GLI3 Gene Set

Dataset MotifMap Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description GLI family zinc finger 3|This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2737)
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Genes

207 target genes of the GLI3 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AAMDC adipogenesis associated, Mth938 domain containing
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAR adenosine deaminase, RNA-specific
ADGRG6 adhesion G protein-coupled receptor G6
ADGRL3 adhesion G protein-coupled receptor L3
ADK adenosine kinase
ADORA1 adenosine A1 receptor
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AIM1L absent in melanoma 1-like
APLN apelin
ARHGAP33 Rho GTPase activating protein 33
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39
ASIC4 acid sensing (proton gated) ion channel family member 4
ATXN7L2 ataxin 7-like 2
BAHD1 bromo adjacent homology domain containing 1
BCL2L1 BCL2-like 1
C2ORF91 chromosome 2 open reading frame 91
CA14 carbonic anhydrase XIV
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CCDC34 coiled-coil domain containing 34
CERCAM cerebral endothelial cell adhesion molecule
CFC1B cripto, FRL-1, cryptic family 1B
CLIC1 chloride intracellular channel 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNTNAP1 contactin associated protein 1
COG4 component of oligomeric golgi complex 4
CRB2 crumbs family member 2
CRYBA2 crystallin, beta A2
CXXC5 CXXC finger protein 5
CYB561D1 cytochrome b561 family, member D1
DCTN2 dynactin 2 (p50)
DGKD diacylglycerol kinase, delta 130kDa
DIS3L2 DIS3 like 3'-5' exoribonuclease 2
DLG4 discs, large homolog 4 (Drosophila)
DLGAP1-AS1 DLGAP1 antisense RNA 1
DNER delta/notch-like EGF repeat containing
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP7 dual specificity phosphatase 7
DYNLL1 dynein, light chain, LC8-type 1
EPS8L3 EPS8-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERF Ets2 repressor factor
ESRRA estrogen-related receptor alpha
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXTL3 exostosin-like glycosyltransferase 3
FAM110D family with sequence similarity 110, member D
FAM170B-AS1 FAM170B antisense RNA 1
FAM213A family with sequence similarity 213, member A
FANCD2 Fanconi anemia, complementation group D2
FBXL8 F-box and leucine-rich repeat protein 8
FILIP1L filamin A interacting protein 1-like
FMNL2 formin-like 2
FNDC1 fibronectin type III domain containing 1
FOXL1 forkhead box L1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FUBP3 far upstream element (FUSE) binding protein 3
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GDNF-AS1 GDNF antisense RNA 1 (head to head)
GGT7 gamma-glutamyltransferase 7
GHR growth hormone receptor
GLI1 GLI family zinc finger 1
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIPAP1 GRIP1 associated protein 1
GSK3B glycogen synthase kinase 3 beta
GTF2IRD1 GTF2I repeat domain containing 1
HDAC9 histone deacetylase 9
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H4L histone cluster 1, H4l
HLX H2.0-like homeobox
HMCN1 hemicentin 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXA1 homeobox A1
HOXD12 homeobox D12
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IER5L immediate early response 5-like
IFT172 intraflagellar transport 172
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
ILF3 interleukin enhancer binding factor 3, 90kDa
ISOC1 isochorismatase domain containing 1
JAKMIP2-AS1 JAKMIP2 antisense RNA 1
JARID2 jumonji, AT rich interactive domain 2
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KIAA0195 KIAA0195
KIAA1462 KIAA1462
KIAA1875 KIAA1875
KIRREL2 kin of IRRE like 2 (Drosophila)
LARP1 La ribonucleoprotein domain family, member 1
LINC00167 long intergenic non-protein coding RNA 167
LINC00950 long intergenic non-protein coding RNA 950
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LOC100128176 uncharacterized LOC100128176
