GMEB1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description glucocorticoid modulatory element binding protein 1|This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 10691)
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Genes

361 genes differentially expressed following the GMEB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC22A10 solute carrier family 22, member 10 3.12045
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.12045
ASPA aspartoacylase 3.12045
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.12045
SHCBP1L SHC SH2-domain binding protein 1-like 3.12045
GFI1 growth factor independent 1 transcription repressor 3.12045
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.12045
TDRD9 tudor domain containing 9 3.12045
OR1L6 olfactory receptor, family 1, subfamily L, member 6 3.12045
CD68 CD68 molecule 3.12045
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.12045
RSPO3 R-spondin 3 3.12045
PAX8 paired box 8 3.12045
SYCP2 synaptonemal complex protein 2 3.12045
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.12045
FAM167A family with sequence similarity 167, member A 3.12045
NPPB natriuretic peptide B 3.12045
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.12045
CELF3 CUGBP, Elav-like family member 3 3.12045
SPINK6 serine peptidase inhibitor, Kazal type 6 3.12045
PGAM4 phosphoglycerate mutase family member 4 3.12045
CCRL2 chemokine (C-C motif) receptor-like 2 3.12045
UMOD uromodulin 3.12045
KRT72 keratin 72, type II 3.12045
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 3.12045
NFE2 nuclear factor, erythroid 2 3.12045
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.12045
TMEM52B transmembrane protein 52B 3.12045
NEUROD2 neuronal differentiation 2 3.12045
ICAM2 intercellular adhesion molecule 2 3.12045
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.12045
LOXL4 lysyl oxidase-like 4 3.12045
ZNF648 zinc finger protein 648 3.12045
IL17B interleukin 17B 3.12045
OXER1 oxoeicosanoid (OXE) receptor 1 3.12045
FXYD3 FXYD domain containing ion transport regulator 3 3.12045
CCDC87 coiled-coil domain containing 87 3.12045
DIO3 deiodinase, iodothyronine, type III 3.12045
MYO1G myosin IG 3.12045
KLLN killin, p53-regulated DNA replication inhibitor 3.12045
HMX3 H6 family homeobox 3 3.12045
CRYAA crystallin, alpha A 3.12045
THEMIS thymocyte selection associated 3.12045
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 3.12045
SLC10A5 solute carrier family 10, member 5 3.12045
EPHB3 EPH receptor B3 3.12045
ARSH arylsulfatase family, member H 3.12045
CDCP2 CUB domain containing protein 2 3.12045
GRXCR1 glutaredoxin, cysteine rich 1 3.12045
CIMIP2A ciliary microtubule inner protein 2A 3.12045
OTOS otospiralin 3.12045
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.12045
DUSP8 dual specificity phosphatase 8 3.12045
FMO2 flavin containing monooxygenase 2 (non-functional) 3.12045
PDC phosducin 3.12045
TFF2 trefoil factor 2 3.12045
IQCF1 IQ motif containing F1 3.12045
PAPOLB poly(A) polymerase beta (testis specific) 3.12045
LY6H lymphocyte antigen 6 complex, locus H 3.12045
IMPG1 interphotoreceptor matrix proteoglycan 1 3.12045
CCDC9B coiled-coil domain containing 9B 3.12045
JAML junction adhesion molecule like 3.12045
SPATA31H1 SPATA31 subfamily H member 1 3.12045
SPEGNB SPEG neighbor 3.12045
CPNE8-AS1 CPNE8 antisense RNA 1 3.12045
LOC128125822 uncharacterized LOC128125822 3.12045
LOC124903372 uncharacterized LOC124903372 3.12045
SRARP steroid receptor associated and regulated protein 3.12045
SMIM35 small integral membrane protein 35 3.12045
SERTM2 serine rich and transmembrane domain containing 2 3.12045
MINDY4B MINDY family member 4B 3.12045
STPG3 sperm-tail PG-rich repeat containing 3 3.12045
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.12045
GATA3 GATA binding protein 3 3.12045
DMBX1 diencephalon/mesencephalon homeobox 1 3.12045
GOLGA7B golgin A7 family, member B 3.12045
IL31RA interleukin 31 receptor A 3.12045
CCDC17 coiled-coil domain containing 17 3.12045
PCDHB12 protocadherin beta 12 3.12045
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.12045
PRB4 proline-rich protein BstNI subfamily 4 3.12045
OASL 2'-5'-oligoadenylate synthetase-like 3.12045
PCDHA8 protocadherin alpha 8 3.12045
LIPJ lipase, family member J 3.12045
AWAT2 acyl-CoA wax alcohol acyltransferase 2 3.12045
MYH13 myosin, heavy chain 13, skeletal muscle 3.12045
GATA2 GATA binding protein 2 3.12045
