GLA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description galactosidase, alpha|This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2717)
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Genes

349 genes differentially expressed following the GLA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FPR2 formyl peptide receptor 2 3.04828
CD1D CD1d molecule 3.04828
CD209 CD209 molecule 3.04828
PGAM4 phosphoglycerate mutase family member 4 3.04828
DNASE1L3 deoxyribonuclease I-like 3 3.04828
TNNI1 troponin I type 1 (skeletal, slow) 3.04828
SSTR1 somatostatin receptor 1 3.04828
HORMAD1 HORMA domain containing 1 3.04828
SIRPB2 signal-regulatory protein beta 2 3.04828
CXORF65 chromosome X open reading frame 65 3.04828
GSTM5 glutathione S-transferase mu 5 3.04828
IGFL3 IGF-like family member 3 3.04828
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.04828
USH1G Usher syndrome 1G (autosomal recessive) 3.04828
FER1L6 fer-1-like family member 6 3.04828
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.04828
TMPRSS11D transmembrane protease, serine 11D 3.04828
HLX H2.0-like homeobox 3.04828
UPK3B uroplakin 3B 3.04828
ELF5 E74-like factor 5 (ets domain transcription factor) 3.04828
MYO7B myosin VIIB 3.04828
PARP3 poly (ADP-ribose) polymerase family, member 3 3.04828
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 3.04828
SLC15A5 solute carrier family 15, member 5 3.04828
ASB17 ankyrin repeat and SOCS box containing 17 3.04828
TAS2R1 taste receptor, type 2, member 1 3.04828
PRDM1 PR domain containing 1, with ZNF domain 3.04828
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.04828
NWD1 NACHT and WD repeat domain containing 1 3.04828
FAM161B family with sequence similarity 161, member B 3.04828
VENTX VENT homeobox 3.04828
HRG histidine-rich glycoprotein 3.04828
TWIST1 twist family bHLH transcription factor 1 3.04828
GRM2 glutamate receptor, metabotropic 2 3.04828
PSD4 pleckstrin and Sec7 domain containing 4 3.04828
RDH16 retinol dehydrogenase 16 (all-trans) 3.04828
CPLX4 complexin 4 3.04828
GALR3 galanin receptor 3 3.04828
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.04828
POSTN periostin, osteoblast specific factor 3.04828
GADL1 glutamate decarboxylase-like 1 3.04828
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.04828
GUCY2F guanylate cyclase 2F, retinal 3.04828
C1ORF146 chromosome 1 open reading frame 146 3.04828
LONRF3 LON peptidase N-terminal domain and ring finger 3 3.04828
PNOC prepronociceptin 3.04828
MYO1G myosin IG 3.04828
MRC1 mannose receptor, C type 1 3.04828
NLRP4 NLR family, pyrin domain containing 4 3.04828
CATSPERT catsper channel auxiliary subunit tau 3.04828
GK3 glycerol kinase 3 3.04828
VEGFD vascular endothelial growth factor D 3.04828
PLAAT4 phospholipase A and acyltransferase 4 3.04828
TCIM transcriptional and immune response regulator 3.04828
ODAD1 outer dynein arm docking complex subunit 1 3.04828
VSIR V-set immunoregulatory receptor 3.04828
TENT2 terminal nucleotidyltransferase 2 3.04828
SELE selectin E 3.04828
ARX aristaless related homeobox 3.04828
MT3 metallothionein 3 3.04828
CFAP157 cilia and flagella associated protein 157 3.04828
DIPK1C divergent protein kinase domain 1C 3.04828
SPMAP1 sperm microtubule associated protein 1 3.04828
SPATA31H1 SPATA31 subfamily H member 1 3.04828
PNMA6F PNMA family member 6F 3.04828
CPNE8-AS1 CPNE8 antisense RNA 1 3.04828
CIMAP1D CIMAP1 family member D 3.04828
INSYN1 inhibitory synaptic factor 1 3.04828
CBLL2 Cbl proto-oncogene like 2 3.04828
CCNP cyclin P 3.04828
CHCT1 CHD1 helical C-terminal domain containing 1 3.04828
ELOA2 elongin A2 3.04828
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 3.04828
KRT86 keratin 86, type II 3.04828
SPRR2F small proline-rich protein 2F 3.04828
GSC goosecoid homeobox 3.04828
CCR8 chemokine (C-C motif) receptor 8 3.04828
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.04828
MIA melanoma inhibitory activity 3.04828
LRIT2 leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 3.04828
TMEM236 transmembrane protein 236 3.04828
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.04828
OR8D4 olfactory receptor, family 8, subfamily D, member 4 3.04828
ITK IL2-inducible T-cell kinase 3.04828
TRIM67 tripartite motif containing 67 3.04828
