GRB2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description growth factor receptor-bound protein 2|The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2885)
Similar Terms
Downloads & Tools

Genes

337 genes differentially expressed following the GRB2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CRYGB crystallin, gamma B 3.87843
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 3.87843
PCDHB10 protocadherin beta 10 3.87843
CCDC13 coiled-coil domain containing 13 3.87843
EMP1 epithelial membrane protein 1 3.87843
MPPED1 metallophosphoesterase domain containing 1 3.87843
TEKT5 tektin 5 3.87843
GDF6 growth differentiation factor 6 3.87843
C8G complement component 8, gamma polypeptide 3.87843
ANKRD31 ankyrin repeat domain 31 3.87843
SPINK6 serine peptidase inhibitor, Kazal type 6 3.87843
POPDC2 popeye domain containing 2 3.87843
GUCY2F guanylate cyclase 2F, retinal 3.87843
IFITM10 interferon induced transmembrane protein 10 3.87843
OXTR oxytocin receptor 3.87843
LEP leptin 3.87843
SNTN sentan, cilia apical structure protein 3.87843
PKP1 plakophilin 1 3.87843
PDYN prodynorphin 3.87843
TMEM196 transmembrane protein 196 3.87843
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.87843
FOXG1 forkhead box G1 3.87843
STRC stereocilin 3.87843
SEPTIN12 septin 12 3.87843
DUSP29 dual specificity phosphatase 29 3.87843
DNAI3 dynein axonemal intermediate chain 3 3.87843
NPM2 nucleophosmin/nucleoplasmin 2 3.87843
SFTPD surfactant protein D 3.77852
GPR26 G protein-coupled receptor 26 3.77852
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.77852
CSTL1 cystatin-like 1 3.77852
FAM221B family with sequence similarity 221, member B 3.77852
TAL2 T-cell acute lymphocytic leukemia 2 3.77852
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 3.77852
BLK BLK proto-oncogene, Src family tyrosine kinase 3.77852
OSGIN1 oxidative stress induced growth inhibitor 1 3.77852
GARIN4 golgi associated RAB2 interactor family member 4 3.77852
FNDC11 fibronectin type III domain containing 11 3.77852
CELF6 CUGBP, Elav-like family member 6 3.77852
NPPC natriuretic peptide C 3.77852
C20ORF204 chromosome 20 open reading frame 204 3.77852
CD8B2 CD8b2 molecule 3.77852
LOC124901449 uncharacterized LOC124901449 3.77852
PRDM13 PR domain containing 13 3.77852
BMP5 bone morphogenetic protein 5 3.77852
MRC1 mannose receptor, C type 1 3.77852
SPHK1 sphingosine kinase 1 3.77852
CFAP54 cilia and flagella associated 54 3.77852
IL18R1 interleukin 18 receptor 1 3.77852
NWD2 NACHT and WD repeat domain containing 2 3.77852
SPEGNB SPEG neighbor 3.77852
MISP mitotic spindle positioning 3.77852
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.77852
RPL3L ribosomal protein L3-like 3.77852
TDRD9 tudor domain containing 9 3.77852
FSCN2 fascin actin-bundling protein 2, retinal 3.77852
LRRC10B leucine rich repeat containing 10B 3.77852
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.77852
DEPP1 DEPP autophagy regulator 1 3.77852
RIMBP3C RIMS binding protein 3C 3.77852
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.77852
CLEC12A C-type lectin domain family 12, member A 3.77852
ZNF726 zinc finger protein 726 3.77852
CCR3 chemokine (C-C motif) receptor 3 3.77852
GTSF1 gametocyte specific factor 1 3.77852
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.77852
AVPR1B arginine vasopressin receptor 1B 3.77852
BEND2 BEN domain containing 2 3.77852
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.77852
ADGRG7 adhesion G protein-coupled receptor G7 3.77852
PRG4 proteoglycan 4 3.77852
PARVG parvin, gamma 3.77852
LY6K lymphocyte antigen 6 complex, locus K 3.77852
TSPAN8 tetraspanin 8 3.77852
KRT80 keratin 80, type II 3.77852
FCMR Fc fragment of IgM receptor 3.77852
WNT16 wingless-type MMTV integration site family, member 16 3.77852
PAPOLB poly(A) polymerase beta (testis specific) 3.77852
FOXC1 forkhead box C1 3.77852
FOXI2 forkhead box I2 3.77852
EXOC3L1 exocyst complex component 3-like 1 3.77852
EXOC3L4 exocyst complex component 3-like 4 3.77852
NAPSA napsin A aspartic peptidase 3.77852
UPK3A uroplakin 3A 3.77852
PLVAP plasmalemma vesicle associated protein 3.77852
