| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/25022668 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in GSK 650394 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PKLR | pyruvate kinase, liver and RBC | 1.87 |
| ITGA1 | integrin, alpha 1 | 1.47 |
| TROAP | trophinin associated protein | 1.28 |
| CKAP2 | cytoskeleton associated protein 2 | 1.17 |
| CCNB1 | cyclin B1 | 1.17 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 1.16 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 1.11 |
| KLK7 | kallikrein-related peptidase 7 | 1.03 |
| SMTN | smoothelin | 0.99 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.94 |
| CKAP2L | cytoskeleton associated protein 2-like | 0.93 |
| CDCA3 | cell division cycle associated 3 | 0.92 |
| SACK1D | scaffolding CK1 anchoring protein D | 0.9 |
| SASH1 | SAM and SH3 domain containing 1 | 0.88 |
| AURKA | aurora kinase A | 0.86 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.85 |
| ANLN | anillin, actin binding protein | 0.84 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.8 |
| TDG | thymine-DNA glycosylase | 0.79 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.78 |
| EPN3 | epsin 3 | 0.78 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.77 |
| PLK1 | polo-like kinase 1 | 0.76 |
| KIF20A | kinesin family member 20A | 0.75 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | 0.74 |
| PRR11 | proline rich 11 | 0.74 |
| CCDC158 | coiled-coil domain containing 158 | 0.72 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.72 |
| CDC25B | cell division cycle 25B | 0.71 |
| CCND1 | cyclin D1 | 0.71 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.7 |
| TP53 | tumor protein p53 | 0.68 |
| AP5S1 | adaptor-related protein complex 5, sigma 1 subunit | 0.68 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.68 |
| PRC1 | protein regulator of cytokinesis 1 | 0.67 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.66 |
| KIF2C | kinesin family member 2C | 0.66 |
| RPL11 | ribosomal protein L11 | 0.66 |
| SGO1 | shugoshin 1 | 0.65 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.65 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.64 |
| ORC1 | origin recognition complex, subunit 1 | 0.64 |
| RAN | RAN, member RAS oncogene family | 0.6 |
| SMOX | spermine oxidase | 0.59 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.59 |
| AURKB | aurora kinase B | 0.59 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.58 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | 0.58 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.57 |
| RNF145 | ring finger protein 145 | 0.57 |
| CCND3 | cyclin D3 | 0.56 |
| TPX2 | TPX2, microtubule-associated | 0.56 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.56 |
| IFRD1 | interferon-related developmental regulator 1 | 0.56 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | 0.56 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.56 |
| CKM | creatine kinase, muscle | 0.55 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.55 |
| CDCA8 | cell division cycle associated 8 | 0.55 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.54 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.54 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.54 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | 0.54 |
| VCAN | versican | 0.53 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.53 |
| LETMD1 | LETM1 domain containing 1 | 0.52 |
| TTYH2 | tweety family member 2 | 0.52 |
| FAM219B | family with sequence similarity 219, member B | 0.52 |
| CCNB2 | cyclin B2 | 0.52 |
| TSPAN3 | tetraspanin 3 | 0.52 |
| LPIN1 | lipin 1 | 0.51 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.51 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.51 |
| PON3 | paraoxonase 3 | 0.51 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.5 |
| KIF23 | kinesin family member 23 | 0.5 |
| GCAT | glycine C-acetyltransferase | 0.49 |
| PACS2 | phosphofurin acidic cluster sorting protein 2 | 0.49 |
| PPL | periplakin | 0.49 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.49 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.49 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.49 |
| EVPL | envoplakin | 0.48 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.48 |
| SASS6 | spindle assembly 6 homolog (C. elegans) | 0.48 |
| CDC20 | cell division cycle 20 | 0.48 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.48 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.47 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.47 |
| DZIP3 | DAZ interacting zinc finger protein 3 | 0.47 |
| CLDN3 | claudin 3 | 0.47 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.46 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.46 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.46 |
| DNAL4 | dynein, axonemal, light chain 4 | 0.46 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.46 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.46 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | 0.46 |
| KMT5A | lysine methyltransferase 5A | 0.46 |
| Symbol | Name | Standardized Value |