C6 complement component 6 3.04828
VCX3B variable charge, X-linked 3B 3.04828
MLN motilin 3.04828
ASB4 ankyrin repeat and SOCS box containing 4 3.04828
WNT16 wingless-type MMTV integration site family, member 16 3.04828
GATA4 GATA binding protein 4 3.04828
MLANA melan-A 3.04828
PCDHGC4 protocadherin gamma subfamily C, 4 3.04828
GDF9 growth differentiation factor 9 3.04828
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.04828
STARD6 StAR-related lipid transfer (START) domain containing 6 3.04828
ARHGAP15 Rho GTPase activating protein 15 3.04828
PVRIG poliovirus receptor related immunoglobulin domain containing 3.04828
EDN3 endothelin 3 3.04828
CCDC27 coiled-coil domain containing 27 3.04828
MUCL1 mucin-like 1 3.04828
BCO1 beta-carotene oxygenase 1 3.04828
RRH retinal pigment epithelium-derived rhodopsin homolog 3.04828
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 3.04828
IL1A interleukin 1, alpha 3.04828
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.04828
PCDH12 protocadherin 12 3.04828
PLA1A phospholipase A1 member A 3.04828
CLEC4G C-type lectin domain family 4, member G 3.04828
CLEC4C C-type lectin domain family 4, member C 3.04828
LDLRAD2 low density lipoprotein receptor class A domain containing 2 3.04828
CPA2 carboxypeptidase A2 (pancreatic) 3.04828
AQP6 aquaporin 6, kidney specific 3.04828
ARR3 arrestin 3, retinal (X-arrestin) 3.04828
CLRN2 clarin 2 3.04828
CXCR4 chemokine (C-X-C motif) receptor 4 3.04828
CTAGE9 CTAGE family, member 9 3.04828
KLF1 Kruppel-like factor 1 (erythroid) 3.04828
EMX2 empty spiracles homeobox 2 3.04828
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.04828
EGR2 early growth response 2 3.04828
TEX12 testis expressed 12 3.04828
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.04828
IGIP IgA-inducing protein 3.04828
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.04828
IL26 interleukin 26 3.04828
CASQ2 calsequestrin 2 (cardiac muscle) 3.04828
LMX1B LIM homeobox transcription factor 1, beta 3.04828
FKBP1C FK506 binding protein 1C 3.04828
TTC24 tetratricopeptide repeat domain 24 3.04828
BTG4 B-cell translocation gene 4 3.04828
CLEC1B C-type lectin domain family 1, member B 3.04828
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.04828
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 3.04828
MUC7 mucin 7, secreted 3.04828
IL9R interleukin 9 receptor 3.04828
STX11 syntaxin 11 3.04828
RUSC1 RUN and SH3 domain containing 1 3.04828
DPRX divergent-paired related homeobox 3.04828
DLX2 distal-less homeobox 2 3.04828
GPR61 G protein-coupled receptor 61 3.04828
DEXI Dexi homolog (mouse) 3.04828
LHX3 LIM homeobox 3 3.04828
GOLGA8H golgin A8 family, member H 3.04828
RAD21L1 RAD21-like 1 (S. pombe) 3.04828
STAB1 stabilin 1 3.04828
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.04828
A3GALT2 alpha 1,3-galactosyltransferase 2 3.04828
SDSL serine dehydratase-like 3.04828
CIDEA cell death-inducing DFFA-like effector a 3.04828
IFNK interferon, kappa 3.04828
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.04828
CLCNKB chloride channel, voltage-sensitive Kb 3.04828
CD86 CD86 molecule 3.04828
CD80 CD80 molecule 3.04828
NUTM2D NUT family member 2D 3.04828
FNDC9 fibronectin type III domain containing 9 3.04828
EPX eosinophil peroxidase 3.04828
BRDT bromodomain, testis-specific 3.04828
IL17C interleukin 17C 3.04828
MR1 major histocompatibility complex, class I-related 3.04828
RORC RAR-related orphan receptor C 3.04828
POPDC2 popeye domain containing 2 3.04828
CLIC5 chloride intracellular channel 5 3.04828
ADAM29 ADAM metallopeptidase domain 29 3.04828
TMEM213 transmembrane protein 213 3.04828
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.01749
PLCL1 phospholipase C-like 1 2.94327
PCDHA13 protocadherin alpha 13 2.94327
CCDC68 coiled-coil domain containing 68 2.94327
TMSB4X thymosin beta 4, X-linked 2.92988
REV1 REV1, polymerase (DNA directed) 2.89615
GSTZ1 glutathione S-transferase zeta 1 2.87336
DDA1 DET1 and DDB1 associated 1 2.81301
FPGT fucose-1-phosphate guanylyltransferase 2.76698
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.72672
RIPK2 receptor-interacting serine-threonine kinase 2 2.72309
MYOF myoferlin 2.69107
CRCP CGRP receptor component 2.68633
TUBD1 tubulin, delta 1 2.66819
