| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/46898058 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in GSK-923295 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 2.2 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 2.2 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 2.2 |
| PPARGC1B | peroxisome proliferator-activated receptor gamma, coactivator 1 beta | 1.96 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.84 |
| C5 | complement component 5 | 1.84 |
| DOCK11 | dedicator of cytokinesis 11 | 1.75 |
| HMCN1 | hemicentin 1 | 1.75 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 1.68 |
| KIF20A | kinesin family member 20A | 1.57 |
| C7 | complement component 7 | 1.53 |
| TROAP | trophinin associated protein | 1.5 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 1.49 |
| SMTN | smoothelin | 1.43 |
| CST6 | cystatin E/M | 1.38 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 1.38 |
| ITM2B | integral membrane protein 2B | 1.37 |
| SBSN | suprabasin | 1.37 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.36 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 1.35 |
| KIFC1 | kinesin family member C1 | 1.33 |
| AURKA | aurora kinase A | 1.29 |
| NCOA4 | nuclear receptor coactivator 4 | 1.28 |
| GAS2L3 | growth arrest-specific 2 like 3 | 1.27 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.26 |
| CKAP2 | cytoskeleton associated protein 2 | 1.25 |
| SGO2 | shugoshin 2 | 1.25 |
| RNF149 | ring finger protein 149 | 1.24 |
| FGB | fibrinogen beta chain | 1.22 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.2 |
| TSPAN3 | tetraspanin 3 | 1.17 |
| CST3 | cystatin C | 1.15 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.15 |
| CDCA8 | cell division cycle associated 8 | 1.14 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.14 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 1.13 |
| CDT1 | chromatin licensing and DNA replication factor 1 | 1.12 |
| BIRC5 | baculoviral IAP repeat containing 5 | 1.11 |
| TP53 | tumor protein p53 | 1.09 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 1.07 |
| VGF | VGF nerve growth factor inducible | 1.03 |
| INCENP | inner centromere protein antigens 135/155kDa | 1.03 |
| MSMO1 | methylsterol monooxygenase 1 | 1.02 |
| C15ORF61 | chromosome 15 open reading frame 61 | 1.01 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.0 |
| POLR3H | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 0.99 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.98 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.98 |
| PLPP3 | phospholipid phosphatase 3 | 0.98 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.97 |
| ZNF296 | zinc finger protein 296 | 0.96 |
| PRC1 | protein regulator of cytokinesis 1 | 0.96 |
| KMT5A | lysine methyltransferase 5A | 0.95 |
| TMEM59 | transmembrane protein 59 | 0.95 |
| KIF18A | kinesin family member 18A | 0.94 |
| KIF23 | kinesin family member 23 | 0.93 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.92 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.91 |
| MCPH1 | microcephalin 1 | 0.91 |
| MRPL53 | mitochondrial ribosomal protein L53 | 0.9 |
| BSN | bassoon presynaptic cytomatrix protein | 0.9 |
| CD63 | CD63 molecule | 0.9 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.89 |
| HBA1 | hemoglobin, alpha 1 | 0.87 |
| APOE | apolipoprotein E | 0.86 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.86 |
| CKM | creatine kinase, muscle | 0.83 |
| PLK1 | polo-like kinase 1 | 0.83 |
| FN1 | fibronectin 1 | 0.81 |
| TDG | thymine-DNA glycosylase | 0.81 |
| TPX2 | TPX2, microtubule-associated | 0.8 |
| PSAP | prosaposin | 0.8 |
| FAS | Fas cell surface death receptor | 0.79 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.79 |
| PRG4 | proteoglycan 4 | 0.78 |
| DAP | death-associated protein | 0.77 |
| PLXNB1 | plexin B1 | 0.77 |
| MVK | mevalonate kinase | 0.77 |
| MORF4L2 | mortality factor 4 like 2 | 0.76 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | 0.76 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.74 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.74 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.74 |
| MVD | mevalonate (diphospho) decarboxylase | 0.73 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.73 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.73 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.72 |
| ANLN | anillin, actin binding protein | 0.72 |
| SC5D | sterol-C5-desaturase | 0.72 |
| CLU | clusterin | 0.71 |
| FSTL1 | follistatin-like 1 | 0.71 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.7 |
| ZNF689 | zinc finger protein 689 | 0.7 |
| KIF11 | kinesin family member 11 | 0.7 |
| CENPF | centromere protein F, 350/400kDa | 0.7 |
| CPA4 | carboxypeptidase A4 | 0.7 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.69 |
| H1-0 | H1.0 linker histone | 0.69 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 0.68 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.68 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZC3H12C | zinc finger CCCH-type containing 12C | -1.91 |
| FANCM | Fanconi anemia, complementation group M | -1.63 |
| CCNA2 | cyclin A2 | -1.56 |
| CCDC71 | coiled-coil domain containing 71 | -1.47 |
| JDP2 | Jun dimerization protein 2 | -1.46 |
| SNX8 | sorting nexin 8 | -1.45 |
| CCDC170 | coiled-coil domain containing 170 | -1.44 |
| CLSPN | claspin | -1.43 |
| ZNF616 | zinc finger protein 616 | -1.43 |
| CEP78 | centrosomal protein 78kDa | -1.43 |
| ZDHHC5 | zinc finger, DHHC-type containing 5 | -1.42 |
| ZNF664 | zinc finger protein 664 | -1.42 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | -1.41 |
| EXO1 | exonuclease 1 | -1.4 |
| TACC1 | transforming, acidic coiled-coil containing protein 1 | -1.4 |
| SOX4 | SRY (sex determining region Y)-box 4 | -1.35 |
| TRAK2 | trafficking protein, kinesin binding 2 | -1.35 |
| PDCD11 | programmed cell death 11 | -1.33 |
| AKAP2 | A kinase (PRKA) anchor protein 2 | -1.29 |
| SCARA3 | scavenger receptor class A, member 3 | -1.27 |
| PPL | periplakin | -1.26 |
| PDLIM2 | PDZ and LIM domain 2 (mystique) | -1.24 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | -1.22 |
| FBXO5 | F-box protein 5 | -1.2 |
| KIAA0753 | KIAA0753 | -1.2 |
| MIDN | midnolin | -1.19 |
| SENP1 | SUMO1/sentrin specific peptidase 1 | -1.19 |
| SH3RF2 | SH3 domain containing ring finger 2 | -1.19 |
| DDX49 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 | -1.17 |
| RRP36 | ribosomal RNA processing 36 homolog (S. cerevisiae) | -1.17 |
| ISG20L2 | interferon stimulated exonuclease gene 20kDa-like 2 | -1.17 |
| SINHCAF | SIN3-HDAC complex associated factor | -1.17 |
| RRM2 | ribonucleotide reductase M2 | -1.17 |
| BMS1 | BMS1 ribosome biogenesis factor | -1.16 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | -1.15 |
| ZNF770 | zinc finger protein 770 | -1.13 |
| RGPD5 | RANBP2-like and GRIP domain containing 5 | -1.13 |
| ZNF768 | zinc finger protein 768 | -1.13 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | -1.12 |
| EVPL | envoplakin | -1.12 |
| ZNF317 | zinc finger protein 317 | -1.11 |
| SUN2 | Sad1 and UNC84 domain containing 2 | -1.11 |
| MCM10 | minichromosome maintenance complex component 10 | -1.11 |
| SRFBP1 | serum response factor binding protein 1 | -1.1 |
| CCDC137 | coiled-coil domain containing 137 | -1.1 |
| GLI2 | GLI family zinc finger 2 | -1.1 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -1.1 |
| GBF1 | golgi brefeldin A resistant guanine nucleotide exchange factor 1 | -1.1 |
| ATAD2 | ATPase family, AAA domain containing 2 | -1.1 |
| MT2A | metallothionein 2A | -1.1 |
| CCDC112 | coiled-coil domain containing 112 | -1.09 |
| S100PBP | S100P binding protein | -1.08 |
| CCNE2 | cyclin E2 | -1.08 |
| CRIPT | cysteine-rich PDZ-binding protein | -1.08 |
| FAM219A | family with sequence similarity 219, member A | -1.08 |
| ANKMY2 | ankyrin repeat and MYND domain containing 2 | -1.08 |
| RBM28 | RNA binding motif protein 28 | -1.07 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -1.07 |
| EHBP1 | EH domain binding protein 1 | -1.07 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -1.05 |
| SGMS1 | sphingomyelin synthase 1 | -1.05 |
| MIEF2 | mitochondrial elongation factor 2 | -1.04 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | -1.04 |
| ZNF395 | zinc finger protein 395 | -1.03 |
| FEM1C | fem-1 homolog c (C. elegans) | -1.03 |
| ONECUT3 | one cut homeobox 3 | -1.02 |
| UTP11 | UTP11 small subunit processome component | -1.02 |
| FAM133B | family with sequence similarity 133, member B | -1.02 |
| SDC1 | syndecan 1 | -1.01 |
| CEP57 | centrosomal protein 57kDa | -1.01 |
| RPGRIP1L | RPGRIP1-like | -1.01 |
| ZIC2 | Zic family member 2 | -1.01 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -1.0 |
| OLFM2 | olfactomedin 2 | -1.0 |
| MCC | mutated in colorectal cancers | -1.0 |
| ZNF740 | zinc finger protein 740 | -0.99 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.99 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.98 |
| FYTTD1 | forty-two-three domain containing 1 | -0.98 |
| WDR46 | WD repeat domain 46 | -0.98 |
| ATF6 | activating transcription factor 6 | -0.97 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -0.97 |
| DIAPH3 | diaphanous-related formin 3 | -0.97 |
| EPN3 | epsin 3 | -0.96 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.95 |
| SIMC1 | SUMO-interacting motifs containing 1 | -0.95 |
| FNIP1 | folliculin interacting protein 1 | -0.95 |
| FRMPD3 | FERM and PDZ domain containing 3 | -0.94 |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | -0.94 |
| RBM23 | RNA binding motif protein 23 | -0.94 |
| ZCCHC9 | zinc finger, CCHC domain containing 9 | -0.94 |
| PITPNM1 | phosphatidylinositol transfer protein, membrane-associated 1 | -0.94 |
| BCAP29 | B-cell receptor-associated protein 29 | -0.94 |
| HYLS1 | hydrolethalus syndrome 1 | -0.94 |
| SPIDR | scaffolding protein involved in DNA repair | -0.93 |
| EHF | ets homologous factor | -0.93 |
| MTSS2 | MTSS I-BAR domain containing 2 | -0.93 |
| NIFK | nucleolar protein interacting with the FHA domain of MKI67 | -0.93 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.93 |
| CDC25B | cell division cycle 25B | -0.92 |
