GSK-LSD1 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/71522234
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Genes

200 proteins with high or low expression in GSK-LSD1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
SCAPER S-phase cyclin A-associated protein in the ER 0.99
VIM vimentin 0.86
GLDC glycine dehydrogenase (decarboxylating) 0.79
IQGAP2 IQ motif containing GTPase activating protein 2 0.75
CD63 CD63 molecule 0.73
CLN3 ceroid-lipofuscinosis, neuronal 3 0.68
WDR20 WD repeat domain 20 0.68
ANKRD24 ankyrin repeat domain 24 0.64
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.63
CLDN3 claudin 3 0.55
MISP3 MISP family member 3 0.52
MKRN3 makorin ring finger protein 3 0.52
IFITM3 interferon induced transmembrane protein 3 0.51
DUOX1 dual oxidase 1 0.51
TTLL4 tubulin tyrosine ligase-like family member 4 0.48
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 0.48
JPT1 Jupiter microtubule associated homolog 1 0.47
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.46
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 0.46
MIDN midnolin 0.44
CAMTA2 calmodulin binding transcription activator 2 0.44
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.44
C5ORF34 chromosome 5 open reading frame 34 0.43
GAS2L1 growth arrest-specific 2 like 1 0.43
ANKRD22 ankyrin repeat domain 22 0.4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.4
PDZD11 PDZ domain containing 11 0.4
FOXP1 forkhead box P1 0.4
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.4
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.39
MAPK14 mitogen-activated protein kinase 14 0.39
CDK14 cyclin-dependent kinase 14 0.38
APOB apolipoprotein B 0.38
ZNF226 zinc finger protein 226 0.38
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.38
ARFGEF3 ARFGEF family member 3 0.38
DXO decapping exoribonuclease 0.37
CTNND2 catenin (cadherin-associated protein), delta 2 0.36
FGF2 fibroblast growth factor 2 (basic) 0.36
COBL cordon-bleu WH2 repeat protein 0.36
USP46 ubiquitin specific peptidase 46 0.35
SIAE sialic acid acetylesterase 0.35
TM7SF2 transmembrane 7 superfamily member 2 0.35
SAMD12 sterile alpha motif domain containing 12 0.35
C7 complement component 7 0.35
TM7SF3 transmembrane 7 superfamily member 3 0.35
RXRG retinoid X receptor, gamma 0.34
TFCP2L1 transcription factor CP2-like 1 0.34
CENPI centromere protein I 0.33
NCOA1 nuclear receptor coactivator 1 0.33
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.33
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.32
PLAAT3 phospholipase A and acyltransferase 3 0.32
EPHA4 EPH receptor A4 0.32
LIMCH1 LIM and calponin homology domains 1 0.31
NDRG2 NDRG family member 2 0.31
DUSP6 dual specificity phosphatase 6 0.31
FAM102B family with sequence similarity 102, member B 0.31
SOX4 SRY (sex determining region Y)-box 4 0.31
HID1 HID1 domain containing 0.3
RNF166 ring finger protein 166 0.3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.3
CPNE5 copine V 0.3
SIRT2 sirtuin 2 0.3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.3
TLL2 tolloid-like 2 0.3
CADPS Ca++-dependent secretion activator 0.3
CCDC57 coiled-coil domain containing 57 0.29
BMP4 bone morphogenetic protein 4 0.29
RAB3IP RAB3A interacting protein 0.29
DTX3L deltex 3 like, E3 ubiquitin ligase 0.29
GPR108 G protein-coupled receptor 108 0.28
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 0.28
LSM10 LSM10, U7 small nuclear RNA associated 0.28
MSMO1 methylsterol monooxygenase 1 0.28
DPYSL2 dihydropyrimidinase-like 2 0.28
TRIB1 tribbles pseudokinase 1 0.28
KLHL8 kelch-like family member 8 0.27
CCDC77 coiled-coil domain containing 77 0.27
TENT4A terminal nucleotidyltransferase 4A 0.27
HAS3 hyaluronan synthase 3 0.27
HFE hemochromatosis 0.27
PLPP2 phospholipid phosphatase 2 0.27
ANKRD13D ankyrin repeat domain 13 family, member D 0.27
RGS3 regulator of G-protein signaling 3 0.26
TPGS2 tubulin polyglutamylase complex subunit 2 0.26
INVS inversin 0.26
TM2D3 TM2 domain containing 3 0.26
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.26
NBR1 neighbor of BRCA1 gene 1 0.26
SUCO SUN domain containing ossification factor 0.26
NPHP3 nephronophthisis 3 (adolescent) 0.26
HDDC3 HD domain containing 3 0.25
DOP1B DOP1 leucine zipper like protein B 0.25
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.25
SON SON DNA binding protein 0.25
PPIE peptidylprolyl isomerase E (cyclophilin E) 0.25
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.25
IKBIP IKBKB interacting protein 0.25
PDIK1L PDLIM1 interacting kinase 1 like 0.25