|---|---|---|
| H1-3 | H1.3 linker histone, cluster member | -1.19 |
| ATAD2 | ATPase family, AAA domain containing 2 | -1.09 |
| H1-0 | H1.0 linker histone | -1.04 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.01 |
| H1-2 | H1.2 linker histone, cluster member | -0.94 |
| ZNF711 | zinc finger protein 711 | -0.93 |
| ATAD2B | ATPase family, AAA domain containing 2B | -0.92 |
| SH2B3 | SH2B adaptor protein 3 | -0.9 |
| MSX2 | msh homeobox 2 | -0.88 |
| H1FX | H1 histone family, member X | -0.86 |
| PER2 | period circadian clock 2 | -0.85 |
| TIGD1 | tigger transposable element derived 1 | -0.84 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.83 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.81 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -0.79 |
| ZNF580 | zinc finger protein 580 | -0.77 |
| WEE1 | WEE1 G2 checkpoint kinase | -0.77 |
| FBXO5 | F-box protein 5 | -0.76 |
| FGB | fibrinogen beta chain | -0.76 |
| ZFP62 | ZFP62 zinc finger protein | -0.74 |
| FAM111B | family with sequence similarity 111, member B | -0.7 |
| VEZF1 | vascular endothelial zinc finger 1 | -0.7 |
| SLBP | stem-loop binding protein | -0.7 |
| JUN | jun proto-oncogene | -0.7 |
| ZNF296 | zinc finger protein 296 | -0.69 |
| TNXB | tenascin XB | -0.67 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.66 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.65 |
| CCDC170 | coiled-coil domain containing 170 | -0.65 |
| MAGEF1 | melanoma antigen family F1 | -0.64 |
| RPGR | retinitis pigmentosa GTPase regulator | -0.63 |
| BBS10 | Bardet-Biedl syndrome 10 | -0.63 |
| SCN11A | sodium channel, voltage gated, type XI alpha subunit | -0.61 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.61 |
| VSIR | V-set immunoregulatory receptor | -0.6 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.6 |
| HELLS | helicase, lymphoid-specific | -0.59 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.59 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.59 |
| HOXA10 | homeobox A10 | -0.59 |
| CCN1 | cellular communication network factor 1 | -0.59 |
| TRMO | tRNA methyltransferase O | -0.59 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.59 |
| MCTS2P | malignant T cell amplified sequence 2, pseudogene | -0.58 |
| SP2 | Sp2 transcription factor | -0.58 |
| ZNF205 | zinc finger protein 205 | -0.56 |
| PCGF1 | polycomb group ring finger 1 | -0.56 |
| HIST3H2A | histone cluster 3, H2a | -0.56 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.55 |
| RAD51AP1 | RAD51 associated protein 1 | -0.54 |
| ADIPOR1 | adiponectin receptor 1 | -0.53 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.53 |
| SERINC3 | serine incorporator 3 | -0.53 |
| PLIN2 | perilipin 2 | -0.52 |
| H1-4 | H1.4 linker histone, cluster member | -0.52 |
| WDR76 | WD repeat domain 76 | -0.51 |
| HIST2H2BF | histone cluster 2, H2bf | -0.51 |
| PIWIL2 | piwi-like RNA-mediated gene silencing 2 | -0.51 |
| HGFAC | HGF activator | -0.51 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.5 |
| C5ORF24 | chromosome 5 open reading frame 24 | -0.5 |
| ZNF33A | zinc finger protein 33A | -0.49 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.49 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.49 |
| NR2C1 | nuclear receptor subfamily 2, group C, member 1 | -0.49 |
| TMEM64 | transmembrane protein 64 | -0.49 |
| ZNF217 | zinc finger protein 217 | -0.48 |
| C12ORF73 | chromosome 12 open reading frame 73 | -0.47 |
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | -0.47 |
| INTU | inturned planar cell polarity protein | -0.47 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.47 |
| MPV17 | MpV17 mitochondrial inner membrane protein | -0.47 |
| PITX1 | paired-like homeodomain 1 | -0.47 |
| SPIN4 | spindlin family, member 4 | -0.46 |
| PHF20L1 | PHD finger protein 20-like 1 | -0.46 |
| CENPU | centromere protein U | -0.46 |
| JADE1 | jade family PHD finger 1 | -0.46 |
| JRK | Jrk homolog (mouse) | -0.46 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.46 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.46 |
| KDM8 | lysine (K)-specific demethylase 8 | -0.46 |
| SUSD2 | sushi domain containing 2 | -0.45 |
| SVBP | small vasohibin binding protein | -0.45 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.45 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.45 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.44 |
| ZC3H10 | zinc finger CCCH-type containing 10 | -0.44 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | -0.44 |
| E2F7 | E2F transcription factor 7 | -0.44 |
| RAB40C | RAB40C, member RAS oncogene family | -0.44 |
| ZNF8 | zinc finger protein 8 | -0.44 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.44 |
| KSR2 | kinase suppressor of ras 2 | -0.44 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | -0.44 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.44 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | -0.44 |
| KIF21B | kinesin family member 21B | -0.43 |
| DCLRE1A | DNA cross-link repair 1A | -0.43 |
| LRRC58 | leucine rich repeat containing 58 | -0.43 |
| INHBA | inhibin, beta A | -0.43 |
