GNAS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description GNAS complex locus|This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012] (NCBI Entrez Gene Database, 2778)
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Genes

284 genes differentially expressed following the GNAS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.20104
SH2D6 SH2 domain containing 6 3.20104
GRXCR2 glutaredoxin, cysteine rich 2 3.20104
HORMAD2 HORMA domain containing 2 3.20104
GLYAT glycine-N-acyltransferase 3.20104
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.20104
NXPH4 neurexophilin 4 3.20104
CELF3 CUGBP, Elav-like family member 3 3.20104
CD19 CD19 molecule 3.20104
ENTHD1 ENTH domain containing 1 3.20104
IZUMO3 IZUMO family member 3 3.20104
SACK1A scaffolding CK1 anchoring protein A 3.20104
SCGN secretagogin, EF-hand calcium binding protein 3.20104
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.20104
ASB15 ankyrin repeat and SOCS box containing 15 3.20104
NAPSA napsin A aspartic peptidase 3.20104
GPR4 G protein-coupled receptor 4 3.20104
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.20104
GJB5 gap junction protein, beta 5, 31.1kDa 3.20104
AADACL3 arylacetamide deacetylase-like 3 3.20104
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 3.20104
SNAI2 snail family zinc finger 2 3.20104
NPB neuropeptide B 3.20104
SLC10A5 solute carrier family 10, member 5 3.20104
NWD1 NACHT and WD repeat domain containing 1 3.20104
HMX3 H6 family homeobox 3 3.20104
TP53TG5 TP53 target 5 3.20104
BFSP2 beaded filament structural protein 2, phakinin 3.20104
TMEM121 transmembrane protein 121 3.20104
DLL4 delta-like 4 (Drosophila) 3.20104
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.20104
ANKK1 ankyrin repeat and kinase domain containing 1 3.20104
CLEC5A C-type lectin domain family 5, member A 3.20104
SMIM9 small integral membrane protein 9 3.20104
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.20104
C9ORF152 chromosome 9 open reading frame 152 3.20104
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.20104
GPR20 G protein-coupled receptor 20 3.20104
FOXD1 forkhead box D1 3.20104
OASL 2'-5'-oligoadenylate synthetase-like 3.20104
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.20104
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.20104
PNLIPRP2 pancreatic lipase-related protein 2 3.20104
CD300LF CD300 molecule-like family member f 3.20104
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.20104
KY kyphoscoliosis peptidase 3.20104
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.20104
ANGPTL8 angiopoietin like 8 3.20104
CCDC198 coiled-coil domain containing 198 3.20104
AJM1 apical junction component 1 homolog 3.20104
SPATA46 spermatogenesis associated 46 3.20104
CCDC190 coiled-coil domain containing 190 3.20104
CHCT1 CHD1 helical C-terminal domain containing 1 3.20104
GSTT4 glutathione S-transferase theta 4 3.20104
CFAP299 cilia and flagella associated protein 299 3.20104
EXOC1L exocyst complex component 1 like 3.20104
LITAFD LITAF domain containing 3.20104
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.20104
ASB9 ankyrin repeat and SOCS box containing 9 3.20104
OSTN osteocrin 3.20104
CLDN5 claudin 5 3.20104
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 3.20104
SPDYE18 speedy/RINGO cell cycle regulator family member E18 3.20104
DMBX1 diencephalon/mesencephalon homeobox 1 3.20104
ZNF575 zinc finger protein 575 3.20104
OVOL3 ovo-like zinc finger 3 3.20104
TLR4 toll-like receptor 4 3.20104
SPMAP1 sperm microtubule associated protein 1 3.20104
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.20104
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.20104
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.20104
GTSF1 gametocyte specific factor 1 3.20104
PGA5 pepsinogen 5, group I (pepsinogen A) 3.20104
GPR132 G protein-coupled receptor 132 3.20104
ASIC4 acid sensing (proton gated) ion channel family member 4 3.20104
WDR93 WD repeat domain 93 3.20104
SYT15 synaptotagmin XV 3.20104
TBC1D3I TBC1 domain family member 3I 3.20104
APOA1 apolipoprotein A-I 3.20104
PCDHA11 protocadherin alpha 11 3.20104
LRCOL1 leucine rich colipase-like 1 3.20104
CTXN2 cortexin 2 3.20104
CABP7 calcium binding protein 7 3.20104
HP haptoglobin 3.20104
STAB1 stabilin 1 3.20104
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.20104
RORC RAR-related orphan receptor C 3.20104
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.20104
TSPAN32 tetraspanin 32 3.20104
PRSS55 protease, serine, 55 3.20104
DMRT1 doublesex and mab-3 related transcription factor 1 3.20104
MC5R melanocortin 5 receptor 3.20104
MAEL maelstrom spermatogenic transposon silencer 3.20104
NUTM2B NUT family member 2B 3.20104
