GPX4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description glutathione peroxidase 4|This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 2879)
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Genes

320 genes differentially expressed following the GPX4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PGM5 phosphoglucomutase 5 2.85387
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.85387
BIRC3 baculoviral IAP repeat containing 3 2.85387
UTS2B urotensin 2B 2.85387
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.85387
BMX BMX non-receptor tyrosine kinase 2.85387
COL15A1 collagen, type XV, alpha 1 2.85387
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.83119
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.83119
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.83119
TAL2 T-cell acute lymphocytic leukemia 2 2.83119
ADGB androglobin 2.83119
PNMA5 paraneoplastic Ma antigen family member 5 2.83119
FOXL1 forkhead box L1 2.83119
BOLA2B bolA family member 2B 2.83119
CFHR3 complement factor H-related 3 2.83119
MYO7B myosin VIIB 2.83119
CARD18 caspase recruitment domain family, member 18 2.83119
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.83119
RXFP2 relaxin/insulin-like family peptide receptor 2 2.83119
CTRC chymotrypsin C (caldecrin) 2.83119
ENTHD1 ENTH domain containing 1 2.83119
CD1C CD1c molecule 2.83119
ATG9B autophagy related 9B 2.83119
CNTNAP4 contactin associated protein-like 4 2.83119
NRROS negative regulator of reactive oxygen species 2.83119
POSTN periostin, osteoblast specific factor 2.83119
PRDM16 PR domain containing 16 2.83119
KHDC1L KH homology domain containing 1-like 2.83119
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.83119
PRR29 proline rich 29 2.83119
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.83119
KRTAP5-9 keratin associated protein 5-9 2.83119
PANO1 proapoptotic nucleolar protein 1 2.83119
IL23R interleukin 23 receptor 2.83119
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.83119
NT5E 5'-nucleotidase, ecto (CD73) 2.83119
CRYGA crystallin, gamma A 2.83119
CRYGB crystallin, gamma B 2.83119
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.83119
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.83119
ARRDC5 arrestin domain containing 5 2.83119
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 2.83119
RLN3 relaxin 3 2.83119
DLL4 delta-like 4 (Drosophila) 2.83119
GNRH2 gonadotropin-releasing hormone 2 2.83119
LRRC61 leucine rich repeat containing 61 2.83119
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.83119
FAM81B family with sequence similarity 81, member B 2.83119
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.83119
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.83119
HTRA4 HtrA serine peptidase 4 2.83119
STMN4 stathmin-like 4 2.83119
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.83119
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.83119
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.83119
ANO3 anoctamin 3 2.83119
WDR64 WD repeat domain 64 2.83119
PAPOLB poly(A) polymerase beta (testis specific) 2.83119
SELE selectin E 2.83119
ATP5ME ATP synthase membrane subunit e 2.83119
STYXL2 serine/threonine/tyrosine interacting like 2 2.83119
TEKTL1 tektin like 1 2.83119
CIMIP2A ciliary microtubule inner protein 2A 2.83119
SPDYE8 speedy/RINGO cell cycle regulator family member E8 2.83119
IRF2-DT IRF2 divergent transcript 2.83119
CFAP276 cilia and flagella associated protein 276 2.83119
GARIN6 golgi associated RAB2 interactor family member 6 2.83119
CIROP ciliated left-right organizer metallopeptidase 2.83119
ANKRD40CL ANKRD40 C-terminal like 2.83119
ALPG alkaline phosphatase, germ cell 2.83119
TMEM40 transmembrane protein 40 2.83119
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.83119
CLDN2 claudin 2 2.83119
PTPRH protein tyrosine phosphatase, receptor type, H 2.83119
