| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | glucose-6-phosphate isomerase|This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 2821) |
| External Link | https://ncbi.nlm.nih.gov/gene/2821 |
| Similar Terms | |
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498 genes differentially expressed following the GPI gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CA2 | carbonic anhydrase II | 0.0133075 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.0121175 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0113635 |
| XPO7 | exportin 7 | 0.0109323 |
| ESR1 | estrogen receptor 1 | 0.0106123 |
| RTN2 | reticulon 2 | 0.0105941 |
| PDLIM3 | PDZ and LIM domain 3 | 0.0103906 |
| MT1H | metallothionein 1H | 0.00957966 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.00926135 |
| GUCY2C | guanylate cyclase 2C | 0.00915113 |
| CD200 | CD200 molecule | 0.00892384 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00886835 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00854462 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.00849178 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00847476 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00835778 |
| DES | desmin | 0.008017 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00799588 |
| GAS1 | growth arrest-specific 1 | 0.00799158 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.0079714 |
| WT1 | Wilms tumor 1 | 0.00794574 |
| WDR61 | WD repeat domain 61 | 0.00787873 |
| COG2 | component of oligomeric golgi complex 2 | 0.00787828 |
| MT1F | metallothionein 1F | 0.00779687 |
| CLTB | clathrin, light chain B | 0.00779599 |
| MT1G | metallothionein 1G | 0.00773401 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | 0.00760499 |
| FRZB | frizzled-related protein | 0.00747881 |
| PRDX2 | peroxiredoxin 2 | 0.00743701 |
| ANXA6 | annexin A6 | 0.00727833 |
| RCAN1 | regulator of calcineurin 1 | 0.00727033 |
| SLC38A1 | solute carrier family 38, member 1 | 0.00725334 |
| ACTC1 | actin, alpha, cardiac muscle 1 | 0.00717829 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.00715134 |
| PLN | phospholamban | 0.00710544 |
| MT1E | metallothionein 1E | 0.00704455 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00703278 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00696949 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00689812 |
| S100A7 | S100 calcium binding protein A7 | 0.00688453 |
| MT1X | metallothionein 1X | 0.00687179 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.00686099 |
| TNNI1 | troponin I type 1 (skeletal, slow) | 0.0068043 |
| MB | myoglobin | 0.00677149 |
| TSPAN7 | tetraspanin 7 | 0.00675426 |
| HEPH | hephaestin | 0.00674057 |
| THY1 | Thy-1 cell surface antigen | 0.00673819 |
| PLK1 | polo-like kinase 1 | 0.00658423 |
| GATA6 | GATA binding protein 6 | 0.00658034 |
| CDC42 | cell division cycle 42 | 0.00655715 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 0.0064815 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00639557 |
| CLIC3 | chloride intracellular channel 3 | 0.00632975 |
| KRT1 | keratin 1, type II | 0.00629695 |
| ACAT1 | acetyl-CoA acetyltransferase 1 | 0.00629042 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00625477 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00624948 |
| MATN2 | matrilin 2 | 0.00623417 |
| FABP1 | fatty acid binding protein 1, liver | 0.00621587 |
| DENND1B | DENN/MADD domain containing 1B | 0.00617135 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00614273 |
| SULF1 | sulfatase 1 | 0.00613576 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.00606801 |
| PODXL | podocalyxin-like | 0.00605648 |
| CPE | carboxypeptidase E | 0.00602177 |
| PWP1 | PWP1 homolog (S. cerevisiae) | 0.00597211 |
| VLDLR | very low density lipoprotein receptor | 0.00597114 |
| NDRG1 | N-myc downstream regulated 1 | 0.00594864 |
| CBR4 | carbonyl reductase 4 | 0.00593538 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.00592205 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | 0.00592095 |
| STON1 | stonin 1 | 0.00590006 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00586007 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00585659 |
| NLGN4X | neuroligin 4, X-linked | 0.00581311 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.00579564 |
| FLNC | filamin C, gamma | 0.00578719 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0057802 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00576305 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | 0.00575213 |
| PEX2 | peroxisomal biogenesis factor 2 | 0.00569868 |
| CALML3 | calmodulin-like 3 | 0.00569475 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00569389 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00568514 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 0.00566271 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00564212 |
| RAB4A | RAB4A, member RAS oncogene family | 0.00561683 |
| OAT | ornithine aminotransferase | 0.00560743 |
| CKM | creatine kinase, muscle | 0.00557311 |
| TAGLN | transgelin | 0.00556543 |
| PLCL1 | phospholipase C-like 1 | 0.00555738 |
| TMEM45A | transmembrane protein 45A | 0.00554894 |
| RXRA | retinoid X receptor, alpha | 0.00554034 |
| POSTN | periostin, osteoblast specific factor | 0.00551629 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | 0.00551297 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0055122 |
| NSG1 | neuron specific gene family member 1 | 0.00550867 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.00550602 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.00549423 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.00547096 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00545351 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | 0.00544088 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00542752 |