EPO erythropoietin 3.20104
TMEM132E transmembrane protein 132E 3.20104
CLIC5 chloride intracellular channel 5 3.20104
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.20104
SVOP SV2 related protein homolog (rat) 3.20104
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.20104
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 3.20104
CFAP47 cilia and flagella associated protein 47 3.20104
IFNL4 interferon, lambda 4 (gene/pseudogene) 3.20104
DRD5 dopamine receptor D5 3.20104
SAMD5 sterile alpha motif domain containing 5 3.20104
NIPAL4 NIPA-like domain containing 4 3.20104
SPINK9 serine peptidase inhibitor, Kazal type 9 3.20104
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.20104
S100Z S100 calcium binding protein Z 3.20104
HHATL hedgehog acyltransferase-like 3.20104
CALR3 calreticulin 3 3.20104
ETNPPL ethanolamine-phosphate phospho-lyase 3.20104
LCNL1 lipocalin-like 1 3.20104
USP17L2 ubiquitin specific peptidase 17-like family member 2 3.20104
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.20104
PF4V1 platelet factor 4 variant 1 3.20104
ADAM20 ADAM metallopeptidase domain 20 3.20104
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.20104
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.20104
DENND2D DENN/MADD domain containing 2D 3.20104
NLRP14 NLR family, pyrin domain containing 14 3.20104
IL33 interleukin 33 3.20104
PLA2G1B phospholipase A2, group IB (pancreas) 3.20104
SLC36A3 solute carrier family 36, member 3 3.20104
CLNK cytokine-dependent hematopoietic cell linker 3.20104
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.20104
NLRP5 NLR family, pyrin domain containing 5 3.20104
MEIS2 Meis homeobox 2 3.20104
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.20104
IGIP IgA-inducing protein 3.20104
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.20104
LHX3 LIM homeobox 3 3.20104
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 3.20104
SNTN sentan, cilia apical structure protein 3.20104
ANKRD7 ankyrin repeat domain 7 3.20104
CLEC4A C-type lectin domain family 4, member A 3.20104
PLCD4 phospholipase C, delta 4 3.20104
GRAPL GRB2-related adaptor protein-like 3.20104
LRRC31 leucine rich repeat containing 31 3.20104
CD27 CD27 molecule 3.20104
ARGFX arginine-fifty homeobox 3.20104
CLCNKB chloride channel, voltage-sensitive Kb 3.20104
PPP1R3D protein phosphatase 1, regulatory subunit 3D 3.13872
NLRP1 NLR family, pyrin domain containing 1 3.13872
RPL18A ribosomal protein L18a 2.77376
KIFAP3 kinesin-associated protein 3 2.74793
DCTPP1 dCTP pyrophosphatase 1 2.66135
PARVB parvin, beta 2.6378
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.63567
SP140 SP140 nuclear body protein 2.56554
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.54869
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.54329
FOXI3 forkhead box I3 2.52983
GAS2L1 growth arrest-specific 2 like 1 2.51948
TRIOBP TRIO and F-actin binding protein 2.502
MLIP muscular LMNA-interacting protein 2.502
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.502
PCDH11X protocadherin 11 X-linked 2.49128
CNR2 cannabinoid receptor 2 (macrophage) 2.48597
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.48597
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 2.42814
C4ORF36 chromosome 4 open reading frame 36 2.40624
KIAA1755 KIAA1755 2.33853
NPSR1 neuropeptide S receptor 1 2.33853
DGAT2 diacylglycerol O-acyltransferase 2 2.33853
SAP25 Sin3A-associated protein, 25kDa 2.33853
KCTD4 potassium channel tetramerization domain containing 4 2.33853
CSNK1D casein kinase 1, delta 2.33653
LCLAT1 lysocardiolipin acyltransferase 1 2.29532
HMGN5 high mobility group nucleosome binding domain 5 2.23758
SRP54 signal recognition particle 54kDa 2.23164
ZC3HC1 zinc finger, C3HC-type containing 1 2.22695
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 2.21618
GATD1 glutamine amidotransferase class 1 domain containing 1 2.20553
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.20314
TENT4A terminal nucleotidyltransferase 4A 2.20314
FAM117B family with sequence similarity 117, member B 2.14347
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.14347
CSKMT citrate synthase lysine methyltransferase 2.14339
C1QTNF12 C1q and TNF related 12 2.13003
FRG1 FSHD region gene 1 2.13003
ZNF385B zinc finger protein 385B 2.11788
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.11234
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.11234
MRPS24 mitochondrial ribosomal protein S24 2.08083
EMC8 ER membrane protein complex subunit 8 2.08083
STRIP2 striatin interacting protein 2 2.06724
WWC3 WWC family member 3 2.02022
C12ORF57 chromosome 12 open reading frame 57 2.02022
C2ORF92 chromosome 2 open reading frame 92 2.02022
CCHCR1 coiled-coil alpha-helical rod protein 1 2.00914
