GRB2 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description growth factor receptor-bound protein 2|The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2885)
External Link https://ncbi.nlm.nih.gov/gene/2885
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Genes

499 genes differentially expressed following the GRB2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA1A heat shock 70kDa protein 1A 0.0185039
ASS1 argininosuccinate synthase 1 0.0145397
SSBP2 single-stranded DNA binding protein 2 0.0143967
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0138796
ADIRF adipogenesis regulatory factor 0.0135839
KRT19 keratin 19, type I 0.0128868
ARHGAP29 Rho GTPase activating protein 29 0.0121219
NUPR1 nuclear protein, transcriptional regulator, 1 0.0121109
POSTN periostin, osteoblast specific factor 0.0113544
MGP matrix Gla protein 0.0112972
CFB complement factor B 0.0112903
PROM1 prominin 1 0.0112645
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.011148
MX1 MX dynamin-like GTPase 1 0.0106804
GPNMB glycoprotein (transmembrane) nmb 0.0106484
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0105853
NT5E 5'-nucleotidase, ecto (CD73) 0.0105151
AHR aryl hydrocarbon receptor 0.0104127
G0S2 G0/G1 switch 2 0.010335
AKR1C2 aldo-keto reductase family 1, member C2 0.0102271
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0102151
LMO2 LIM domain only 2 (rhombotin-like 1) 0.0100355
MXRA5 matrix-remodelling associated 5 0.00989194
FHL1 four and a half LIM domains 1 0.00974089
IL1R1 interleukin 1 receptor, type I 0.00973848
RTN2 reticulon 2 0.00969605
IFI6 interferon, alpha-inducible protein 6 0.00961541
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00956455
ISLR immunoglobulin superfamily containing leucine-rich repeat 0.00952787
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00951127
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.00946838
MFAP5 microfibrillar associated protein 5 0.00939798
ACKR3 atypical chemokine receptor 3 0.00922522
TSPYL5 TSPY-like 5 0.00912405
LGALS1 lectin, galactoside-binding, soluble, 1 0.0090654
ATF3 activating transcription factor 3 0.00904022
FN1 fibronectin 1 0.00902791
CLEC3B C-type lectin domain family 3, member B 0.00901516
BEX4 brain expressed, X-linked 4 0.00896273
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.00894353
PLAAT3 phospholipase A and acyltransferase 3 0.00891128
FRMD4B FERM domain containing 4B 0.00887883
ANPEP alanyl (membrane) aminopeptidase 0.00885304
COL5A2 collagen, type V, alpha 2 0.00881454
COL15A1 collagen, type XV, alpha 1 0.00868431
CTSK cathepsin K 0.00862436
TGFBI transforming growth factor, beta-induced, 68kDa 0.00858187
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.00840653
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.00838617
LAMB1 laminin, beta 1 0.00837164
CCL20 chemokine (C-C motif) ligand 20 0.00834122
IFI27 interferon, alpha-inducible protein 27 0.00827919
NDRG1 N-myc downstream regulated 1 0.00815175
ANXA1 annexin A1 0.00813479
LIMCH1 LIM and calponin homology domains 1 0.00809818
FABP4 fatty acid binding protein 4, adipocyte 0.00805609
TPPP3 tubulin polymerization-promoting protein family member 3 0.00796213
CXCL8 chemokine (C-X-C motif) ligand 8 0.00794626
FTH1 ferritin, heavy polypeptide 1 0.00789372
GSN gelsolin 0.00789293
TPBG trophoblast glycoprotein 0.00787894
CTSH cathepsin H 0.00785187
CP ceruloplasmin (ferroxidase) 0.00782342
TUFT1 tuftelin 1 0.00781885
IL6 interleukin 6 0.00781405
CALB1 calbindin 1, 28kDa 0.00780754
AKR1C1 aldo-keto reductase family 1, member C1 0.00780213
OSR2 odd-skipped related transciption factor 2 0.00777311
PTK2 protein tyrosine kinase 2 0.00775965
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0077139
FILIP1L filamin A interacting protein 1-like 0.00771038
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 0.00769976
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 0.00769881
C3 complement component 3 0.00767528
KRT7 keratin 7, type II 0.00766013
MT1M metallothionein 1M 0.00755715
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00752862
STC1 stanniocalcin 1 0.00750566
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.00748487
KRT23 keratin 23, type I 0.00744028
AKAP12 A kinase (PRKA) anchor protein 12 0.00743919
LAMB3 laminin, beta 3 0.00741246
THBS2 thrombospondin 2 0.00739123
SPRED2 sprouty-related, EVH1 domain containing 2 0.00737736
AEBP1 AE binding protein 1 0.00736378
NID2 nidogen 2 (osteonidogen) 0.00736073
ZNF706 zinc finger protein 706 0.00734883
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.00734305
AGR2 anterior gradient 2 0.00730661
SFRP1 secreted frizzled-related protein 1 0.00730547
CPE carboxypeptidase E 0.00728832
SP100 SP100 nuclear antigen 0.00728254
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00727247
BIK BCL2-interacting killer (apoptosis-inducing) 0.00726375
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.00725666
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.00724187
RAB9A RAB9A, member RAS oncogene family 0.00722674
CRYAB crystallin, alpha B 0.00720684
INSR insulin receptor 0.0071707
PFDN4 prefoldin subunit 4 0.00715847
AREG amphiregulin 0.00712432
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.00712379
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00711318
PLAU plasminogen activator, urokinase 0.00708828
DPT dermatopontin 0.0070803
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.00703309
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00702217
SSPN sarcospan 0.00698636
SAT1 spermidine/spermine N1-acetyltransferase 1 0.00698276
SGK1 serum/glucocorticoid regulated kinase 1 0.00694842
CDCP1 CUB domain containing protein 1 0.00694058
DEFB1 defensin, beta 1 0.00693716
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0069252
MECOM MDS1 and EVI1 complex locus 0.00684483
GSTP1 glutathione S-transferase pi 1 0.00684201
CFH complement factor H 0.0068386
COL14A1 collagen, type XIV, alpha 1 0.00683103
OSBPL2 oxysterol binding protein-like 2 0.00683069
OLFML2A olfactomedin-like 2A 0.00681711
HMOX1 heme oxygenase 1 0.00676798
STAP2 signal transducing adaptor family member 2 0.0067398
OGN osteoglycin 0.00671145
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.00670285
PSAP prosaposin 0.00668444
DPYSL2 dihydropyrimidinase-like 2 0.00668028
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.00667803
GPX2 glutathione peroxidase 2 0.0066769
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00667441
YPEL5 yippee-like 5 (Drosophila) 0.00667189
DCN decorin 0.00667024
SQLE squalene epoxidase 0.00665382
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00665088
INAVA innate immunity activator 0.00664253
GAS7 growth arrest-specific 7 0.00663064
LIMK2 LIM domain kinase 2 0.00662266
KLHL24 kelch-like family member 24 0.00659361
FXR1 fragile X mental retardation, autosomal homolog 1 0.00658557
SDC4 syndecan 4 0.00655889
SCUBE2 signal peptide, CUB domain, EGF-like 2 0.00654876
FADS3 fatty acid desaturase 3 0.00654082
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 0.00653433
FBLN1 fibulin 1 0.00653269
COL3A1 collagen, type III, alpha 1 0.0065185
SGCE sarcoglycan, epsilon 0.00650871
PRNP prion protein 0.0064868
EPCAM epithelial cell adhesion molecule 0.00648571
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.00646023
CLDN7 claudin 7 0.00645733
IGSF3 immunoglobulin superfamily, member 3 0.00644708
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.00644595
CSTA cystatin A (stefin A) 0.00643813
SOX4 SRY (sex determining region Y)-box 4 0.00643353
PCOLCE procollagen C-endopeptidase enhancer 0.00642927
ISG15 ISG15 ubiquitin-like modifier 0.00642849
IER5 immediate early response 5 0.00641795
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.00641727
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0064051
HSPB1 heat shock 27kDa protein 1 0.00639631
PTGIS prostaglandin I2 (prostacyclin) synthase 0.00638448
PRSS8 protease, serine, 8 0.00637715
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.00633474
ITGAV integrin, alpha V 0.00633399
PELI1 pellino E3 ubiquitin protein ligase 1 0.00629537
ASPN asporin 0.00629401
MTUS1 microtubule associated tumor suppressor 1 0.00628544
CALCOCO2 calcium binding and coiled-coil domain 2 0.00627603
PDGFRL platelet-derived growth factor receptor-like 0.00627468
ANK2 ankyrin 2, neuronal 0.00624897
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00622541
COL6A3 collagen, type VI, alpha 3 0.0062124
IGF1R insulin-like growth factor 1 receptor 0.00620545
ZBTB10 zinc finger and BTB domain containing 10 0.0062033
TFPI2 tissue factor pathway inhibitor 2 0.00619552
JMJD1C jumonji domain containing 1C 0.00618756
ZNF423 zinc finger protein 423 0.0061758
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.00615797
ZFPM2 zinc finger protein, FOG family member 2 0.00612907
CAB39 calcium binding protein 39 0.00610976
FXYD3 FXYD domain containing ion transport regulator 3 0.00610617
IGFBP5 insulin-like growth factor binding protein 5 0.00609927
AKR1C3 aldo-keto reductase family 1, member C3 0.00609681
TSPAN1 tetraspanin 1 0.00607792
RIN2 Ras and Rab interactor 2 0.00607126
PPP1R7 protein phosphatase 1, regulatory subunit 7 0.00606649
SLC38A1 solute carrier family 38, member 1 0.0060604
TSPO translocator protein (18kDa) 0.00605242
GAS6 growth arrest-specific 6 0.00604391
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00602822
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.00601083
S100A10 S100 calcium binding protein A10 0.00600467
SCPEP1 serine carboxypeptidase 1 0.0059876
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.00597815
HECA headcase homolog (Drosophila) 0.00597064
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.00594667
HEBP2 heme binding protein 2 0.00593874
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.0059262
MVP major vault protein 0.005921
CYRIA CYFIP related Rac1 interactor A 0.00592002
FBN1 fibrillin 1 0.00591893
VCAN versican 0.00589437
NUAK1 NUAK family, SNF1-like kinase, 1 0.00589338
PLAT plasminogen activator, tissue 0.00586864
KLF4 Kruppel-like factor 4 (gut) 0.00584084
MYOF myoferlin 0.00583864
ANXA2P2 annexin A2 pseudogene 2 0.00583449
SIRPA signal-regulatory protein alpha 0.00582299
PER2 period circadian clock 2 0.00582289
DES desmin 0.00580294
DTX4 deltex 4, E3 ubiquitin ligase 0.00578413
BST2 bone marrow stromal cell antigen 2 0.00577917
PAN2 PAN2 poly(A) specific ribonuclease subunit 0.00577382
PALLD palladin, cytoskeletal associated protein 0.00577228
KCTD12 potassium channel tetramerization domain containing 12 0.00576782
MBNL2 muscleblind-like splicing regulator 2 0.00576765
RNF103 ring finger protein 103 0.00574736
INHBA inhibin, beta A 0.00573535
ARMCX1 armadillo repeat containing, X-linked 1 0.00572104
THBS4 thrombospondin 4 0.00570461
RRBP1 ribosome binding protein 1 0.0057027
EGFL6 EGF-like-domain, multiple 6 0.0056893
KDM6A lysine (K)-specific demethylase 6A 0.00567198
ECM1 extracellular matrix protein 1 0.00566937
EFNA1 ephrin-A1 0.0056378
OLFML3 olfactomedin-like 3 0.00563478
EPS8L1 EPS8-like 1 0.00562753
MIR22HG MIR22 host gene 0.00562484
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.00561915
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0056117
ANXA2 annexin A2 0.00560793
MN1 meningioma (disrupted in balanced translocation) 1 0.00560709
PLXNB2 plexin B2 0.00560562
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.00560379
HDLBP high density lipoprotein binding protein 0.00559086
EFHD1 EF-hand domain family, member D1 0.00557996
NEU1 sialidase 1 (lysosomal sialidase) 0.00556872
CCNG2 cyclin G2 0.00556711
MB myoglobin 0.00556077
TIMP2 TIMP metallopeptidase inhibitor 2 0.00555474
ADGRL4 adhesion G protein-coupled receptor L4 0.00554388
CD44 CD44 molecule (Indian blood group) 0.00553272
FADS1 fatty acid desaturase 1 0.00552183
XAF1 XIAP associated factor 1 0.00551793
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00551599
STC2 stanniocalcin 2 0.00551224
C14ORF132 chromosome 14 open reading frame 132 0.00551087
THBS1 thrombospondin 1 0.00550584
DEPTOR DEP domain containing MTOR-interacting protein 0.00549209
SNAI2 snail family zinc finger 2 0.0054845
ADGRG2 adhesion G protein-coupled receptor G2 0.00547933
THBD thrombomodulin 0.00547546

decreased expression

Symbol Name Standardized Value
WDR7 WD repeat domain 7 -0.0127517
WASHC4 WASH complex subunit 4 -0.0125348
ARG1 arginase 1 -0.0112492
KRT1 keratin 1, type II -0.0103494
COPS7A COP9 signalosome subunit 7A -0.00998813
SIRT3 sirtuin 3 -0.00958285
ECI2 enoyl-CoA delta isomerase 2 -0.00947569
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.00941129
JCHAIN joining chain of multimeric IgA and IgM -0.00914544
S100A12 S100 calcium binding protein A12 -0.00906859
KIF20A kinesin family member 20A -0.00881801
ADAT1 adenosine deaminase, tRNA-specific 1 -0.00861028
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -0.00829981
DCXR dicarbonyl/L-xylulose reductase -0.00829908
CCNA2 cyclin A2 -0.00810613
FBXO11 F-box protein 11 -0.00806097
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.00803396
HP haptoglobin -0.00800089
MAP7 microtubule-associated protein 7 -0.00793547
BANK1 B-cell scaffold protein with ankyrin repeats 1 -0.00781027
PLP1 proteolipid protein 1 -0.00779199
BIRC5 baculoviral IAP repeat containing 5 -0.00758354
NRGN neurogranin (protein kinase C substrate, RC3) -0.00753863
AKAP7 A kinase (PRKA) anchor protein 7 -0.00746116
SFTPA2 surfactant protein A2 -0.00741393
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.00733831
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -0.00724267
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -0.00721255
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.00716008
CST7 cystatin F (leukocystatin) -0.00711742
HBD hemoglobin, delta -0.00704565
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -0.00703232
RXYLT1 ribitol xylosyltransferase 1 -0.00703219
PHB2 prohibitin 2 -0.00702986
GPM6A glycoprotein M6A -0.00699172
TPI1 triosephosphate isomerase 1 -0.00695686
QDPR quinoid dihydropteridine reductase -0.00694388
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -0.0069077
TARP TCR gamma alternate reading frame protein -0.00688255
NUSAP1 nucleolar and spindle associated protein 1 -0.00684908
PRTN3 proteinase 3 -0.00681672
VSNL1 visinin-like 1 -0.00678713
DEFA4 defensin, alpha 4, corticostatin -0.00676454
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00675472
GJA1 gap junction protein, alpha 1, 43kDa -0.00672023
F12 coagulation factor XII (Hageman factor) -0.00669819
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -0.00666677
PLK1 polo-like kinase 1 -0.00654306
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00653429
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00648531
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00646037
GAL galanin/GMAP prepropeptide -0.00645013
AHSP alpha hemoglobin stabilizing protein -0.00634672
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.00633603
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.00632113
PLPP3 phospholipid phosphatase 3 -0.00630205
PTCH1 patched 1 -0.00629686
ITK IL2-inducible T-cell kinase -0.00626462
CDC20 cell division cycle 20 -0.00625287
PMP2 peripheral myelin protein 2 -0.0062319
FOXM1 forkhead box M1 -0.00621955
L1TD1 LINE-1 type transposase domain containing 1 -0.00621662
DSG1 desmoglein 1 -0.00621214
ALAS2 5'-aminolevulinate synthase 2 -0.00616406
KDM5D lysine (K)-specific demethylase 5D -0.00616375
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00614384
EPB42 erythrocyte membrane protein band 4.2 -0.0061276
SELL selectin L -0.00611134
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -0.00610028
BAALC brain and acute leukemia, cytoplasmic -0.00608946
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.00608038
CDCA3 cell division cycle associated 3 -0.00607393
HOPX HOP homeobox -0.00605578
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -0.00605162
DCK deoxycytidine kinase -0.00604727
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -0.00604002
GSTA1 glutathione S-transferase alpha 1 -0.00602887
BPI bactericidal/permeability-increasing protein -0.00602065
FASN fatty acid synthase -0.0060042
CD59 CD59 molecule, complement regulatory protein -0.00599193
MAT2B methionine adenosyltransferase II, beta -0.0059448
GPR171 G protein-coupled receptor 171 -0.005904
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 -0.005899
CLCA1 chloride channel accessory 1 -0.00588453
CLCN3 chloride channel, voltage-sensitive 3 -0.00586877
DUSP2 dual specificity phosphatase 2 -0.00583306
TXNL1 thioredoxin-like 1 -0.0058273
PRF1 perforin 1 (pore forming protein) -0.00582687
GRIA2 glutamate receptor, ionotropic, AMPA 2 -0.00581296
MARCKSL1 MARCKS-like 1 -0.00580081
AZU1 azurocidin 1 -0.0057777
SRP72 signal recognition particle 72kDa -0.00575747
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.00574341
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.00572932
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -0.00572846
TMEM38B transmembrane protein 38B -0.00570933
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -0.00567217
GSAP gamma-secretase activating protein -0.00566605
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) -0.00564808
FABP7 fatty acid binding protein 7, brain -0.00562238
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00562002
KRT6A keratin 6A, type II -0.00561688
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.00558066
SALL1 spalt-like transcription factor 1 -0.00557677
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.00556944
HMBS hydroxymethylbilane synthase -0.00556182
THAP12 THAP domain containing 12 -0.00555002
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -0.00554897
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -0.00554514
NANOG Nanog homeobox -0.00552398
IL2RB interleukin 2 receptor, beta -0.00550474
GLRX5 glutaredoxin 5 -0.00549861
CD320 CD320 molecule -0.00548896
NEK2 NIMA-related kinase 2 -0.00547905
CHKB choline kinase beta -0.00547007
LY6D lymphocyte antigen 6 complex, locus D -0.0054301
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.00542424
ADGRL3 adhesion G protein-coupled receptor L3 -0.005403
KIF4A kinesin family member 4A -0.00538811
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -0.00535493
PITX3 paired-like homeodomain 3 -0.00534973
IL7R interleukin 7 receptor -0.00534292
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -0.00532665
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.00530373
KRAS Kirsten rat sarcoma viral oncogene homolog -0.0052964
OTULINL OTU deubiquitinase with linear linkage specificity like -0.00527725
NES nestin -0.00527008
SFTPB surfactant protein B -0.00526884
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 -0.0051868
HPF1 histone PARylation factor 1 -0.0051656
LTF lactotransferrin -0.00514355
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.00513602
HOXB6 homeobox B6 -0.00513001
CHPT1 choline phosphotransferase 1 -0.00510935
WFDC1 WAP four-disulfide core domain 1 -0.00510064
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.00509178
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.00508576
MAP2K6 mitogen-activated protein kinase kinase 6 -0.00508548
NR5A1 nuclear receptor subfamily 5, group A, member 1 -0.00506653
MMP8 matrix metallopeptidase 8 -0.00506583
DMTN dematin actin binding protein -0.00506344
LMNB1 lamin B1 -0.00504363
FXN frataxin -0.00503804
HAUS4 HAUS augmin-like complex, subunit 4 -0.00502102
FOXG1 forkhead box G1 -0.00501166
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A -0.00501097
ENO2 enolase 2 (gamma, neuronal) -0.00501072
PUF60 poly-U binding splicing factor 60KDa -0.00501009
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.00500481
ELANE elastase, neutrophil expressed -0.00497441
HAL histidine ammonia-lyase -0.00493991
RPP40 ribonuclease P/MRP 40kDa subunit -0.00491865
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.00491679
FCMR Fc fragment of IgM receptor -0.00490252
NEFM neurofilament, medium polypeptide -0.00489901
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 -0.00488952
KRT16 keratin 16, type I -0.0048869
TYRP1 tyrosinase-related protein 1 -0.00488188
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -0.00486954
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -0.00486932
NEIL3 nei endonuclease VIII-like 3 (E. coli) -0.00486442
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.00485556
DSC1 desmocollin 1 -0.00485091
DLL3 delta-like 3 (Drosophila) -0.00484352
MED22 mediator complex subunit 22 -0.004827
ADGRE1 adhesion G protein-coupled receptor E1 -0.00482633
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 -0.00481235
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.00480637
LOR loricrin -0.00479804
IL18RAP interleukin 18 receptor accessory protein -0.0047974
