GLI2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description GLI family zinc finger 2|This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2736)
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Genes

326 genes differentially expressed following the GLI2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OSBPL7 oxysterol binding protein-like 7 3.45079
TMPRSS11E transmembrane protease, serine 11E 3.45079
CSF1 colony stimulating factor 1 (macrophage) 3.45079
MYL5 myosin, light chain 5, regulatory 3.45079
NME8 NME/NM23 family member 8 3.45079
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 3.45079
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 3.45079
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 3.45079
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 3.45079
ZNF285 zinc finger protein 285 3.45079
DENND1C DENN/MADD domain containing 1C 3.45079
JOSD2 Josephin domain containing 2 3.45079
DNAH8 dynein, axonemal, heavy chain 8 3.45079
SLC10A4 solute carrier family 10, member 4 3.45079
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.45079
CFAP73 cilia and flagella associated protein 73 3.45079
EFCAB8 EF-hand calcium binding domain 8 3.45079
BATF basic leucine zipper transcription factor, ATF-like 3.44036
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.44036
TMEM100 transmembrane protein 100 3.44036
MFAP5 microfibrillar associated protein 5 3.44036
SPINK1 serine peptidase inhibitor, Kazal type 1 3.44036
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.44036
NCMAP noncompact myelin associated protein 3.44036
PGBDF plakoglobin binding and degradation factor 3.44036
PCDHB9 protocadherin beta 9 3.44036
PON1 paraoxonase 1 3.44036
LHX1 LIM homeobox 1 3.44036
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.44036
TMEM176B transmembrane protein 176B 3.44036
SHCBP1L SHC SH2-domain binding protein 1-like 3.44036
GPR20 G protein-coupled receptor 20 3.44036
ANKRD30B ankyrin repeat domain 30B 3.44036
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 3.44036
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.44036
NWD1 NACHT and WD repeat domain containing 1 3.44036
PRDM1 PR domain containing 1, with ZNF domain 3.44036
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 3.44036
SHISA7 shisa family member 7 3.44036
SPACA5 sperm acrosome associated 5 3.44036
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.44036
CPLX3 complexin 3 3.44036
LGALS9 lectin, galactoside-binding, soluble, 9 3.44036
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.44036
GLIS1 GLIS family zinc finger 1 3.44036
RGPD1 RANBP2-like and GRIP domain containing 1 3.44036
PTK6 protein tyrosine kinase 6 3.44036
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.44036
SLC23A3 solute carrier family 23, member 3 3.44036
ICAM2 intercellular adhesion molecule 2 3.44036
MINDY4B MINDY family member 4B 3.44036
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.44036
PROC protein C (inactivator of coagulation factors Va and VIIIa) 3.44036
SPATC1 spermatogenesis and centriole associated 1 3.44036
PRDM7 PR domain containing 7 3.44036
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.44036
WDR93 WD repeat domain 93 3.44036
HAL histidine ammonia-lyase 3.44036
SAMD15 sterile alpha motif domain containing 15 3.44036
FKBP6 FK506 binding protein 6, 36kDa 3.44036
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.44036
SEPTIN12 septin 12 3.44036
H2BW1 H2B.W histone 1 3.44036
ALKAL1 ALK and LTK ligand 1 3.44036
TEKTIP1 tektin bundle interacting protein 1 3.44036
FLACC1 flagellum associated containing coiled-coil domains 1 3.44036
SMIM41 small integral membrane protein 41 3.44036
PHF24 PHD finger protein 24 3.44036
LINGO3 leucine rich repeat and Ig domain containing 3 3.44036
VCX3B variable charge, X-linked 3B 3.44036
S100B S100 calcium binding protein B 3.44036
PRR18 proline rich 18 3.44036
OVGP1 oviductal glycoprotein 1, 120kDa 3.44036
GJA4 gap junction protein, alpha 4, 37kDa 3.44036
COL20A1 collagen, type XX, alpha 1 3.44036
