GLI1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description GLI family zinc finger 1|This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (NCBI Entrez Gene Database, 2735)
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Genes

315 genes differentially expressed following the GLI1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.82064
LRRC52 leucine rich repeat containing 52 2.82064
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.82064
MBD3L3 methyl-CpG binding domain protein 3-like 3 2.82064
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.82064
GIMAP2 GTPase, IMAP family member 2 2.82064
FBLN7 fibulin 7 2.82064
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.82064
TDRD9 tudor domain containing 9 2.82064
LCN12 lipocalin 12 2.82064
SPP2 secreted phosphoprotein 2, 24kDa 2.82064
ATP9B ATPase, class II, type 9B 2.82064
MILR1 mast cell immunoglobulin-like receptor 1 2.82064
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.82064
CTRC chymotrypsin C (caldecrin) 2.82064
LIPH lipase, member H 2.82064
DUXB double homeobox B 2.82064
NPPC natriuretic peptide C 2.82064
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.82064
SLC46A2 solute carrier family 46, member 2 2.82064
TMEM176A transmembrane protein 176A 2.82064
TRIM15 tripartite motif containing 15 2.82064
SLC35G5 solute carrier family 35, member G5 2.82064
LACTBL1 lactamase, beta-like 1 2.82064
SYCE3 synaptonemal complex central element protein 3 2.82064
TMEM132C transmembrane protein 132C 2.82064
CLCF1 cardiotrophin-like cytokine factor 1 2.82064
ERAP2 endoplasmic reticulum aminopeptidase 2 2.82064
CCDC87 coiled-coil domain containing 87 2.82064
CCDC83 coiled-coil domain containing 83 2.82064
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.82064
TMEM52B transmembrane protein 52B 2.82064
AMPD1 adenosine monophosphate deaminase 1 2.82064
ANKRD30B ankyrin repeat domain 30B 2.82064
PASD1 PAS domain containing 1 2.82064
TDO2 tryptophan 2,3-dioxygenase 2.82064
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.82064
DLL4 delta-like 4 (Drosophila) 2.82064
PNOC prepronociceptin 2.82064
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.82064
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.82064
CORO6 coronin 6 2.82064
LGALS4 lectin, galactoside-binding, soluble, 4 2.82064
MYO1G myosin IG 2.82064
GRP gastrin-releasing peptide 2.82064
SP6 Sp6 transcription factor 2.82064
GYS1 glycogen synthase 1 (muscle) 2.82064
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.82064
MAP3K7CL MAP3K7 C-terminal like 2.82064
CATSPERT catsper channel auxiliary subunit tau 2.82064
PLCZ1 phospholipase C, zeta 1 2.82064
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.82064
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.82064
TMPRSS3 transmembrane protease, serine 3 2.82064
TREX2 three prime repair exonuclease 2 2.82064
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.82064
SMTNL1 smoothelin-like 1 2.82064
CD70 CD70 molecule 2.82064
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.82064
LTB lymphotoxin beta (TNF superfamily, member 3) 2.82064
MLN motilin 2.82064
ALX4 ALX homeobox 4 2.82064
ERLN endoregulin 2.82064
PNMA6F PNMA family member 6F 2.82064
FAM240A family with sequence similarity 240 member A 2.82064
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.82064
CPNE8-AS1 CPNE8 antisense RNA 1 2.82064
H2BK1 H2B.K variant histone 1 2.82064
TMA7B translation machinery associated 7 homolog B 2.82064
TENT5D terminal nucleotidyltransferase 5D 2.82064
CHCT1 CHD1 helical C-terminal domain containing 1 2.82064
BEND2 BEN domain containing 2 2.82064
SOAT2 sterol O-acyltransferase 2 2.82064
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.82064
PCDHA7 protocadherin alpha 7 2.82064
ACTL8 actin-like 8 2.82064
ISM2 isthmin 2 2.82064
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.82064
