GSK-1070916 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/46885626
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Genes

199 proteins with high or low expression in GSK-1070916 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
APOB apolipoprotein B 4.47
NDFIP1 Nedd4 family interacting protein 1 3.88
TMEM59 transmembrane protein 59 3.75
ITM2C integral membrane protein 2C 3.49
PAH phenylalanine hydroxylase 3.45
LAPTM4A lysosomal protein transmembrane 4 alpha 3.43
ITM2B integral membrane protein 2B 3.07
NRIP1 nuclear receptor interacting protein 1 3.02
NDFIP2 Nedd4 family interacting protein 2 2.96
NBR1 neighbor of BRCA1 gene 1 2.95
APLP2 amyloid beta (A4) precursor-like protein 2 2.85
IFNGR1 interferon gamma receptor 1 2.81
APOE apolipoprotein E 2.78
LRP10 low density lipoprotein receptor-related protein 10 2.74
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.73
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.65
NCOA4 nuclear receptor coactivator 4 2.53
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.51
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.39
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.37
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.31
INPP5J inositol polyphosphate-5-phosphatase J 2.27
RNF149 ring finger protein 149 2.25
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.24
ACVR1B activin A receptor, type IB 2.23
APP amyloid beta (A4) precursor protein 2.21
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.2
FGFR4 fibroblast growth factor receptor 4 2.16
PSAP prosaposin 2.16
AREG amphiregulin 2.16
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.11
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.09
SQSTM1 sequestosome 1 2.02
PLD3 phospholipase D family, member 3 2.02
SERINC1 serine incorporator 1 2.01
RNF130 ring finger protein 130 2.01
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.0
IDI1 isopentenyl-diphosphate delta isomerase 1 1.97
RNF13 ring finger protein 13 1.91
SQLE squalene epoxidase 1.88
ABHD2 abhydrolase domain containing 2 1.88
CALCOCO2 calcium binding and coiled-coil domain 2 1.87
NPDC1 neural proliferation, differentiation and control, 1 1.87
PTPRS protein tyrosine phosphatase, receptor type, S 1.83
MSMO1 methylsterol monooxygenase 1 1.76
SLC38A2 solute carrier family 38, member 2 1.74
IL13RA1 interleukin 13 receptor, alpha 1 1.69
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.67
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.66
OSMR oncostatin M receptor 1.64
SDC4 syndecan 4 1.62
TMEM248 transmembrane protein 248 1.6
LDLR low density lipoprotein receptor 1.6
MFGE8 milk fat globule-EGF factor 8 protein 1.59
TP53 tumor protein p53 1.58
FAT1 FAT atypical cadherin 1 1.57
FGFBP1 fibroblast growth factor binding protein 1 1.56
LPIN1 lipin 1 1.56
TM7SF2 transmembrane 7 superfamily member 2 1.56
TMEM185B transmembrane protein 185B 1.55
SERINC3 serine incorporator 3 1.54
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.54
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.51
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1.5
BMPR1A bone morphogenetic protein receptor, type IA 1.49
MFAP3L microfibrillar-associated protein 3-like 1.48
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.47
MVK mevalonate kinase 1.46
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 1.46
UNC5B unc-5 homolog B (C. elegans) 1.46
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.45
H1-0 H1.0 linker histone 1.43
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.43
ACSS2 acyl-CoA synthetase short-chain family member 2 1.42
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 1.41
FIG4 FIG4 phosphoinositide 5-phosphatase 1.37
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.35
PCGF3 polycomb group ring finger 3 1.34
SLFN5 schlafen family member 5 1.34
SLC49A4 solute carrier family 49 member 4 1.33
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.33
DHCR7 7-dehydrocholesterol reductase 1.32
FBXL20 F-box and leucine-rich repeat protein 20 1.32
ERG28 ergosterol biosynthesis 28 homolog 1.3
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.3
CLDND1 claudin domain containing 1 1.29
TRIM2 tripartite motif containing 2 1.27
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.25
MAP2 microtubule-associated protein 2 1.25
IRF9 interferon regulatory factor 9 1.25
MPZL2 myelin protein zero-like 2 1.24
NEO1 neogenin 1 1.23
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.21
TGFBR1 transforming growth factor, beta receptor 1 1.2
RHOB ras homolog family member B 1.19
DNASE2 deoxyribonuclease II, lysosomal 1.19
GDF15 growth differentiation factor 15 1.19
TYK2 tyrosine kinase 2 1.18

