GSK1059615 Gene Set

Dataset LINCS KinomeScan Kinase Inhibitor Targets
Category physical interactions
Type small molecule
Description A thiazolidinone that is the 5-{[4-(pyridin-4-yl)quinolin-6-yl]methylene} derivative of 1,3-thiazolidine-2,4-dione. A PI3K inhibitor (Chemical Entities of Biological Interest Ontology, CHEBI_71955)
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Genes

56 kinases inhibited by the GSK1059615 small molecule from the KinomeScan Kinase Inhibitor Targets dataset.

Symbol Name Standardized Value
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.36211
CLK3 CDC-like kinase 3 1.36211
MAPK15 mitogen-activated protein kinase 15 1.36211
STK17A serine/threonine kinase 17a 1.35325
CLK4 CDC-like kinase 4 1.35325
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 1.35325
HIPK2 homeodomain interacting protein kinase 2 1.35325
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 1.35325
CLK2 CDC-like kinase 2 1.35325
IRAK1 interleukin-1 receptor-associated kinase 1 1.34449
SLK STE20-like kinase 1.34449
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 1.33582
STK17B serine/threonine kinase 17b 1.31878
STK33 serine/threonine kinase 33 1.31878
DAPK3 death-associated protein kinase 3 1.31878
AAK1 AP2 associated kinase 1 1.28583
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 1.28583
RIOK1 RIO kinase 1 1.28583
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 1.28583
HIPK3 homeodomain interacting protein kinase 3 1.26991
CSNK2A2 casein kinase 2, alpha prime polypeptide 1.26991
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 1.26991
RIOK3 RIO kinase 3 1.25436
DAPK2 death-associated protein kinase 2 1.2317
CDK7 cyclin-dependent kinase 7 1.2317
BMPR1B bone morphogenetic protein receptor, type IB 1.20983
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 1.20983
MYLK4 myosin light chain kinase family, member 4 1.19568
TSSK1B testis-specific serine kinase 1B 1.19568
CSNK1G3 casein kinase 1, gamma 3 1.18186
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1.18186
CSNK1E casein kinase 1, epsilon 1.16838
DMPK dystrophia myotonica-protein kinase 1.14877
TAOK1 TAO kinase 1 1.1424
CSNK1D casein kinase 1, delta 1.10576
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.09992
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 1.09415
HIPK4 homeodomain interacting protein kinase 4 1.09415
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 1.08283
CIT citron rho-interacting serine/threonine kinase 1.06105
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.04035
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.04035
STK16 serine/threonine kinase 16 1.03535
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 1.01127
GRK7 G protein-coupled receptor kinase 7 1.01127
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 0.993117
PHKG2 phosphorylase kinase, gamma 2 (testis) 0.984392
DAPK1 death-associated protein kinase 1 0.967615
HIPK1 homeodomain interacting protein kinase 1 0.947851
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.940302
CDK8 cyclin-dependent kinase 8 0.93295
AXL AXL receptor tyrosine kinase 0.922275
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.91201
MELK maternal embryonic leucine zipper kinase 0.889549
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.860727
CDK15 cyclin-dependent kinase 15 0.860727