Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCNP_SHH_UP_LATE.V1_UP
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362 genes differentially expressed following the GCNP_SHH_UP_LATE.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
AARD alanine and arginine rich domain containing protein
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARL5A ADP-ribosylation factor-like 5A
ASB3 ankyrin repeat and SOCS box containing 3
ATAD2B ATPase family, AAA domain containing 2B
AURKA aurora kinase A
AURKB aurora kinase B
BOK BCL2-related ovarian killer
C1ORF174 chromosome 1 open reading frame 174
CASD1 CAS1 domain containing 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CD5 CD5 molecule
CD6 CD6 molecule
CD80 CD80 molecule
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDCA7 cell division cycle associated 7
CDK1 cyclin-dependent kinase 1
CFDP1 craniofacial development protein 1
CHEK1 checkpoint kinase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLCN5 chloride channel, voltage-sensitive 5
CLIC4 chloride intracellular channel 4
CLIP4 CAP-GLY domain containing linker protein family, member 4
COIL coilin
COPB1 coatomer protein complex, subunit beta 1
COX7B cytochrome c oxidase subunit VIIb
CREM cAMP responsive element modulator
CUL4A cullin 4A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DES desmin
DIDO1 death inducer-obliterator 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
E2F8 E2F transcription factor 8
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF3A eukaryotic translation initiation factor 3, subunit A
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELOVL2 ELOVL fatty acid elongase 2
FAM60A family with sequence similarity 60, member A
FANCC Fanconi anemia, complementation group C
FANCM Fanconi anemia, complementation group M
FBXO11 F-box protein 11
FMR1NB fragile X mental retardation 1 neighbor
FOXA1 forkhead box A1
FRMD6 FERM domain containing 6
FTSJ3 FtsJ homolog 3 (E. coli)
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GBP2 guanylate binding protein 2, interferon-inducible
GFM2 G elongation factor, mitochondrial 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HNF1A HNF1 homeobox A
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HSPB2 heat shock 27kDa protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF2 insulin-like growth factor 2
INCENP inner centromere protein antigens 135/155kDa
IVNS1ABP influenza virus NS1A binding protein
KIF2C kinesin family member 2C
KIFC1 kinesin family member C1
KRTAP6-3 keratin associated protein 6-3
LARP7 La ribonucleoprotein domain family, member 7
LBR lamin B receptor
LEFTY1 left-right determination factor 1
LIG1 ligase I, DNA, ATP-dependent
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LOXL2 lysyl oxidase-like 2
LRRC23 leucine rich repeat containing 23
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MATR3 matrin 3
MBD2 methyl-CpG binding domain protein 2
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MDN1 MDN1, midasin homolog (yeast)
METAP1 methionyl aminopeptidase 1
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MIS18BP1 MIS18 binding protein 1
MOB1A MOB kinase activator 1A
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MRPL18 mitochondrial ribosomal protein L18
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit
NKX2-2 NK2 homeobox 2
NOP56 NOP56 ribonucleoprotein
NPAS1 neuronal PAS domain protein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPTX1 neuronal pentraxin I
NR5A2 nuclear receptor subfamily 5, group A, member 2
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1
NUSAP1 nucleolar and spindle associated protein 1
NXF1 nuclear RNA export factor 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBDC1 polysaccharide biosynthesis domain containing 1
PCNT pericentrin
PCSK2 proprotein convertase subtilisin/kexin type 2
PFDN6 prefoldin subunit 6
PHTF2 putative homeodomain transcription factor 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK2 polo-like kinase 2
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLRMT polymerase (RNA) mitochondrial (DNA directed)
PRC1 protein regulator of cytokinesis 1
PSMC3IP PSMC3 interacting protein
PSME4 proteasome (prosome, macropain) activator subunit 4
PTCD3 pentatricopeptide repeat domain 3
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAG2 recombination activating gene 2
RLIM ring finger protein, LIM domain interacting
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RYK receptor-like tyrosine kinase
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SARDH sarcosine dehydrogenase
SDC2 syndecan 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SGOL1 shugoshin-like 1 (S. pombe)
SIX4 SIX homeobox 4
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLTM SAFB-like, transcription modulator
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SMIM11 small integral membrane protein 11
SMIM20 small integral membrane protein 20
SOCS2 suppressor of cytokine signaling 2
SPATA5 spermatogenesis associated 5
SPOP speckle-type POZ protein
SQRDL sulfide quinone reductase-like (yeast)
SRSF1 serine/arginine-rich splicing factor 1
SRSF10 serine/arginine-rich splicing factor 10
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STRN3 striatin, calmodulin binding protein 3
SYT4 synaptotagmin IV
TARDBP TAR DNA binding protein
TEAD3 TEA domain family member 3
THOP1 thimet oligopeptidase 1
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TK1 thymidine kinase 1, soluble
TM9SF3 transmembrane 9 superfamily member 3
TMOD3 tropomodulin 3 (ubiquitous)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TRIP13 thyroid hormone receptor interactor 13
UFD1L ubiquitin fusion degradation 1 like (yeast)
UNG uracil-DNA glycosylase
USP39 ubiquitin specific peptidase 39
VCAN versican
VPRBP Vpr (HIV-1) binding protein
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
XPO1 exportin 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFX zinc finger protein, X-linked
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMYM6 zinc finger, MYM-type 6
ZNF281 zinc finger protein 281
ZNF638 zinc finger protein 638
