GNE Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase|The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10020)
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Genes

361 genes differentially expressed following the GNE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LRRD1 leucine-rich repeats and death domain containing 1 3.67782
SIGLEC7 sialic acid binding Ig-like lectin 7 3.67782
BATF basic leucine zipper transcription factor, ATF-like 3.67782
FNDC7 fibronectin type III domain containing 7 3.67782
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.67782
KCNRG potassium channel regulator 3.67782
BIRC3 baculoviral IAP repeat containing 3 3.67782
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.67782
SFTPD surfactant protein D 3.67782
BAAT bile acid CoA:amino acid N-acyltransferase 3.67782
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.67782
EPHX4 epoxide hydrolase 4 3.67782
PAX9 paired box 9 3.67782
PDE7B phosphodiesterase 7B 3.67782
PI15 peptidase inhibitor 15 3.67782
PRICKLE4 prickle homolog 4 (Drosophila) 3.67782
NXPH3 neurexophilin 3 3.67782
PGAM2 phosphoglycerate mutase 2 (muscle) 3.67782
TRIM15 tripartite motif containing 15 3.67782
FGL1 fibrinogen-like 1 3.67782
TM4SF1 transmembrane 4 L six family member 1 3.67782
NCF1 neutrophil cytosolic factor 1 3.67782
BLK BLK proto-oncogene, Src family tyrosine kinase 3.67782
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 3.67782
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 3.67782
RPL3L ribosomal protein L3-like 3.67782
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 3.67782
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.67782
PRR29 proline rich 29 3.67782
LVRN laeverin 3.67782
RTP1 receptor (chemosensory) transporter protein 1 3.67782
HIC1 hypermethylated in cancer 1 3.67782
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.67782
SPAG8 sperm associated antigen 8 3.67782
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.67782
LHX1 LIM homeobox 1 3.67782
EYA4 EYA transcriptional coactivator and phosphatase 4 3.67782
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.67782
SPHK1 sphingosine kinase 1 3.67782
TMC8 transmembrane channel-like 8 3.67782
TMEM79 transmembrane protein 79 3.67782
TTLL9 tubulin tyrosine ligase-like family member 9 3.67782
C8ORF74 chromosome 8 open reading frame 74 3.67782
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.67782
NPIPA2 nuclear pore complex interacting protein family, member A2 3.67782
LRRC66 leucine rich repeat containing 66 3.67782
HYPK huntingtin interacting protein K 3.67782
PRDM12 PR domain containing 12 3.67782
DENND6B DENN/MADD domain containing 6B 3.67782
CPLX1 complexin 1 3.67782
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.67782
CFHR3 complement factor H-related 3 3.67782
FAM240A family with sequence similarity 240 member A 3.67782
UNC93A unc-93 homolog A (C. elegans) 3.67782
UNC5CL unc-5 homolog C (C. elegans)-like 3.67782
DNAAF1 dynein, axonemal, assembly factor 1 3.67782
FMO2 flavin containing monooxygenase 2 (non-functional) 3.67782
FOXN4 forkhead box N4 3.67782
WNT16 wingless-type MMTV integration site family, member 16 3.67782
PCP4L1 Purkinje cell protein 4 like 1 3.67782
GATA3 GATA binding protein 3 3.67782
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 3.67782
DLK1 delta-like 1 homolog (Drosophila) 3.67782
KY kyphoscoliosis peptidase 3.67782
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 3.67782
ERVW-1 endogenous retrovirus group W, member 1 3.67782
SERTM2 serine rich and transmembrane domain containing 2 3.67782
GSG1L2 GSG1 like 2 3.67782
CLEC20A C-type lectin domain containing 20A 3.67782
TEX46 testis expressed 46 3.67782
DEUP1 deuterosome assembly protein 1 3.67782
CATSPERZ catsper channel auxiliary subunit zeta 3.67782
MAB21L4 mab-21 like 4 3.67782
TCIM transcriptional and immune response regulator 3.67782
H3-5 H3.5 histone 3.67782
H1-6 H1.6 linker histone, cluster member 3.67782
LGSN lengsin, lens protein with glutamine synthetase domain 3.67782
GDF6 growth differentiation factor 6 3.67782
SAMD11 sterile alpha motif domain containing 11 3.67782
ZBTB16 zinc finger and BTB domain containing 16 3.67782
IRF4 interferon regulatory factor 4 3.67782
VIT vitrin 3.67782
LY6H lymphocyte antigen 6 complex, locus H 3.67782
SLC35D3 solute carrier family 35, member D3 3.67782
LIPF lipase, gastric 3.67782
FAM3D family with sequence similarity 3, member D 3.67782