TBX20 T-box 20 3.77852
BCAP29 B-cell receptor-associated protein 29 3.77852
DYNLT4 dynein light chain Tctex-type 4 3.77852
TMEM229A transmembrane protein 229A 3.77852
CAPN14 calpain 14 3.77852
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.77852
SEPTIN14 septin 14 3.77852
TRIM60 tripartite motif containing 60 3.77852
FAM43B family with sequence similarity 43, member B 3.77852
MEDAG mesenteric estrogen-dependent adipogenesis 3.77852
LOC124909439 uncharacterized LOC124909439 3.77852
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.77852
HAPLN2 hyaluronan and proteoglycan link protein 2 3.77852
C1QL3 complement component 1, q subcomponent-like 3 3.77852
SAG S-antigen; retina and pineal gland (arrestin) 3.77852
CHI3L2 chitinase 3-like 2 3.77852
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.77852
SIGLEC15 sialic acid binding Ig-like lectin 15 3.77852
RGS13 regulator of G-protein signaling 13 3.77852
SPHKAP SPHK1 interactor, AKAP domain containing 3.77852
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.77852
FNDC8 fibronectin type III domain containing 8 3.77852
CTSW cathepsin W 3.77852
PRTN3 proteinase 3 3.77852
OR5B2 olfactory receptor, family 5, subfamily B, member 2 3.77852
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.77852
NCR3 natural cytotoxicity triggering receptor 3 3.77852
CTRB1 chymotrypsinogen B1 3.77852
CASS4 Cas scaffolding protein family member 4 3.77852
PLGLB2 plasminogen-like B2 3.77852
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.77852
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.77852
PDCD1LG2 programmed cell death 1 ligand 2 3.77852
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.77852
C2CD4D C2 calcium-dependent domain containing 4D 3.77852
KLK15 kallikrein-related peptidase 15 3.77852
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 3.77852
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.77852
APOC4 apolipoprotein C-IV 3.77852
NPBWR1 neuropeptides B/W receptor 1 3.77852
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.77852
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.77852
WFDC1 WAP four-disulfide core domain 1 3.77852
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.77852
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.77852
TPSG1 tryptase gamma 1 3.77852
AQP3 aquaporin 3 (Gill blood group) 3.77852
CEL carboxyl ester lipase 3.77852
NUTM2B NUT family member 2B 3.77852
MT1M metallothionein 1M 3.77852
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.77852
PTCH2 patched 2 3.77852
OTP orthopedia homeobox 3.77852
CDCP2 CUB domain containing protein 2 3.77852
FKBP1C FK506 binding protein 1C 3.77852
IRX5 iroquois homeobox 5 3.77852
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.77852
SYT5 synaptotagmin V 3.77852
CLNK cytokine-dependent hematopoietic cell linker 3.77852
ZNF404 zinc finger protein 404 3.77852
OR52N1 olfactory receptor, family 52, subfamily N, member 1 3.77852
NEUROD4 neuronal differentiation 4 3.77852
SPATA31A6 SPATA31 subfamily A, member 6 3.77852
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.77852
CHRDL2 chordin-like 2 3.77852
TAS2R46 taste receptor, type 2, member 46 3.77852
TAS2R43 taste receptor, type 2, member 43 3.77852
RSAD2 radical S-adenosyl methionine domain containing 2 3.77852
RTN4RL1 reticulon 4 receptor-like 1 3.77852
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 3.77852
ST18 suppression of tumorigenicity 18, zinc finger 3.77852
POU4F2 POU class 4 homeobox 2 3.77852
BTBD16 BTB (POZ) domain containing 16 3.77852
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.77852
NPR3 natriuretic peptide receptor 3 3.77852
MPZL3 myelin protein zero-like 3 3.66866
ATP5F1A ATP synthase F1 subunit alpha 3.39849
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 3.38577
BICD1 bicaudal D homolog 1 (Drosophila) 3.32242
FHIP2A FHF complex subunit HOOK interacting protein 2A 3.29901
SPATA18 spermatogenesis associated 18 3.2984
PAGR1 PAXIP1 associated glutamate-rich protein 1 3.24371
GPHRA golgi pH regulator A 3.10093
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.99218