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 2.00108

decreased expression

Symbol Name Standardized Value
UPK2 uroplakin 2 -3.20104
MED4 mediator complex subunit 4 -3.20104
KCTD11 potassium channel tetramerization domain containing 11 -3.20104
DOC2B double C2-like domains, beta -3.20104
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -3.20104
GGACT gamma-glutamylamine cyclotransferase -3.20104
CFAP100 cilia and flagella associated protein 100 -3.20104
FAT1 FAT atypical cadherin 1 -2.93098
STPG4 sperm-tail PG-rich repeat containing 4 -2.81764
CNN1 calponin 1, basic, smooth muscle -2.78326
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.78052
C1ORF146 chromosome 1 open reading frame 146 -2.77915
C11ORF87 chromosome 11 open reading frame 87 -2.77915
AOC1 amine oxidase, copper containing 1 -2.77915
OXER1 oxoeicosanoid (OXE) receptor 1 -2.77915
VPREB3 pre-B lymphocyte 3 -2.77915
RAG1 recombination activating gene 1 -2.77915
ZPBP zona pellucida binding protein -2.77915
NPIPA5 nuclear pore complex interacting protein family, member A5 -2.77915
CHD5 chromodomain helicase DNA binding protein 5 -2.77915
TTLL2 tubulin tyrosine ligase-like family member 2 -2.77915
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -2.77915
LHX1 LIM homeobox 1 -2.77915
TMPRSS13 transmembrane protease, serine 13 -2.77915
ALLC allantoicase -2.77915
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -2.77915
C1QL2 complement component 1, q subcomponent-like 2 -2.77915
AMBP alpha-1-microglobulin/bikunin precursor -2.77915
DRD3 dopamine receptor D3 -2.77915
LURAP1L leucine rich adaptor protein 1-like -2.77915
DNAH2 dynein, axonemal, heavy chain 2 -2.77915
LYG2 lysozyme G-like 2 -2.77915
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -2.77915
C11ORF42 chromosome 11 open reading frame 42 -2.77915
SLC46A3 solute carrier family 46, member 3 -2.77915
CCNB3 cyclin B3 -2.77915
BCAS1 breast carcinoma amplified sequence 1 -2.77915
SRI sorcin -2.77471
NABP2 nucleic acid binding protein 2 -2.7572
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.73719
VASH2 vasohibin 2 -2.72556
CALCB calcitonin-related polypeptide beta -2.64472
MARCKSL1 MARCKS-like 1 -2.64236
ADAM32 ADAM metallopeptidase domain 32 -2.58014
B9D1 B9 protein domain 1 -2.48555
LHX4 LIM homeobox 4 -2.47971
B4GAT1-DT B4GAT1 divergent transcript -2.47315
LMBR1 limb development membrane protein 1 -2.46289
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.43654
UBA5 ubiquitin-like modifier activating enzyme 5 -2.42962
SLC25A27 solute carrier family 25, member 27 -2.42962
NCAPD2 non-SMC condensin I complex, subunit D2 -2.37364
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.37364
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.37364
PMP22 peripheral myelin protein 22 -2.37364
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.37364
ZNF225 zinc finger protein 225 -2.37364
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -2.33853
MICB MHC class I polypeptide-related sequence B -2.33853
OSTC oligosaccharyltransferase complex subunit (non-catalytic) -2.30739
ST7L suppression of tumorigenicity 7 like -2.27883
JAM2 junctional adhesion molecule 2 -2.26842
BMP8A bone morphogenetic protein 8a -2.26815
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.26491
TMEM240 transmembrane protein 240 -2.25889
GLCCI1 glucocorticoid induced 1 -2.25776
C1ORF94 chromosome 1 open reading frame 94 -2.20717
C12ORF56 chromosome 12 open reading frame 56 -2.20553
PTPRO protein tyrosine phosphatase, receptor type, O -2.20314
C12ORF43 chromosome 12 open reading frame 43 -2.15061
ZNF775 zinc finger protein 775 -2.13396
RIPK4 receptor-interacting serine-threonine kinase 4 -2.13003
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -2.11234
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.11234
YBX1 Y box binding protein 1 -2.09828
CACHD1 cache domain containing 1 -2.08732
XYLT1 xylosyltransferase I -2.08474
ITM2B integral membrane protein 2B -2.07887
PDE9A phosphodiesterase 9A -2.06724
ZZZ3 zinc finger, ZZ-type containing 3 -2.05808
NCOA1 nuclear receptor coactivator 1 -2.05647
SMC1B structural maintenance of chromosomes 1B -2.05419
MCM2 minichromosome maintenance complex component 2 -2.03751
CCDC80 coiled-coil domain containing 80 -2.03459
CROCC ciliary rootlet coiled-coil, rootletin -2.02022
SKIDA1 SKI/DACH domain containing 1 -2.02022
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.02022
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 -2.01858
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.01858
ALOX12 arachidonate 12-lipoxygenase -2.01858
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.01253
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.01