CFAP74 cilia and flagella associated protein 74 3.44036
MYBPHL myosin binding protein H-like 3.44036
CATSPERD catsper channel auxiliary subunit delta 3.44036
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.44036
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.44036
FAM43A family with sequence similarity 43, member A 3.44036
CIMIP4 ciliary microtubule inner protein 4 3.44036
C1QL2 complement component 1, q subcomponent-like 2 3.44036
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.44036
SLC45A2 solute carrier family 45, member 2 3.44036
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.44036
IAPP islet amyloid polypeptide 3.44036
CDK3 cyclin-dependent kinase 3 3.44036
S1PR1 sphingosine-1-phosphate receptor 1 3.44036
CXCL16 chemokine (C-X-C motif) ligand 16 3.44036
SLC46A3 solute carrier family 46, member 3 3.44036
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 3.44036
NPFFR1 neuropeptide FF receptor 1 3.44036
LMOD2 leiomodin 2 (cardiac) 3.44036
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.44036
CLEC4C C-type lectin domain family 4, member C 3.44036
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.44036
FIBIN fin bud initiation factor homolog (zebrafish) 3.44036
EVPLL envoplakin-like 3.44036
IL19 interleukin 19 3.44036
TMEM61 transmembrane protein 61 3.44036
TBC1D10C TBC1 domain family, member 10C 3.44036
TSLP thymic stromal lymphopoietin 3.44036
TCEA3 transcription elongation factor A (SII), 3 3.44036
CT55 cancer/testis antigen 55 3.44036
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.44036
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.44036
EDN2 endothelin 2 3.44036
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.44036
EFCAB3 EF-hand calcium binding domain 3 3.44036
MAMDC4 MAM domain containing 4 3.44036
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.44036
PDZRN4 PDZ domain containing ring finger 4 3.44036
SFRP4 secreted frizzled-related protein 4 3.44036
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.44036
MYLK4 myosin light chain kinase family, member 4 3.44036
TSPAN16 tetraspanin 16 3.44036
GPR150 G protein-coupled receptor 150 3.44036
RASA4 RAS p21 protein activator 4 3.44036
LAMB4 laminin, beta 4 3.44036
NPY2R neuropeptide Y receptor Y2 3.44036
ZNF835 zinc finger protein 835 3.44036
MOG myelin oligodendrocyte glycoprotein 3.44036
TCAP titin-cap 3.44036
PENK proenkephalin 3.44036
RELN reelin 3.44036
SIRPG signal-regulatory protein gamma 3.44036
HK3 hexokinase 3 (white cell) 3.44036
VSTM1 V-set and transmembrane domain containing 1 3.44036
OCM oncomodulin 3.44036
ITGB6 integrin, beta 6 3.44036
ANKRD53 ankyrin repeat domain 53 3.44036
GPR68 G protein-coupled receptor 68 3.44036
ART1 ADP-ribosyltransferase 1 3.44036
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.44036
AHSG alpha-2-HS-glycoprotein 3.44036
COL12A1 collagen, type XII, alpha 1 3.44036
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.44036
TGM3 transglutaminase 3 3.44036
FOXP3 forkhead box P3 3.44036
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.44036
BCAS1 breast carcinoma amplified sequence 1 3.44036
CLCA1 chloride channel accessory 1 3.44036
SCN3B sodium channel, voltage gated, type III beta subunit 3.44036
TGM1 transglutaminase 1 3.44036
ZMYND10 zinc finger, MYND-type containing 10 3.44036
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.44036
MPZL2 myelin protein zero-like 2 3.44036
PRCD progressive rod-cone degeneration 3.44036
GPR179 G protein-coupled receptor 179 3.44036
C17ORF78 chromosome 17 open reading frame 78 3.44036
CPZ carboxypeptidase Z 3.44036
TMEM213 transmembrane protein 213 3.44036
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 3.44036
KRT17 keratin 17, type I 3.44036
OR4M2 olfactory receptor, family 4, subfamily M, member 2 3.44036
CTNND2 catenin (cadherin-associated protein), delta 2 3.35384
GSG1 germ cell associated 1 3.35368
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 3.33859
SCART1 scavenger receptor protein family member 3.33859