JAM2 junctional adhesion molecule 2 2.99218
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.95802
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.8984
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.88564
AKAP9 A kinase (PRKA) anchor protein 9 2.82819
NVL nuclear VCP-like 2.65691
GTPBP3 GTP binding protein 3 (mitochondrial) 2.64438
PCDH9 protocadherin 9 2.6198
ATG9B autophagy related 9B 2.6198
RUMY3 RUMY family member 3 2.6198
SV2B synaptic vesicle glycoprotein 2B 2.6198
SOWAHD sosondowah ankyrin repeat domain family member D 2.6198
BBS5 Bardet-Biedl syndrome 5 2.6198
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.6198
PROK2 prokineticin 2 2.6198
PNPLA4 patatin-like phospholipase domain containing 4 2.59834
AGBL3 ATP/GTP binding protein-like 3 2.58447
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.58212
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.55263
PPP1R3E protein phosphatase 1, regulatory subunit 3E 2.48617
LAGE3 L antigen family, member 3 2.45521
UNC79 unc-79 homolog (C. elegans) 2.45521
CLU clusterin 2.41437
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.39644
PADI4 peptidyl arginine deiminase, type IV 2.38068
TMEM248 transmembrane protein 248 2.37048
SMIM38 small integral membrane protein 38 2.36383
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.36173
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 2.33795
DNM2 dynamin 2 2.31414
GTF2I general transcription factor IIi 2.30647
USP53 ubiquitin specific peptidase 53 2.29032
DCP1A decapping mRNA 1A 2.28045
PCNX1 pecanex 1 2.28045
H2AC13 H2A clustered histone 13 2.28029
GOLGA3 golgin A3 2.28029
TLL2 tolloid-like 2 2.24978
KCTD1 potassium channel tetramerization domain containing 1 2.21211
CTTNBP2 cortactin binding protein 2 2.20242
ANO5 anoctamin 5 2.18719
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 2.16626
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 2.14594
RAMAC RNA guanine-7 methyltransferase activating subunit 2.14
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.11854
ZSWIM8 zinc finger, SWIM-type containing 8 2.10569
PPHLN1 periphilin 1 2.10569
ZNF649 zinc finger protein 649 2.10325
NPIPB2 nuclear pore complex interacting protein family member B2 2.09948
TGFBR3L transforming growth factor, beta receptor III-like 2.09948
TTN titin 2.09336
SPACA6 sperm acrosome associated 6 2.07543
FCHO1 FCH domain only 1 2.07462
CBLN1 cerebellin 1 precursor 2.06822
PRPF38B pre-mRNA processing factor 38B 2.01014
HTATSF1 HIV-1 Tat specific factor 1 2.0086
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.00337
CNTN3 contactin 3 (plasmacytoma associated) 2.00337
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 2.00065
DIAPH3 diaphanous-related formin 3 2.00065

decreased expression

Symbol Name Standardized Value
ILDR2 immunoglobulin-like domain containing receptor 2 -3.87843
C9ORF43 chromosome 9 open reading frame 43 -3.87843
KIF19 kinesin family member 19 -3.87843
FBXO43 F-box protein 43 -3.87843
ZEB1 zinc finger E-box binding homeobox 1 -3.87843
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 -3.87843
RAI2 retinoic acid induced 2 -3.87843
S100A2 S100 calcium binding protein A2 -3.77852
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -3.77852
OLIG1 oligodendrocyte transcription factor 1 -3.77852
UPK1A uroplakin 1A -3.77852
LCN15 lipocalin 15 -3.77852
ZBTB47 zinc finger and BTB domain containing 47 -3.77852
TMEM236 transmembrane protein 236 -3.77852
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -3.77852
GLRA1 glycine receptor, alpha 1 -3.77852
CCL5 chemokine (C-C motif) ligand 5 -3.77852
MPZL2 myelin protein zero-like 2 -3.77852
SP140 SP140 nuclear body protein -3.77852
DGAT1 diacylglycerol O-acyltransferase 1 -3.77852
DGCR6 DiGeorge syndrome critical region gene 6 -3.77852
PITPNM3 PITPNM family member 3 -3.77852
C1QTNF2 C1q and tumor necrosis factor related protein 2 -3.77852
ARSI arylsulfatase family, member I -3.77852
AKAP3 A kinase (PRKA) anchor protein 3 -3.77852
CLCN1 chloride channel, voltage-sensitive 1 -3.77852
ZGLP1 zinc finger, GATA-like protein 1 -3.77852