low expression

Symbol Name Standardized Value
TET2 tet methylcytosine dioxygenase 2 -2.77
NAV3 neuron navigator 3 -2.58
TRIB1 tribbles pseudokinase 1 -2.46
MCM10 minichromosome maintenance complex component 10 -2.12
HPSE heparanase -2.02
CKS2 CDC28 protein kinase regulatory subunit 2 -2.0
AMD1 adenosylmethionine decarboxylase 1 -1.99
CCNE2 cyclin E2 -1.94
WDR76 WD repeat domain 76 -1.9
RRM2 ribonucleotide reductase M2 -1.88
ODC1 ornithine decarboxylase 1 -1.82
WEE1 WEE1 G2 checkpoint kinase -1.81
PCLAF PCNA clamp associated factor -1.71
CTSZ cathepsin Z -1.71
DUOX1 dual oxidase 1 -1.68
CDCA7 cell division cycle associated 7 -1.66
UBE2C ubiquitin-conjugating enzyme E2C -1.66
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.66
MDM1 Mdm1 nuclear protein homolog (mouse) -1.63
FAM111B family with sequence similarity 111, member B -1.61
USP37 ubiquitin specific peptidase 37 -1.58
TTLL4 tubulin tyrosine ligase-like family member 4 -1.57
EXO1 exonuclease 1 -1.57
CDC6 cell division cycle 6 -1.56
CDCA5 cell division cycle associated 5 -1.53
SLBP stem-loop binding protein -1.53
CLSPN claspin -1.52
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -1.51
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.48
ORC6 origin recognition complex, subunit 6 -1.45
RAD54L RAD54-like (S. cerevisiae) -1.45
SCARA3 scavenger receptor class A, member 3 -1.44
M1AP meiosis 1 associated protein -1.43
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial -1.42
AEN apoptosis enhancing nuclease -1.42
CDC20 cell division cycle 20 -1.41
CCNA2 cyclin A2 -1.39
HSF2 heat shock transcription factor 2 -1.39
NRP1 neuropilin 1 -1.35
TYMS thymidylate synthetase -1.34
NABP1 nucleic acid binding protein 1 -1.34
PTTG1 pituitary tumor-transforming 1 -1.32
ESRRA estrogen-related receptor alpha -1.32
MGA MGA, MAX dimerization protein -1.3
MEX3A mex-3 RNA binding family member A -1.3
PRELID3B PRELI domain containing 3B -1.3
CUEDC2 CUE domain containing 2 -1.3
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -1.3
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -1.3
SYTL3 synaptotagmin-like 3 -1.28
E2F7 E2F transcription factor 7 -1.26
DEPDC7 DEP domain containing 7 -1.26
PRELID1 PRELI domain containing 1 -1.25
PLD6 phospholipase D family, member 6 -1.22
SASS6 spindle assembly 6 homolog (C. elegans) -1.22
FBXO5 F-box protein 5 -1.21
FBRSL1 fibrosin-like 1 -1.21
TNS4 tensin 4 -1.19
PIMREG PICALM interacting mitotic regulator -1.19
DONSON downstream neighbor of SON -1.17
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -1.17
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.14
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -1.14
NET1 neuroepithelial cell transforming 1 -1.13
CDC7 cell division cycle 7 -1.13
PRC1 protein regulator of cytokinesis 1 -1.13
BARD1 BRCA1 associated RING domain 1 -1.13
RBIS ribosomal biogenesis factor -1.13
UBE2T ubiquitin-conjugating enzyme E2T -1.13
TPX2 TPX2, microtubule-associated -1.12
UCK2 uridine-cytidine kinase 2 -1.12
TK1 thymidine kinase 1, soluble -1.11
RAD51 RAD51 recombinase -1.11
LARP4 La ribonucleoprotein domain family, member 4 -1.1
TRAK2 trafficking protein, kinesin binding 2 -1.1
ZUP1 zinc finger containing ubiquitin peptidase 1 -1.1
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 -1.1
PHF19 PHD finger protein 19 -1.09
OBI1 ORC ubiquitin ligase 1 -1.09
NAV2 neuron navigator 2 -1.08
PLK2 polo-like kinase 2 -1.08
FOXM1 forkhead box M1 -1.08
UCK1 uridine-cytidine kinase 1 -1.08
CDC123 cell division cycle 123 -1.07
KIF22 kinesin family member 22 -1.07
DNA2 DNA replication helicase/nuclease 2 -1.07
CMC1 C-x(9)-C motif containing 1 -1.07
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -1.06
ANLN anillin, actin binding protein -1.06
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.06
S100A5 S100 calcium binding protein A5 -1.05
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -1.04
ARHGAP11A Rho GTPase activating protein 11A -1.04
EGR1 early growth response 1 -1.04
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -1.04
PSRC1 proline/serine-rich coiled-coil 1 -1.04
TRAF5 TNF receptor-associated factor 5 -1.04
CASP2 caspase 2, apoptosis-related cysteine peptidase -1.03
UBE2A ubiquitin-conjugating enzyme E2A -1.03
BLM Bloom syndrome, RecQ helicase-like -1.02