PUF60 poly-U binding splicing factor 60KDa 2.82064
ELF5 E74-like factor 5 (ets domain transcription factor) 2.82064
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 2.82064
CD274 CD274 molecule 2.82064
AGTR1 angiotensin II receptor, type 1 2.82064
VCX2 variable charge, X-linked 2 2.82064
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.82064
GOLGA6L4 golgin A6 family-like 4 2.82064
PNPLA1 patatin-like phospholipase domain containing 1 2.82064
TAS1R2 taste receptor, type 1, member 2 2.82064
TAS1R1 taste receptor, type 1, member 1 2.82064
BLNK B-cell linker 2.82064
TSPO2 translocator protein 2 2.82064
CDSN corneodesmosin 2.82064
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.82064
MIA melanoma inhibitory activity 2.82064
AWAT2 acyl-CoA wax alcohol acyltransferase 2 2.82064
TLR8 toll-like receptor 8 2.82064
PARP3 poly (ADP-ribose) polymerase family, member 3 2.82064
RGSL1 regulator of G-protein signaling like 1 2.82064
FAM177B family with sequence similarity 177, member B 2.82064
TRADD TNFRSF1A-associated via death domain 2.82064
C16ORF78 chromosome 16 open reading frame 78 2.82064
CLEC4D C-type lectin domain family 4, member D 2.82064
FIBIN fin bud initiation factor homolog (zebrafish) 2.82064
PCDHGA4 protocadherin gamma subfamily A, 4 2.82064
PCDHGA2 protocadherin gamma subfamily A, 2 2.82064
SHISA8 shisa family member 8 2.82064
OR52K1 olfactory receptor, family 52, subfamily K, member 1 2.82064
CALHM1 calcium homeostasis modulator 1 2.82064
POU4F1 POU class 4 homeobox 1 2.82064
WFDC6 WAP four-disulfide core domain 6 2.82064
CDC20B cell division cycle 20B 2.82064
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.82064
EFCAB3 EF-hand calcium binding domain 3 2.82064
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.82064
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 2.82064
C11ORF96 chromosome 11 open reading frame 96 2.82064
AQP8 aquaporin 8 2.82064
CRYBB3 crystallin, beta B3 2.82064
CDHR5 cadherin-related family member 5 2.82064
BCO1 beta-carotene oxygenase 1 2.82064
IL19 interleukin 19 2.82064
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.82064
SI sucrase-isomaltase (alpha-glucosidase) 2.82064
QRFP pyroglutamylated RFamide peptide 2.82064
CSF1R colony stimulating factor 1 receptor 2.82064
GPR150 G protein-coupled receptor 150 2.82064
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.82064
TM4SF19 transmembrane 4 L six family member 19 2.82064
NKAIN3 Na+/K+ transporting ATPase interacting 3 2.82064
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.82064
ZPBP zona pellucida binding protein 2.82064
SIGLEC15 sialic acid binding Ig-like lectin 15 2.82064
PDCD1LG2 programmed cell death 1 ligand 2 2.82064
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.82064
SLC22A24 solute carrier family 22, member 24 2.82064
CATIP ciliogenesis associated TTC17 interacting protein 2.82064
FBXO47 F-box protein 47 2.82064
KLK2 kallikrein-related peptidase 2 2.82064
PRR35 proline rich 35 2.82064
BSPH1 binder of sperm protein homolog 1 2.82064
TICRR TOPBP1-interacting checkpoint and replication regulator 2.82064
RWDD2A RWD domain containing 2A 2.82064
CRYBA1 crystallin, beta A1 2.82064
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.82064
NLRP8 NLR family, pyrin domain containing 8 2.82064
SMYD1 SET and MYND domain containing 1 2.82064
CIDEA cell death-inducing DFFA-like effector a 2.82064
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.82064
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.82064
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.82064
PRAM1 PML-RARA regulated adaptor molecule 1 2.82064
EPO erythropoietin 2.82064
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.82064
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.82064
MT1A metallothionein 1A 2.82064
JUP junction plakoglobin 2.82064
