GOT1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description glutamic-oxaloacetic transaminase 1, soluble|Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2805)
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Genes

320 genes differentially expressed following the GOT1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
USH1G Usher syndrome 1G (autosomal recessive) 3.18984
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.18984
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.18984
NANOS3 nanos homolog 3 (Drosophila) 3.18984
MAGEA2 melanoma antigen family A2 3.18984
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.18984
PRODH2 proline dehydrogenase (oxidase) 2 3.18984
ZBTB42 zinc finger and BTB domain containing 42 3.18984
SGPP2 sphingosine-1-phosphate phosphatase 2 3.18984
SLC25A41 solute carrier family 25, member 41 3.18984
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.18984
ADGRE3 adhesion G protein-coupled receptor E3 3.18984
PI16 peptidase inhibitor 16 3.18984
SLC22A10 solute carrier family 22, member 10 3.18984
RNF151 ring finger protein 151 3.18984
FOLR1 folate receptor 1 (adult) 3.18984
UPK3A uroplakin 3A 3.18984
CD6 CD6 molecule 3.18984
INHBA inhibin, beta A 3.18984
NAPSA napsin A aspartic peptidase 3.18984
EQTN equatorin, sperm acrosome associated 3.18984
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.18984
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.18984
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.18984
AADACL4 arylacetamide deacetylase-like 4 3.18984
CRYGC crystallin, gamma C 3.18984
IL2RA interleukin 2 receptor, alpha 3.18984
TAS2R13 taste receptor, type 2, member 13 3.18984
SPX spexin hormone 3.18984
LOC105378220 macrophage receptor MARCO-like 3.18984
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.18984
STAP1 signal transducing adaptor family member 1 3.18984
ERAP2 endoplasmic reticulum aminopeptidase 2 3.18984
SPDEF SAM pointed domain containing ETS transcription factor 3.18984
G6PC2 glucose-6-phosphatase, catalytic, 2 3.18984
MEIKIN meiotic kinetochore factor 3.18984
FABP12 fatty acid binding protein 12 3.18984
PAX2 paired box 2 3.18984
SLC15A5 solute carrier family 15, member 5 3.18984
CEP295NL CEP295 N-terminal like 3.18984
LRG1 leucine-rich alpha-2-glycoprotein 1 3.18984
NEU4 sialidase 4 3.18984
SSTR5 somatostatin receptor 5 3.18984
ASPA aspartoacylase 3.18984
OTUD6A OTU deubiquitinase 6A 3.18984
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.18984
GPHB5 glycoprotein hormone beta 5 3.18984
CD34 CD34 molecule 3.18984
HHEX hematopoietically expressed homeobox 3.18984
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.18984
SPATS1 spermatogenesis associated, serine-rich 1 3.18984
BTBD2 BTB (POZ) domain containing 2 3.18984
PTH1R parathyroid hormone 1 receptor 3.18984
ZAR1 zygote arrest 1 3.18984
OPRM1 opioid receptor, mu 1 3.18984
FMO1 flavin containing monooxygenase 1 3.18984
FMO2 flavin containing monooxygenase 2 (non-functional) 3.18984
TMEM40 transmembrane protein 40 3.18984
WNT16 wingless-type MMTV integration site family, member 16 3.18984
TSPAN1 tetraspanin 1 3.18984
STING1 stimulator of interferon response cGAMP interactor 1 3.18984
H1-6 H1.6 linker histone, cluster member 3.18984
SPMIP11 sperm microtubule inner protein 11 3.18984
H4C15 H4 clustered histone 15 3.18984
C20ORF204 chromosome 20 open reading frame 204 3.18984
H4C14 H4 clustered histone 14 3.18984
STPG3 sperm-tail PG-rich repeat containing 3 3.18984
GSTT4 glutathione S-transferase theta 4 3.18984
GARIN1A golgi associated RAB2 interactor 1A 3.18984
C1QTNF12 C1q and TNF related 12 3.18984
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.18984
VSIR V-set immunoregulatory receptor 3.18984
TBX10 T-box 10 3.18984
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.18984
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.18984
TBX3 T-box 3 3.18984
TLR6 toll-like receptor 6 3.18984