ZNF644 zinc finger protein 644

decreased expression

Symbol Name
ACOT1 acyl-CoA thioesterase 1
ACTN4 actinin, alpha 4
ACVR1 activin A receptor, type I
ADAM7 ADAM metallopeptidase domain 7
ADCY9 adenylate cyclase 9
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGTRAP angiotensin II receptor-associated protein
AMOTL2 angiomotin like 2
ANKRD33B ankyrin repeat domain 33B
ANXA7 annexin A7
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARG1 arginase 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ART5 ADP-ribosyltransferase 5
ATAD3A ATPase family, AAA domain containing 3A
AXIN1 axin 1
B3GAT3 beta-1,3-glucuronyltransferase 3
BCL2L2 BCL2-like 2
C19ORF60 chromosome 19 open reading frame 60
CCDC71L coiled-coil domain containing 71-like
CD276 CD276 molecule
CD52 CD52 molecule
CDCP1 CUB domain containing protein 1
CDHR5 cadherin-related family member 5
CLCN6 chloride channel, voltage-sensitive 6
CLRN3 clarin 3
CNGA2 cyclic nucleotide gated channel alpha 2
CNN1 calponin 1, basic, smooth muscle
CNN2 calponin 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CSF2RBP1 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) pseudogene 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDA1 DET1 and DDB1 associated 1
DHODH dihydroorotate dehydrogenase (quinone)
DHRSX dehydrogenase/reductase (SDR family) X-linked
DLG4 discs, large homolog 4 (Drosophila)
DLX5 distal-less homeobox 5
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPPA5 developmental pluripotency associated 5
DSCR8 Down syndrome critical region 8
EBI3 Epstein-Barr virus induced 3
EDN1 endothelin 1
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EIF6 eukaryotic translation initiation factor 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA3 EPH receptor A3
EPHB6 EPH receptor B6
ESRP1 epithelial splicing regulatory protein 1
EYA1 EYA transcriptional coactivator and phosphatase 1
F8A1 coagulation factor VIII-associated 1
FAHD1 fumarylacetoacetate hydrolase domain containing 1
FAM111A family with sequence similarity 111, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FMO1 flavin containing monooxygenase 1
FOXD3 forkhead box D3
FRRS1 ferric-chelate reductase 1
FZD9 frizzled class receptor 9
GCM2 glial cells missing homolog 2 (Drosophila)
GJB6 gap junction protein, beta 6, 30kDa
GLA galactosidase, alpha
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR3 G protein-coupled receptor 3
GRB7 growth factor receptor-bound protein 7
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
H2AFJ H2A histone family, member J
HSPG2 heparan sulfate proteoglycan 2
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HYOU1 hypoxia up-regulated 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL4R interleukin 4 receptor
IRF9 interferon regulatory factor 9
ITGA7 integrin, alpha 7
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KANK3 KN motif and ankyrin repeat domains 3
KIAA1161 KIAA1161
KLK6 kallikrein-related peptidase 6
KLK8 kallikrein-related peptidase 8
KPNA1 karyopherin alpha 1 (importin alpha 5)
LAMC2 laminin, gamma 2
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS4 lectin, galactoside-binding, soluble, 4
LOR loricrin
LSR lipolysis stimulated lipoprotein receptor
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MDFI MyoD family inhibitor
MED12 mediator complex subunit 12
MEF2A myocyte enhancer factor 2A
MIIP migration and invasion inhibitory protein
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MRPL3 mitochondrial ribosomal protein L3
MUC3A mucin 3A, cell surface associated
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NBEAL2 neurobeachin-like 2
NCOA6 nuclear receptor coactivator 6
NCOA7 nuclear receptor coactivator 7
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
NECAP2 NECAP endocytosis associated 2
NMI N-myc (and STAT) interactor
NPTN neuroplastin
NRP2 neuropilin 2
NTHL1 nth endonuclease III-like 1 (E. coli)
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARP8 poly (ADP-ribose) polymerase family, member 8
PDCD7 programmed cell death 7
PDZK1IP1 PDZK1 interacting protein 1
PEMT phosphatidylethanolamine N-methyltransferase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PITX3 paired-like homeodomain 3
PLD2 phospholipase D2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTH1R parathyroid hormone 1 receptor
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRU protein tyrosine phosphatase, receptor type, U
PUS1 pseudouridylate synthase 1
RAB34 RAB34, member RAS oncogene family
RBBP6 retinoblastoma binding protein 6
RBKS ribokinase
RHD Rh blood group, D antigen
RMDN3 regulator of microtubule dynamics 3
RP9 retinitis pigmentosa 9 (autosomal dominant)
S100A11 S100 calcium binding protein A11
S100A13 S100 calcium binding protein A13
S1PR1 sphingosine-1-phosphate receptor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SELL selectin L
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A45 solute carrier family 25, member 45
SLC25A47 solute carrier family 25, member 47
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SNX21 sorting nexin family member 21
SOX18 SRY (sex determining region Y)-box 18
SSBP4 single stranded DNA binding protein 4
STX1A syntaxin 1A (brain)
STX2 syntaxin 2
STX3 syntaxin 3
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCEA2 transcription elongation factor A (SII), 2
TGFB3 transforming growth factor, beta 3
TMEM214 transmembrane protein 214
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TTC23 tetratricopeptide repeat domain 23
TUBA4B tubulin, alpha 4b
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBE3C ubiquitin protein ligase E3C
VEGFC vascular endothelial growth factor C
VIPR2 vasoactive intestinal peptide receptor 2
VNN1 vanin 1
VSNL1 visinin-like 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WLS wntless Wnt ligand secretion mediator
WNK2 WNK lysine deficient protein kinase 2
WWC1 WW and C2 domain containing 1
ZC3H12C zinc finger CCCH-type containing 12C
ZDHHC5 zinc finger, DHHC-type containing 5
ZFYVE19 zinc finger, FYVE domain containing 19
ZIK1 zinc finger protein interacting with K protein 1
ZNHIT2 zinc finger, HIT-type containing 2