GCT Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description A Giant Cell Tumor (GCT) cell line derived from a human fibrous histiocytoma lung metastasis (Experimental Factor Ontology, EFO_0002182)
External Link https://depmap.org/portal/cell_line/ACH-000835
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Genes

290 gene knockdowns changing fitness of GCT relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
ACVR2A activin A receptor, type IIA 9.33239
WDR91 WD repeat domain 91 9.00319
COQ6 coenzyme Q6 monooxygenase 8.12013
USP26 ubiquitin specific peptidase 26 7.61243
ACVR1B activin A receptor, type IB 7.53984
COQ8B coenzyme Q8B 6.98599
FBXL18 F-box and leucine-rich repeat protein 18 6.73128
ZNF845 zinc finger protein 845 6.00353
PIWIL4 piwi-like RNA-mediated gene silencing 4 5.66813
MIDEAS mitotic deacetylase associated SANT domain protein 5.52905
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 5.46899
OR3A1 olfactory receptor, family 3, subfamily A, member 1 5.41467
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 5.22145
SWSAP1 SWIM-type zinc finger 7 associated protein 1 5.02316
TRIO trio Rho guanine nucleotide exchange factor 4.96481
TVP23A trans-golgi network vesicle protein 23 homolog A (S. cerevisiae) 4.92147
LRRC43 leucine rich repeat containing 43 4.87303
OR51T1 olfactory receptor, family 51, subfamily T, member 1 4.83569
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 4.75789
TMOD3 tropomodulin 3 (ubiquitous) 4.74014
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 4.67934
CLEC2A C-type lectin domain family 2, member A 4.52746
RNF111 ring finger protein 111 4.51758
ABHD3 abhydrolase domain containing 3 4.46025
CLCN6 chloride channel, voltage-sensitive 6 4.45566
CCS copper chaperone for superoxide dismutase 4.26182
F2R coagulation factor II (thrombin) receptor 4.13653
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 4.09854
NAGLU N-acetylglucosaminidase, alpha 4.07309
JPH1 junctophilin 1 4.05282
MSN moesin 4.05059
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 4.03169
TMEM200A transmembrane protein 200A 4.03033
TRIP10 thyroid hormone receptor interactor 10 4.02834
PCDHA11 protocadherin alpha 11 3.99763
TRIM41 tripartite motif containing 41 3.99053
MTMR7 myotubularin related protein 7 3.98299
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 3.97981
TGIF2 TGFB-induced factor homeobox 2 3.88887
AFDN afadin, adherens junction formation factor 3.88619
FAM53C family with sequence similarity 53, member C 3.86821
CNTRL centriolin 3.84838
PSKH2 protein serine kinase H2 3.74928
ACO1 aconitase 1, soluble 3.70564
ANKHD1 ankyrin repeat and KH domain containing 1 3.69848
BRAF B-Raf proto-oncogene, serine/threonine kinase 3.65768
C6ORF10 chromosome 6 open reading frame 10 3.62077
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 3.60125
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 3.5831
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 3.57599
F3 coagulation factor III (thromboplastin, tissue factor) 3.51885
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 3.50823
KRT35 keratin 35, type I 3.47549
DLG5 discs, large homolog 5 (Drosophila) 3.44122
TMEM260 transmembrane protein 260 3.43769
UBL7 ubiquitin-like 7 3.43082
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 3.41552
FBXO42 F-box protein 42 3.4137
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.40345
MARVELD3 MARVEL domain containing 3 3.402
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 3.39623
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.38394
TBRG1 transforming growth factor beta regulator 1 3.32366
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 3.30018
PIAS1 protein inhibitor of activated STAT, 1 3.26665
KRTAP3-3 keratin associated protein 3-3 3.26148
RPA4 replication protein A4, 30kDa 3.26104
SMAD4 SMAD family member 4 3.25142
ZC3H12B zinc finger CCCH-type containing 12B 3.23394
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 3.22276
BRIP1 BRCA1 interacting protein C-terminal helicase 1 3.21833
UFSP2 UFM1-specific peptidase 2 3.18998
CLHC1 clathrin heavy chain linker domain containing 1 3.16018
DNAAF5 dynein, axonemal, assembly factor 5 3.15172
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 3.15027
ELOVL1 ELOVL fatty acid elongase 1 3.12994
PDS5B PDS5 cohesin associated factor B 3.12138
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 3.12002
UCK2 uridine-cytidine kinase 2 3.11388
PCNT pericentrin 3.1135
MTMR6 myotubularin related protein 6 3.1059
MAGEB10 melanoma antigen family B10 3.10122
OR14C36 olfactory receptor, family 14, subfamily C, member 36 3.08857
ERCC4 excision repair cross-complementation group 4 3.03773
HOXA1 homeobox A1 3.0345
PHF24 PHD finger protein 24 3.02323
USP30 ubiquitin specific peptidase 30 3.01199
ASCL4 achaete-scute family bHLH transcription factor 4 3.01062