CLEC6A C-type lectin domain family 6, member A 3.12045
LRRN4CL LRRN4 C-terminal like 3.12045
GDF7 growth differentiation factor 7 3.12045
FMR1NB fragile X mental retardation 1 neighbor 3.12045
PGLYRP3 peptidoglycan recognition protein 3 3.12045
SBSN suprabasin 3.12045
CCR9 chemokine (C-C motif) receptor 9 3.12045
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.12045
SLC45A2 solute carrier family 45, member 2 3.12045
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.12045
IFITM10 interferon induced transmembrane protein 10 3.12045
CFAP47 cilia and flagella associated protein 47 3.12045
DPRX divergent-paired related homeobox 3.12045
ARR3 arrestin 3, retinal (X-arrestin) 3.12045
BTNL2 butyrophilin-like 2 3.12045
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.12045
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.12045
CT55 cancer/testis antigen 55 3.12045
ERICH4 glutamate-rich 4 3.12045
MOBP myelin-associated oligodendrocyte basic protein 3.12045
AQP9 aquaporin 9 3.12045
ZNF132 zinc finger protein 132 3.12045
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.12045
A3GALT2 alpha 1,3-galactosyltransferase 2 3.12045
ZNF366 zinc finger protein 366 3.12045
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.12045
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 3.12045
KLHL41 kelch-like family member 41 3.12045
MKRN3 makorin ring finger protein 3 3.12045
ASTL astacin-like metallo-endopeptidase (M12 family) 3.12045
SST somatostatin 3.12045
KIAA1210 KIAA1210 3.12045
RAB40AL RAB40A, member RAS oncogene family-like 3.12045
AMN amnion associated transmembrane protein 3.12045
RGCC regulator of cell cycle 3.12045
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.12045
LMOD3 leiomodin 3 (fetal) 3.12045
PCDHGA2 protocadherin gamma subfamily A, 2 3.12045
NT5C1A 5'-nucleotidase, cytosolic IA 3.12045
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.12045
LGALS12 lectin, galactoside-binding, soluble, 12 3.12045
APOC2 apolipoprotein C-II 3.12045
C16ORF78 chromosome 16 open reading frame 78 3.12045
TRIM7 tripartite motif containing 7 3.12045
IGIP IgA-inducing protein 3.12045
TSPAN16 tetraspanin 16 3.12045
TSPAN19 tetraspanin 19 3.12045
SPNS3 spinster homolog 3 (Drosophila) 3.12045
AMER3 APC membrane recruitment protein 3 3.12045
NR2E1 nuclear receptor subfamily 2, group E, member 1 3.12045
SSTR1 somatostatin receptor 1 3.12045
CHRM4 cholinergic receptor, muscarinic 4 3.12045
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.12045
TMPRSS15 transmembrane protease, serine 15 3.12045
FCAR Fc fragment of IgA receptor 3.12045
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.12045
CFI complement factor I 3.12045
PARPBP PARP1 binding protein 3.12045
THBD thrombomodulin 3.12045
RTN4RL1 reticulon 4 receptor-like 1 3.12045
CD8A CD8a molecule 3.12045
BPIFC BPI fold containing family C 3.12045
CLEC18A C-type lectin domain family 18, member A 3.12045
TMEM150B transmembrane protein 150B 3.12045
OR3A3 olfactory receptor, family 3, subfamily A, member 3 3.12045
ZMYND15 zinc finger, MYND-type containing 15 3.12045
GRAPL GRB2-related adaptor protein-like 3.12045
PPY pancreatic polypeptide 3.12045
PF4V1 platelet factor 4 variant 1 3.12045
TBC1D26 TBC1 domain family, member 26 3.12045
ZPLD1 zona pellucida-like domain containing 1 3.12045
ADAM18 ADAM metallopeptidase domain 18 3.12045
SMN2 survival of motor neuron 2, centromeric 2.87303
DOCK5 dedicator of cytokinesis 5 2.84286
CFAP410 cilia and flagella associated protein 410 2.8389
AGO4 argonaute RISC catalytic component 4 2.79004
SORBS1 sorbin and SH3 domain containing 1 2.78483
PUF60 poly-U binding splicing factor 60KDa 2.73673
TUBA1B tubulin, alpha 1b 2.71385
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.69964
TPM2 tropomyosin 2 (beta) 2.67423
VWA3A von Willebrand factor A domain containing 3A 2.5778
UBE2F ubiquitin-conjugating enzyme E2F (putative) 2.5778
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.54152
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.54152
C6ORF52 chromosome 6 open reading frame 52 2.5295
EFHC2 EF-hand domain (C-terminal) containing 2 2.51894
PSMC3IP PSMC3 interacting protein 2.49585
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 2.49585
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 2.49522
ZNF660 zinc finger protein 660 2.47452
FBXW11 F-box and WD repeat domain containing 11 2.47176
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.46579