LIPH lipase, member H -3.77852
NR4A3 nuclear receptor subfamily 4, group A, member 3 -3.77852
ALX4 ALX homeobox 4 -3.77852
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -3.77852
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -3.77852
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -3.77852
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -3.77852
CA10 carbonic anhydrase X -3.66484
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.45317
H3-3B H3.3 histone B -3.45317
C17ORF49 chromosome 17 open reading frame 49 -3.28863
IL6ST-DT IL6ST divergent transcript -3.23918
FAM50B family with sequence similarity 50, member B -3.18387
CORO1A coronin, actin binding protein, 1A -2.89719
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -2.84337
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -2.82819
ABHD14A abhydrolase domain containing 14A -2.78984
CRIP3 cysteine-rich protein 3 -2.76496
HHLA1 HERV-H LTR-associating 1 -2.75866
SAT1 spermidine/spermine N1-acetyltransferase 1 -2.75132
SNRPG small nuclear ribonucleoprotein polypeptide G -2.71993
SBSPON somatomedin B and thrombospondin, type 1 domain containing -2.64694
DCLK3 doublecortin-like kinase 3 -2.64694
CC2D2B coiled-coil and C2 domain containing 2B -2.64694
TSLIG3C tRNA splicing ligase complex subunit 3C -2.64694
TFF3 trefoil factor 3 (intestinal) -2.64694
CCDC152 coiled-coil domain containing 152 -2.64694
FN1 fibronectin 1 -2.60592
CEP83 centrosomal protein 83kDa -2.58456
SCARF1 scavenger receptor class F, member 1 -2.56417
GRIK2 glutamate receptor, ionotropic, kainate 2 -2.55263
TLCD3A TLC domain containing 3A -2.55062
CNTNAP3 contactin associated protein-like 3 -2.5123
RBM4B RNA binding motif protein 4B -2.50885
ZNF383 zinc finger protein 383 -2.46612
DHFR dihydrofolate reductase -2.46335
ANKRD10 ankyrin repeat domain 10 -2.4568
RAB37 RAB37, member RAS oncogene family -2.41437
TMEM150B transmembrane protein 150B -2.41437
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.39896
SYNDIG1L synapse differentiation inducing 1-like -2.39644
SNX14 sorting nexin 14 -2.3876
TMEM106C transmembrane protein 106C -2.3427
SAR1A secretion associated, Ras related GTPase 1A -2.34001
VSTM2B V-set and transmembrane domain containing 2B -2.34001
KIRREL2 kin of IRRE like 2 (Drosophila) -2.34001
TRIM14 tripartite motif containing 14 -2.33795
WWC3 WWC family member 3 -2.30647
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.3055
SNAP91 synaptosomal-associated protein, 91kDa -2.3055
SMAP2 small ArfGAP2 -2.28045
STK25 serine/threonine kinase 25 -2.27002
ISOC2 isochorismatase domain containing 2 -2.23859
MIX23 mitochondrial matrix import factor 23 -2.22562
VMP1 vacuole membrane protein 1 -2.20498
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.20242
MATK megakaryocyte-associated tyrosine kinase -2.20242
C14ORF119 chromosome 14 open reading frame 119 -2.2017
DCAKD dephospho-CoA kinase domain containing -2.2017
MATN3 matrilin 3 -2.19875
NBPF14 neuroblastoma breakpoint family, member 14 -2.19842
RPL21 ribosomal protein L21 -2.19159
BTG3 BTG family, member 3 -2.18719
KHDC1 KH homology domain containing 1 -2.18719
COPS5 COP9 signalosome subunit 5 -2.18533
NCALD neurocalcin delta -2.17898
SMIM3 small integral membrane protein 3 -2.1714
ZNF641 zinc finger protein 641 -2.15981
TTLL11 tubulin tyrosine ligase-like family member 11 -2.15981
ZNF562 zinc finger protein 562 -2.15818
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.14594
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.11365
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -2.11365
IQGAP3 IQ motif containing GTPase activating protein 3 -2.09948
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.07482
GMNN geminin, DNA replication inhibitor -2.07462
MITD1 MIT, microtubule interacting and transport, domain containing 1 -2.07423
NELL2 NEL-like 2 (chicken) -2.06712
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.06712
LHFPL3 lipoma HMGIC fusion partner-like 3 -2.04088
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.04088
CKS1B CDC28 protein kinase regulatory subunit 1B -2.02193