GPI anchor biosynthetic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. (Gene Ontology, GO_0006506)
External Link http://amigo.geneontology.org/amigo/term/GO:0006506
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Genes

27 genes participating in the GPI anchor biosynthetic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
MPPE1 metallophosphoesterase 1
PGAP1 post-GPI attachment to proteins 1
PGAP2 post-GPI attachment to proteins 2
PGAP3 post-GPI attachment to proteins 3
PGAP4 post-GPI attachment to proteins GalNAc transferase 4
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIGM phosphatidylinositol glycan anchor biosynthesis, class M
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGO phosphatidylinositol glycan anchor biosynthesis, class O
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PIGW phosphatidylinositol glycan anchor biosynthesis, class W
PIGY phosphatidylinositol glycan anchor biosynthesis, class Y
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
SLC30A5 solute carrier family 30 (zinc transporter), member 5