GDNF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description glial cell derived neurotrophic factor|This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 2668)
External Link http://www.ncbi.nlm.nih.gov/gene/2668
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Genes

32 interacting proteins for GDNF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BAMBI BMP and activin membrane-bound inhibitor
BCAR1 breast cancer anti-estrogen resistance 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COPS5 COP9 signalosome subunit 5
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
FKBP1A FK506 binding protein 1A, 12kDa
GFRA1 GDNF family receptor alpha 1
GFRA2 GDNF family receptor alpha 2
HRAS Harvey rat sarcoma viral oncogene homolog
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K7CL MAP3K7 C-terminal like
MAPK8 mitogen-activated protein kinase 8
NCAM1 neural cell adhesion molecule 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PTK2 protein tyrosine kinase 2
PXN paxillin
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RET ret proto-oncogene
RRAS related RAS viral (r-ras) oncogene homolog
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD9 SMAD family member 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase