GNAQ Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description guanine nucleotide binding protein (G protein), q polypeptide|This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 2776)
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Genes

362 genes differentially expressed following the GNAQ gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.4069
WNT3A wingless-type MMTV integration site family, member 3A 3.4069
HES3 hes family bHLH transcription factor 3 3.4069
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.4069
CCNB3 cyclin B3 3.4069
SLC25A41 solute carrier family 25, member 41 3.4069
PROB1 proline-rich basic protein 1 3.4069
CCL5 chemokine (C-C motif) ligand 5 3.4069
GJB5 gap junction protein, beta 5, 31.1kDa 3.4069
PAX7 paired box 7 3.4069
APOA2 apolipoprotein A-II 3.4069
FETUB fetuin B 3.4069
PDYN prodynorphin 3.4069
GFRA3 GDNF family receptor alpha 3 3.4069
SBK2 SH3 domain binding kinase family, member 2 3.4069
CFHR3 complement factor H-related 3 3.4069
TMPRSS11F transmembrane protease, serine 11F 3.4069
CST11 cystatin 11 3.4069
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 3.4069
MYBPHL myosin binding protein H-like 3.4069
MAP3K7CL MAP3K7 C-terminal like 3.4069
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative) 3.4069
SLC16A11 solute carrier family 16, member 11 3.4069
PRICKLE4 prickle homolog 4 (Drosophila) 3.4069
TMEM176A transmembrane protein 176A 3.4069
OLIG3 oligodendrocyte transcription factor 3 3.4069
NUGGC nuclear GTPase, germinal center associated 3.4069
PRDM16 PR domain containing 16 3.4069
CLCN1 chloride channel, voltage-sensitive 1 3.4069
RNF39 ring finger protein 39 3.4069
HIC1 hypermethylated in cancer 1 3.4069
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 3.4069
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.4069
ARSH arylsulfatase family, member H 3.4069
CCDC87 coiled-coil domain containing 87 3.4069
RNASE6 ribonuclease, RNase A family, k6 3.4069
PCDHGA11 protocadherin gamma subfamily A, 11 3.4069
HRG histidine-rich glycoprotein 3.4069
ATOH1 atonal homolog 1 (Drosophila) 3.4069
BRICD5 BRICHOS domain containing 5 3.4069
GPR22 G protein-coupled receptor 22 3.4069
LIM2 lens intrinsic membrane protein 2, 19kDa 3.4069
KCNRG potassium channel regulator 3.4069
ADGB androglobin 3.4069
CXCL2 chemokine (C-X-C motif) ligand 2 3.4069
GUCY2F guanylate cyclase 2F, retinal 3.4069
LRRC10B leucine rich repeat containing 10B 3.4069
RGPD4 RANBP2-like and GRIP domain containing 4 3.4069
TTLL9 tubulin tyrosine ligase-like family member 9 3.4069
SHE Src homology 2 domain containing E 3.4069
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.4069
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A 3.4069
SYCP2 synaptonemal complex protein 2 3.4069
SPATA31G1 SPATA31 subfamily G member 1 3.4069
LOC122539214 Zinc finger protein LOC122539214 3.4069
STING1 stimulator of interferon response cGAMP interactor 1 3.4069
TLE7 TLE family member 7 3.4069
ARX aristaless related homeobox 3.4069
OXSR1 oxidative stress responsive 1 3.4069
YIPF7 Yip1 domain family, member 7 3.4069
ROPN1L rhophilin associated tail protein 1-like 3.4069
CXCL13 chemokine (C-X-C motif) ligand 13 3.4069
KRT80 keratin 80, type II 3.4069
SPRR2F small proline-rich protein 2F 3.4069
FOXN4 forkhead box N4 3.4069
CCN6 cellular communication network factor 6 3.4069
CLXN calaxin 3.4069
CIMAP2 ciliary microtubule associated protein 2 3.4069
THSD8 thrombospondin type 1 domain containing 8 3.4069
DUSP13B dual specificity phosphatase 13B 3.4069
C8ORF90 chromosome 8 open reading frame 90 3.4069
LOC124903233 uncharacterized LOC124903233 3.4069
H3C14 H3 clustered histone 14 3.4069
TMEM269 transmembrane protein 269 3.4069
IQCN IQ motif containing N 3.4069
TENT5D terminal nucleotidyltransferase 5D 3.4069
GARIN1A golgi associated RAB2 interactor 1A 3.4069
RTL9 retrotransposon Gag like 9 3.4069
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 3.4069
TMPRSS4 transmembrane protease, serine 4 3.4069
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.4069
CKM creatine kinase, muscle 3.4069
IL31RA interleukin 31 receptor A 3.4069
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.4069
TRIM60 tripartite motif containing 60 3.4069
TEX101 testis expressed 101 3.4069
ZBTB16 zinc finger and BTB domain containing 16 3.4069
LOC128125816 uncharacterized LOC128125816 3.4069
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.4069
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.4069
FPR2 formyl peptide receptor 2 3.4069
CXCL16 chemokine (C-X-C motif) ligand 16 3.4069
IL6 interleukin 6 3.4069
ADRB3 adrenoceptor beta 3 3.4069
CSAG2 CSAG family, member 2 3.4069
PNPLA1 patatin-like phospholipase domain containing 1 3.4069
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.4069
OR2D3 olfactory receptor, family 2, subfamily D, member 3 3.4069
FAM131C family with sequence similarity 131, member C 3.4069
IL1RN interleukin 1 receptor antagonist 3.4069
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.4069
ZFP3 ZFP3 zinc finger protein 3.4069
INSRR insulin receptor-related receptor 3.4069
TLR5 toll-like receptor 5 3.4069
ZNF99 zinc finger protein 99 3.4069
FXYD3 FXYD domain containing ion transport regulator 3 3.4069
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.4069
GOLGA6C golgin A6 family, member C 3.4069
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.4069
HAVCR1 hepatitis A virus cellular receptor 1 3.4069
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.4069
PCDHGA3 protocadherin gamma subfamily A, 3 3.4069
LMOD3 leiomodin 3 (fetal) 3.4069
VWA3B von Willebrand factor A domain containing 3B 3.4069
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.4069
LRRK2 leucine-rich repeat kinase 2 3.4069
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.4069
FLRT3 fibronectin leucine rich transmembrane protein 3 3.4069
CPSF4L cleavage and polyadenylation specific factor 4-like 3.4069
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 3.4069
CNTF ciliary neurotrophic factor 3.4069
DYDC1 DPY30 domain containing 1 3.4069
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.4069
KLHL6 kelch-like family member 6 3.4069
GRK1 G protein-coupled receptor kinase 1 3.4069
THTPA thiamine triphosphatase 3.4069
AQP4 aquaporin 4 3.4069
C9ORF64 chromosome 9 open reading frame 64 3.4069
ZNF843 zinc finger protein 843 3.4069
ASTL astacin-like metallo-endopeptidase (M12 family) 3.4069
SAMD5 sterile alpha motif domain containing 5 3.4069
TRIM7 tripartite motif containing 7 3.4069
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.4069
EFCC1 EF-hand and coiled-coil domain containing 1 3.4069
TYR tyrosinase 3.4069
KLHDC1 kelch domain containing 1 3.4069
CCDC78 coiled-coil domain containing 78 3.4069
EOMES eomesodermin 3.4069
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.4069
PHACTR3 phosphatase and actin regulator 3 3.4069
TMPPE transmembrane protein with metallophosphoesterase domain 3.4069
PLCD4 phospholipase C, delta 4 3.4069
ATP10B ATPase, class V, type 10B 3.4069
MSR1 macrophage scavenger receptor 1 3.4069
LY96 lymphocyte antigen 96 3.4069
ZC3H12D zinc finger CCCH-type containing 12D 3.4069
TPPP3 tubulin polymerization-promoting protein family member 3 3.4069
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.4069
FCRLB Fc receptor-like B 3.4069
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.4069
VAV1 vav 1 guanine nucleotide exchange factor 3.4069
IP6K3 inositol hexakisphosphate kinase 3 3.4069
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.4069
ESAM endothelial cell adhesion molecule 3.4069
CARD6 caspase recruitment domain family, member 6 3.4069
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 3.4069
CLCNKB chloride channel, voltage-sensitive Kb 3.4069
CLEC2A C-type lectin domain family 2, member A 3.4069
FGF10 fibroblast growth factor 10 3.4069
TMEM86B transmembrane protein 86B 3.4069
GLT6D1 glycosyltransferase 6 domain containing 1 3.4069
CLPSL2 colipase-like 2 3.4069
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 3.4069
POPDC2 popeye domain containing 2 3.4069
ABRA actin binding Rho activating protein 3.4069
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.4069
TGM3 transglutaminase 3 3.4069
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 3.4069
PSD2 pleckstrin and Sec7 domain containing 2 3.4069
IER5L immediate early response 5-like 3.4069
RORC RAR-related orphan receptor C 3.4069
FRMPD2 FERM and PDZ domain containing 2 3.4069
KDM6A lysine (K)-specific demethylase 6A 3.37363
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 3.30789
RUNDC3B RUN domain containing 3B 3.26576
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 3.26576
BMPER BMP binding endothelial regulator 3.24716
PNRC2 proline-rich nuclear receptor coactivator 2 3.11777
CCDC93 coiled-coil domain containing 93 3.11777
ADRA2A adrenoceptor alpha 2A 3.05202