ZNF346 zinc finger protein 346 2.45393
UBAC1 UBA domain containing 1 2.42956
RAP2C RAP2C, member of RAS oncogene family 2.40575
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.40575
FKBP6 FK506 binding protein 6, 36kDa 2.40575
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.40575
YPEL2 yippee-like 2 (Drosophila) 2.40014
LRRC38 leucine rich repeat containing 38 2.33493
PLD3 phospholipase D family, member 3 2.29841
TDP2 tyrosyl-DNA phosphodiesterase 2 2.28198
ADRA1A adrenoceptor alpha 1A 2.26459
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.262
LSM12 LSM12 homolog (S. cerevisiae) 2.23668
TTBK2 tau tubulin kinase 2 2.22421
MCRS1 microspherule protein 1 2.22324
TSPAN4 tetraspanin 4 2.21379
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 2.2068
HMGB2 high mobility group box 2 2.20394
SARS2 seryl-tRNA synthetase 2, mitochondrial 2.20394
CGNL1 cingulin-like 1 2.20384
DOK5 docking protein 5 2.1822
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.1822
LRRN3 leucine rich repeat neuronal 3 2.17614
ANKRD16 ankyrin repeat domain 16 2.17614
ZBTB7B zinc finger and BTB domain containing 7B 2.17614
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.17614
ZNF74 zinc finger protein 74 2.16858
RMP24 ribonuclease MRP subunit p24 2.15108
TMED1 transmembrane emp24 protein transport domain containing 1 2.13731
RHCG Rh family, C glycoprotein 2.13731
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.13731
PLCD4 phospholipase C, delta 4 2.13731
MFAP5 microfibrillar associated protein 5 2.13731
GREP1 glycine rich extracellular protein 1 2.13731
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 2.13731
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.11183
ZNF248 zinc finger protein 248 2.10675
TESK2 testis-specific kinase 2 2.10675
RANGRF RAN guanine nucleotide release factor 2.10675
CHIC2 cysteine-rich hydrophobic domain 2 2.10675
SEC11A SEC11 homolog A (S. cerevisiae) 2.10364
SEZ6L2 seizure related 6 homolog (mouse)-like 2 2.07933
SMIM38 small integral membrane protein 38 2.06419
NPAS2 neuronal PAS domain protein 2 2.06419
WAPL WAPL cohesin release factor 2.06264
TBC1D23 TBC1 domain family, member 23 2.06009
MAN2A1 mannosidase, alpha, class 2A, member 1 2.05936
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.05827
NOTCH2NLA notch 2 N-terminal like A 2.05626
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.05271
NBAS neuroblastoma amplified sequence 2.05179
ASB7 ankyrin repeat and SOCS box containing 7 2.04061
RABEPK Rab9 effector protein with kelch motifs 2.03764
GSE1 Gse1 coiled-coil protein 2.03573
GAS1 growth arrest-specific 1 2.03573
SULF2 sulfatase 2 2.03342
ERCC4 excision repair cross-complementation group 4 2.02842
DNAAF2 dynein, axonemal, assembly factor 2 2.00237

decreased expression

Symbol Name Standardized Value
SPMAP2L sperm microtubule associated protein 2 like -3.12045
PSCA prostate stem cell antigen -3.12045
CRYGN crystallin, gamma N -3.12045
GYS2 glycogen synthase 2 (liver) -3.12045
TLDC2 TBC/LysM-associated domain containing 2 -3.12045
TPH1 tryptophan hydroxylase 1 -3.12045
FGF21 fibroblast growth factor 21 -3.12045
GH1 growth hormone 1 -3.12045
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -3.12045
PDCD1 programmed cell death 1 -3.12045
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -3.12045
KCNIP3 Kv channel interacting protein 3, calsenilin -3.12045
CLEC11A C-type lectin domain family 11, member A -3.12045
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -3.12045
LOC122526780 uncharacterized LOC122526780 -3.12045
CFAP157 cilia and flagella associated protein 157 -3.12045
RTL5 retrotransposon Gag like 5 -3.12045
GBP4 guanylate binding protein 4 -3.12045
CDKN2A cyclin-dependent kinase inhibitor 2A -3.12045
BHLHA9 basic helix-loop-helix family, member a9 -3.12045
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.12045
COL20A1 collagen, type XX, alpha 1 -3.12045
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -3.12045
HPCAL4 hippocalcin like 4 -3.12045
SSUH2 ssu-2 homolog (C. elegans) -3.12045
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -3.12045
GPR61 G protein-coupled receptor 61 -3.12045
RASL11B RAS-like, family 11, member B -3.12045
LOC107986837 uncharacterized LOC107986837 -3.12045
MSMP microseminoprotein, prostate associated -3.12045
AMH anti-Mullerian hormone -3.12045
CALR3 calreticulin 3 -3.12045
KLK4 kallikrein-related peptidase 4 -3.12045
IL19 interleukin 19 -3.12045