ZNF575 zinc finger protein 575 3.18984
CXCL16 chemokine (C-X-C motif) ligand 16 3.18984
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.18984
OR7C1 olfactory receptor, family 7, subfamily C, member 1 3.18984
VIT vitrin 3.18984
PTPRC protein tyrosine phosphatase, receptor type, C 3.18984
PCDHA8 protocadherin alpha 8 3.18984
SPDYC speedy/RINGO cell cycle regulator family member C 3.18984
ARMS2 age-related maculopathy susceptibility 2 3.18984
MROH5 maestro heat-like repeat family member 5 3.18984
SOAT2 sterol O-acyltransferase 2 3.18984
PLEK2 pleckstrin 2 3.18984
ABHD15 abhydrolase domain containing 15 3.18984
PTH parathyroid hormone 3.18984
PGLYRP2 peptidoglycan recognition protein 2 3.18984
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.18984
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.18984
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.18984
GJD4 gap junction protein, delta 4, 40.1kDa 3.18984
ACTL8 actin-like 8 3.18984
MAGEB17 melanoma antigen family B17 3.18984
TBC1D10C TBC1 domain family, member 10C 3.18984
INHA inhibin, alpha 3.18984
GOLGA6A golgin A6 family, member A 3.18984
TDRD10 tudor domain containing 10 3.18984
TRADD TNFRSF1A-associated via death domain 3.18984
CPA2 carboxypeptidase A2 (pancreatic) 3.18984
CDH10 cadherin 10, type 2 (T2-cadherin) 3.18984
TBXA2R thromboxane A2 receptor 3.18984
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.18984
KISS1 KiSS-1 metastasis-suppressor 3.18984
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 3.18984
FAM163A family with sequence similarity 163, member A 3.18984
HSF4 heat shock transcription factor 4 3.18984
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.18984
PLA2G4E phospholipase A2, group IVE 3.18984
MYF5 myogenic factor 5 3.18984
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.18984
C18ORF63 chromosome 18 open reading frame 63 3.18984
EFCAB9 EF-hand calcium binding domain 9 3.18984
UBQLNL ubiquilin-like 3.18984
FATE1 fetal and adult testis expressed 1 3.18984
LCN1 lipocalin 1 3.18984
THBD thrombomodulin 3.18984
FBXO40 F-box protein 40 3.18984
C11ORF42 chromosome 11 open reading frame 42 3.18984
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.18984
CPN2 carboxypeptidase N, polypeptide 2 3.18984
TM4SF19 transmembrane 4 L six family member 19 3.18984
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.18984
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.18984
MB myoglobin 3.18984
CCDC177 coiled-coil domain containing 177 3.18984
UPK1A uroplakin 1A 3.18984
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.18984
FAIM2 Fas apoptotic inhibitory molecule 2 3.18984
NMBR neuromedin B receptor 3.18984
FAM135B family with sequence similarity 135, member B 3.18984
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 3.18984
CTXN3 cortexin 3 3.18984
ITGB7 integrin, beta 7 3.18984
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.18984
TPPP2 tubulin polymerization-promoting protein family member 2 3.18984
TPPP3 tubulin polymerization-promoting protein family member 3 3.18984
LYZ lysozyme 3.18984
SOSTDC1 sclerostin domain containing 1 3.18984
C1ORF105 chromosome 1 open reading frame 105 3.18984
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 3.18984
ZMYND15 zinc finger, MYND-type containing 15 3.18984
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.18984
ALLC allantoicase 3.18984
GRAP2 GRB2-related adaptor protein 2 3.18984
CD8A CD8a molecule 3.18984
APOL3 apolipoprotein L, 3 3.18984
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.18984
ASCL2 achaete-scute family bHLH transcription factor 2 3.18984
CCDC28A coiled-coil domain containing 28A 3.18984
RNF224 ring finger protein 224 3.18984
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.18984
CD226 CD226 molecule 3.18984
IFNK interferon, kappa 3.18984
TMEM176A transmembrane protein 176A 3.18984
SUN3 Sad1 and UNC84 domain containing 3 3.18984
IL17B interleukin 17B 3.18984
APOL4 apolipoprotein L, 4 3.18984