TMEM19 transmembrane protein 19 2.66709
CYB561A3 cytochrome b561 family, member A3 2.61221
DACH1 dachshund family transcription factor 1 2.59116
CHRM2 cholinergic receptor, muscarinic 2 2.56749
GANAB glucosidase, alpha; neutral AB 2.51177
TP63 tumor protein p63 2.45297
RNF17 ring finger protein 17 2.44221
MTRES1 mitochondrial transcription rescue factor 1 2.43511
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.36684
ADAM22 ADAM metallopeptidase domain 22 2.35995
PATJ PATJ crumbs cell polarity complex component 2.34419
IRX3 iroquois homeobox 3 2.33992
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 2.33091
ISYNA1 inositol-3-phosphate synthase 1 2.32599
JUND jun D proto-oncogene 2.31266
ULK1 unc-51 like autophagy activating kinase 1 2.27325
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.25628
RPS19 ribosomal protein S19 2.22869
REDIC1 regulator of DNA class I crossover intermediates 1 2.21396
EMC6 ER membrane protein complex subunit 6 2.21377
NFE2L1 nuclear factor, erythroid 2-like 1 2.18651
CARD14 caspase recruitment domain family, member 14 2.18438
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 2.17496
RBM8A RNA binding motif protein 8A 2.17148
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2.15282
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 2.15282
POU3F4 POU class 3 homeobox 4 2.15072
NUCB1 nucleobindin 1 2.15072
MYO9B myosin IXB 2.12833
H2AZ1 H2A.Z variant histone 1 2.12833
SEZ6L seizure related 6 homolog (mouse)-like 2.10982
PYCARD PYD and CARD domain containing 2.10982
RBM44 RNA binding motif protein 44 2.10982
NTSR1 neurotensin receptor 1 (high affinity) 2.10982
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.10982
FZD2 frizzled class receptor 2 2.10073
RPL7A ribosomal protein L7a 2.09961
DMAC1 distal membrane arm assembly component 1 2.07325
TWIST2 twist family bHLH transcription factor 2 2.07325
SEC14L2 SEC14-like 2 (S. cerevisiae) 2.06581
MRRF mitochondrial ribosome recycling factor 2.06305
TATDN3 TatD DNase domain containing 3 2.06066
CCDC127 coiled-coil domain containing 127 2.06066
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.05974
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.03048
RHOQ ras homolog family member Q 2.02638
RGS7BP regulator of G-protein signaling 7 binding protein 2.01966
ANXA9 annexin A9 2.01693
RPLP2 ribosomal protein, large, P2 2.01693
TPGS2 tubulin polyglutamylase complex subunit 2 2.01409
NCAPG non-SMC condensin I complex, subunit G 2.00386
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.00028

decreased expression

Symbol Name Standardized Value
C2CD2L C2CD2-like -3.04828
PEX5 peroxisomal biogenesis factor 5 -3.04828
GPR18 G protein-coupled receptor 18 -3.04828
SAXO1 stabilizer of axonemal microtubules 1 -3.04828
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -3.04828
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -3.04828
AKAP6 A kinase (PRKA) anchor protein 6 -3.04828
LDHD lactate dehydrogenase D -3.04828
ADPRHL1 ADP-ribosylhydrolase like 1 -3.04828
JAG2 jagged 2 -3.04828
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -3.04828
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -3.04828
ACSS1 acyl-CoA synthetase short-chain family member 1 -3.04828
PANX2 pannexin 2 -3.04828
GAL3ST3 galactose-3-O-sulfotransferase 3 -2.94241
SLC22A25 solute carrier family 22, member 25 -2.92988
RTL5 retrotransposon Gag like 5 -2.92988
CCDC63 coiled-coil domain containing 63 -2.92988
GSTM2 glutathione S-transferase mu 2 (muscle) -2.92988
C6ORF58 chromosome 6 open reading frame 58 -2.92988
NPIPB7 nuclear pore complex interacting protein family, member B7 -2.92988
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.92988
H4C12 H4 clustered histone 12 -2.92988
TLDC2 TBC/LysM-associated domain containing 2 -2.92988
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -2.92988
GRM6 glutamate receptor, metabotropic 6 -2.92988
SYNPO2L synaptopodin 2-like -2.92988
OSGIN1 oxidative stress induced growth inhibitor 1 -2.92988
GGACT gamma-glutamylamine cyclotransferase -2.92988
OR2A14 olfactory receptor, family 2, subfamily A, member 14 -2.92988
S1PR5 sphingosine-1-phosphate receptor 5 -2.92988
IL6 interleukin 6 -2.92988
TMEM179 transmembrane protein 179 -2.92988
