GPVI-mediated activation cascade Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-114604
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Genes

34 proteins participating in the GPVI-mediated activation cascade pathway from the Reactome Pathways 2024 dataset.

Symbol Name
CDC42 cell division cycle 42
CLEC1B C-type lectin domain family 1, member B
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
GP6 glycoprotein VI (platelet)
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LYN LYN proto-oncogene, Src family tyrosine kinase
PDPK1 3-phosphoinositide dependent protein kinase 1
PDPN podoplanin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCZ protein kinase C, zeta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOG ras homolog family member G
SYK spleen tyrosine kinase
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor