GFI1B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description growth factor independent 1B transcription repressor|This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 8328)
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Genes

328 genes differentially expressed following the GFI1B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFAP141 cilia and flagella associated protein 141 3.04343
PNMA8B PNMA family member 8B 3.04343
THRSP thyroid hormone responsive 3.04343
CLDN14 claudin 14 3.04343
ZNF365 zinc finger protein 365 3.04343
SPRR2F small proline-rich protein 2F 3.04343
PRRT4 proline-rich transmembrane protein 4 3.04343
NAPSA napsin A aspartic peptidase 3.04343
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.04343
SPON2 spondin 2, extracellular matrix protein 3.04343
MAP3K7CL MAP3K7 C-terminal like 3.04343
C4ORF50 chromosome 4 open reading frame 50 3.04343
ZNF396 zinc finger protein 396 3.04343
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.04343
EQTN equatorin, sperm acrosome associated 3.04343
CXCR6 chemokine (C-X-C motif) receptor 6 3.04343
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.04343
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.04343
CD79A CD79a molecule, immunoglobulin-associated alpha 3.04343
TENT5D terminal nucleotidyltransferase 5D 3.04343
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.04343
CCNP cyclin P 3.04343
H4C12 H4 clustered histone 12 3.04343
ATP13A4 ATPase type 13A4 3.04343
ERFE erythroferrone 3.04343
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.04343
CEMP1 cementum protein 1 2.92993
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.92993
KLHL33 kelch-like family member 33 2.92993
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.92993
FGD2 FYVE, RhoGEF and PH domain containing 2 2.92993
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 2.92993
SYCP2 synaptonemal complex protein 2 2.92993
GAGE2A G antigen 2A 2.92993
CD96 CD96 molecule 2.92993
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.92993
INHBC inhibin, beta C 2.92993
SLC22A14 solute carrier family 22, member 14 2.92993
HRH1 histamine receptor H1 2.92993
STKLD1 serine/threonine kinase-like domain containing 1 2.92993
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.92993
SCGN secretagogin, EF-hand calcium binding protein 2.92993
GJA10 gap junction protein, alpha 10, 62kDa 2.92993
SKOR2 SKI family transcriptional corepressor 2 2.92993
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.92993
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.92993
PAX3 paired box 3 2.92993
TUBB8 tubulin, beta 8 class VIII 2.92993
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.92993
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.92993
SSTR3 somatostatin receptor 3 2.92993
TMEM191B transmembrane protein 191B 2.92993
SH2D6 SH2 domain containing 6 2.92993
RIMBP2 RIMS binding protein 2 2.92993
ADGRE3 adhesion G protein-coupled receptor E3 2.92993
GNLY granulysin 2.92993
HEATR9 HEAT repeat containing 9 2.92993
CELF3 CUGBP, Elav-like family member 3 2.92993
TMEM176B transmembrane protein 176B 2.92993
DNASE1L3 deoxyribonuclease I-like 3 2.92993
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.92993
HGD homogentisate 1,2-dioxygenase 2.92993
TM4SF1 transmembrane 4 L six family member 1 2.92993
SSTR1 somatostatin receptor 1 2.92993
TRIM73 tripartite motif containing 73 2.92993
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.92993
MCHR2 melanin-concentrating hormone receptor 2 2.92993
LTB4R2 leukotriene B4 receptor 2 2.92993
CCER2 coiled-coil glutamate-rich protein 2 2.92993
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.92993
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.92993
ASB4 ankyrin repeat and SOCS box containing 4 2.92993
SRPK3 SRSF protein kinase 3 2.92993
FAM228A family with sequence similarity 228, member A 2.92993
GATA2 GATA binding protein 2 2.92993
ALPG alkaline phosphatase, germ cell 2.92993
SMIM38 small integral membrane protein 38 2.92993
H2BC3 H2B clustered histone 3 2.92993
LY6S lymphocyte antigen 6 family member S 2.92993
C17ORF113 chromosome 17 open reading frame 113 2.92993
H4C14 H4 clustered histone 14 2.92993
AKAIN1 A-kinase anchor inhibitor 1 2.92993
CLEC20A C-type lectin domain containing 20A 2.92993
SEPTIN12 septin 12 2.92993
GSTT4 glutathione S-transferase theta 4 2.92993
CBY2 chibby family member 2 2.92993
CATSPERZ catsper channel auxiliary subunit zeta 2.92993
CCDC42 coiled-coil domain containing 42 2.92993
LTA lymphotoxin alpha 2.92993
PRG4 proteoglycan 4 2.92993
TFEC transcription factor EC 2.92993
TLR8 toll-like receptor 8 2.92993
TLR7 toll-like receptor 7 2.92993
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.92993
SCRT2 scratch family zinc finger 2 2.92993
NPIPB9 nuclear pore complex interacting protein family, member B9 2.92993
CBLN3 cerebellin 3 precursor 2.92993
LGALS7B lectin, galactoside-binding, soluble, 7B 2.92993
CLDN2 claudin 2 2.92993
MIP major intrinsic protein of lens fiber 2.92993
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.92993
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.92993
TMEM119 transmembrane protein 119 2.92993
GPR83 G protein-coupled receptor 83 2.92993
PNPLA1 patatin-like phospholipase domain containing 1 2.92993
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.92993
HID1 HID1 domain containing 2.92993
IL1RN interleukin 1 receptor antagonist 2.92993
PGA5 pepsinogen 5, group I (pepsinogen A) 2.92993
LSP1 lymphocyte-specific protein 1 2.92993
CREB3L3 cAMP responsive element binding protein 3-like 3 2.92993
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.92993
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) 2.92993
ST18 suppression of tumorigenicity 18, zinc finger 2.92993
LRCOL1 leucine rich colipase-like 1 2.92993
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.92993
KRTAP5-11 keratin associated protein 5-11 2.92993
RBMXL2 RNA binding motif protein, X-linked-like 2 2.92993
ERICH6 glutamate-rich 6 2.92993
S100A14 S100 calcium binding protein A14 2.92993
FAM222B family with sequence similarity 222, member B 2.92993
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.92993
SCML4 sex comb on midleg-like 4 (Drosophila) 2.92993
PMP2 peripheral myelin protein 2 2.92993
DYTN dystrotelin 2.92993
PHOSPHO1 phosphatase, orphan 1 2.92993
LYZL4 lysozyme-like 4 2.92993
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.92993
CLCNKA chloride channel, voltage-sensitive Ka 2.92993
LRRC31 leucine rich repeat containing 31 2.92993
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.92993
POTEI POTE ankyrin domain family, member I 2.92993
PAQR6 progestin and adipoQ receptor family member VI 2.92993
MAGEB17 melanoma antigen family B17 2.92993
CST1 cystatin SN 2.92993
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.92993
LMNTD1 lamin tail domain containing 1 2.92993
IL36R interleukin 36 receptor 2.92993
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.92993
CRHBP corticotropin releasing hormone binding protein 2.92993
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.92993
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.92993
CAPSL calcyphosine-like 2.92993
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.92993
MEPE matrix extracellular phosphoglycoprotein 2.92993
LRRN4 leucine rich repeat neuronal 4 2.92993
GOLGA8K golgin A8 family, member K 2.92993
PDCD1LG2 programmed cell death 1 ligand 2 2.92993
TAPBPL TAP binding protein-like 2.92993
IGSF3 immunoglobulin superfamily, member 3 2.92993
CCDC27 coiled-coil domain containing 27 2.92993
ZNF471 zinc finger protein 471 2.92993
TAT tyrosine aminotransferase 2.92993
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.92993
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.92993
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.92993
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.92993
KLK11 kallikrein-related peptidase 11 2.92993
SAMD5 sterile alpha motif domain containing 5 2.92993
NLRP14 NLR family, pyrin domain containing 14 2.92993
CXCL2 chemokine (C-X-C motif) ligand 2 2.92993
MYO1A myosin IA 2.92993
ASGR2 asialoglycoprotein receptor 2 2.92993
GLRA3 glycine receptor, alpha 3 2.92993
