GCT Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description A Giant Cell Tumor (GCT) cell line derived from a human fibrous histiocytoma lung metastasis (Experimental Factor Ontology, EFO_0002182)
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Genes

277 genes with high or low expression in GCT relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 3.2746
PEX16 peroxisomal biogenesis factor 16 3.22646
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 3.03912
EIF3G eukaryotic translation initiation factor 3, subunit G 3.00773
PDCD2 programmed cell death 2 2.97786
FARSA phenylalanyl-tRNA synthetase, alpha subunit 2.94271
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.61729
EIF4A1 eukaryotic translation initiation factor 4A1 2.61258
PTTG1 pituitary tumor-transforming 1 2.5572
ZBTB22 zinc finger and BTB domain containing 22 2.4901
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.47707
ARFIP2 ADP-ribosylation factor interacting protein 2 2.42133
NHP2 NHP2 ribonucleoprotein 2.4084
TNIP1 TNFAIP3 interacting protein 1 2.3435
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1 2.25095
PTTG3P pituitary tumor-transforming 3, pseudogene 2.25086
TFDP3 transcription factor Dp family, member 3 2.23022
GLB1L galactosidase, beta 1-like 2.22437
TMEM132A transmembrane protein 132A 2.22082
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2.19155
TRAPPC4 trafficking protein particle complex 4 2.14031
TBL3 transducin (beta)-like 3 2.13883
SRPR signal recognition particle receptor (docking protein) 2.12818
CCDC85B coiled-coil domain containing 85B 2.10673
SOD2 superoxide dismutase 2, mitochondrial 2.09629
PDLIM7 PDZ and LIM domain 7 (enigma) 2.08169
KIF20A kinesin family member 20A 2.07685
ERCC6 excision repair cross-complementation group 6 2.05402
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 2.02581
RASIP1 Ras interacting protein 1 2.02192
PLSCR3 phospholipid scramblase 3 2.01167
ATG7 autophagy related 7 2.01038
GNL1 guanine nucleotide binding protein-like 1 2.00643
ZPR1 ZPR1 zinc finger 1.99601
GGCX gamma-glutamyl carboxylase 1.97214
RUVBL2 RuvB-like AAA ATPase 2 1.96452
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 1.93088
MRPL33 mitochondrial ribosomal protein L33 1.92373
SAR1B secretion associated, Ras related GTPase 1B 1.91213
NELFE negative elongation factor complex member E 1.90425
FXR2 fragile X mental retardation, autosomal homolog 2 1.89903
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 1.8797
RIC8A RIC8 guanine nucleotide exchange factor A 1.86934
FBXL8 F-box and leucine-rich repeat protein 8 1.8672
GCDH glutaryl-CoA dehydrogenase 1.85633
TICAM1 toll-like receptor adaptor molecule 1 1.82423
MMP24 matrix metallopeptidase 24 (membrane-inserted) 1.81894
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 1.81836
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 1.80329
UBE3B ubiquitin protein ligase E3B 1.79994
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 1.79757
CDC20 cell division cycle 20 1.79403
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 1.78536
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.78192
SNHG3 small nucleolar RNA host gene 3 1.78191
RING1 ring finger protein 1 1.77828
INTS5 integrator complex subunit 5 1.76983
CIAO1 cytosolic iron-sulfur assembly component 1 1.76732
HARS histidyl-tRNA synthetase 1.7664
ARF3 ADP-ribosylation factor 3 1.76636
DXO decapping exoribonuclease 1.76582
MAGEC1 melanoma antigen family C1 1.76377
CLEC1B C-type lectin domain family 1, member B 1.76266
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 1.75591
TSG101 tumor susceptibility 101 1.75527
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 1.7527
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 1.75202
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 1.74593
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 1.73577
MEA1 male-enhanced antigen 1 1.72512
ANKHD1 ankyrin repeat and KH domain containing 1 1.71794
MRPS16 mitochondrial ribosomal protein S16 1.71704
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 1.7137
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.70934
IL1B interleukin 1, beta 1.70692
CTAG2 cancer/testis antigen 2 1.70626
TMEM158 transmembrane protein 158 (gene/pseudogene) 1.69624
FAM13C family with sequence similarity 13, member C 1.69482
ADGRL4 adhesion G protein-coupled receptor L4 1.68422
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 1.67526
CEP250 centrosomal protein 250kDa 1.67259
RNF17 ring finger protein 17 1.66847
MC5R melanocortin 5 receptor 1.66796
POU4F3 POU class 4 homeobox 3 1.66644
TNR tenascin R 1.65571
TRIM27 tripartite motif containing 27 1.6539
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 1.6529
TCP11L1 t-complex 11, testis-specific-like 1 1.65205