| SLN | sarcolipin | 0.00542459 |
| SRP72 | signal recognition particle 72kDa | 0.00540751 |
| DSG1 | desmoglein 1 | 0.00540194 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00539911 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.00538898 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 0.00538832 |
| FBXO21 | F-box protein 21 | 0.00537655 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00535278 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00533489 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.00533351 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 0.00532848 |
| TFF1 | trefoil factor 1 | 0.00531856 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00531226 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.00531036 |
| FERMT1 | fermitin family member 1 | 0.00530401 |
| OSR2 | odd-skipped related transciption factor 2 | 0.00530022 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) | 0.0052749 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.00527327 |
| NUP85 | nucleoporin 85kDa | 0.00527261 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00526209 |
| PKP2 | plakophilin 2 | 0.00522612 |
| KLK8 | kallikrein-related peptidase 8 | 0.00521672 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00521232 |
| RAB25 | RAB25, member RAS oncogene family | 0.00515978 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.00514849 |
| MEF2C | myocyte enhancer factor 2C | 0.00513733 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00513123 |
| TOR1A | torsin family 1, member A (torsin A) | 0.0051303 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.00508657 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.00507586 |
| PUF60 | poly-U binding splicing factor 60KDa | 0.00507162 |
| SOSTDC1 | sclerostin domain containing 1 | 0.0050649 |
| COMP | cartilage oligomeric matrix protein | 0.00503747 |
| MT2A | metallothionein 2A | 0.00502863 |
| KLHL41 | kelch-like family member 41 | 0.00500968 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00500297 |
| NELL2 | NEL-like 2 (chicken) | 0.00498494 |
| UNG | uracil-DNA glycosylase | 0.00498256 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.00498125 |
| CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | 0.00497697 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | 0.00495471 |
| ENO3 | enolase 3 (beta, muscle) | 0.00493938 |
| SST | somatostatin | 0.00492026 |
| AMH | anti-Mullerian hormone | 0.00491715 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.00490137 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0049007 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.00489907 |
| NREP | neuronal regeneration related protein | 0.0048971 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.00489669 |
| CDC20 | cell division cycle 20 | 0.00486777 |
| RAI2 | retinoic acid induced 2 | 0.00486541 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.00486292 |
| CHKB | choline kinase beta | 0.00486155 |
| RHCG | Rh family, C glycoprotein | 0.00486067 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00485014 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.00483136 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00483037 |
| EFHD1 | EF-hand domain family, member D1 | 0.00482501 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.00482012 |
| FCGBP | Fc fragment of IgG binding protein | 0.00481671 |
| PDLIM5 | PDZ and LIM domain 5 | 0.00480044 |
| E2F2 | E2F transcription factor 2 | 0.00479634 |
| GRAMD2B | GRAM domain containing 2B | 0.00478779 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | 0.00477771 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | 0.00476001 |
| CALB1 | calbindin 1, 28kDa | 0.00474834 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00474558 |
| THOC7 | THO complex 7 | 0.00473969 |
| GYG1 | glycogenin 1 | 0.00473966 |
| TNNI2 | troponin I type 2 (skeletal, fast) | 0.0047306 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.00472226 |
| RTF1 | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.00470863 |
| SCG5 | secretogranin V | 0.00470375 |
| LY6D | lymphocyte antigen 6 complex, locus D | 0.00470078 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | 0.0046935 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.0046897 |
| GRAMD1C | GRAM domain containing 1C | 0.00468624 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | 0.00468002 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.00467799 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.00467329 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0046715 |
| LOR | loricrin | 0.00465628 |
| EAF2 | ELL associated factor 2 | 0.00464912 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00461109 |
| SET | SET nuclear proto-oncogene | 0.00460565 |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 | 0.0046046 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.00459431 |
| UBE2N | ubiquitin-conjugating enzyme E2N | 0.00457311 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00456823 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 0.00456816 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00456763 |
| COQ8A | coenzyme Q8A | 0.0045646 |
| LEFTY1 | left-right determination factor 1 | 0.00455745 |
| C7 | complement component 7 | 0.00455721 |
| TMPO | thymopoietin | 0.00455561 |
| PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | 0.00455288 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00454933 |