PRDM6 PR domain containing 6 -2.92988
SIX1 SIX homeobox 1 -2.92988
MGAM maltase-glucoamylase -2.92988
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 -2.92988
TINAGL1 tubulointerstitial nephritis antigen-like 1 -2.92988
CCDC92B coiled-coil domain containing 92B -2.92988
IP6K3 inositol hexakisphosphate kinase 3 -2.92988
HSF5 heat shock transcription factor family member 5 -2.92988
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.92988
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.92988
LRRC38 leucine rich repeat containing 38 -2.92988
GPR150 G protein-coupled receptor 150 -2.92988
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.92988
TTC29 tetratricopeptide repeat domain 29 -2.92988
NTF4 neurotrophin 4 -2.92988
AMN amnion associated transmembrane protein -2.92988
GRK7 G protein-coupled receptor kinase 7 -2.92988
AOC3 amine oxidase, copper containing 3 -2.92988
ETNPPL ethanolamine-phosphate phospho-lyase -2.92988
MST1 macrophage stimulating 1 -2.92988
TYRO3 TYRO3 protein tyrosine kinase -2.85045
GRIP1 glutamate receptor interacting protein 1 -2.81281
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.81043
TBC1D13 TBC1 domain family, member 13 -2.80692
AGER advanced glycosylation end product-specific receptor -2.76844
NTPCR nucleoside-triphosphatase, cancer-related -2.64497
LRRC75A leucine rich repeat containing 75A -2.62189
SPAG1 sperm associated antigen 1 -2.57718
ZNF527 zinc finger protein 527 -2.56749
ZNF696 zinc finger protein 696 -2.56749
CFAP43 cilia and flagella associated protein 43 -2.56749
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.56749
DAD1 defender against cell death 1 -2.53028
TNS2 tensin 2 -2.51168
DCAF15 DDB1 and CUL4 associated factor 15 -2.51168
CXCL17 chemokine (C-X-C motif) ligand 17 -2.51168
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') -2.49533
ARRDC1 arrestin domain containing 1 -2.46346
SLC39A13 solute carrier family 39 (zinc transporter), member 13 -2.42366
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.41673
TMX2 thioredoxin-related transmembrane protein 2 -2.3649
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.35716
PAIP2 poly(A) binding protein interacting protein 2 -2.34999
FANCD2 Fanconi anemia, complementation group D2 -2.32897
CEP126 centrosomal protein 126kDa -2.32599
CA8 carbonic anhydrase VIII -2.32406
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.29651
DDIT4L DNA-damage-inducible transcript 4-like -2.28177
MED6 mediator complex subunit 6 -2.23412
COQ6 coenzyme Q6 monooxygenase -2.21751
DNAAF3 dynein, axonemal, assembly factor 3 -2.19509
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.19509
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.16182
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.16035
DSCAM Down syndrome cell adhesion molecule -2.16035
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.16035
NEIL2 nei endonuclease VIII-like 2 (E. coli) -2.12386
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.10982
TMEM14A transmembrane protein 14A -2.09961
ZMAT1 zinc finger, matrin-type 1 -2.09961
FHIP1A FHF complex subunit HOOK interacting protein 1A -2.09268
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.07668
ZNF808 zinc finger protein 808 -2.07325
USO1 USO1 vesicle transport factor -2.07325
XKR6 XK, Kell blood group complex subunit-related family, member 6 -2.0602
GAPVD1 GTPase activating protein and VPS9 domains 1 -2.0602
DST dystonin -2.0602
FKBP7 FK506 binding protein 7 -2.05627
MOSPD3 motile sperm domain containing 3 -2.05461
RHOBTB1 Rho-related BTB domain containing 1 -2.05423
CD276 CD276 molecule -2.04986
PNKP polynucleotide kinase 3'-phosphatase -2.04613
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.03779
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 -2.03377
COL4A5 collagen, type IV, alpha 5 -2.02827
FRMD6 FERM domain containing 6 -2.02827
GPR161 G protein-coupled receptor 161 -2.02444
AMPH amphiphysin -2.02444
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.02444
BRAT1 BRCA1-associated ATM activator 1 -2.01409
ONECUT1 one cut homeobox 1 -2.01409
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.00958
CERS6 ceramide synthase 6 -2.00801
ZSCAN18 zinc finger and SCAN domain containing 18 -2.00028