TBX22 T-box 22 3.67782
TBX20 T-box 20 3.67782
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 3.67782
TSGA10IP testis specific, 10 interacting protein 3.67782
CHRD chordin 3.67782
AMBP alpha-1-microglobulin/bikunin precursor 3.67782
OVOL1 ovo-like zinc finger 1 3.67782
CDKN2A cyclin-dependent kinase inhibitor 2A 3.67782
PGC progastricsin (pepsinogen C) 3.67782
BHLHA9 basic helix-loop-helix family, member a9 3.67782
ZNF575 zinc finger protein 575 3.67782
C1ORF162 chromosome 1 open reading frame 162 3.67782
S1PR1 sphingosine-1-phosphate receptor 1 3.67782
SIM2 single-minded family bHLH transcription factor 2 3.67782
ANXA10 annexin A10 3.67782
VSX2 visual system homeobox 2 3.67782
LTC4S leukotriene C4 synthase 3.67782
ASCL1 achaete-scute family bHLH transcription factor 1 3.67782
TRADD TNFRSF1A-associated via death domain 3.67782
KISS1 KiSS-1 metastasis-suppressor 3.67782
GFI1B growth factor independent 1B transcription repressor 3.67782
SSC5D scavenger receptor cysteine rich family, 5 domains 3.67782
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.67782
KLK15 kallikrein-related peptidase 15 3.67782
MLIP muscular LMNA-interacting protein 3.67782
ERMN ermin, ERM-like protein 3.67782
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.67782
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 3.67782
EPHA5 EPH receptor A5 3.67782
RBM20 RNA binding motif protein 20 3.67782
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.67782
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 3.67782
SHOX short stature homeobox 3.67782
PTGDS prostaglandin D2 synthase 21kDa (brain) 3.67782
IGFBP7 insulin-like growth factor binding protein 7 3.67782
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.67782
CCDC184 coiled-coil domain containing 184 3.67782
WFDC8 WAP four-disulfide core domain 8 3.67782
C11ORF16 chromosome 11 open reading frame 16 3.67782
PSKH2 protein serine kinase H2 3.67782
KLF4 Kruppel-like factor 4 (gut) 3.67782
SNX31 sorting nexin 31 3.67782
NOX1 NADPH oxidase 1 3.67782
GLOD5 glyoxalase domain containing 5 3.67782
UBQLNL ubiquilin-like 3.67782
RANBP3L RAN binding protein 3-like 3.67782
DYDC1 DPY30 domain containing 1 3.67782
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 3.67782
FIBIN fin bud initiation factor homolog (zebrafish) 3.67782
CCDC27 coiled-coil domain containing 27 3.67782
ERICH3 glutamate-rich 3 3.67782
TMEM139 transmembrane protein 139 3.67782
TBC1D21 TBC1 domain family, member 21 3.67782
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.67782
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 3.67782
CCNO cyclin O 3.67782
ADRA1B adrenoceptor alpha 1B 3.67782
OTP orthopedia homeobox 3.67782
ANXA1 annexin A1 3.67782
ANXA8 annexin A8 3.67782
EOMES eomesodermin 3.67782
TTC22 tetratricopeptide repeat domain 22 3.67782
DRC7 dynein regulatory complex subunit 7 3.67782
LIF leukemia inhibitory factor 3.67782
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.67782
EVI2A ecotropic viral integration site 2A 3.67782
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.67782
AOC1 amine oxidase, copper containing 1 3.67782
GSDMA gasdermin A 3.67782
VWC2L von Willebrand factor C domain containing protein 2-like 3.67782
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.67782
ALLC allantoicase 3.67782
MEIS1 Meis homeobox 1 3.67782
RUMY3 RUMY family member 3 3.67782
OTOP2 otopetrin 2 3.67782
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.67782
SLC30A10 solute carrier family 30, member 10 3.67782
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 3.67782
OTOP3 otopetrin 3 3.67782
GPR62 G protein-coupled receptor 62 3.67782
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.67782
EFCC1 EF-hand and coiled-coil domain containing 1 3.67782
APOL6 apolipoprotein L, 6 3.67782
CARD9 caspase recruitment domain family, member 9 3.67782
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 3.67782
ORM2 orosomucoid 2 3.67782
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.67782
PLGLB1 plasminogen-like B1 3.67782
OTUD6B OTU domain containing 6B 3.63505
DSCAML1 Down syndrome cell adhesion molecule like 1 3.50332
RPS11 ribosomal protein S11 3.1968
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 3.14852
GLB1L galactosidase, beta 1-like 3.07956
PDZD7 PDZ domain containing 7 3.07826
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 3.04824
AHNAK AHNAK nucleoprotein 3.03773
LOC102723564 uncharacterized LOC102723564 2.91939
CRIP3 cysteine-rich protein 3 2.89298
CFAP44 cilia and flagella associated protein 44 2.89298
PPP1R3F protein phosphatase 1, regulatory subunit 3F 2.88606
BCAR1 breast cancer anti-estrogen resistance 1 2.87771
GSKIP GSK3B interacting protein 2.87215
TMEM232 transmembrane protein 232 2.83684
TMPRSS2 transmembrane protease, serine 2 2.7949
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.7535
ZC2HC1A zinc finger, C2HC-type containing 1A 2.7203
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.69189
CTPS1 CTP synthase 1 2.68524
B2M beta-2-microglobulin 2.64711
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.62427
TMEM201 transmembrane protein 201 2.61097
HECA headcase homolog (Drosophila) 2.58098
SESN1 sestrin 1 2.56099
THRAP3 thyroid hormone receptor associated protein 3 2.55442
CHML choroideremia-like (Rab escort protein 2) 2.55092
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.5475
RWDD3 RWD domain containing 3 2.5475
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 2.49667
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 2.48665
CFAP276 cilia and flagella associated protein 276 2.45719
SCN3B sodium channel, voltage gated, type III beta subunit 2.45719
NIT1 nitrilase 1 2.45013
WBP2NL WBP2 N-terminal like 2.43838
HHAT hedgehog acyltransferase 2.41956
TECTA tectorin alpha 2.41786
PAH phenylalanine hydroxylase 2.41786
OR2H2 olfactory receptor, family 2, subfamily H, member 2 2.41786
GYPE glycophorin E (MNS blood group) 2.41786
MATN4 matrilin 4 2.41786
SOX21 SRY (sex determining region Y)-box 21 2.41786
EPHA8 EPH receptor A8 2.41786
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.41786
PRKDC protein kinase, DNA-activated, catalytic polypeptide 2.40876
SERINC2 serine incorporator 2 2.40769
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 2.38386
USP48 ubiquitin specific peptidase 48 2.38064
NET1 neuroepithelial cell transforming 1 2.36594
SOX4 SRY (sex determining region Y)-box 4 2.36594
ANKRD53 ankyrin repeat domain 53 2.34923
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 2.34923
PUS7 pseudouridylate synthase 7 (putative) 2.34174
RINL Ras and Rab interactor-like 2.34174
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.34174
ZNF180 zinc finger protein 180 2.3132
TMEM131 transmembrane protein 131 2.30286
KATNIP katanin interacting protein 2.30286
NASP nuclear autoantigenic sperm protein (histone-binding) 2.28578
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 2.26045
GPR108 G protein-coupled receptor 108 2.25926
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 2.2577
LMBR1L limb development membrane protein 1-like 2.25559
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.25189
TMCO1 transmembrane and coiled-coil domains 1 2.24944
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.22404
ELOVL7 ELOVL fatty acid elongase 7 2.14152
NDFIP1 Nedd4 family interacting protein 1 2.14152
SIPA1 signal-induced proliferation-associated 1 2.14152
ASPHD2 aspartate beta-hydroxylase domain containing 2 2.13862
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 2.12662
MRFAP1 Morf4 family associated protein 1 2.10462
ETFB electron-transfer-flavoprotein, beta polypeptide 2.10462
EPHB1 EPH receptor B1 2.06451
CDH24 cadherin 24, type 2 2.05856
SLC7A6OS solute carrier family 7, member 6 opposite strand 2.05856
RFXANK regulatory factor X-associated ankyrin-containing protein 2.0552
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2.04738
CHMP2B charged multivesicular body protein 2B 2.04738
RNF182 ring finger protein 182 2.03357
SLC60A1 solute carrier family 60 member 1 2.02065
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.02043
USP10 ubiquitin specific peptidase 10 2.02003
SUOX sulfite oxidase 2.01068

decreased expression

Symbol Name Standardized Value
ADAT3 adenosine deaminase, tRNA-specific 3 -3.67782
ACBD6 acyl-CoA binding domain containing 6 -3.67782
GIPR gastric inhibitory polypeptide receptor -3.67782
ACTL6B actin-like 6B -3.67782
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -3.67782
TEX38 testis expressed 38 -3.67782
ESR1 estrogen receptor 1 -3.67782
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -3.67782
CRLF2 cytokine receptor-like factor 2 -3.67782
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -3.67782
GRM6 glutamate receptor, metabotropic 6 -3.67782
ZNF597 zinc finger protein 597 -3.67782
PLIN4 perilipin 4 -3.67782
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -3.67782