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.83119
NKX2-5 NK2 homeobox 5 2.83119
IFITM2 interferon induced transmembrane protein 2 2.83119
FRMD7 FERM domain containing 7 2.83119
FAM3D family with sequence similarity 3, member D 2.83119
ZNF98 zinc finger protein 98 2.83119
NRN1 neuritin 1 2.83119
MAGEB6 melanoma antigen family B6 2.83119
C3ORF80 chromosome 3 open reading frame 80 2.83119
C1ORF162 chromosome 1 open reading frame 162 2.83119
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.83119
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.83119
HNF1B HNF1 homeobox B 2.83119
COX8C cytochrome c oxidase subunit VIIIC 2.83119
TAS1R2 taste receptor, type 1, member 2 2.83119
OPN5 opsin 5 2.83119
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 2.83119
CELA2A chymotrypsin-like elastase family, member 2A 2.83119
OVOL3 ovo-like zinc finger 3 2.83119
SRPX2 sushi-repeat containing protein, X-linked 2 2.83119
SPZ1 spermatogenic leucine zipper 1 2.83119
TPSB2 tryptase beta 2 (gene/pseudogene) 2.83119
AKNAD1 AKNA domain containing 1 2.83119
MUC13 mucin 13, cell surface associated 2.83119
MUC15 mucin 15, cell surface associated 2.83119
ALOXE3 arachidonate lipoxygenase 3 2.83119
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.83119
VWA7 von Willebrand factor A domain containing 7 2.83119
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.83119
GLT1D1 glycosyltransferase 1 domain containing 1 2.83119
TMEM207 transmembrane protein 207 2.83119
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.83119
IGFBP1 insulin-like growth factor binding protein 1 2.83119
EFCAB9 EF-hand calcium binding domain 9 2.83119
HHLA2 HERV-H LTR-associating 2 2.83119
HHATL hedgehog acyltransferase-like 2.83119
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.83119
CPSF4L cleavage and polyadenylation specific factor 4-like 2.83119
KLF1 Kruppel-like factor 1 (erythroid) 2.83119
ZNF843 zinc finger protein 843 2.83119
HK3 hexokinase 3 (white cell) 2.83119
ZNF112 zinc finger protein 112 2.83119
ERVV-1 endogenous retrovirus group V, member 1 2.83119
POU4F1 POU class 4 homeobox 1 2.83119
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.83119
MEIS2 Meis homeobox 2 2.83119
GJB6 gap junction protein, beta 6, 30kDa 2.83119
CCNA1 cyclin A1 2.83119
WNT2 wingless-type MMTV integration site family member 2 2.83119
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.83119
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.83119
CLEC1A C-type lectin domain family 1, member A 2.83119
LY96 lymphocyte antigen 96 2.83119
ZC3H12D zinc finger CCCH-type containing 12D 2.83119
CLEC9A C-type lectin domain family 9, member A 2.83119
CTSF cathepsin F 2.83119
SOSTDC1 sclerostin domain containing 1 2.83119
UBXN10 UBX domain protein 10 2.83119
CD28 CD28 molecule 2.83119
SH2D1A SH2 domain containing 1A 2.83119
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.83119
KRT17 keratin 17, type I 2.83119
PXT1 peroxisomal, testis specific 1 2.83119
CD8B CD8b molecule 2.83119
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.83119
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.83119
KIF15 kinesin family member 15 2.83119
ADGRF1 adhesion G protein-coupled receptor F1 2.83119
RORC RAR-related orphan receptor C 2.83119
EXOSC8 exosome component 8 2.83119
TEX38 testis expressed 38 2.83119
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.83119
GHRH growth hormone releasing hormone 2.83119
TAS2R46 taste receptor, type 2, member 46 2.83119
RHAG Rh-associated glycoprotein 2.83119
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.83119
NGB neuroglobin 2.83119
ASGR1 asialoglycoprotein receptor 1 2.83119
R3HDML R3H domain containing-like 2.83119
ADRA1B adrenoceptor alpha 1B 2.83119
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.83119
WNK4 WNK lysine deficient protein kinase 4 2.83119
RTN4RL1 reticulon 4 receptor-like 1 2.83119
