GRN Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description granulin|Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2896)
External Link http://www.ncbi.nlm.nih.gov/gene/2896
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Genes

104 interacting proteins for GRN from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ADCY8 adenylate cyclase 8 (brain)
APOA2 apolipoprotein A-II
ATN1 atrophin 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATXN7 ataxin 7
C6ORF48 chromosome 6 open reading frame 48
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CANX calnexin
CAPNS1 calpain, small subunit 1
CCNG1 cyclin G1
CCNT1 cyclin T1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDK9 cyclin-dependent kinase 9
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLCA1 chloride channel accessory 1
CLINT1 clathrin interactor 1
CLTCL1 clathrin, heavy chain-like 1
CMYA5 cardiomyopathy associated 5
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRY1 cryptochrome circadian clock 1
CSNK2B casein kinase 2, beta polypeptide
DLK1 delta-like 1 homolog (Drosophila)
EED embryonic ectoderm development
ELANE elastase, neutrophil expressed
EXO1 exonuclease 1
FAM131C family with sequence similarity 131, member C
FBXO6 F-box protein 6
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GFI1B growth factor independent 1B transcription repressor
GLRX3 glutaredoxin 3
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HAX1 HCLS1 associated protein X-1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HK3 hexokinase 3 (white cell)
HOXA1 homeobox A1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPG2 heparan sulfate proteoglycan 2
KPNB1 karyopherin (importin) beta 1
KRT18 keratin 18, type I
LIMA1 LIM domain and actin binding 1
LIN7C lin-7 homolog C (C. elegans)
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MASTL microtubule associated serine/threonine kinase-like
NCAPD2 non-SMC condensin I complex, subunit D2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PGAP1 post-GPI attachment to proteins 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITPNA phosphatidylinositol transfer protein, alpha
POT1 protection of telomeres 1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSAP prosaposin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RIF1 replication timing regulatory factor 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RYK receptor-like tyrosine kinase
SBF1 SET binding factor 1
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SIRT3 sirtuin 3
SLPI secretory leukocyte peptidase inhibitor
SMAD9 SMAD family member 9
SORT1 sortilin 1
SQRDL sulfide quinone reductase-like (yeast)
TAT tyrosine aminotransferase
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TGM2 transglutaminase 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TJP1 tight junction protein 1
TJP3 tight junction protein 3
TLK2 tousled-like kinase 2
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TOP3B topoisomerase (DNA) III beta
TPM3 tropomyosin 3
TRIB3 tribbles pseudokinase 3
TTF2 transcription termination factor, RNA polymerase II
UGDH UDP-glucose 6-dehydrogenase
UQCRH ubiquinol-cytochrome c reductase hinge protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WFS1 Wolfram syndrome 1 (wolframin)
WSB1 WD repeat and SOCS box containing 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XPO1 exportin 1
YY1 YY1 transcription factor