TCF20 transcription factor 20 (AR1) 3.01058
LMNB1 lamin B1 3.00078
RIMS3 regulating synaptic membrane exocytosis 3 2.98469
TOM1 target of myb1 (chicken) 2.96886
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.96489
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 2.94713
KRT27 keratin 27, type I 2.93667
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.92543
TRIM56 tripartite motif containing 56 2.92441
AOC2 amine oxidase, copper containing 2 (retina-specific) 2.90942
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.90039
MOCS2 molybdenum cofactor synthesis 2 2.89648
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.8834
SH2D3A SH2 domain containing 3A 2.85138
MAP3K7 mitogen-activated protein kinase kinase kinase 7 2.84809
IL1R1 interleukin 1 receptor, type I 2.84597
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.84023
TTC9 tetratricopeptide repeat domain 9 2.83874
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.83025
ZFP1 ZFP1 zinc finger protein 2.82629
MORC2 MORC family CW-type zinc finger 2 2.82321
CCDC6 coiled-coil domain containing 6 2.81604
ODR4 odr-4 GPCR localization factor homolog 2.80144
UNC5D unc-5 homolog D (C. elegans) 2.78778
STX19 syntaxin 19 2.76069
MRTFA myocardin related transcription factor A 2.75124
AGBL5 ATP/GTP binding protein-like 5 2.75045
TGFBR3L transforming growth factor, beta receptor III-like 2.7418
JMJD4 jumonji domain containing 4 2.72544
ULBP2 UL16 binding protein 2 2.70735
ZNF791 zinc finger protein 791 2.7067
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.70662
LGALS13 lectin, galactoside-binding, soluble, 13 2.70548
KIAA2018 KIAA2018 2.69941
CRH corticotropin releasing hormone 2.69081
DIDO1 death inducer-obliterator 1 2.68644
TXK TXK tyrosine kinase 2.68208
ATG9A autophagy related 9A 2.67781
FBP1 fructose-1,6-bisphosphatase 1 2.67596
RB1CC1 RB1-inducible coiled-coil 1 2.67523
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2.66522
ALX1 ALX homeobox 1 2.65708
RNF31 ring finger protein 31 2.6567
RAD51AP2 RAD51 associated protein 2 2.65546
SLC41A3 solute carrier family 41, member 3 2.655
TTLL11 tubulin tyrosine ligase-like family member 11 2.65059
ZNF622 zinc finger protein 622 2.6353
ANKRD62 ankyrin repeat domain 62 2.6338
ZNF384 zinc finger protein 384 2.62444
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.61569
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 2.5974
TP53BP2 tumor protein p53 binding protein 2 2.57428
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.57244
SMLR1 small leucine-rich protein 1 2.56826
SMYD5 SMYD family member 5 2.56781
NAF1 nuclear assembly factor 1 ribonucleoprotein 2.5671
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.56047
JUN jun proto-oncogene 2.55977
AK3 adenylate kinase 3 2.55778
SORT1 sortilin 1 2.55004
PNPLA6 patatin-like phospholipase domain containing 6 2.54314
ZFX zinc finger protein, X-linked 2.53949
UGCG UDP-glucose ceramide glucosyltransferase 2.52831
OR52B6 olfactory receptor, family 52, subfamily B, member 6 2.51808
GIN1 gypsy retrotransposon integrase 1 2.51226
WDR81 WD repeat domain 81 2.50851
HRH4 histamine receptor H4 2.50851
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.5064
NUP188 nucleoporin 188kDa 2.50377
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 2.48996
UNC119B unc-119 homolog B (C. elegans) 2.48692
PRR23C proline rich 23C 2.48087
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.47965
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.47324
TRPC1 transient receptor potential cation channel, subfamily C, member 1 2.47079
CELF1 CUGBP, Elav-like family member 1 2.46962
PARP2 poly (ADP-ribose) polymerase 2 2.46083
FAM189A2 family with sequence similarity 189, member A2 2.44898
CRYBB2 crystallin, beta B2 2.44675
LIMK1 LIM domain kinase 1 2.43479
MPRIP myosin phosphatase Rho interacting protein 2.43476
ZFP37 ZFP37 zinc finger protein 2.42528
PMM2 phosphomannomutase 2 2.41771
OR52N1 olfactory receptor, family 52, subfamily N, member 1 2.41123
TMEM74 transmembrane protein 74 2.39433
USF1 upstream transcription factor 1 2.39031
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.38584
PCCB propionyl CoA carboxylase, beta polypeptide 2.38017
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.36596
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.35814
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.35548
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.35239
LARP6 La ribonucleoprotein domain family, member 6 2.34467
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.34376
QSOX2 quiescin Q6 sulfhydryl oxidase 2 2.34277
STK11 serine/threonine kinase 11 2.33378
DNM1 dynamin 1 2.33329
S1PR5 sphingosine-1-phosphate receptor 5 2.32517
PHRF1 PHD and ring finger domains 1 2.31896
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 2.31594
ZNF121 zinc finger protein 121 2.3067