APOL6 apolipoprotein L, 6 3.18984
AREG amphiregulin 3.18984
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.18984
XCR1 chemokine (C motif) receptor 1 3.18984
ACKR2 atypical chemokine receptor 2 3.18984
CLCA4 chloride channel accessory 4 3.18984
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 3.12233
CFAP119 cilia and flagella associated protein 119 3.12233
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2.99162
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.99162
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.79867
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.78757
RPS29 ribosomal protein S29 2.78757
COA6 cytochrome c oxidase assembly factor 6 2.75723
H2BC15 H2B clustered histone 15 2.72313
PDE11A phosphodiesterase 11A 2.71346
PKN2 protein kinase N2 2.68101
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 2.57741
KRABD3 KRAB domain containing 3 2.57741
PTGES3L prostaglandin E synthase 3 (cytosolic)-like 2.5671
UBAP2L ubiquitin associated protein 2-like 2.52142
ZNF521 zinc finger protein 521 2.52075
NELFA negative elongation factor complex member A 2.49021
ZNF12 zinc finger protein 12 2.47675
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.40252
CXADR coxsackie virus and adenovirus receptor 2.39532
IL17C interleukin 17C 2.39532
NLRP10 NLR family, pyrin domain containing 10 2.39532
RPS27 ribosomal protein S27 2.37421
SPEF1 sperm flagellar 1 2.33268
TMEM44 transmembrane protein 44 2.32909
ISCA2 iron-sulfur cluster assembly 2 2.32909
NLRP1 NLR family, pyrin domain containing 1 2.32346
LOXL3 lysyl oxidase-like 3 2.315
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.30893
MTM1 myotubularin 1 2.27633
TMEM196 transmembrane protein 196 2.22911
CD38 CD38 molecule 2.22911
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.22911
FLNC filamin C, gamma 2.22911
C2ORF72 chromosome 2 open reading frame 72 2.22911
NMUR1 neuromedin U receptor 1 2.22911
FBXO15 F-box protein 15 2.22911
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.22911
C18ORF32 chromosome 18 open reading frame 32 2.2209
DARS1 aspartyl-tRNA synthetase 1 2.19262
LGALS1 lectin, galactoside-binding, soluble, 1 2.1683
MFF mitochondrial fission factor 2.1683
NSUN7 NOP2/Sun domain family, member 7 2.16426
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2.16254
NXPH1 neurexophilin 1 2.16254
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.12405
EIF5A2 eukaryotic translation initiation factor 5A2 2.07777
WNT2B wingless-type MMTV integration site family, member 2B 2.06478
MAST2 microtubule associated serine/threonine kinase 2 2.06395
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.05628
SCARA5 scavenger receptor class A, member 5 2.05608
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 2.05248
GJA1 gap junction protein, alpha 1, 43kDa 2.05086
TESC tescalcin 2.05086
VWA5A von Willebrand factor A domain containing 5A 2.05086
ATP5F1D ATP synthase F1 subunit delta 2.04229
PPP1R16A protein phosphatase 1, regulatory subunit 16A 2.01807
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.00153

decreased expression

Symbol Name Standardized Value
TSPAN33 tetraspanin 33 -3.18984
RIOK3 RIO kinase 3 -3.18984
ANKRD45 ankyrin repeat domain 45 -3.18984
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -3.18984
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -3.18984
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -3.18984
ZBTB7C zinc finger and BTB domain containing 7C -3.18984
REEP6 receptor accessory protein 6 -3.12706
INA internexin neuronal intermediate filament protein, alpha -3.11187
ROM1 retinal outer segment membrane protein 1 -3.05009
TLE6 transducin-like enhancer of split 6 -3.05009
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -3.05009
MAPK15 mitogen-activated protein kinase 15 -3.05009
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -3.05009
GH2 growth hormone 2 -3.05009
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.05009