ZNF324 zinc finger protein 324 3.33859
STXBP5 syntaxin binding protein 5 (tomosyn) 3.2438
TACC2 transforming, acidic coiled-coil containing protein 2 2.90679
ADAM23 ADAM metallopeptidase domain 23 2.804
MOGS mannosyl-oligosaccharide glucosidase 2.69524
ZC3H14 zinc finger CCCH-type containing 14 2.69136
SYN1 synapsin I 2.67882
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.6783
RPL14 ribosomal protein L14 2.65362
LYRM1 LYR motif containing 1 2.59931
MROH1 maestro heat-like repeat family member 1 2.56002
RXRA retinoid X receptor, alpha 2.55157
CDK1 cyclin-dependent kinase 1 2.55026
TPST2 tyrosylprotein sulfotransferase 2 2.55026
LIMCH1 LIM and calponin homology domains 1 2.54297
ZNF33A zinc finger protein 33A 2.53118
CREB3L1 cAMP responsive element binding protein 3-like 1 2.43046
C1QL1 complement component 1, q subcomponent-like 1 2.41285
ODAD4 outer dynein arm docking complex subunit 4 2.32646
MYO1H myosin IH 2.32646
INHA inhibin, alpha 2.32646
CNTD1 cyclin N-terminal domain containing 1 2.32646
STYK1 serine/threonine/tyrosine kinase 1 2.32646
C19ORF12 chromosome 19 open reading frame 12 2.30268
MAK16 MAK16 homolog (S. cerevisiae) 2.29975
MYO1B myosin IB 2.29148
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 2.28404
TXN thioredoxin 2.27142
RPS21 ribosomal protein S21 2.27142
ETNK2 ethanolamine kinase 2 2.26768
SPATA6L spermatogenesis associated 6-like 2.25708
H2AC13 H2A clustered histone 13 2.23399
DCHS1 dachsous cadherin-related 1 2.23399
TMSB4X thymosin beta 4, X-linked 2.22651
ZSWIM1 zinc finger, SWIM-type containing 1 2.20646
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 2.18754
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.18619
SEPTIN7 septin 7 2.17225
LIN52 lin-52 DREAM MuvB core complex component 2.13489
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 2.13489
RPL13A ribosomal protein L13a 2.11852
ATG5 autophagy related 5 2.08663
AHCTF1 AT hook containing transcription factor 1 2.0805
TMEM126B transmembrane protein 126B 2.05751
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 2.0557
GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 2.05116
HFE hemochromatosis 2.04734
ZNF791 zinc finger protein 791 2.04157
ELOA elongin A 2.0343
PRNP prion protein 2.02904
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2.02363
RPS9 ribosomal protein S9 2.00235

decreased expression

Symbol Name Standardized Value
OXSM 3-oxoacyl-ACP synthase, mitochondrial -3.45079
USP27X ubiquitin specific peptidase 27, X-linked -3.45079
PLK2 polo-like kinase 2 -3.45079
ECT2L epithelial cell transforming 2 like -3.45079
SCUBE2 signal peptide, CUB domain, EGF-like 2 -3.45079
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -3.45079
CRYGB crystallin, gamma B -3.45079
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -3.45079
C22ORF23 chromosome 22 open reading frame 23 -3.45079
STAMBPL1 STAM binding protein-like 1 -3.45079
PDE1A phosphodiesterase 1A, calmodulin-dependent -3.45079
FIZ1 FLT3-interacting zinc finger 1 -3.44036
FAT3 FAT atypical cadherin 3 -3.44036
ZNF768 zinc finger protein 768 -3.44036
OMD osteomodulin -3.44036
CYSRT1 cysteine-rich tail protein 1 -3.42939
VSTM5 V-set and transmembrane domain containing 5 -3.42939
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -3.42939
ACADL acyl-CoA dehydrogenase, long chain -3.42939
IL17C interleukin 17C -3.42939
ANPEP alanyl (membrane) aminopeptidase -3.42939
PADI1 peptidyl arginine deiminase, type I -3.42939
TSKS testis-specific serine kinase substrate -3.42939
H4C6 H4 clustered histone 6 -3.42939
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -3.42939
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 -3.42939
UCMA upper zone of growth plate and cartilage matrix associated -3.42939
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -3.42939
MEOX2 mesenchyme homeobox 2 -3.42939
SP140 SP140 nuclear body protein -3.42939
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -3.42939
SLC46A1 solute carrier family 46 (folate transporter), member 1 -3.42939