LOC151484 uncharacterized LOC151484
LPCAT3 lysophosphatidylcholine acyltransferase 3
LYPD6 LY6/PLAUR domain containing 6
MAP7D1 MAP7 domain containing 1
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAT2A methionine adenosyltransferase II, alpha
MIF4GD MIF4G domain containing
MIG7 mig-7
MINK1 misshapen-like kinase 1
MIR2052 microRNA 2052
MIR3193 microRNA 3193
MIR487B microRNA 487b
MIR921 microRNA 921
MIR96 microRNA 96
MMP28 matrix metallopeptidase 28
MORC1 MORC family CW-type zinc finger 1
MRPL2 mitochondrial ribosomal protein L2
MRPS18A mitochondrial ribosomal protein S18A
MSL1 male-specific lethal 1 homolog (Drosophila)
MUSK muscle, skeletal, receptor tyrosine kinase
NARR nine-amino acid residue-repeats
NAV2-AS5 NAV2 antisense RNA 5
NAV3 neuron navigator 3
NCAM1 neural cell adhesion molecule 1
NCLN nicalin
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFRKB nuclear factor related to kappaB binding protein
NRP1 neuropilin 1
NTM neurotrimin
NTN1 netrin 1
NTN3 netrin 3
NUP35 nucleoporin 35kDa
NUP37 nucleoporin 37kDa
ODF2 outer dense fiber of sperm tails 2
PACRG PARK2 co-regulated
PALLD palladin, cytoskeletal associated protein
PCDHGA2 protocadherin gamma subfamily A, 2
PDE4A phosphodiesterase 4A, cAMP-specific
PDLIM7 PDZ and LIM domain 7 (enigma)
PDPN podoplanin
PEBP1 phosphatidylethanolamine binding protein 1
PHACTR2 phosphatase and actin regulator 2
PI15 peptidase inhibitor 15
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPP5D1 PPP5 tetratricopeptide repeat domain containing 1
PRDM8 PR domain containing 8
PRMT7 protein arginine methyltransferase 7
PROX1 prospero homeobox 1
PRR3 proline rich 3
PRUNE2 prune homolog 2 (Drosophila)
PTCH1 patched 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAB37 RAB37, member RAS oncogene family
RAI1 retinoic acid induced 1
RAI14 retinoic acid induced 14
RAP1GAP RAP1 GTPase activating protein
RARG retinoic acid receptor, gamma
RBBP6 retinoblastoma binding protein 6
RCCD1 RCC1 domain containing 1
RDH10 retinol dehydrogenase 10 (all-trans)
RGS22 regulator of G-protein signaling 22
RGS6 regulator of G-protein signaling 6
RNF220 ring finger protein 220
SAMD1 sterile alpha motif domain containing 1
SAMD12-AS1 SAMD12 antisense RNA 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERGEF secretion regulating guanine nucleotide exchange factor
SH3BP1 SH3-domain binding protein 1
SLC26A10 solute carrier family 26, member 10
SLC35F6 solute carrier family 35, member F6
SLC39A5 solute carrier family 39 (zinc transporter), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SNCB synuclein, beta
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX8 SRY (sex determining region Y)-box 8
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4
SPTBN4 spectrin, beta, non-erythrocytic 4
SRGAP2B SLIT-ROBO Rho GTPase activating protein 2B
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
SUFU suppressor of fused homolog (Drosophila)
SYNPO2 synaptopodin 2
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TASP1 taspase, threonine aspartase, 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCF4 transcription factor 4
TENM3 teneurin transmembrane protein 3
TESK1 testis-specific kinase 1
TGIF2 TGFB-induced factor homeobox 2
TGIF2-C20ORF24 TGIF2-C20orf24 readthrough
THADA thyroid adenoma associated
THRAP3 thyroid hormone receptor associated protein 3
THSD7B thrombospondin, type I, domain containing 7B
TMEM184B transmembrane protein 184B
TMEM231 transmembrane protein 231
TMEM256 transmembrane protein 256
TNNC1 troponin C type 1 (slow)
TRAF3IP2 TRAF3 interacting protein 2
TSKU tsukushi, small leucine rich proteoglycan
TSPO2 translocator protein 2
TULP3 tubby like protein 3
TYROBP TYRO protein tyrosine kinase binding protein
UNC80 unc-80 homolog (C. elegans)
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
WDR38 WD repeat domain 38
ZFP90 ZFP90 zinc finger protein
ZNF362 zinc finger protein 362
ZNRF3 zinc and ring finger 3