NACAD NAC alpha domain containing 2.30278
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.30252
RPL41 ribosomal protein L41 2.29683
ZNF408 zinc finger protein 408 2.29154
DUXA double homeobox A 2.28688
MMP21 matrix metallopeptidase 21 2.28404
IL1RAP interleukin 1 receptor accessory protein 2.28231
DMRTA2 DMRT-like family A2 2.28215
EVA1A eva-1 homolog A (C. elegans) 2.27832
WBP2NL WBP2 N-terminal like 2.2767
MIMS1 mitochondrial inner membrane scaffold 1 2.27429
HSPA14 heat shock 70kDa protein 14 2.27292
STK3 serine/threonine kinase 3 2.26771
SPATA24 spermatogenesis associated 24 2.26142
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.25947
SCARF2 scavenger receptor class F, member 2 2.25927
RNF213 ring finger protein 213 2.25179
KLHL26 kelch-like family member 26 2.24742
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 2.24469
VSX1 visual system homeobox 1 2.24087
DSCC1 DNA replication and sister chromatid cohesion 1 2.23967
ITPK1 inositol-tetrakisphosphate 1-kinase 2.23037
PHKB phosphorylase kinase, beta 2.22404
ZNRF4 zinc and ring finger 4 2.22271
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 2.22218
OR1N2 olfactory receptor, family 1, subfamily N, member 2 2.21273
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.21237
BOD1 biorientation of chromosomes in cell division 1 2.21204
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.20984
BSG basigin (Ok blood group) 2.20702
IPO8 importin 8 2.20011
SLC43A3 solute carrier family 43, member 3 2.19962
PMVK phosphomevalonate kinase 2.19544
CNN2 calponin 2 2.1933
FAM117B family with sequence similarity 117, member B 2.18943
MRTFB myocardin related transcription factor B 2.18678
OR10G4 olfactory receptor, family 10, subfamily G, member 4 2.18607
PODXL2 podocalyxin-like 2 2.1838
ZNF692 zinc finger protein 692 2.1786
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.17355
BRCA1 breast cancer 1, early onset 2.17337
MAP2K1 mitogen-activated protein kinase kinase 1 2.17193
GAN gigaxonin 2.16455
TECTB tectorin beta 2.16426
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 2.1614
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.16034
THAP7 THAP domain containing 7 2.14939
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.1471
VAX2 ventral anterior homeobox 2 2.14485
KIFBP kinesin family binding protein 2.14084
BTN1A1 butyrophilin, subfamily 1, member A1 2.1349
RBM23 RNA binding motif protein 23 2.13488
KIAA1328 KIAA1328 2.13334
MUC7 mucin 7, secreted 2.13137
NCOA4 nuclear receptor coactivator 4 2.12734
MEN1 multiple endocrine neoplasia I 2.12509
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.12143
MRPL40 mitochondrial ribosomal protein L40 2.12003
TECR trans-2,3-enoyl-CoA reductase 2.11898
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.11432
IMPACT impact RWD domain protein 2.11407
FGD6 FYVE, RhoGEF and PH domain containing 6 2.11237
CLK4 CDC-like kinase 4 2.10956
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 2.10063
SHD Src homology 2 domain containing transforming protein D 2.09995
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 2.09876
CHD2 chromodomain helicase DNA binding protein 2 2.09341
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.09121
DYNLRB2 dynein, light chain, roadblock-type 2 2.09108
MT1HL1 metallothionein 1H-like 1 2.09021
ZNF329 zinc finger protein 329 2.08852
OR51B4 olfactory receptor, family 51, subfamily B, member 4 2.0884
ACACA acetyl-CoA carboxylase alpha 2.08826
CMIP c-Maf inducing protein 2.08627
FANCI Fanconi anemia, complementation group I 2.08511
QTRT1 queuine tRNA-ribosyltransferase 1 2.08124
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.0681
NOS1 nitric oxide synthase 1 (neuronal) 2.05762
C20ORF196 chromosome 20 open reading frame 196 2.05559
NBN nibrin 2.053
FANCL Fanconi anemia, complementation group L 2.0499
FAM210B family with sequence similarity 210, member B 2.04969
MSL1 male-specific lethal 1 homolog (Drosophila) 2.04944
RNF130 ring finger protein 130 2.04799
TMPO thymopoietin 2.04456
ZNF706 zinc finger protein 706 2.04125
PARL presenilin associated, rhomboid-like 2.03669
DRG1 developmentally regulated GTP binding protein 1 2.03489
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.0346
RTN4IP1 reticulon 4 interacting protein 1 2.03183
ATP10A ATPase, class V, type 10A 2.03131
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) 2.02665
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.02571
OR6S1 olfactory receptor, family 6, subfamily S, member 1 2.01925
ZDHHC11 zinc finger, DHHC-type containing 11 2.01569
TESC tescalcin 2.01405
ACACB acetyl-CoA carboxylase beta 2.01332
UBA7 ubiquitin-like modifier activating enzyme 7 2.00958
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.00891
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 2.0042
OR4F15 olfactory receptor, family 4, subfamily F, member 15 2.0037