SLITRK1 SLIT and NTRK-like family, member 1 2.83119
NPC1L1 NPC1-like 1 2.83119
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.83119
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 2.78346
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.77901
CAMLG calcium modulating ligand 2.66371
PLRG1 pleiotropic regulator 1 2.6363
NKAIN3 Na+/K+ transporting ATPase interacting 3 2.56346
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2.52165
RPP38 ribonuclease P/MRP 38kDa subunit 2.51037
MRPS18C mitochondrial ribosomal protein S18C 2.47862
NRXN1 neurexin 1 2.47257
ERI3 ERI1 exoribonuclease family member 3 2.45205
APP amyloid beta (A4) precursor protein 2.40733
TUBB1 tubulin, beta 1 class VI 2.37319
SERBP1 SERPINE1 mRNA binding protein 1 2.36012
POLR1F RNA polymerase I subunit F 2.31774
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 2.30027
ZBTB11 zinc finger and BTB domain containing 11 2.29952
GOLGA6C golgin A6 family, member C 2.28616
DYDC1 DPY30 domain containing 1 2.28333
KLHDC8A kelch domain containing 8A 2.28333
RAD51AP1 RAD51 associated protein 1 2.28333
PDE10A phosphodiesterase 10A 2.27523
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.26029
RBM42 RNA binding motif protein 42 2.25593
TMEM80 transmembrane protein 80 2.25369
FAM184B family with sequence similarity 184, member B 2.24956
FAM184A family with sequence similarity 184, member A 2.24841
C6ORF120 chromosome 6 open reading frame 120 2.24758
ARF6 ADP-ribosylation factor 6 2.243
DOLPP1 dolichyldiphosphatase 1 2.23172
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 2.23172
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.18304
MZT2B mitotic spindle organizing protein 2B 2.18304
ZSCAN26 zinc finger and SCAN domain containing 26 2.18304
GVQW3 GVQW motif containing 3 2.15366
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.14495
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14 2.11916
ZNF410 zinc finger protein 410 2.11564
KTN1 kinectin 1 (kinesin receptor) 2.11249
KHNYN KH and NYN domain containing 2.0873
IL13RA1 interleukin 13 receptor, alpha 1 2.07351
PMPCB peptidase (mitochondrial processing) beta 2.07179
CDO1 cysteine dioxygenase type 1 2.07179
ZNF507 zinc finger protein 507 2.0506
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.04456
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.03333
TEKT3 tektin 3 2.01305
TIPE3 TNF alpha induced protein 8 like 3 2.01071
ZNF74 zinc finger protein 74 2.0064
NEK11 NIMA-related kinase 11 2.00577
SMAD3 SMAD family member 3 2.00246
RHOJ ras homolog family member J 2.00246
PYGL phosphorylase, glycogen, liver 2.00111
ATG4D autophagy related 4D, cysteine peptidase 2.00111
SLC35F5 solute carrier family 35, member F5 2.00111

decreased expression

Symbol Name Standardized Value
TRHR thyrotropin-releasing hormone receptor -2.85387
GPX4 glutathione peroxidase 4 -2.85387
HEYL hes-related family bHLH transcription factor with YRPW motif-like -2.85387
RAB36 RAB36, member RAS oncogene family -2.83119
PADI4 peptidyl arginine deiminase, type IV -2.83119
RGPD5 RANBP2-like and GRIP domain containing 5 -2.83119
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 -2.83119
USP32 ubiquitin specific peptidase 32 -2.83119
SFN stratifin -2.83119
ANKRD33 ankyrin repeat domain 33 -2.83119
ZNF471 zinc finger protein 471 -2.83119
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -2.83119
FBXO36 F-box protein 36 -2.83119
LRRC73 leucine rich repeat containing 73 -2.83119
ATF7IP activating transcription factor 7 interacting protein -2.83119
MRPL32 mitochondrial ribosomal protein L32 -2.83119
SCG2 secretogranin II -2.83119
AGTR1 angiotensin II receptor, type 1 -2.83119
SPAAR small regulatory polypeptide of amino acid response -2.83119
SLC16A12 solute carrier family 16, member 12 -2.83119
NXPH4 neurexophilin 4 -2.83119
MAGEA4 melanoma antigen family A4 -2.83119
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.83119