BMP8B bone morphogenetic protein 8b -3.42939
TGFB3 transforming growth factor, beta 3 -3.42939
MPZ myelin protein zero -3.42939
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 -3.42939
BHMT betaine--homocysteine S-methyltransferase -3.42939
CCDC159 coiled-coil domain containing 159 -3.42939
EBF4 early B-cell factor 4 -3.42939
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -3.42939
NUTM2F NUT family member 2F -3.42939
COL9A2 collagen, type IX, alpha 2 -3.42939
SP140L SP140 nuclear body protein-like -3.42939
SPTBN5 spectrin, beta, non-erythrocytic 5 -3.42939
SF3B1 splicing factor 3b, subunit 1, 155kDa -3.40251
ZNF773 zinc finger protein 773 -3.23934
HEYL hes-related family bHLH transcription factor with YRPW motif-like -3.23934
DACH1 dachshund family transcription factor 1 -3.20065
EXOC2 exocyst complex component 2 -2.91082
ANKRD13B ankyrin repeat domain 13B -2.88093
RAB3A RAB3A, member RAS oncogene family -2.88093
TMX1 thioredoxin-related transmembrane protein 1 -2.88093
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.86815
IFT80 intraflagellar transport 80 -2.77244
SPATA13 spermatogenesis associated 13 -2.68126
AUP1 ancient ubiquitous protein 1 -2.66207
CDK11A cyclin-dependent kinase 11A -2.66042
SLIT2 slit homolog 2 (Drosophila) -2.66042
TEX2 testis expressed 2 -2.65747
DCP1B decapping mRNA 1B -2.57746
AHCY adenosylhomocysteinase -2.55216
ZNF230 zinc finger protein 230 -2.54297
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.54297
TOR3A torsin family 3, member A -2.51082
ITGA6 integrin, alpha 6 -2.51082
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.46422
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -2.4608
ZNF552 zinc finger protein 552 -2.4604
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.45387
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 -2.44726
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -2.36744
ECSIT ECSIT signalling integrator -2.32646
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -2.32646
C1RL complement component 1, r subcomponent-like -2.32646
CADM1 cell adhesion molecule 1 -2.3123
AFF3 AF4/FMR2 family, member 3 -2.27849
H2BC21 H2B clustered histone 21 -2.2738
ZNF547 zinc finger protein 547 -2.2738
XKR5 XK, Kell blood group complex subunit-related family, member 5 -2.2738
DDAH1 dimethylarginine dimethylaminohydrolase 1 -2.27142
MED9 mediator complex subunit 9 -2.27115
SETD9 SET domain containing 9 -2.23399
WASHC4 WASH complex subunit 4 -2.21152
HTRA3 HtrA serine peptidase 3 -2.21152
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) -2.21152
SCX scleraxis basic helix-loop-helix transcription factor -2.21152
FOXO6 forkhead box O6 -2.21152
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.21152
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.21152
ACE angiotensin I converting enzyme -2.21152
TTC39C tetratricopeptide repeat domain 39C -2.21152
RHOXF1 Rhox homeobox family, member 1 -2.20311
MICU2 mitochondrial calcium uptake 2 -2.20311
MYO1D myosin ID -2.20311
SLC45A3 solute carrier family 45, member 3 -2.19469
RBL2 retinoblastoma-like 2 -2.18542
DUSP5 dual specificity phosphatase 5 -2.16321
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.16321
AARS1 alanyl-tRNA synthetase 1 -2.08663
TFR2 transferrin receptor 2 -2.0777
LRRC7 leucine rich repeat containing 7 -2.0777
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.0777
ZNF630 zinc finger protein 630 -2.07754
BMP6 bone morphogenetic protein 6 -2.07754
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.06444
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -2.05751
IGSF21 immunoglobin superfamily, member 21 -2.05743
KEAP1 kelch-like ECH-associated protein 1 -2.04157
GLI3 GLI family zinc finger 3 -2.02569
RBM28 RNA binding motif protein 28 -2.02219
ITM2B integral membrane protein 2B -2.02184
PANX1 pannexin 1 -2.01804
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 -2.01468
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) -2.0031