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -3.12045
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -3.12045
VMO1 vitelline membrane outer layer 1 homolog (chicken) -3.12045
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -3.09787
CLDN15 claudin 15 -2.92552
CRB2 crumbs family member 2 -2.84395
BAIAP2L1 BAI1-associated protein 2-like 1 -2.74852
ZNF624 zinc finger protein 624 -2.71709
GBA1 glucosylceramidase beta 1 -2.68666
SOX8 SRY (sex determining region Y)-box 8 -2.67389
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) -2.5778
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.57309
H4C2 H4 clustered histone 2 -2.56662
SERTM1 serine-rich and transmembrane domain containing 1 -2.5585
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -2.51894
NOL11 nucleolar protein 11 -2.51084
FYTTD1 forty-two-three domain containing 1 -2.50738
AHCYL2 adenosylhomocysteinase-like 2 -2.47851
NAP1L1 nucleosome assembly protein 1-like 1 -2.47851
SCLT1 sodium channel and clathrin linker 1 -2.47851
NCMAP noncompact myelin associated protein -2.47851
GPATCH3 G patch domain containing 3 -2.47851
PAWR PRKC, apoptosis, WT1, regulator -2.44064
AKR1D1 aldo-keto reductase family 1, member D1 -2.43013
TMEM132B transmembrane protein 132B -2.41505
KCTD14 potassium channel tetramerization domain containing 14 -2.40076
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.37499
RBBP7 retinoblastoma binding protein 7 -2.35243
WAC WW domain containing adaptor with coiled-coil -2.33787
RSU1 Ras suppressor protein 1 -2.33787
PRPF38A pre-mRNA processing factor 38A -2.33787
QTMAN queuosine-tRNA mannosyltransferase -2.3251
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.3251
DGKD diacylglycerol kinase, delta 130kDa -2.32302
TMEM272 transmembrane protein 272 -2.31826
TMEM81 transmembrane protein 81 -2.31826
LPAR1 lysophosphatidic acid receptor 1 -2.29247
FAM107B family with sequence similarity 107, member B -2.28228
TIPIN TIMELESS interacting protein -2.2709
VCF2 VCP nuclear cofactor family member 2 -2.26035
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.22421
PDLIM5 PDZ and LIM domain 5 -2.22421
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.22421
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -2.22233
ERF Ets2 repressor factor -2.2068
CENPM centromere protein M -2.1921
ATG4A autophagy related 4A, cysteine peptidase -2.18211
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -2.17872
H2AJ H2A.J histone -2.17614
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M -2.17614
PRR36 proline rich 36 -2.1747
MEAF6 MYST/Esa1-associated factor 6 -2.13731
UBE2O ubiquitin-conjugating enzyme E2O -2.13731
NANOS3 nanos homolog 3 (Drosophila) -2.13731
RCAN2 regulator of calcineurin 2 -2.11183
ZBTB22 zinc finger and BTB domain containing 22 -2.10809
SSRP1 structure specific recognition protein 1 -2.10675
CASR calcium-sensing receptor -2.10675
CDC123 cell division cycle 123 -2.10675
PCDHA1 protocadherin alpha 1 -2.10675
E2F1 E2F transcription factor 1 -2.10675
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 -2.10675
PCDHA13 protocadherin alpha 13 -2.10675
JAG2 jagged 2 -2.10675
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.10675
BTK Bruton agammaglobulinemia tyrosine kinase -2.10675
RABL6 RAB, member RAS oncogene family-like 6 -2.10656
OXA1L oxidase (cytochrome c) assembly 1-like -2.09411
RNLS renalase, FAD-dependent amine oxidase -2.09077
NUTF2 nuclear transport factor 2 -2.09077
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -2.09077
ERCC1 excision repair cross-complementation group 1 -2.08012
MOB1A MOB kinase activator 1A -2.07933
SDCBP syndecan binding protein (syntenin) -2.07933
ATG4B autophagy related 4B, cysteine peptidase -2.07933
IFITM2 interferon induced transmembrane protein 2 -2.07933
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.07137
GPR156 G protein-coupled receptor 156 -2.05271
SPRY2 sprouty homolog 2 (Drosophila) -2.05271
FAXDC2 fatty acid hydroxylase domain containing 2 -2.05051
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -2.0491
UCMA upper zone of growth plate and cartilage matrix associated -2.04736
FBXO21 F-box protein 21 -2.04509
TTYH2 tweety family member 2 -2.04061
C11ORF24 chromosome 11 open reading frame 24 -2.03573
ZNF444 zinc finger protein 444 -2.03573
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.03573
ARHGAP17 Rho GTPase activating protein 17 -2.03573
SUMF2 sulfatase modifying factor 2 -2.00237