GSK1059615_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.16792
HMGA2 high mobility group AT-hook 2 0.11998
JMJD1C jumonji domain containing 1C 0.109815
PDE4D phosphodiesterase 4D, cAMP-specific 0.0920923
YAP1 Yes-associated protein 1 0.0845762
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0796188
MMP12 matrix metallopeptidase 12 0.073179
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0683851
RAB7A RAB7A, member RAS oncogene family 0.0602158
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0508832
ANK2 ankyrin 2, neuronal 0.0505695
EHBP1 EH domain binding protein 1 0.0500162
NLGN1 neuroligin 1 0.0474039
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0463414
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0458637
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0456737
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0449566
BCHE butyrylcholinesterase 0.0426465
USP34 ubiquitin specific peptidase 34 0.0420416
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0412108
MACF1 microtubule-actin crosslinking factor 1 0.037767
RTN4 reticulon 4 0.0371237
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0369969
ASPH aspartate beta-hydroxylase 0.0363324
VMP1 vacuole membrane protein 1 0.0342229
DENND5A DENN/MADD domain containing 5A 0.0331565
MTAP methylthioadenosine phosphorylase 0.0329835
PDGFC platelet derived growth factor C 0.032969
NPC1 Niemann-Pick disease, type C1 0.0323282
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0321075
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0320133
ZFAND3 zinc finger, AN1-type domain 3 0.0308578
FNIP1 folliculin interacting protein 1 0.0304047
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0293282
NABP1 nucleic acid binding protein 1 0.0288204
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0282774
MCL1 myeloid cell leukemia 1 0.0277086
RIMS2 regulating synaptic membrane exocytosis 2 0.0275639
TAS2R14 taste receptor, type 2, member 14 0.0269708
USP9X ubiquitin specific peptidase 9, X-linked 0.0266406
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026434
SETX senataxin 0.0263328
ADIPOR2 adiponectin receptor 2 0.0259235
TMEM41B transmembrane protein 41B 0.0257084
TPM3 tropomyosin 3 0.0253372
EDARADD EDAR-associated death domain 0.0252421
CCNG2 cyclin G2 0.0250707
NBEAL1 neurobeachin-like 1 0.0247645
RABGAP1L RAB GTPase activating protein 1-like 0.0247366
SLC38A2 solute carrier family 38, member 2 0.0245036
GOLGB1 golgin B1 0.0243127
LPP LIM domain containing preferred translocation partner in lipoma 0.0242942
DNAH14 dynein, axonemal, heavy chain 14 0.0237666
SPATS2 spermatogenesis associated, serine-rich 2 0.02376
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0237359
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0235994
TRIO trio Rho guanine nucleotide exchange factor 0.0235184
IPO7 importin 7 0.0233316
CEP112 centrosomal protein 112kDa 0.0232746
N4BP2L2 NEDD4 binding protein 2-like 2 0.0231235
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0230608
DST dystonin 0.0225807
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0224656
NHSL1 NHS-like 1 0.0221646
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0218988
PCBP2 poly(rC) binding protein 2 0.0217682
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0214323
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0214159
ZSWIM6 zinc finger, SWIM-type containing 6 0.0213431
INTS6 integrator complex subunit 6 0.0212955
XPOT exportin, tRNA 0.0210255
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0209984
NIBAN1 niban apoptosis regulator 1 0.020916
EXOC6B exocyst complex component 6B 0.0208101
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0207796
ANKRD12 ankyrin repeat domain 12 0.0207228
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0206032
AFF4 AF4/FMR2 family, member 4 0.0203771
DOCK3 dedicator of cytokinesis 3 0.0201787
MAP1B microtubule-associated protein 1B 0.0200846
HSPA8 heat shock 70kDa protein 8 0.0199691
ZEB1 zinc finger E-box binding homeobox 1 0.0199585
ZBTB20 zinc finger and BTB domain containing 20 0.0199422
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0199013
CUX1 cut-like homeobox 1 0.0197534
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0197431
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0197106
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0194364
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.019348
PRKCE protein kinase C, epsilon 0.019323
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0193138
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0192964
DSCAM Down syndrome cell adhesion molecule 0.0190673
DPYD dihydropyrimidine dehydrogenase 0.019032
EXOC4 exocyst complex component 4 0.019003
CANX calnexin 0.0188913