PRPS1 phosphoribosyl pyrophosphate synthetase 1 -0.00479728
COMMD10 COMM domain containing 10 -0.00479621
MCM5 minichromosome maintenance complex component 5 -0.00478659
MRPS2 mitochondrial ribosomal protein S2 -0.00478561
TLK2 tousled-like kinase 2 -0.00477426
NCAN neurocan -0.00475193
UBE2N ubiquitin-conjugating enzyme E2N -0.00475046
NME1 NME/NM23 nucleoside diphosphate kinase 1 -0.00474483
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0047443
TMEM14A transmembrane protein 14A -0.00474055
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.00473586
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -0.0047343
MCM2 minichromosome maintenance complex component 2 -0.00473154
MRPS27 mitochondrial ribosomal protein S27 -0.00473123
C20ORF27 chromosome 20 open reading frame 27 -0.00472737
TMEM14B transmembrane protein 14B -0.00472413
LRRC31 leucine rich repeat containing 31 -0.00471961
GNLY granulysin -0.00471217
MRPS7 mitochondrial ribosomal protein S7 -0.00470042
EPAS1 endothelial PAS domain protein 1 -0.00469899
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -0.00469687
CAPZB capping protein (actin filament) muscle Z-line, beta -0.00468731
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) -0.0046801
ETNPPL ethanolamine-phosphate phospho-lyase -0.00467859
ZNF274 zinc finger protein 274 -0.00467458
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -0.00466798
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0046508
CCR7 chemokine (C-C motif) receptor 7 -0.00464534
NME4 NME/NM23 nucleoside diphosphate kinase 4 -0.00464141
ALG6 ALG6, alpha-1,3-glucosyltransferase -0.00464134
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.00463068
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.00461881
NLE1 notchless homolog 1 (Drosophila) -0.00461815
PIMREG PICALM interacting mitotic regulator -0.0046028
RUFY3 RUN and FYVE domain containing 3 -0.00459857
C6 complement component 6 -0.00459687
HPR haptoglobin-related protein -0.0045818
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.00457746
SRM spermidine synthase -0.00456801
FARSA phenylalanyl-tRNA synthetase, alpha subunit -0.00455353
OAZ2 ornithine decarboxylase antizyme 2 -0.00454284
SMYD2 SET and MYND domain containing 2 -0.0045419
SET SET nuclear proto-oncogene -0.00453877
OXA1L oxidase (cytochrome c) assembly 1-like -0.00453614
RGS4 regulator of G-protein signaling 4 -0.0045353
MRPL39 mitochondrial ribosomal protein L39 -0.00453432
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.00453377
UNG uracil-DNA glycosylase -0.00452292
TRIM58 tripartite motif containing 58 -0.00451638
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 -0.00449258
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.00449021
SFTPD surfactant protein D -0.00448892
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.00448267
MYT1L myelin transcription factor 1-like -0.00447835
ORM1 orosomucoid 1 -0.00447618
FKBP11 FK506 binding protein 11, 19 kDa -0.00447613
DLK1 delta-like 1 homolog (Drosophila) -0.0044695
GRWD1 glutamate-rich WD repeat containing 1 -0.00446864
VTI1B vesicle transport through interaction with t-SNAREs 1B -0.00446864
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -0.00446789
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -0.00446775
GYS2 glycogen synthase 2 (liver) -0.0044668
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -0.00446336
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.00446014
CRCT1 cysteine-rich C-terminal 1 -0.00445979
SNHG20 small nucleolar RNA host gene 20 -0.00445772
CALML5 calmodulin-like 5 -0.00445023
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -0.00444624
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.00444144
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -0.0044249
LRRN3 leucine rich repeat neuronal 3 -0.00442011
PMEL premelanosome protein -0.00441879
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.00441293
CFHR4 complement factor H-related 4 -0.0044076
RANBP1 RAN binding protein 1 -0.00440529
KRT10 keratin 10, type I -0.00439127
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 -0.0043853
FOCAD focadhesin -0.00437911
CPB2 carboxypeptidase B2 (plasma) -0.00437611