| VPS26C | VPS26 endosomal protein sorting factor C | 0.00454705 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | 0.00454166 |
| UBA5 | ubiquitin-like modifier activating enzyme 5 | 0.00453742 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.00452546 |
| SEPHS1 | selenophosphate synthetase 1 | 0.00451106 |
| DUOX2 | dual oxidase 2 | 0.00451103 |
| MYOT | myotilin | 0.00450367 |
| LRRC41 | leucine rich repeat containing 41 | 0.00448145 |
| H1-10 | H1.10 linker histone | 0.00447728 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.00447292 |
| LY75 | lymphocyte antigen 75 | 0.00446483 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.00446341 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.00446008 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 0.00444771 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.00444523 |
| PER3 | period circadian clock 3 | 0.0044443 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 0.00443961 |
| SMYD3 | SET and MYND domain containing 3 | 0.00443791 |
| ACADM | acyl-CoA dehydrogenase, C-4 to C-12 straight chain | 0.00442203 |
| KLF11 | Kruppel-like factor 11 | 0.00441776 |
| DACH1 | dachshund family transcription factor 1 | 0.0044116 |
| ACYP2 | acylphosphatase 2, muscle type | 0.00440544 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00440413 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.00439897 |
| KLK7 | kallikrein-related peptidase 7 | 0.00439322 |
| CRYAB | crystallin, alpha B | 0.0043918 |
| TPM3 | tropomyosin 3 | 0.00439064 |
| HOXA5 | homeobox A5 | 0.00436921 |
| MDFIC | MyoD family inhibitor domain containing | 0.00436519 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.00435346 |
| TNNC2 | troponin C type 2 (fast) | 0.00434524 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.00434002 |
| SLC25A32 | solute carrier family 25 (mitochondrial folate carrier), member 32 | 0.0043396 |
| APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 | 0.00433661 |
| PALLD | palladin, cytoskeletal associated protein | 0.00433244 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | 0.00431389 |
| NELL1 | NEL-like 1 (chicken) | 0.00430153 |
| PKNOX1 | PBX/knotted 1 homeobox 1 | 0.00429241 |
| PHYH | phytanoyl-CoA 2-hydroxylase | 0.00428907 |
| CLCA4 | chloride channel accessory 4 | 0.00428113 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | 0.00428097 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | 0.00427425 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.00427396 |
| SDC2 | syndecan 2 | 0.00427276 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | 0.00426635 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00426157 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.00424837 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00424655 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.00424643 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | 0.00423729 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0114007 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0111374 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00982742 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00953319 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.0092284 |
| LTF | lactotransferrin | -0.00921702 |
| PON2 | paraoxonase 2 | -0.00911922 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00905243 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00902815 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00892356 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00876535 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0086298 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00843535 |
| IFI44L | interferon-induced protein 44-like | -0.00832449 |
| MAGEA3 | melanoma antigen family A3 | -0.00829951 |
| MMD | monocyte to macrophage differentiation-associated | -0.008214 |
| CES1 | carboxylesterase 1 | -0.0081006 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | -0.00801819 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00789947 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00789917 |
| PRAME | preferentially expressed antigen in melanoma | -0.00788271 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00779759 |
| PXDC1 | PX domain containing 1 | -0.00778191 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.00764159 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00760543 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00749396 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00749125 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0074636 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.00730659 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00724343 |
| IFRD1 | interferon-related developmental regulator 1 | -0.00697336 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00696793 |
| GPNMB | glycoprotein (transmembrane) nmb | -0.006896 |
| GDF15 | growth differentiation factor 15 | -0.00688356 |
| ADM | adrenomedullin | -0.00687475 |
| GNAS | GNAS complex locus | -0.00685772 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00683844 |
| CFB | complement factor B | -0.00661744 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00659181 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | -0.00655862 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.00655356 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00655102 |
| FOXF2 | forkhead box F2 | -0.00654253 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00651004 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | -0.00646639 |
| HP | haptoglobin | -0.00646259 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -0.00646148 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00643937 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00635649 |