NOTCH2NLC notch 2 N-terminal like C 3.01949
RHOF ras homolog family member F (in filopodia) 2.92911
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2.91417
SPIRE1 spire-type actin nucleation factor 1 2.88557
ANKIB1 ankyrin repeat and IBR domain containing 1 2.88557
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.78195
INPP5J inositol polyphosphate-5-phosphatase J 2.73006
BEND4 BEN domain containing 4 2.6775
MAPK14 mitogen-activated protein kinase 14 2.65575
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.63411
OSBPL10 oxysterol binding protein-like 10 2.62616
ARHGAP42 Rho GTPase activating protein 42 2.58641
SLC35E2B solute carrier family 35, member E2B 2.58348
C1ORF116 chromosome 1 open reading frame 116 2.5217
ACAN aggrecan 2.50439
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.50439
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.43475
NPAS2 neuronal PAS domain protein 2 2.42089
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 2.41161
TMPRSS5 transmembrane protease, serine 5 2.41161
SLC16A6 solute carrier family 16, member 6 2.40865
PRIM2 primase, DNA, polypeptide 2 (58kDa) 2.40467
GON7 GON7 subunit of KEOPS complex 2.36543
FAM3C family with sequence similarity 3, member C 2.35711
NKIRAS2 NFKB inhibitor interacting Ras-like 2 2.35422
SRPK2 SRSF protein kinase 2 2.3363
NEURL1B neuralized E3 ubiquitin protein ligase 1B 2.32834
ACAA1 acetyl-CoA acyltransferase 1 2.32834
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.32493
RPL3L ribosomal protein L3-like 2.31964
REM2 RAS (RAD and GEM)-like GTP binding 2 2.29204
TECTA tectorin alpha 2.29204
PCDH20 protocadherin 20 2.29204
HBEGF heparin-binding EGF-like growth factor 2.29204
CTSO cathepsin O 2.29204
ZNF524 zinc finger protein 524 2.29204
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.29204
CFAP74 cilia and flagella associated protein 74 2.29204
ZCCHC18 zinc finger, CCHC domain containing 18 2.29204
TTC17 tetratricopeptide repeat domain 17 2.29204
SLC44A5 solute carrier family 44, member 5 2.27634
DOCK7 dedicator of cytokinesis 7 2.26874
PGS1 phosphatidylglycerophosphate synthase 1 2.26007
TJP3 tight junction protein 3 2.25708
POU6F1 POU class 6 homeobox 1 2.25708
WDR41 WD repeat domain 41 2.25708
PCSK1 proprotein convertase subtilisin/kexin type 1 2.24385
ADCY1 adenylate cyclase 1 (brain) 2.23539
FLCN folliculin 2.22155
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 2.2177
TMEM220 transmembrane protein 220 2.18043
FIGN fidgetin 2.17958
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.15313
TTC33 tetratricopeptide repeat domain 33 2.15226
DCLRE1C DNA cross-link repair 1C 2.11555
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.10286
FIGNL1 fidgetin-like 1 2.10007
KPNA5 karyopherin alpha 5 (importin alpha 6) 2.07401
BCAP31 B-cell receptor-associated protein 31 2.05402
DCAF8 DDB1 and CUL4 associated factor 8 2.04794
NUTM1 NUT midline carcinoma, family member 1 2.04286
KCTD5 potassium channel tetramerization domain containing 5 2.03807
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 2.02661
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 2.02537
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 2.00446
FYB2 FYN binding protein 2 2.0012

decreased expression

Symbol Name Standardized Value
KIAA2012 KIAA2012 -3.4069
ZNF473 zinc finger protein 473 -3.4069
COL11A2 collagen, type XI, alpha 2 -3.4069
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -3.4069
MPZL2 myelin protein zero-like 2 -3.4069
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.4069
SOX8 SRY (sex determining region Y)-box 8 -3.4069
SSUH2 ssu-2 homolog (C. elegans) -3.4069
C22ORF15 chromosome 22 open reading frame 15 -3.4069
MYF6 myogenic factor 6 (herculin) -3.4069
TGM2 transglutaminase 2 -3.4069
PADI2 peptidyl arginine deiminase, type II -3.4069
BMP4 bone morphogenetic protein 4 -3.4069
SNPH syntaphilin -3.4069
LDHC lactate dehydrogenase C -3.4069
FAM161B family with sequence similarity 161, member B -3.4069
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -3.4069
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -3.4069
CEP295NL CEP295 N-terminal like -3.4069
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -3.4069
NFAM1 NFAT activating protein with ITAM motif 1 -3.4069
COL7A1 collagen, type VII, alpha 1 -3.4069
KLF9 Kruppel-like factor 9 -3.4069
ESR1 estrogen receptor 1 -3.4069
PCDHA11 protocadherin alpha 11 -3.4069
MYZAP myocardial zonula adherens protein -3.4069
