GSK-343 Gene Set
Genes
28 genes differentially expressed following the GSK-343 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
INSIG1
|
insulin induced gene 1
|
4.7148
|
|
FDPS
|
farnesyl diphosphate synthase
|
4.46082
|
|
ST3GAL5
|
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
|
4.1807
|
|
ALDOC
|
aldolase C, fructose-bisphosphate
|
4.09386
|
|
FADS1
|
fatty acid desaturase 1
|
3.92444
|
|
DHCR24
|
24-dehydrocholesterol reductase
|
3.91475
|
|
TBX2
|
T-box 2
|
3.90447
|
|
MSMO1
|
methylsterol monooxygenase 1
|
3.8227
|
|
CYP51A1
|
cytochrome P450, family 51, subfamily A, polypeptide 1
|
3.78825
|
|
ACAT2
|
acetyl-CoA acetyltransferase 2
|
3.71906
|
|
SCD
|
stearoyl-CoA desaturase (delta-9-desaturase)
|
3.71656
|
|
NR3C1
|
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
|
3.69318
|
|
SQLE
|
squalene epoxidase
|
3.56148
|
|
SLC2A6
|
solute carrier family 2 (facilitated glucose transporter), member 6
|
3.55158
|
|
HMGCS1
|
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
|
3.54558
|
|
SQSTM1
|
sequestosome 1
|
3.50037
|
|
ERG28
|
ergosterol biosynthesis 28 homolog
|
3.49445
|
|
TSPO
|
translocator protein (18kDa)
|
3.43715
|
|
DHCR7
|
7-dehydrocholesterol reductase
|
3.37596
|
|
FDFT1
|
farnesyl-diphosphate farnesyltransferase 1
|
3.37211
|
|
LPIN1
|
lipin 1
|
3.32716
|
|
SC5D
|
sterol-C5-desaturase
|
3.32356
|
|
PNPLA3
|
patatin-like phospholipase domain containing 3
|
3.27834
|
|
NSDHL
|
NAD(P) dependent steroid dehydrogenase-like
|
3.25854
|
|
IDI1
|
isopentenyl-diphosphate delta isomerase 1
|
3.1839
|
|
LSS
|
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
|
3.10345
|
|
HSD17B7
|
hydroxysteroid (17-beta) dehydrogenase 7
|
3.06417
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
E2F2
|
E2F transcription factor 2
|
-6.4565
|