TDO2 tryptophan 2,3-dioxygenase 2.92993
FAM9B family with sequence similarity 9, member B 2.92993
NMUR2 neuromedin U receptor 2 2.92993
PCDHGA12 protocadherin gamma subfamily A, 12 2.92993
PODN podocan 2.92993
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.92993
TAS2R13 taste receptor, type 2, member 13 2.92993
HAS3 hyaluronan synthase 3 2.92993
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.92993
UBA7 ubiquitin-like modifier activating enzyme 7 2.92993
PRSS36 protease, serine, 36 2.92993
LACTBL1 lactamase, beta-like 1 2.92993
SPDYE11 speedy/RINGO cell cycle regulator family member E11 2.92993
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.92993
FAM216B family with sequence similarity 216, member B 2.92993
TWIST1 twist family bHLH transcription factor 1 2.92993
PSG11 pregnancy specific beta-1-glycoprotein 11 2.92993
ANXA8 annexin A8 2.92993
GHRH growth hormone releasing hormone 2.92993
RAB7B RAB7B, member RAS oncogene family 2.92993
RND3 Rho family GTPase 3 2.91247
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.83412
DOC2B double C2-like domains, beta 2.76729
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.76729
ODAD1 outer dynein arm docking complex subunit 1 2.76729
SMTNL2 smoothelin-like 2 2.72532
RNF38 ring finger protein 38 2.70466
NDN necdin, melanoma antigen (MAGE) family member 2.66577
HDAC10 histone deacetylase 10 2.65316
C1ORF167 chromosome 1 open reading frame 167 2.61758
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) 2.60769
PRPS2 phosphoribosyl pyrophosphate synthetase 2 2.59832
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.54851
IL17RE interleukin 17 receptor E 2.50899
SELENOV selenoprotein V 2.49263
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.4813
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.40459
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.40459
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.39569
COMMD2 COMM domain containing 2 2.39352
SALL1 spalt-like transcription factor 1 2.38103
STX6 syntaxin 6 2.37546
GRIA3 glutamate receptor, ionotropic, AMPA 3 2.32928
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 2.29402
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 2.29344
RORC RAR-related orphan receptor C 2.29344
PEX14 peroxisomal biogenesis factor 14 2.26125
SH3KBP1 SH3-domain kinase binding protein 1 2.25432
TTC23 tetratricopeptide repeat domain 23 2.25408
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.24183
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.2417
ANAPC10 anaphase promoting complex subunit 10 2.2417
FAM161A family with sequence similarity 161, member A 2.23054
ZNF771 zinc finger protein 771 2.2121
HEATR3 HEAT repeat containing 3 2.21096
DOCK3 dedicator of cytokinesis 3 2.20116
RIOK1 RIO kinase 1 2.17566
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 2.16012
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 2.14645
RARS2 arginyl-tRNA synthetase 2, mitochondrial 2.13596
PGS1 phosphatidylglycerophosphate synthase 1 2.13386
PMEPA1 prostate transmembrane protein, androgen induced 1 2.13112
CREG1 cellular repressor of E1A-stimulated genes 1 2.11393
EPHB6 EPH receptor B6 2.09234
NBPF9 neuroblastoma breakpoint family, member 9 2.07651
EFCAB7 EF-hand calcium binding domain 7 2.06922
PEX19 peroxisomal biogenesis factor 19 2.06922
TRIM11 tripartite motif containing 11 2.06922
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 2.0403
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 2.03987
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.03585
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.02381
NOP56 NOP56 ribonucleoprotein 2.02353
PHB1 prohibitin 1 2.019

decreased expression

Symbol Name Standardized Value
HBEGF heparin-binding EGF-like growth factor -3.04343
AOAH acyloxyacyl hydrolase (neutrophil) -3.04343
KRTDAP keratinocyte differentiation-associated protein -3.04343
NTNG2 netrin G2 -3.04343
PANK4 pantothenate kinase 4 -3.04343
ESR1 estrogen receptor 1 -2.92993
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.92993
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.92993
NEFM neurofilament, medium polypeptide -2.92993
AOC1 amine oxidase, copper containing 1 -2.92993
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.92993
TMEM86B transmembrane protein 86B -2.92993
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -2.92993
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.92993
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.92993
LGALS9 lectin, galactoside-binding, soluble, 9 -2.92993
KLHL34 kelch-like family member 34 -2.92993
NECAB3 N-terminal EF-hand calcium binding protein 3 -2.92993
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.92993
ZNF461 zinc finger protein 461 -2.92993
KIAA2012 KIAA2012 -2.92993
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -2.92993
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.92993
INTS10 integrator complex subunit 10 -2.92993
CCDC74B coiled-coil domain containing 74B -2.92993
APOB apolipoprotein B -2.92993
CAPN2 calpain 2, (m/II) large subunit -2.92993
GTF2A1L general transcription factor IIA, 1-like -2.92993
ZC3H7B zinc finger CCCH-type containing 7B -2.92993
SMIM17 small integral membrane protein 17 -2.92993
TTYH2 tweety family member 2 -2.92993
NFE2 nuclear factor, erythroid 2 -2.92993
CFAP210 cilia and flagella associated protein 210 -2.92993
LRRC26 leucine rich repeat containing 26 -2.92993
DUSP22 dual specificity phosphatase 22 -2.8557
ERLEC1 endoplasmic reticulum lectin 1 -2.84286
VWC2 von Willebrand factor C domain containing 2 -2.80445
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -2.76729
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.65413
TARS3 threonyl-tRNA synthetase 3 -2.65413
C5ORF47 chromosome 5 open reading frame 47 -2.65087
DYNC2I2 dynein 2 intermediate chain 2 -2.58827
MTPAP mitochondrial poly(A) polymerase -2.581
FASTKD1 FAST kinase domains 1 -2.56829
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.51693
ATAD5 ATPase family, AAA domain containing 5 -2.49455
NRCAM neuronal cell adhesion molecule -2.45483
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.37546
DPY19L1 dpy-19-like 1 (C. elegans) -2.348
CCDC137 coiled-coil domain containing 137 -2.33349
SIRT4 sirtuin 4 -2.31329
FCGBP Fc fragment of IgG binding protein -2.28715
CNTN5 contactin 5 -2.28715
PAM peptidylglycine alpha-amidating monooxygenase -2.28192
FOXB1 forkhead box B1 -2.25004
DENND1B DENN/MADD domain containing 1B -2.25004
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -2.23054
ZNF804B zinc finger protein 804B -2.2294
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -2.21371
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.20824
NTF4 neurotrophin 4 -2.20824
STAT4 signal transducer and activator of transcription 4 -2.20824
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.20824
C22ORF23 chromosome 22 open reading frame 23 -2.20824
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.20116
UBA6 ubiquitin-like modifier activating enzyme 6 -2.20116
SARDH sarcosine dehydrogenase -2.16822
LIMD1 LIM domains containing 1 -2.16822
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.15373
TXNL1 thioredoxin-like 1 -2.14517
SDC2 syndecan 2 -2.13596
SAMD13 sterile alpha motif domain containing 13 -2.13596
TOP1MT topoisomerase (DNA) I, mitochondrial -2.12285
MYO5A myosin VA (heavy chain 12, myoxin) -2.11735
CCDC50 coiled-coil domain containing 50 -2.11067
RASAL2 RAS protein activator like 2 -2.10391
CD72 CD72 molecule -2.10391
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 -2.10378
CENPQ centromere protein Q -2.09013
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -2.08894
COG3 component of oligomeric golgi complex 3 -2.08486
TASOR transcription activation suppressor -2.08267
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.07467
ZRANB3 zinc finger, RAN-binding domain containing 3 -2.07084
MYO5B myosin VB -2.07022
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -2.06922
API5 apoptosis inhibitor 5 -2.05499
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.04472
ONECUT2 one cut homeobox 2 -2.04313
RP1L1 retinitis pigmentosa 1-like 1 -2.0403