PATE1 prostate and testis expressed 1 2.82064
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.82064
DMRTC1 DMRT-like family C1 2.82064
CDCP2 CUB domain containing protein 2 2.82064
AOC1 amine oxidase, copper containing 1 2.82064
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.82064
ERMN ermin, ERM-like protein 2.82064
BMX BMX non-receptor tyrosine kinase 2.82064
AKR1B15 aldo-keto reductase family 1, member B15 2.82064
LOXL4 lysyl oxidase-like 4 2.82064
MRLN myoregulin 2.82064
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.82064
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.82064
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.82064
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 2.74452
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.74452
MOSPD3 motile sperm domain containing 3 2.73545
GFRA2 GDNF family receptor alpha 2 2.68069
STK32C serine/threonine kinase 32C 2.65397
GOLGA8A golgin A8 family, member A 2.65153
SPMIP11 sperm microtubule inner protein 11 2.60024
CD34 CD34 molecule 2.60024
CPNE3 copine III 2.55701
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 2.54991
SWI5 SWI5 recombination repair homolog (yeast) 2.54991
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.52645
CETN2 centrin, EF-hand protein, 2 2.50433
LRRC57 leucine rich repeat containing 57 2.50433
CAV1 caveolin 1, caveolae protein, 22kDa 2.50319
PTTG1 pituitary tumor-transforming 1 2.45368
CSPG4 chondroitin sulfate proteoglycan 4 2.45235
CLCNKB chloride channel, voltage-sensitive Kb 2.45235
ZNF98 zinc finger protein 98 2.42199
C5AR2 complement component 5a receptor 2 2.41463
MNT MAX network transcriptional repressor 2.39363
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 2.37304
TM7SF2 transmembrane 7 superfamily member 2 2.36166
SHLD3 shieldin complex subunit 3 2.31467
LAMB2 laminin, beta 2 (laminin S) 2.31378
PHIP pleckstrin homology domain interacting protein 2.31234
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.2488
ANKRD54 ankyrin repeat domain 54 2.24103
MRPS16 mitochondrial ribosomal protein S16 2.22438
C19ORF25 chromosome 19 open reading frame 25 2.22421
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.2231
ZFP1 ZFP1 zinc finger protein 2.19819
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 2.19544
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 2.16819
LMO4 LIM domain only 4 2.16099
CHMP2B charged multivesicular body protein 2B 2.1603
BEST1 bestrophin 1 2.15069
ELF2 E74-like factor 2 (ets domain transcription factor) 2.15069
KIRREL3 kin of IRRE like 3 (Drosophila) 2.15069
PHAX phosphorylated adaptor for RNA export 2.13654
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2.1114
DCP1A decapping mRNA 1A 2.11049
SEC11C SEC11 homolog C (S. cerevisiae) 2.09539
MED8 mediator complex subunit 8 2.06838
LIPI lipase, member I 2.05691
NHLH2 nescient helix loop helix 2 2.05576
KCTD12 potassium channel tetramerization domain containing 12 2.05006
TCF19 transcription factor 19 2.03571
RCC1L RCC1 like 2.03328
ZFP14 ZFP14 zinc finger protein 2.02985
FIGNL1 fidgetin-like 1 2.0242
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.02357
ZNF789 zinc finger protein 789 2.02252
MAOB monoamine oxidase B 2.02252
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.01408
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.01394
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.00394

decreased expression

Symbol Name Standardized Value
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.82064
SERF1A small EDRK-rich factor 1A (telomeric) -2.82064
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.82064
ARRDC4 arrestin domain containing 4 -2.82064
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.82064
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.82064
CAPN6 calpain 6 -2.82064
AKAP14 A kinase (PRKA) anchor protein 14 -2.82064
