| Dataset | CM4AI KOLF21J CRISPRi Gene Perturbation Atlas |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | GLE1 RNA export mediator|This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2733) |
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89 genes differentially expressed following the GLE1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
| Symbol | Name | Standardized Value |
|---|---|---|
| UPP1 | uridine phosphorylase 1 | 2.28754 |
| MMP9 | matrix metallopeptidase 9 | 2.28754 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | 2.28754 |
| CTU1 | cytosolic thiouridylase subunit 1 | 2.28754 |
| SRSF10 | serine/arginine-rich splicing factor 10 | 2.28754 |
| ASRGL1 | asparaginase like 1 | 2.28754 |
| ZNF865 | zinc finger protein 865 | 2.1805 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 2.1805 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | 2.1805 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 2.1805 |
| KPTN | kaptin (actin binding protein) | 2.1805 |
| PDLIM3 | PDZ and LIM domain 3 | 2.1805 |
| THAP8 | THAP domain containing 8 | 2.1805 |
| NOSTRIN | nitric oxide synthase trafficking | 2.1805 |
| CYP2A13 | cytochrome P450, family 2, subfamily A, polypeptide 13 | 2.1805 |
| METTL1 | methyltransferase like 1 | 2.1805 |
| C5 | complement component 5 | 2.1805 |
| UBXN8 | UBX domain protein 8 | 2.1805 |
| CYP11A1 | cytochrome P450, family 11, subfamily A, polypeptide 1 | 2.1805 |
| PLCB2 | phospholipase C, beta 2 | 2.1805 |
| KLC2 | kinesin light chain 2 | 2.1805 |
| PRR3 | proline rich 3 | 2.1805 |
| SLC10A4 | solute carrier family 10, member 4 | 2.1805 |
| MEIS3 | Meis homeobox 3 | 2.1805 |
| FTL | ferritin, light polypeptide | 2.1805 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 2.1805 |
| SWSAP1 | SWIM-type zinc finger 7 associated protein 1 | 2.1805 |
| SV2B | synaptic vesicle glycoprotein 2B | 2.1805 |
| SMAD6 | SMAD family member 6 | 2.1805 |
| SLC25A53 | solute carrier family 25, member 53 | 2.1805 |
| DCAF12L1 | DDB1 and CUL4 associated factor 12-like 1 | 2.1805 |
| PLEKHH3 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 | 2.1805 |
| TOR2A | torsin family 2, member A | 2.1805 |
| CCR10 | chemokine (C-C motif) receptor 10 | 2.1805 |
| ZNF114 | zinc finger protein 114 | 2.1805 |
| KAT2B | K(lysine) acetyltransferase 2B | 2.1805 |
| MYOZ1 | myozenin 1 | 2.1805 |
| FRMPD4 | FERM and PDZ domain containing 4 | 2.1805 |
| KCNV2 | potassium channel, voltage gated modifier subfamily V, member 2 | 2.16388 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | 2.14801 |
| KLHL9 | kelch-like family member 9 | 2.11175 |
| API5 | apoptosis inhibitor 5 | 2.11081 |
| PLCD1 | phospholipase C, delta 1 | 2.0363 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SYF2 | SYF2 pre-mRNA-splicing factor | -2.28754 |
| STON2 | stonin 2 | -2.28754 |
| PUS3 | pseudouridylate synthase 3 | -2.28754 |
| MTMR2 | myotubularin related protein 2 | -2.28754 |
| GRM8 | glutamate receptor, metabotropic 8 | -2.28754 |
| GMEB1 | glucocorticoid modulatory element binding protein 1 | -2.28754 |
| SDC1 | syndecan 1 | -2.28754 |
| VPS4A | vacuolar protein sorting 4 homolog A (S. cerevisiae) | -2.28754 |
| MADD | MAP-kinase activating death domain | -2.28754 |
| TCTN3 | tectonic family member 3 | -2.28754 |
| PRKCH | protein kinase C, eta | -2.28754 |
| COA7 | cytochrome c oxidase assembly factor 7 (putative) | -2.28754 |
| TSPYL5 | TSPY-like 5 | -2.28754 |
| TRAK1 | trafficking protein, kinesin binding 1 | -2.28754 |
| ZNF275 | zinc finger protein 275 | -2.28754 |
| VCP | valosin containing protein | -2.28754 |
| SEC14L2 | SEC14-like 2 (S. cerevisiae) | -2.28754 |
| ATL3 | atlastin GTPase 3 | -2.19686 |
| DENND1B | DENN/MADD domain containing 1B | -2.19686 |
| HMCN1 | hemicentin 1 | -2.1805 |
| PGAM5 | phosphoglycerate mutase family member 5 | -2.1805 |
| NADK | NAD kinase | -2.1805 |
| TRMT61B | tRNA methyltransferase 61B | -2.1805 |
| TMLHE | trimethyllysine hydroxylase, epsilon | -2.1805 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -2.1805 |
| GPM6B | glycoprotein M6B | -2.1805 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | -2.1805 |
| ASPSCR1 | alveolar soft part sarcoma chromosome region, candidate 1 | -2.1805 |
| TTF1 | transcription termination factor, RNA polymerase I | -2.1805 |
| OSBPL11 | oxysterol binding protein-like 11 | -2.1805 |
| KANSL2 | KAT8 regulatory NSL complex subunit 2 | -2.1805 |
| INTS4 | integrator complex subunit 4 | -2.1805 |
| CHMP1B | charged multivesicular body protein 1B | -2.1805 |
| ATL2 | atlastin GTPase 2 | -2.11425 |
| ITSN2 | intersectin 2 | -2.11081 |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | -2.11081 |
| STMN3 | stathmin-like 3 | -2.11081 |
| L3MBTL3 | l(3)mbt-like 3 (Drosophila) | -2.11081 |
| CYB5D1 | cytochrome b5 domain containing 1 | -2.11081 |
| SHPRH | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | -2.11081 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -2.11081 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -2.11081 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | -2.11081 |
| ADPRS | ADP-ribosylserine hydrolase | -2.06317 |
| GTF3C5 | general transcription factor IIIC, polypeptide 5, 63kDa | -2.0577 |
| TRAPPC9 | trafficking protein particle complex 9 | -2.01234 |