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 1.64892
BAG6 BCL2-associated athanogene 6 1.64728
LUZP1 leucine zipper protein 1 1.64532
SPANXC SPANX family, member C 1.64487
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 1.6361
INSRR insulin receptor-related receptor 1.63547
BRD8 bromodomain containing 8 1.63354
PRPF8 pre-mRNA processing factor 8 1.6327
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 1.62767
CD5L CD5 molecule-like 1.61982
LAS1L LAS1-like (S. cerevisiae) 1.61675
SRY sex determining region Y 1.61638
MMP3 matrix metallopeptidase 3 1.61566
PRIM2 primase, DNA, polypeptide 2 (58kDa) 1.61128
COLEC10 collectin sub-family member 10 (C-type lectin) 1.6108
NUP43 nucleoporin 43kDa 1.61024
AOX1 aldehyde oxidase 1 1.59491
CSF3 colony stimulating factor 3 (granulocyte) 1.59439
EML3 echinoderm microtubule associated protein like 3 1.593
TFB1M transcription factor B1, mitochondrial 1.5918
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 1.58889
PHF1 PHD finger protein 1 1.58777
IPO7 importin 7 1.58652
TRPC4 transient receptor potential cation channel, subfamily C, member 4 1.58646
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 1.582
MTCH1 mitochondrial carrier 1 1.58072
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.57666
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.57556
PFAS phosphoribosylformylglycinamidine synthase 1.5711
SART1 squamous cell carcinoma antigen recognized by T cells 1.5616
SHBG sex hormone-binding globulin 1.55728
MAGEC2 melanoma antigen family C2 1.5471
GYPA glycophorin A (MNS blood group) 1.54709
TRIO trio Rho guanine nucleotide exchange factor 1.53601
SIGLEC15 sialic acid binding Ig-like lectin 15 1.53007
GREM1 gremlin 1, DAN family BMP antagonist 1.52774
RPL26L1 ribosomal protein L26-like 1 1.52762
MMP1 matrix metallopeptidase 1 1.5256
NOP16 NOP16 nucleolar protein 1.52547
PPP4R4 protein phosphatase 4, regulatory subunit 4 1.52286
TUBA3C tubulin, alpha 3c 1.5168
IL6 interleukin 6 1.51517
NMT1 N-myristoyltransferase 1 1.51475
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 1.51245
ACE angiotensin I converting enzyme 1.5109
HEMK1 HemK methyltransferase family member 1 1.49952
EIF6 eukaryotic translation initiation factor 6 1.49705
PAX3 paired box 3 1.49455
HMBS hydroxymethylbilane synthase 1.49412
PDE10A phosphodiesterase 10A 1.49229
CLCA3P chloride channel accessory 3, pseudogene 1.4869
MAGEA10 melanoma antigen family A10 1.48557
MAGEA11 melanoma antigen family A11 1.48287
MON1B MON1 secretory trafficking family member B 1.47617
GEMIN4 gem (nuclear organelle) associated protein 4 1.47579
GANAB glucosidase, alpha; neutral AB 1.4725
NRIP3 nuclear receptor interacting protein 3 1.47202
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 1.47167
TAAR2 trace amine associated receptor 2 1.46983
TMED1 transmembrane emp24 protein transport domain containing 1 1.46976
RNASEH2A ribonuclease H2, subunit A 1.46845
CUL7 cullin 7 1.46626
TFCP2 transcription factor CP2 1.46303
OR3A1 olfactory receptor, family 3, subfamily A, member 1 1.46286
MSN moesin 1.46009
AASS aminoadipate-semialdehyde synthase 1.45978
TRPV5 transient receptor potential cation channel, subfamily V, member 5 1.4565
STARD8 StAR-related lipid transfer (START) domain containing 8 1.45561
GSPT1 G1 to S phase transition 1 1.45176
INTS1 integrator complex subunit 1 1.44662
TPCN1 two pore segment channel 1 1.44314
AKAP10 A kinase (PRKA) anchor protein 10 1.43841
RFX1 regulatory factor X, 1 (influences HLA class II expression) 1.43824
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 1.43729
PNPLA2 patatin-like phospholipase domain containing 2 1.43678
PTCH2 patched 2 1.43348
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 1.43319
CXCL8 chemokine (C-X-C motif) ligand 8 1.4324
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 1.42861
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 1.42652
TMCO6 transmembrane and coiled-coil domains 6 1.42407
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 1.42252
COL5A2 collagen, type V, alpha 2 1.42212
PSRC1 proline/serine-rich coiled-coil 1 1.42028
CD68 CD68 molecule 1.41916
PA2G4 proliferation-associated 2G4, 38kDa 1.41888
UCN urocortin 1.41796

low expression

Symbol Name Standardized Value
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -3.53725
CNOT4 CCR4-NOT transcription complex, subunit 4 -3.51027
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -3.0301
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.92329
SH3YL1 SH3 and SYLF domain containing 1 -2.91479
TWISTNB TWIST neighbor -2.82299
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) -2.61802
ZNF180 zinc finger protein 180 -2.58414
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene -2.55094
KRIT1 KRIT1, ankyrin repeat containing -2.53276
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -2.48521
SIGLEC6 sialic acid binding Ig-like lectin 6 -2.47368
RNF38 ring finger protein 38 -2.34957
THOC1 THO complex 1 -2.31248
ZNF273 zinc finger protein 273 -2.26798
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -2.23521
THAP1 THAP domain containing, apoptosis associated protein 1 -2.20982
MAP3K15 mitogen-activated protein kinase kinase kinase 15 -2.19372
TUBGCP5 tubulin, gamma complex associated protein 5 -2.17279
ZBED4 zinc finger, BED-type containing 4 -2.15587
ZNF107 zinc finger protein 107 -2.15532
DLD dihydrolipoamide dehydrogenase -2.13071
DNM3 dynamin 3 -2.08294
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.05567
ZNF654 zinc finger protein 654 -2.02636
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -2.01914
ELP3 elongator acetyltransferase complex subunit 3 -2.0125
ZNF675 zinc finger protein 675 -1.98302
NEURL1 neuralized E3 ubiquitin protein ligase 1 -1.96233
PAIP1 poly(A) binding protein interacting protein 1 -1.93564
ATP9B ATPase, class II, type 9B -1.92053
ZNF236 zinc finger protein 236 -1.91822
NEK11 NIMA-related kinase 11 -1.87342
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) -1.86558
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -1.8635
OFD1 oral-facial-digital syndrome 1 -1.83205
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -1.83002
RP2 retinitis pigmentosa 2 (X-linked recessive) -1.82409
SGPP1 sphingosine-1-phosphate phosphatase 1 -1.8027
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 -1.80201
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -1.80132
PHKA2 phosphorylase kinase, alpha 2 (liver) -1.76983
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -1.76891
CLOCK clock circadian regulator -1.75688
JAG2 jagged 2 -1.74503
DIP interstitial pneumonitis, desquamative, familial -1.70799
LDB3 LIM domain binding 3 -1.68366
ZFR zinc finger RNA binding protein -1.68361
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -1.66736
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -1.66538
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -1.6653
MAOA monoamine oxidase A -1.66333
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -1.66316
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -1.66186
SON SON DNA binding protein -1.65404
NME3 NME/NM23 nucleoside diphosphate kinase 3 -1.63858
NUP54 nucleoporin 54kDa -1.62838
WRB tryptophan rich basic protein -1.61557
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -1.61261
FAM3C family with sequence similarity 3, member C -1.59418
KDM5C lysine (K)-specific demethylase 5C -1.57932
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -1.56303
ZNF84 zinc finger protein 84 -1.56074
MRPS6 mitochondrial ribosomal protein S6 -1.55913
PILRB paired immunoglobin-like type 2 receptor beta -1.55446
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -1.55371
MCF2L MCF.2 cell line derived transforming sequence-like -1.54751
TBC1D19 TBC1 domain family, member 19 -1.53968
RHOD ras homolog family member D -1.53919
CCDC40 coiled-coil domain containing 40 -1.53372
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -1.53022
RABGAP1L RAB GTPase activating protein 1-like -1.52456
PRR5 proline rich 5 (renal) -1.52106
TSNAXIP1 translin-associated factor X interacting protein 1 -1.51957
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -1.51205
FMO4 flavin containing monooxygenase 4 -1.50788
SYCP2 synaptonemal complex protein 2 -1.5014
VWA1 von Willebrand factor A domain containing 1 -1.50003
CECR7 cat eye syndrome chromosome region, candidate 7 (non-protein coding) -1.49909
STAU2 staufen double-stranded RNA binding protein 2 -1.499
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -1.49729
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -1.4963
CASP3 caspase 3, apoptosis-related cysteine peptidase -1.4903
PHKA1 phosphorylase kinase, alpha 1 (muscle) -1.48939
TRAPPC2 trafficking protein particle complex 2 -1.48881
ARID4B AT rich interactive domain 4B (RBP1-like) -1.48422
GTF2A1 general transcription factor IIA, 1, 19/37kDa -1.4771
TOR3A torsin family 3, member A -1.47496
KDM6A lysine (K)-specific demethylase 6A -1.47461
DENND4C DENN/MADD domain containing 4C -1.47289
NFYB nuclear transcription factor Y, beta -1.47282
RBM8A RNA binding motif protein 8A -1.47218
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -1.46581
RFPL3 ret finger protein-like 3 -1.46363
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -1.46259
MTERF3 mitochondrial transcription termination factor 3 -1.45513
DMTF1 cyclin D binding myb-like transcription factor 1 -1.45058
NHEJ1 nonhomologous end-joining factor 1 -1.44516
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -1.43768
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -1.43232
RINT1 RAD50 interactor 1 -1.42485
PSPH phosphoserine phosphatase -1.42339