protein 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TNS3 tensin 3