OCA2 oculocutaneous albinism II -2.82064
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.82064
TLE5 TLE family member 5, transcriptional modulator -2.82064
ABLIM3 actin binding LIM protein family, member 3 -2.82064
SLA2 Src-like-adaptor 2 -2.82064
RNF170 ring finger protein 170 -2.82064
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.82064
ANKRD37 ankyrin repeat domain 37 -2.82064
NPSR1 neuropeptide S receptor 1 -2.74452
SP7 Sp7 transcription factor -2.74452
TTLL8 tubulin tyrosine ligase-like family member 8 -2.74452
ATOH7 atonal homolog 7 (Drosophila) -2.74452
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.74452
KISS1R KISS1 receptor -2.74452
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -2.74452
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.74452
HORMAD2 HORMA domain containing 2 -2.74452
PLAAT4 phospholipase A and acyltransferase 4 -2.74452
MCHR1 melanin-concentrating hormone receptor 1 -2.74452
CAPN9 calpain 9 -2.74452
MGAM maltase-glucoamylase -2.74452
DUSP8 dual specificity phosphatase 8 -2.74452
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.74452
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.74452
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.74452
SLC22A25 solute carrier family 22, member 25 -2.74452
PYDC1 PYD (pyrin domain) containing 1 -2.74452
INHBA inhibin, beta A -2.74452
FOXA2 forkhead box A2 -2.74452
SEPTIN12 septin 12 -2.74452
GRM6 glutamate receptor, metabotropic 6 -2.74452
CLIC2 chloride intracellular channel 2 -2.74452
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.74452
CFAP47 cilia and flagella associated protein 47 -2.74452
NOX1 NADPH oxidase 1 -2.74452
ANKRD53 ankyrin repeat domain 53 -2.74452
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -2.74452
AMH anti-Mullerian hormone -2.74452
MRAP melanocortin 2 receptor accessory protein -2.74452
EFCAB12 EF-hand calcium binding domain 12 -2.74452
C11ORF42 chromosome 11 open reading frame 42 -2.74452
TMEM255A transmembrane protein 255A -2.74452
KIF12 kinesin family member 12 -2.74452
AGBL4 ATP/GTP binding protein-like 4 -2.74452
LRRC4C leucine rich repeat containing 4C -2.72885
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -2.65169
VANGL2 VANGL planar cell polarity protein 2 -2.64935
MYO10 myosin X -2.64903
PAK1IP1 PAK1 interacting protein 1 -2.64374
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -2.61223
MTARC2 mitochondrial amidoxime reducing component 2 -2.60792
TNC tenascin C -2.59726
C20ORF203 chromosome 20 open reading frame 203 -2.59726
ARL1 ADP-ribosylation factor-like 1 -2.55868
PLAC8 placenta-specific 8 -2.55868
SHISAL2A shisa like 2A -2.55868
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.39576
PRR3 proline rich 3 -2.31435
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -2.27891
RIMOC1 RAB7A interacting MON1-CCZ1 complex subunit 1 -2.26214
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.26104
NOS1 nitric oxide synthase 1 (neuronal) -2.26086
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.2488
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.21635
PRDX4 peroxiredoxin 4 -2.20878
PLRG1 pleiotropic regulator 1 -2.15247
TLCD4 TLC domain containing 4 -2.1114
CHRM5 cholinergic receptor, muscarinic 5 -2.11049
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -2.10743
KLHL9 kelch-like family member 9 -2.10743
ZNF519 zinc finger protein 519 -2.09883
SAXO6 stabilizer of axonemal microtubules 6 -2.09848
ARHGAP29 Rho GTPase activating protein 29 -2.0973
VWA2 von Willebrand factor A domain containing 2 -2.09539
EML5 echinoderm microtubule associated protein like 5 -2.08765
USP2 ubiquitin specific peptidase 2 -2.07684
AK6 adenylate kinase 6 -2.05673
TMSB15C thymosin beta 15C -2.0555
ING1 inhibitor of growth family, member 1 -2.0555
TANGO6 transport and golgi organization 6 homolog (Drosophila) -2.00394