GPX4 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description glutathione peroxidase 4|This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 2879)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_GPX4
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Genes

54 co-expressed genes for GPX4 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARF5 ADP-ribosylation factor 5
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
BANF1 barrier to autointegration factor 1
BCAP31 B-cell receptor-associated protein 31
C9ORF16 chromosome 9 open reading frame 16
CANX calnexin
CLTA clathrin, light chain A
COPE coatomer protein complex, subunit epsilon
COPS5 COP9 signalosome subunit 5
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CSNK2B casein kinase 2, beta polypeptide
CYC1 cytochrome c-1
DAP death-associated protein
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DRG1 developmentally regulated GTP binding protein 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
FASTK Fas-activated serine/threonine kinase
GANAB glucosidase, alpha; neutral AB
GLB1 galactosidase, beta 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPAA1 glycosylphosphatidylinositol anchor attachment 1
GPX4 glutathione peroxidase 4
JTB jumping translocation breakpoint
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
MAP2K2 mitogen-activated protein kinase kinase 2
MYL12B myosin, light chain 12B, regulatory
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
PDAP1 PDGFA associated protein 1
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALY RALY heterogeneous nuclear ribonucleoprotein
RER1 retention in endoplasmic reticulum sorting receptor 1
RHEB Ras homolog enriched in brain
SRP9 signal recognition particle 9kDa
SSR2 signal sequence receptor, beta (translocon-associated protein beta)
SSR4 signal sequence receptor, delta
TECR trans-2,3-enoyl-CoA reductase
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM147 transmembrane protein 147
TRAPPC3 trafficking protein particle complex 3
UBA1 ubiquitin-like modifier activating enzyme 1
WBP2 WW domain binding protein 2