LRRC37B leucine rich repeat containing 37B -2.83119
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -2.83119
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.83119
ITK IL2-inducible T-cell kinase -2.83119
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -2.83119
AP4B1 adaptor-related protein complex 4, beta 1 subunit -2.83119
DQX1 DEAQ box RNA-dependent ATPase 1 -2.83119
CD27 CD27 molecule -2.83119
TCAP titin-cap -2.83119
KLK6 kallikrein-related peptidase 6 -2.83119
SLC22A24 solute carrier family 22, member 24 -2.83119
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.83119
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -2.83119
ARHGAP40 Rho GTPase activating protein 40 -2.83119
CEND1 cell cycle exit and neuronal differentiation 1 -2.83119
WDR49 WD repeat domain 49 -2.83119
ZPBP zona pellucida binding protein -2.83119
LYG2 lysozyme G-like 2 -2.83119
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -2.83119
BTNL2 butyrophilin-like 2 -2.83119
BLTP1 bridge-like lipid transfer protein family member 1 -2.78201
LDB2 LIM domain binding 2 -2.78201
GPC1 glypican 1 -2.78201
LZTR1 leucine-zipper-like transcription regulator 1 -2.74028
TMPRSS11D transmembrane protease, serine 11D -2.71851
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -2.67991
ATP5MK ATP synthase membrane subunit k -2.66163
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.64587
HCST hematopoietic cell signal transducer -2.63491
SP140L SP140 nuclear body protein-like -2.63491
MISP3 MISP family member 3 -2.60987
DDB1 damage-specific DNA binding protein 1, 127kDa -2.60841
IL15 interleukin 15 -2.59461
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.58817
PRAM1 PML-RARA regulated adaptor molecule 1 -2.56693
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -2.51037
CCDC32 coiled-coil domain containing 32 -2.51037
USP2 ubiquitin specific peptidase 2 -2.4968
KLHL17 kelch-like family member 17 -2.4968
SOCS1 suppressor of cytokine signaling 1 -2.47469
RIPK2 receptor-interacting serine-threonine kinase 2 -2.44419
SELENBP1 selenium binding protein 1 -2.42379
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.38583
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -2.28333
MIPOL1 mirror-image polydactyly 1 -2.27746
ENG endoglin -2.27379
RAB5A RAB5A, member RAS oncogene family -2.27379
ZBTB33 zinc finger and BTB domain containing 33 -2.26087
TMEM200C transmembrane protein 200C -2.25659
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 -2.25492
SMIM38 small integral membrane protein 38 -2.25369
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.25369
DERL3 derlin 3 -2.25369
CCDC170 coiled-coil domain containing 170 -2.25369
ZNF469 zinc finger protein 469 -2.25121
PRXL2C peroxiredoxin like 2C -2.24072
CAPN15 calpain 15 -2.22492
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.15366
YY2 YY2 transcription factor -2.1481
MRTFA myocardin related transcription factor A -2.13884
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -2.13854
GRM3 glutamate receptor, metabotropic 3 -2.13617
ZNF417 zinc finger protein 417 -2.1293
HEATR3 HEAT repeat containing 3 -2.12501
SPIN1 spindlin 1 -2.11768
SYPL2 synaptophysin-like 2 -2.0985
MMS22L MMS22-like, DNA repair protein -2.09685
PRDM5 PR domain containing 5 -2.09403
GPC6 glypican 6 -2.08559
TOGARAM2 TOG array regulator of axonemal microtubules 2 -2.08236
GCH1 GTP cyclohydrolase 1 -2.08027
SACK1E scaffolding CK1 anchoring protein E -2.07179
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.05426
ICMT isoprenylcysteine carboxyl methyltransferase -2.0506
DNASE1 deoxyribonuclease I -2.03958
PHF20 PHD finger protein 20 -2.03333
TMEM201 transmembrane protein 201 -2.03063
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -2.0064
SREK1IP1 SREK1-interacting protein 1 -2.00246
TLK2 tousled-like kinase 2 -2.00111
CAPN13 calpain 13 -2.00111
AIM2 absent in melanoma 2 -2.00111