ZNF557 zinc finger protein 557 -3.67782
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -3.67782
INSYN1 inhibitory synaptic factor 1 -3.67782
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -3.67782
SPACDR sperm acrosome developmental regulator -3.67782
LRRK2 leucine-rich repeat kinase 2 -3.67782
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -3.67782
FBXO43 F-box protein 43 -3.67782
H4C12 H4 clustered histone 12 -3.67782
PLCL1 phospholipase C-like 1 -3.67782
PDCD1LG2 programmed cell death 1 ligand 2 -3.67782
TSPAN16 tetraspanin 16 -3.67782
SMIM35 small integral membrane protein 35 -3.67782
BRDT bromodomain, testis-specific -3.67782
TMEM225B transmembrane protein 225B -3.67782
ZNF547 zinc finger protein 547 -3.67782
DRD4 dopamine receptor D4 -3.67782
JAKMIP1 janus kinase and microtubule interacting protein 1 -3.63606
SHANK3 SH3 and multiple ankyrin repeat domains 3 -3.11376
TRIM25 tripartite motif containing 25 -2.96045
ZDHHC19 zinc finger, DHHC-type containing 19 -2.88228
ZNF888 zinc finger protein 888 -2.88228
GTPBP3 GTP binding protein 3 (mitochondrial) -2.87215
TTC7A tetratricopeptide repeat domain 7A -2.87215
KPNA6 karyopherin alpha 6 (importin alpha 7) -2.83704
TMOD1 tropomodulin 1 -2.64182
ARMC5 armadillo repeat containing 5 -2.64182
C12ORF42 chromosome 12 open reading frame 42 -2.64182
ADRA2B adrenoceptor alpha 2B -2.64182
TMEM231 transmembrane protein 231 -2.56036
FRZB frizzled-related protein -2.52207
RPL41 ribosomal protein L41 -2.52155
CSAD cysteine sulfinic acid decarboxylase -2.4959
EMC1 ER membrane protein complex subunit 1 -2.48721
MANEAL mannosidase, endo-alpha-like -2.47672
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -2.47184
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 -2.45719
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.43881
SMN1 survival of motor neuron 1, telomeric -2.43619
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.41966
ENTREP3 endosomal transmembrane epsin interactor 3 -2.41929
TMEM175 transmembrane protein 175 -2.41786
SEC23IP SEC23 interacting protein -2.40013
CCL28 chemokine (C-C motif) ligand 28 -2.38064
FAM133B family with sequence similarity 133, member B -2.36147
ZDHHC11 zinc finger, DHHC-type containing 11 -2.34174
HPF1 histone PARylation factor 1 -2.33413
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.33309
PRICKLE3 prickle homolog 3 (Drosophila) -2.33309
TMEM35A transmembrane protein 35A -2.33309
PHEX phosphate regulating endopeptidase homolog, X-linked -2.33309
MYB v-myb avian myeloblastosis viral oncogene homolog -2.32043
URM1 ubiquitin related modifier 1 -2.29544
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -2.28578
IL17RA interleukin 17 receptor A -2.27974
MARCHF5 membrane associated ring-CH-type finger 5 -2.27523
KMT5B lysine methyltransferase 5B -2.27334
MAN1A2 mannosidase, alpha, class 1A, member 2 -2.26045
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -2.24218
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -2.21844
CCDC157 coiled-coil domain containing 157 -2.21844
ZFYVE27 zinc finger, FYVE domain containing 27 -2.20646
ATXN3 ataxin 3 -2.20267
MCF2 MCF.2 cell line derived transforming sequence -2.18866
WDR24 WD repeat domain 24 -2.18866
POFUT1 protein O-fucosyltransferase 1 -2.18041
STXBP5L syntaxin binding protein 5-like -2.1681
ADGRG5 adhesion G protein-coupled receptor G5 -2.10407
FGFRL1 fibroblast growth factor receptor-like 1 -2.10407
XPR1 xenotropic and polytropic retrovirus receptor 1 -2.10138
DGKB diacylglycerol kinase, beta 90kDa -2.10138
ZSCAN31 zinc finger and SCAN domain containing 31 -2.10138
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -2.0975
RAB10 RAB10, member RAS oncogene family -2.08824
EIF4A1 eukaryotic translation initiation factor 4A1 -2.05994
STAG1 stromal antigen 1 -2.05736
ZNF235 zinc finger protein 235 -2.05497
ZNF800 zinc finger protein 800 -2.04972
RET ret proto-oncogene -2.04944
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.04944
SCO2 SCO2 cytochrome c oxidase assembly protein -2.03718
BICD1 bicaudal D homolog 1 (Drosophila) -2.02897
ZNF732 zinc finger protein 732 -2.02897
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.02897
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -2.02808
ITGB4 integrin, beta 4 -2.0225
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -2.01902
CYB5A cytochrome b5 type A (microsomal) -2.00561
LRRC58 leucine rich repeat containing 58 -2.00473