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -3.4069
BEND6 BEN domain containing 6 -3.4069
C2ORF81 chromosome 2 open reading frame 81 -3.4069
CFAP90 cilia and flagella associated protein 90 -3.4069
ZCCHC12 zinc finger, CCHC domain containing 12 -3.4069
CHL1 cell adhesion molecule L1-like -3.4069
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -3.4069
GDA guanine deaminase -3.4069
PTPRN protein tyrosine phosphatase, receptor type, N -3.4069
HUS1B HUS1 checkpoint homolog b (S. pombe) -3.4069
CD40 CD40 molecule, TNF receptor superfamily member 5 -3.4069
BCO1 beta-carotene oxygenase 1 -3.4069
FSD2 fibronectin type III and SPRY domain containing 2 -3.32681
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -3.32681
ELMO2 engulfment and cell motility 2 -3.31337
TGFBR3L transforming growth factor, beta receptor III-like -3.29787
RPLP0 ribosomal protein, large, P0 -3.19871
SEC24C SEC24 family member C -3.08302
EIF5A eukaryotic translation initiation factor 5A -2.85345
PRICKLE1 prickle homolog 1 (Drosophila) -2.76882
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.75285
LDAF1 lipid droplet assembly factor 1 -2.66553
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -2.6651
TMEM63A transmembrane protein 63A -2.63411
KLRG1 killer cell lectin-like receptor subfamily G, member 1 -2.62393
RABEPK Rab9 effector protein with kelch motifs -2.62393
ZNF684 zinc finger protein 684 -2.60817
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.58865
CNBD2 cyclic nucleotide binding domain containing 2 -2.58865
STAB2 stabilin 2 -2.58865
UBIAD1 UbiA prenyltransferase domain containing 1 -2.58792
ZDHHC7 zinc finger, DHHC-type containing 7 -2.5868
CHKA choline kinase alpha -2.58641
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 -2.58348
VGF VGF nerve growth factor inducible -2.57516
ZNF577 zinc finger protein 577 -2.57516
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -2.51418
RPL10 ribosomal protein L10 -2.50439
CADM2 cell adhesion molecule 2 -2.48165
AFF4 AF4/FMR2 family, member 4 -2.47926
LINC02762 long intergenic non-protein coding RNA 2762 -2.45663
REP15 RAB15 effector protein -2.45663
DTX2 deltex 2, E3 ubiquitin ligase -2.44658
ARL9 ADP-ribosylation factor-like 9 -2.43184
JAG2 jagged 2 -2.43184
EIF1AX eukaryotic translation initiation factor 1A, X-linked -2.43184
WDR31 WD repeat domain 31 -2.43184
NUDT4B nudix hydrolase 4B -2.43184
SAMM50 SAMM50 sorting and assembly machinery component -2.42517
RPL24 ribosomal protein L24 -2.4232
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.42089
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.42089
ZNF223 zinc finger protein 223 -2.42089
ARG1 arginase 1 -2.39434
KRT18 keratin 18, type I -2.38191
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.36543
TET2 tet methylcytosine dioxygenase 2 -2.3644
EPPK1 epiplakin 1 -2.33213
NBN nibrin -2.31872
GAPVD1 GTPase activating protein and VPS9 domains 1 -2.29862
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.29209
LYN LYN proto-oncogene, Src family tyrosine kinase -2.29204
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.29204
LMOD1 leiomodin 1 (smooth muscle) -2.29204
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.29204
FPGT fucose-1-phosphate guanylyltransferase -2.29204
LYRM1 LYR motif containing 1 -2.29204
CANT1 calcium activated nucleotidase 1 -2.27353
PRUNE1 prune exopolyphosphatase 1 -2.25708
EMP2 epithelial membrane protein 2 -2.25708
MRPL40 mitochondrial ribosomal protein L40 -2.24214
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.23539
NRG4 neuregulin 4 -2.21999
PDE8A phosphodiesterase 8A -2.21895
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -2.18355
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.16375
HDAC2 histone deacetylase 2 -2.14472
PLA2G3 phospholipase A2, group III -2.10829
ANGPTL2 angiopoietin-like 2 -2.06764
ITGA7 integrin, alpha 7 -2.06663
PARD6B par-6 family cell polarity regulator beta -2.05904
GAS2 growth arrest-specific 2 -2.03994
PABPC1L poly(A) binding protein, cytoplasmic 1-like -2.02363
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -2.02306
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.02306
XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like -2.01596
RAB39B RAB39B, member RAS oncogene family -2.01103
RAB3C RAB3C, member RAS oncogene family -2.00481
MED27 mediator complex subunit 27 -2.00228
ZMAT4 zinc finger, matrin-type 4 -2.00211