| AUTS2 | autism susceptibility candidate 2 | -0.00634259 |
| COMT | catechol-O-methyltransferase | -0.00631919 |
| CCDC88A | coiled-coil domain containing 88A | -0.00631732 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.00630482 |
| TEX10 | testis expressed 10 | -0.00626858 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00625306 |
| RGS1 | regulator of G-protein signaling 1 | -0.00625136 |
| COCH | cochlin | -0.00624769 |
| PERP | PERP, TP53 apoptosis effector | -0.00622621 |
| TGFA | transforming growth factor, alpha | -0.00621853 |
| PEG10 | paternally expressed 10 | -0.00619598 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00618005 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.00617025 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.00612677 |
| FGG | fibrinogen gamma chain | -0.00609959 |
| SLC34A2 | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | -0.0060783 |
| ATP9A | ATPase, class II, type 9A | -0.00606655 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0060636 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.00606254 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00601537 |
| KRT18 | keratin 18, type I | -0.00599645 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00599424 |
| CLDN1 | claudin 1 | -0.00597518 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00597164 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.00594629 |
| CCDC86 | coiled-coil domain containing 86 | -0.00594136 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00592063 |
| GPX4 | glutathione peroxidase 4 | -0.00586586 |
| PDGFC | platelet derived growth factor C | -0.00584908 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00584287 |
| MNDA | myeloid cell nuclear differentiation antigen | -0.0058174 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00580426 |
| G6PD | glucose-6-phosphate dehydrogenase | -0.00579541 |
| BEX1 | brain expressed, X-linked 1 | -0.00578144 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0057007 |
| SLC16A6 | solute carrier family 16, member 6 | -0.00568761 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00568664 |
| ATF3 | activating transcription factor 3 | -0.00565444 |
| CD52 | CD52 molecule | -0.00565336 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.00564855 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00564075 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.00562704 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.00560575 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00559825 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.00559753 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00553125 |
| HMOX1 | heme oxygenase 1 | -0.00552821 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00552163 |
| SFTPD | surfactant protein D | -0.00548949 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | -0.00548544 |
| SFTPB | surfactant protein B | -0.00546848 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00546447 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00545326 |
| AGR2 | anterior gradient 2 | -0.00544422 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | -0.00541766 |
| MMP7 | matrix metallopeptidase 7 | -0.00541633 |
| PTK2 | protein tyrosine kinase 2 | -0.00537608 |
| PLCB4 | phospholipase C, beta 4 | -0.00536929 |
| NDUFB1 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | -0.00533292 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.00532369 |
| VGLL4 | vestigial-like family member 4 | -0.00531308 |
| UPK1B | uroplakin 1B | -0.00528796 |
| NKX2-1 | NK2 homeobox 1 | -0.00528063 |
| C3 | complement component 3 | -0.00527025 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | -0.00525745 |
| KLHL24 | kelch-like family member 24 | -0.0052531 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.00525087 |
| VWF | von Willebrand factor | -0.00522099 |
| ABHD11 | abhydrolase domain containing 11 | -0.00521601 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00519692 |
| IFI44 | interferon-induced protein 44 | -0.00517816 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.00516296 |
| MAGEA12 | melanoma antigen family A12 | -0.00515738 |
| FPR1 | formyl peptide receptor 1 | -0.00515146 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.00513349 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00511304 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.00511188 |
| TBL2 | transducin (beta)-like 2 | -0.00508902 |
| BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor | -0.0050664 |
| ZNF160 | zinc finger protein 160 | -0.00505904 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00504724 |
| TAGLN2 | transgelin 2 | -0.00502633 |
| IL1R1 | interleukin 1 receptor, type I | -0.00500033 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00499454 |
| MMP9 | matrix metallopeptidase 9 | -0.00499069 |
| PPIF | peptidylprolyl isomerase F | -0.00498847 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.0049845 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00498315 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.00498035 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00497108 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.00496299 |
| CST1 | cystatin SN | -0.0049506 |
| MLF2 | myeloid leukemia factor 2 | -0.00493612 |
| S100A12 | S100 calcium binding protein A12 | -0.00493551 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -0.0049328 |
| KRT23 | keratin 23, type I | -0.00491617 |
| PIP | prolactin-induced protein | -0.00491262 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -0.00490948 |