EIF5 eukaryotic translation initiation factor 5 0.0188166
MSRB3 methionine sulfoxide reductase B3 0.0188033
BPTF bromodomain PHD finger transcription factor 0.0186253
NAV3 neuron navigator 3 0.0184484

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.26114
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108211
TMSB10 thymosin beta 10 -0.105901
AREG amphiregulin -0.0827056
FTL ferritin, light polypeptide -0.074624
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0594428
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0509985
PTMA prothymosin, alpha -0.0499268
ANXA1 annexin A1 -0.0495209
MYL12B myosin, light chain 12B, regulatory -0.0473657
CNRIP1 cannabinoid receptor interacting protein 1 -0.0381247
PFN1 profilin 1 -0.0368479
KIF5B kinesin family member 5B -0.0350832
RPS3 ribosomal protein S3 -0.0338081
YBX3 Y box binding protein 3 -0.0336436
RPS19 ribosomal protein S19 -0.0325433
EDN1 endothelin 1 -0.0313682
RPL36 ribosomal protein L36 -0.0311358
RPL8 ribosomal protein L8 -0.0305053
RPL19 ribosomal protein L19 -0.0300746
RPL23 ribosomal protein L23 -0.0298952
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0294906
YBX1 Y box binding protein 1 -0.0291961
RPLP1 ribosomal protein, large, P1 -0.0290516
RPS8 ribosomal protein S8 -0.0285078
HSPB1 heat shock 27kDa protein 1 -0.0277746
RPL35A ribosomal protein L35a -0.0271649
H1-0 H1.0 linker histone -0.0270288
BIRC3 baculoviral IAP repeat containing 3 -0.0267186
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0266381
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0262498
ATP5F1B ATP synthase F1 subunit beta -0.0260214
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0260091
NAP1L1 nucleosome assembly protein 1-like 1 -0.0254821
CXADR coxsackie virus and adenovirus receptor -0.0253118
RPS6 ribosomal protein S6 -0.0250145
RPS24 ribosomal protein S24 -0.0244284
RPL26 ribosomal protein L26 -0.023386
GCG glucagon -0.0230977
RPLP2 ribosomal protein, large, P2 -0.0227872
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0220308
HMGA1 high mobility group AT-hook 1 -0.021958
WDR45B WD repeat domain 45B -0.0219314
TPT1 tumor protein, translationally-controlled 1 -0.0213449
RPS27A ribosomal protein S27a -0.0212735
TPI1 triosephosphate isomerase 1 -0.0212028
RPL12 ribosomal protein L12 -0.0210157
PEG10 paternally expressed 10 -0.0203407
MGAT4C MGAT4 family, member C -0.0203132
TOP2A topoisomerase (DNA) II alpha 170kDa -0.020188
CCND1 cyclin D1 -0.020008
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.019952
LDHB lactate dehydrogenase B -0.0195526
RPL34 ribosomal protein L34 -0.0190021
TMEM123 transmembrane protein 123 -0.0189498
RPL11 ribosomal protein L11 -0.0186369
KDM3A lysine (K)-specific demethylase 3A -0.0185522
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0185024
RPS16 ribosomal protein S16 -0.0184381
PGK1 phosphoglycerate kinase 1 -0.0183502
RPL38 ribosomal protein L38 -0.0182438
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0181923
ECT2 epithelial cell transforming 2 -0.0178912
GNAS GNAS complex locus -0.0176356
LMAN1 lectin, mannose-binding, 1 -0.0175316
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0174533
NACA nascent polypeptide-associated complex alpha subunit -0.0174402
VDAC1 voltage-dependent anion channel 1 -0.0172496
LOC112694756 uncharaterized LOC112694756 -0.0170569
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.017052
RPL32 ribosomal protein L32 -0.0170388
SEPTIN7 septin 7 -0.0169685
CLDN1 claudin 1 -0.0168527
RPL28 ribosomal protein L28 -0.0166683
BTG3 BTG family, member 3 -0.0166164
HMGB2 high mobility group box 2 -0.0165572
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0165538
RAD21 RAD21 homolog (S. pombe) -0.0164832
RACK1 receptor for activated C kinase 1 -0.0163695
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0163185
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0162054
RPS14 ribosomal protein S14 -0.0160973
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0156229
SMC4 structural maintenance of chromosomes 4 -0.0156107
ATP5F1E ATP synthase F1 subunit epsilon -0.0153136
RPS29 ribosomal protein S29 -0.015249
RPS21 ribosomal protein S21 -0.0150638
CELF2 CUGBP, Elav-like family member 2 -0.0150177
WSB1 WD repeat and SOCS box containing 1 -0.0150104
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0150001
RPS5 ribosomal protein S5 -0.0149339
ZNF292 zinc finger protein 292 -0.0149008
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0148758
R3HDM1 R3H domain containing 1 -0.0147872
CCDC88A coiled-coil domain containing 88A -0.0147802
RPL31 ribosomal protein L31 -0.0147579
HMGB1 high mobility group box 1 -0.0147132
NCOR1 nuclear receptor corepressor 1 -0.0146536
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0146209
RPL18 ribosomal protein L18 -0.0143949