low expression

Symbol Name Standardized Value
NAAA N-acylethanolamine acid amidase -1.06
ZFP37 ZFP37 zinc finger protein -0.66
ZNF518B zinc finger protein 518B -0.65
COA5 cytochrome c oxidase assembly factor 5 -0.64
ZFP36 ZFP36 ring finger protein -0.61
ZBED6 zinc finger, BED-type containing 6 -0.61
SFI1 Sfi1 homolog, spindle assembly associated (yeast) -0.61
GRHL2 grainyhead-like 2 (Drosophila) -0.56
KIAA1324L KIAA1324-like -0.52
FRMD6 FERM domain containing 6 -0.51
TMEM51 transmembrane protein 51 -0.49
ZNF503 zinc finger protein 503 -0.48
METTL6 methyltransferase like 6 -0.48
TMEM184A transmembrane protein 184A -0.47
ALG12 ALG12, alpha-1,6-mannosyltransferase -0.45
TMCC1 transmembrane and coiled-coil domain family 1 -0.44
FKTN fukutin -0.43
PTPRD protein tyrosine phosphatase, receptor type, D -0.4
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) -0.4
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -0.4
PPT1 palmitoyl-protein thioesterase 1 -0.39
ZBTB43 zinc finger and BTB domain containing 43 -0.39
PIP prolactin-induced protein -0.38
PXN paxillin -0.38
PBX3 pre-B-cell leukemia homeobox 3 -0.38
FBXL15 F-box and leucine-rich repeat protein 15 -0.37
TACSTD2 tumor-associated calcium signal transducer 2 -0.37
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.36
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.36
KDF1 keratinocyte differentiation factor 1 -0.36
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -0.35
EIF5A2 eukaryotic translation initiation factor 5A2 -0.35
MARCHF6 membrane associated ring-CH-type finger 6 -0.35
DAP death-associated protein -0.34
FOSL2 FOS-like antigen 2 -0.34
C16ORF70 chromosome 16 open reading frame 70 -0.34
RFXANK regulatory factor X-associated ankyrin-containing protein -0.34
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 -0.33
CLASP1 cytoplasmic linker associated protein 1 -0.32
CTHRC1 collagen triple helix repeat containing 1 -0.32
MEX3C mex-3 RNA binding family member C -0.31
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.31
KDM5B lysine (K)-specific demethylase 5B -0.31
LRATD2 LRAT domain containing 2 -0.31
KCTD2 potassium channel tetramerization domain containing 2 -0.31
HECA headcase homolog (Drosophila) -0.31
ZSCAN29 zinc finger and SCAN domain containing 29 -0.3
ITGA7 integrin, alpha 7 -0.3
TATDN2 TatD DNase domain containing 2 -0.3
DENND4A DENN/MADD domain containing 4A -0.29
ZNF57 zinc finger protein 57 -0.29
C15ORF41 chromosome 15 open reading frame 41 -0.29
CTSV cathepsin V -0.28
FBRSL1 fibrosin-like 1 -0.28
METTL9 methyltransferase like 9 -0.28
S100A14 S100 calcium binding protein A14 -0.28
CDC42SE2 CDC42 small effector 2 -0.27
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.27
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -0.27
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.27
MCRIP1 MAPK regulated corepressor interacting protein 1 -0.27
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.26
ELAC1 elaC ribonuclease Z 1 -0.26
ANO8 anoctamin 8 -0.26
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -0.26
MISO1 mitochondrial inner membrane subdomain organizer 1 -0.26
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -0.26
COPRS coordinator of PRMT5, differentiation stimulator -0.26
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -0.26
IRF6 interferon regulatory factor 6 -0.25
BBS2 Bardet-Biedl syndrome 2 -0.25
SESN2 sestrin 2 -0.25
CPVL carboxypeptidase, vitellogenic-like -0.25
PAQR7 progestin and adipoQ receptor family member VII -0.25
NHEJ1 nonhomologous end-joining factor 1 -0.25
MORC4 MORC family CW-type zinc finger 4 -0.25
STK17B serine/threonine kinase 17b -0.25
MTA1 metastasis associated 1 -0.25
F3 coagulation factor III (thromboplastin, tissue factor) -0.24
PSAP prosaposin -0.24
ZYX zyxin -0.24
CRYBG1 crystallin beta-gamma domain containing 1 -0.24
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.24
PEX6 peroxisomal biogenesis factor 6 -0.24
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.24
PRDM10 PR domain containing 10 -0.23
JARID2 jumonji, AT rich interactive domain 2 -0.23
ZNF516 zinc finger protein 516 -0.23
MIER3 mesoderm induction early response 1, family member 3 -0.23
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.23
TTC17 tetratricopeptide repeat domain 17 -0.23
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 -0.23
TRIM15 tripartite motif containing 15 -0.23
WDR77 WD repeat domain 77 -0.23
METTL25 methyltransferase like 25 -0.23
GMIP GEM interacting protein -0.23
DPY30 dpy-30 homolog (C. elegans) -0.23
HAPLN3 hyaluronan and proteoglycan link protein 3 -0.23
EML1 echinoderm microtubule associated protein like 1 -0.22
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.22