| BDNF | brain-derived neurotrophic factor | -0.00490856 |
| EGR1 | early growth response 1 | -0.00489551 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00488599 |
| PLIN1 | perilipin 1 | -0.00488028 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00486557 |
| SGCE | sarcoglycan, epsilon | -0.0048499 |
| CD83 | CD83 molecule | -0.00484846 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00483864 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.00481075 |
| FGA | fibrinogen alpha chain | -0.0047993 |
| COBL | cordon-bleu WH2 repeat protein | -0.00478772 |
| RTN1 | reticulon 1 | -0.00478333 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00477356 |
| BPIFA1 | BPI fold containing family A, member 1 | -0.00476176 |
| CLDN10 | claudin 10 | -0.00475705 |
| MAGED1 | melanoma antigen family D1 | -0.00475344 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00474049 |
| MTIF2 | mitochondrial translational initiation factor 2 | -0.0047341 |
| SFTPA2 | surfactant protein A2 | -0.00472896 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00472581 |
| ZNF91 | zinc finger protein 91 | -0.00472083 |
| PON3 | paraoxonase 3 | -0.00470004 |
| MFAP3L | microfibrillar-associated protein 3-like | -0.00469776 |
| DCT | dopachrome tautomerase | -0.00469454 |
| ZNF394 | zinc finger protein 394 | -0.00468685 |
| BUD31 | BUD31 homolog (S. cerevisiae) | -0.00468183 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00465661 |
| EPCAM | epithelial cell adhesion molecule | -0.00465461 |
| S100B | S100 calcium binding protein B | -0.00465456 |
| NARS1 | asparaginyl-tRNA synthetase 1 | -0.00465287 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.00465259 |
| SLC12A7 | solute carrier family 12 (potassium/chloride transporter), member 7 | -0.00465017 |
| ELOVL2 | ELOVL fatty acid elongase 2 | -0.00464499 |
| ANKRD28 | ankyrin repeat domain 28 | -0.00461966 |
| EDN1 | endothelin 1 | -0.00461283 |
| CYBB | cytochrome b-245, beta polypeptide | -0.00461151 |
| ELF5 | E74-like factor 5 (ets domain transcription factor) | -0.00460196 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.00459778 |
| CTSC | cathepsin C | -0.00459505 |
| SSX1 | synovial sarcoma, X breakpoint 1 | -0.00459035 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00458754 |
| SALL1 | spalt-like transcription factor 1 | -0.00458512 |
| EMP1 | epithelial membrane protein 1 | -0.00457884 |
| KRT7 | keratin 7, type II | -0.00456653 |
| CUX1 | cut-like homeobox 1 | -0.00455583 |
| PLA1A | phospholipase A1 member A | -0.00454904 |
| DHDDS | dehydrodolichyl diphosphate synthase | -0.00454593 |
| LY96 | lymphocyte antigen 96 | -0.00453498 |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | -0.00452383 |
| NTS | neurotensin | -0.00451662 |
| FOXE1 | forkhead box E1 | -0.00450893 |
| POGK | pogo transposable element with KRAB domain | -0.004504 |
| UFD1 | ubiquitin recognition factor in ER associated degradation 1 | -0.00450234 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.00449042 |
| RIN3 | Ras and Rab interactor 3 | -0.00448837 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | -0.00448479 |
| WDTC1 | WD and tetratricopeptide repeats 1 | -0.00447252 |
| TFIP11 | tuftelin interacting protein 11 | -0.00446692 |
| FOLR1 | folate receptor 1 (adult) | -0.00445399 |
| USP6NL | USP6 N-terminal like | -0.00444329 |
| MRPL40 | mitochondrial ribosomal protein L40 | -0.00444166 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | -0.00444123 |
| TSC22D1 | TSC22 domain family, member 1 | -0.00443964 |
| FOXC1 | forkhead box C1 | -0.00443775 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.00442647 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00442624 |
| DDRGK1 | DDRGK domain containing 1 | -0.00440335 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.0044016 |
| USP47 | ubiquitin specific peptidase 47 | -0.00439571 |
| DUSP10 | dual specificity phosphatase 10 | -0.00438216 |
| GLRX | glutaredoxin (thioltransferase) | -0.00438073 |
| RPS27L | ribosomal protein S27-like | -0.00437258 |
| CCDC176 | coiled-coil domain containing 176 | -0.00437051 |
| ZNF721 | zinc finger protein 721 | -0.00436123 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.00435779 |
| TRIB3 | tribbles pseudokinase 3 | -0.00435363 |
| AMPD3 | adenosine monophosphate deaminase 3 | -0.00435193 |
| MAGEA10 | melanoma antigen family A10 | -0.00435144 |
| RGS3 | regulator of G-protein signaling 3 | -0.0043456 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00434228 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0043409 |
| SHOX2 | short stature homeobox 2 | -0.00433581 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.00433408 |
| SPEN | spen family transcriptional repressor | -0.0043122 |
| CPD | carboxypeptidase D | -0.00430886 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00430776 |
| C4BPA | complement component 4 binding protein, alpha | -0.00430501 |
| PGD | phosphogluconate dehydrogenase | -0.00430246 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.00428997 |
| NOP2 | NOP2 nucleolar protein | -0.00428254 |
| TSPAN14 | tetraspanin 14 | -0.00427862 |
| RHOB | ras homolog family member B | -0.00427807 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00426597 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00426392 |
| PLS1 | plastin 1 | -0.00426131 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.00425635 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00425379 |
| PIR | pirin (iron-binding nuclear protein) | -0.00424044 |
| IRS2 | insulin receptor substrate 2 | -0.00423969 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00423482 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.0042232 |