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -3.05009
GADL1 glutamate decarboxylase-like 1 -3.05009
CIMIP3 ciliary microtubule inner protein 3 -3.05009
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -3.05009
SUSD2 sushi domain containing 2 -3.05009
PAX7 paired box 7 -3.05009
PGA5 pepsinogen 5, group I (pepsinogen A) -3.05009
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -3.05009
BBS5 Bardet-Biedl syndrome 5 -3.05009
IGSF22 immunoglobulin superfamily, member 22 -3.05009
SPINK9 serine peptidase inhibitor, Kazal type 9 -3.05009
HCK HCK proto-oncogene, Src family tyrosine kinase -3.05009
PIWIL1 piwi-like RNA-mediated gene silencing 1 -3.05009
VCX3B variable charge, X-linked 3B -3.05009
AANAT aralkylamine N-acetyltransferase -3.05009
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -3.05009
LGALS14 lectin, galactoside-binding, soluble, 14 -3.05009
ZNF114 zinc finger protein 114 -2.92549
C1ORF116 chromosome 1 open reading frame 116 -2.91255
MORN2 MORN repeat containing 2 -2.90993
MFSD12 major facilitator superfamily domain containing 12 -2.79492
NOTCH1 notch 1 -2.73519
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.70981
TOR4A torsin family 4, member A -2.68147
CCDC110 coiled-coil domain containing 110 -2.68107
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -2.63049
CDC20 cell division cycle 20 -2.61143
CSNK1E casein kinase 1, epsilon -2.5963
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 -2.57741
CALHM6 calcium homeostasis modulator family member 6 -2.57741
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -2.51031
CDK7 cyclin-dependent kinase 7 -2.50524
CDK12 cyclin-dependent kinase 12 -2.47675
PTPRG protein tyrosine phosphatase, receptor type, G -2.47236
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -2.46059
CNFN cornifelin -2.45075
CIAO1 cytosolic iron-sulfur assembly component 1 -2.41415
ANAPC10 anaphase promoting complex subunit 10 -2.41226
ZNF628 zinc finger protein 628 -2.40252
BIK BCL2-interacting killer (apoptosis-inducing) -2.39956
PICK1 protein interacting with PRKCA 1 -2.39934
GREB1 growth regulation by estrogen in breast cancer 1 -2.36827
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.33736
BAIAP2 BAI1-associated protein 2 -2.26318
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.26273
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.25738
TMEM19 transmembrane protein 19 -2.25072
CLTA clathrin, light chain A -2.24023
TRUB1 TruB pseudouridine (psi) synthase family member 1 -2.22465
PCTP phosphatidylcholine transfer protein -2.18403
PDE5A phosphodiesterase 5A, cGMP-specific -2.18022
FUBP3 far upstream element (FUSE) binding protein 3 -2.17537
FOXL2 forkhead box L2 -2.1683
AKR1C3 aldo-keto reductase family 1, member C3 -2.16426
AMDHD2 amidohydrolase domain containing 2 -2.16254
EXOSC6 exosome component 6 -2.16254
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.16254
NUTM1 NUT midline carcinoma, family member 1 -2.16187
ZNF331 zinc finger protein 331 -2.12405
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.1213
BPGM 2,3-bisphosphoglycerate mutase -2.11388
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) -2.089
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.07889
DUSP15 dual specificity phosphatase 15 -2.07889
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.07889
ARL4A ADP-ribosylation factor-like 4A -2.07777
LIN7A lin-7 homolog A (C. elegans) -2.07246
STON2 stonin 2 -2.07246
SYN3 synapsin III -2.07111
FBXL7 F-box and leucine-rich repeat protein 7 -2.06493
JAM2 junctional adhesion molecule 2 -2.06493
BICRAL BICRA like chromatin remodeling complex associated protein -2.06395
H2BC21 H2B clustered histone 21 -2.05608
E2F3 E2F transcription factor 3 -2.05608
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -2.04229
CSPG4 chondroitin sulfate proteoglycan 4 -2.02882
RBL2 retinoblastoma-like 2 -2.00936
TRA2B transformer 2 beta homolog (Drosophila) -2.00764