GNB1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description guanine nucleotide binding protein (G protein), beta polypeptide 1|Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] (NCBI Entrez Gene Database, 2782)
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Genes

321 genes differentially expressed following the GNB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PDILT protein disulfide isomerase-like, testis expressed 3.36761
PLIN1 perilipin 1 3.36761
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.36761
SPINK6 serine peptidase inhibitor, Kazal type 6 3.36761
WNT3A wingless-type MMTV integration site family, member 3A 3.36761
GLYAT glycine-N-acyltransferase 3.36761
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.36761
IQCJ IQ motif containing J 3.36761
DUSP10 dual specificity phosphatase 10 3.36761
FFAR4 free fatty acid receptor 4 3.36761
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.36761
SLC46A3 solute carrier family 46, member 3 3.36761
GPR6 G protein-coupled receptor 6 3.36761
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.36761
CD5 CD5 molecule 3.36761
MYBPHL myosin binding protein H-like 3.36761
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.36761
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.36761
WDR87 WD repeat domain 87 3.36761
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.36761
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 3.36761
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.36761
NUGGC nuclear GTPase, germinal center associated 3.36761
GPR26 G protein-coupled receptor 26 3.36761
ACY3 aminoacylase 3 3.36761
FAM9B family with sequence similarity 9, member B 3.36761
EPHB3 EPH receptor B3 3.36761
NR4A2 nuclear receptor subfamily 4, group A, member 2 3.36761
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.36761
LEP leptin 3.36761
FXYD2 FXYD domain containing ion transport regulator 2 3.36761
PSD2 pleckstrin and Sec7 domain containing 2 3.36761
R3HDML R3H domain containing-like 3.36761
SPN sialophorin 3.36761
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.36761
SLC23A3 solute carrier family 23, member 3 3.36761
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.36761
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.36761
EDDM3B epididymal protein 3B 3.36761
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.36761
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.36761
CRH corticotropin releasing hormone 3.36761
KYNU kynureninase 3.36761
OC90 otoconin 90 3.36761
IRX5 iroquois homeobox 5 3.36761
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.36761
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.36761
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.36761
ROPN1B rhophilin associated tail protein 1B 3.36761
AVPR1A arginine vasopressin receptor 1A 3.36761
VN1R1 vomeronasal 1 receptor 1 3.36761
MLN motilin 3.36761
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 3.36761
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.36761
PCP4L1 Purkinje cell protein 4 like 1 3.36761
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 3.36761
GOLGA6L7 golgin A6 family like 7 3.36761
PCNX1 pecanex 1 3.36761
SPEGNB SPEG neighbor 3.36761
LRRC8C-DT LRRC8C divergent transcript 3.36761
C1ORF232 chromosome 1 open reading frame 230 3.36761
STPG3 sperm-tail PG-rich repeat containing 3 3.36761
DNAAF6 dynein axonemal assembly factor 6 3.36761
H2BW2 H2B.W histone 2 3.36761
TERB2 telomere repeat binding bouquet formation protein 2 3.36761
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.36761
RTL9 retrotransposon Gag like 9 3.36761
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.36761
FMR1NB fragile X mental retardation 1 neighbor 3.36761
ARHGAP15 Rho GTPase activating protein 15 3.36761
IL31RA interleukin 31 receptor A 3.36761
LTBP2 latent transforming growth factor beta binding protein 2 3.36761
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.36761
RHOXF2 Rhox homeobox family, member 2 3.36761
RLBP1 retinaldehyde binding protein 1 3.36761
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 3.36761
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.36761
FPR3 formyl peptide receptor 3 3.36761
FPR1 formyl peptide receptor 1 3.36761
AXDND1 axonemal dynein light chain domain containing 1 3.36761
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 3.36761
IL1R1 interleukin 1 receptor, type I 3.36761
RBM44 RNA binding motif protein 44 3.36761
PLB1 phospholipase B1 3.36761
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.36761
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.36761
FAM186A family with sequence similarity 186, member A 3.36761
TBX3 T-box 3 3.36761
ZIC4 Zic family member 4 3.36761
LIX1 Lix1 homolog (chicken) 3.36761
SLC22A10 solute carrier family 22, member 10 3.36761
BANF2 barrier to autointegration factor 2 3.36761
FIGLA folliculogenesis specific basic helix-loop-helix 3.36761
FNDC8 fibronectin type III domain containing 8 3.36761
LRRC46 leucine rich repeat containing 46 3.36761
AKR1B15 aldo-keto reductase family 1, member B15 3.36761
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.36761
SLC38A3 solute carrier family 38, member 3 3.36761
NOG noggin 3.36761
CLDN34 claudin 34 3.36761
CERKL ceramide kinase-like 3.36761
SPZ1 spermatogenic leucine zipper 1 3.36761
CAPSL calcyphosine-like 3.36761
ANKRD62 ankyrin repeat domain 62 3.36761
TSPAN32 tetraspanin 32 3.36761
HSPB2 heat shock 27kDa protein 2 3.36761
CH25H cholesterol 25-hydroxylase 3.36761
OR8H1 olfactory receptor, family 8, subfamily H, member 1 3.36761
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.36761
KRT15 keratin 15, type I 3.36761
LRRC32 leucine rich repeat containing 32 3.36761
KLHL6 kelch-like family member 6 3.36761
C11ORF91 chromosome 11 open reading frame 91 3.36761
ARR3 arrestin 3, retinal (X-arrestin) 3.36761
HRCT1 histidine rich carboxyl terminus 1 3.36761
OR14J1 olfactory receptor, family 14, subfamily J, member 1 3.36761
NTN5 netrin 5 3.36761
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.36761
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.36761
PROK1 prokineticin 1 3.36761
C20ORF144 chromosome 20 open reading frame 144 3.36761
ART1 ADP-ribosyltransferase 1 3.36761
CHI3L2 chitinase 3-like 2 3.36761
ALOXE3 arachidonate lipoxygenase 3 3.36761
CPSF4L cleavage and polyadenylation specific factor 4-like 3.36761
GCOM1 GRINL1A complex locus 1 3.36761
BPI bactericidal/permeability-increasing protein 3.36761
TIGD3 tigger transposable element derived 3 3.36761
UBXN10 UBX domain protein 10 3.36761
ZIM2 zinc finger, imprinted 2 3.36761
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.36761
MUC16 mucin 16, cell surface associated 3.36761
FGG fibrinogen gamma chain 3.36761
PRSS55 protease, serine, 55 3.36761
PHOX2A paired-like homeobox 2a 3.36761
TMEM86B transmembrane protein 86B 3.36761
CHAD chondroadherin 3.36761
OTP orthopedia homeobox 3.36761
ZBED6 zinc finger, BED-type containing 6 3.36761
FOXP3 forkhead box P3 3.36761
ETV3L ets variant 3-like 3.36761
IL10RA interleukin 10 receptor, alpha 3.36761
SFTA2 surfactant associated 2 3.36761
TMPRSS13 transmembrane protease, serine 13 3.36761
PCDHAC1 protocadherin alpha subfamily C, 1 3.36761
GLT6D1 glycosyltransferase 6 domain containing 1 3.36761
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.36761
ADRA1B adrenoceptor alpha 1B 3.36761
PADI4 peptidyl arginine deiminase, type IV 3.36761
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 3.36761
GRAPL GRB2-related adaptor protein-like 3.36761
GH1 growth hormone 1 3.36761
CARNS1 carnosine synthase 1 3.36761
PXT1 peroxisomal, testis specific 1 3.36761
ACKR2 atypical chemokine receptor 2 3.36761
FADS6 fatty acid desaturase 6 3.36761
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.36761
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.36761
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.36761
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.36761
C9ORF57 chromosome 9 open reading frame 57 3.36761
MMP3 matrix metallopeptidase 3 3.36761
ZSCAN9 zinc finger and SCAN domain containing 9 3.03008
ZIC2 Zic family member 2 2.98765
TOP2A topoisomerase (DNA) II alpha 170kDa 2.95379
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.83712
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.78598
COPS6 COP9 signalosome subunit 6 2.72284
SESTD1 SEC14 and spectrin domains 1 2.70627
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2.67563
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.65969
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.61957
H2AC25 H2A clustered histone 25 2.61678
WWOX WW domain containing oxidoreductase 2.60734
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.58102
NOPCHAP1 NOP protein chaperone 1 2.58081
KCTD15 potassium channel tetramerization domain containing 15 2.56069
UXT ubiquitously-expressed, prefoldin-like chaperone 2.51168
FBXO21 F-box protein 21 2.42665
CLDN12 claudin 12 2.41382
E2F5 E2F transcription factor 5, p130-binding 2.3828
ENG endoglin 2.37682
H2BC15 H2B clustered histone 15 2.3721
PHACTR4 phosphatase and actin regulator 4 2.35889
NXF1 nuclear RNA export factor 1 2.35444
MICA MHC class I polypeptide-related sequence A 2.35117
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.34809
LMF2 lipase maturation factor 2 2.34809
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 2.30434
CTNS cystinosin, lysosomal cystine transporter 2.27195
TMEM88 transmembrane protein 88 2.26102
SHOX2 short stature homeobox 2 2.26102
FNTB farnesyltransferase, CAAX box, beta 2.26102
WDR91 WD repeat domain 91 2.23971
GJB7 gap junction protein, beta 7, 25kDa 2.23858
AKR1D1 aldo-keto reductase family 1, member D1 2.20947
HAPLN2 hyaluronan and proteoglycan link protein 2 2.20947
RPH3A rabphilin 3A 2.20947
SHLD3 shieldin complex subunit 3 2.20947
SLC22A24 solute carrier family 22, member 24 2.20947
PSD4 pleckstrin and Sec7 domain containing 4 2.20947
EPHA10 EPH receptor A10 2.20947
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.20367
LSMEM1 leucine-rich single-pass membrane protein 1 2.19092
CD99 CD99 molecule 2.1842
RPN2 ribophorin II 2.1718
XRN1 5'-3' exoribonuclease 1 2.16637
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.13933
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.11584
SLC22A17 solute carrier family 22, member 17 2.11034
COL27A1 collagen, type XXVII, alpha 1 2.08229
TEP1 telomerase-associated protein 1 2.05696
MSRA methionine sulfoxide reductase A 2.05625
MUS81 MUS81 structure-specific endonuclease subunit 2.05409
TCF12 transcription factor 12 2.02743
CPVL carboxypeptidase, vitellogenic-like 2.01905
RPL37 ribosomal protein L37 2.01011
NPAT nuclear protein, ataxia-telangiectasia locus 2.01011
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.00312

decreased expression

Symbol Name Standardized Value
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -3.36761
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -3.36761
RGPD5 RANBP2-like and GRIP domain containing 5 -3.36761
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -3.36761
FLT3LG fms-related tyrosine kinase 3 ligand -3.36761
GAL3ST2 galactose-3-O-sulfotransferase 2 -3.36761
CCR3 chemokine (C-C motif) receptor 3 -3.36761
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -3.36761
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -3.36761
POF1B premature ovarian failure, 1B -3.36761
BLCAP bladder cancer associated protein -3.36761
ADAM21 ADAM metallopeptidase domain 21 -3.36761
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -3.36761
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.36761
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -3.36761
CHRND cholinergic receptor, nicotinic, delta (muscle) -3.36761
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -3.36761
CHADL chondroadherin-like -3.36761
DNAH2 dynein, axonemal, heavy chain 2 -3.36761
NOTO notochord homeobox -3.36761
CD22 CD22 molecule -3.36761
LPO lactoperoxidase -3.36761
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -3.36761
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -3.36761
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 -3.36761
THBD thrombomodulin -3.36761
CFAP65 cilia and flagella associated protein 65 -3.36761
SIGLEC7 sialic acid binding Ig-like lectin 7 -3.36761
SVOP SV2 related protein homolog (rat) -3.36761
PODNL1 podocan-like 1 -3.36761
RIPPLY2 ripply transcriptional repressor 2 -3.36761
LOC122526780 uncharacterized LOC122526780 -3.36761
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -3.36761
ABLIM3 actin binding LIM protein family, member 3 -3.36761
C11ORF42 chromosome 11 open reading frame 42 -3.36761
CDK20 cyclin-dependent kinase 20 -3.36761
C22ORF42 chromosome 22 open reading frame 42 -3.36761
BAHCC1 BAH domain and coiled-coil containing 1 -3.36761
ELN elastin -3.3427
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -3.14891
BRD4 bromodomain containing 4 -3.03931
FDX2 ferredoxin 2 -3.03931
NDNF neuron-derived neurotrophic factor -3.0358
LINC02560 long intergenic non-protein coding RNA 2560 -3.0358
PHETA2 PH domain containing endocytic trafficking adaptor 2 -2.98765
LINC02762 long intergenic non-protein coding RNA 2762 -2.96886
TTLL5 tubulin tyrosine ligase-like family member 5 -2.93911
CREG2 cellular repressor of E1A-stimulated genes 2 -2.89851
COPS3 COP9 signalosome subunit 3 -2.67563
TRIM56 tripartite motif containing 56 -2.66214
TMEM181 transmembrane protein 181 -2.65219
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -2.61978
SEPTIN8 septin 8 -2.55902
RTF2 replication termination factor 2 -2.50472
CDYL chromodomain protein, Y-like -2.4944
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 -2.4944
PLAUR plasminogen activator, urokinase receptor -2.41975
SIRT4 sirtuin 4 -2.3828
NTNG2 netrin G2 -2.3828
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.3828
SYNM synemin, intermediate filament protein -2.3828
MYOZ1 myozenin 1 -2.3828
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.38154
EXOC3L2 exocyst complex component 3-like 2 -2.38154
ASB16 ankyrin repeat and SOCS box containing 16 -2.38154
UPK1B uroplakin 1B -2.38154
ZFP57 ZFP57 zinc finger protein -2.37682
TRAPPC6A trafficking protein particle complex 6A -2.33537
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -2.31688
LIG3 ligase III, DNA, ATP-dependent -2.3166
KLHL28 kelch-like family member 28 -2.31176
HCK HCK proto-oncogene, Src family tyrosine kinase -2.30891
RBM48 RNA binding motif protein 48 -2.30325
GPX8 glutathione peroxidase 8 (putative) -2.28734
ARHGAP17 Rho GTPase activating protein 17 -2.2847
RNF141 ring finger protein 141 -2.25806
TEX15 testis expressed 15 -2.24085
MBD5 methyl-CpG binding domain protein 5 -2.22267
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.22088
RRAGC Ras-related GTP binding C -2.19883
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic -2.18792
SLIT3 slit homolog 3 (Drosophila) -2.18763
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.14522
STK11 serine/threonine kinase 11 -2.14522
ATF6 activating transcription factor 6 -2.13772
ZNF664-RFLNA ZNF664-RFLNA readthrough -2.13315
EXOC5 exocyst complex component 5 -2.12908
FAM43A family with sequence similarity 43, member A -2.12608
NMT2 N-myristoyltransferase 2 -2.11584
TTLL11 tubulin tyrosine ligase-like family member 11 -2.11475
PGCKA1 PDCD10 and GCKIII kinases associated 1 -2.11034
POFUT4 protein O-fucosyltransferase 4 -2.11034
PKD1 polycystic kidney disease 1 (autosomal dominant) -2.11034
ZNG1F Zn regulated GTPase metalloprotein activator 1F -2.10869
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.07395
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -2.0446
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.04055
CCM2 cerebral cavernous malformation 2 -2.04055
SARAF store-operated calcium entry-associated regulatory factor -2.03842
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.01973
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.01011
MYOZ3 myozenin 3 -2.00682